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TPA로 야기된 HL-60 세포의 기질부착 저해작용을 이용한 Protein Kinase C 저해 생약의 탐색
김선희,안종석,김삼용,유관희,안병준 충남대학교 약학대학 의약품개발연구소 1993 藥學論文集 Vol.9 No.-
Thirty-five kinds of herbal drugs, believed to be active for treatment of tumors, were selected as the experimental materials for observing their effects on TPA-induced adherence of HL-60 cell and activity of protein kinase C. They were extracted with ethyl ether(E) and ethyl acetate(EA), methanol(M) in sequence. Among the extracts, Sophorae Flos(EA), Paeoniae Radix(EA), Equisetum hiemale(EA), Phellodendri Cortex(E, EA), Mori Cortex radicis(EA), Ferula assafoetida(E, EA), Sophora subprostrata(EA, M) and Cnidium monnieri(E) inhibited the TPA-in-duced adherence of HL-60 cell more than 50% and Sophorae Flos(E, EA, M), Paeoniae Radix(E, EA, M), Eguisetum hiemale(E), Phellodenri Cortex(E,H), Mori Cortex radicis(M), Ferula assafoetida(M), Sophora subprostrata(EA, M), Cnidium monnieri(M) and Artemisia argyi(M) showed inhibiting effects on the activity of protein kinase C more than 50%. The extracts showing good inhibiting effects on the adherence and enzyme activity were Sophorae Flos(EA), Paeoniae Radix(EA), Phellodendri Cortex(E), Sophora subsprostrate(EA) and Equisetum hiemale(EA).
실험적 뇌지주막하출혈 토끼에서의 Malonate 농도 측정
김재중,하영수,백승렬,장정순,김유삼 대한신경외과학회 1995 Journal of Korean neurosurgical society Vol.24 No.10
Malonate is regarded as a reversible competitive inhibitor of succinate dehydrogenase and malate transport in the Krebs cycle and showed neurotoxicity by persistent NMDA receptor activation due to inhibition of ATP production and glutamate utilization. However, little was known about its biological effects and the range of normal concentration of malonate in central nervous system. In order to understand the relationship between malonate and vasospsasm, malonate concentrations in rabbit model of experimental subarachnoid hemorrhage were measured at 0, 4th, and 7th day following SAH in serum, cerebrospinal fluid, and urine using malonyl-CoA synthetase. The results were as follows : 1) Malonate level is increased significantly in serum at the 4th day after subarachnoid hemorrhage that followed by vasospasm(p<0.01). 2) CSF malonate concentration tends to increase at post-SAH 7th day but statistically not significant. 3) The change of urine malonate concentration is not significant. These results suggest that early increase of serum malonate level is significant because clinically important vasospam begin from the fourth through the seven day after hemorrhage. The increased level of serum malonate at this time is due to impairment of cellular metabolism following delayed cerebral ischemia and may influence to development of vasospasm. In conclusion, the measurement of serum malonate concentration after subarachnoid hemorrhage is one of possible candidates for the early diagnosis of vasospasm.
Sam Yu 서울대학교 사회발전연구소 2012 Journal of Asian Sociology Vol.41 No.2
This article is concerned with two responses to recent discourses on the classification of welfare regimes. The first is a rising interest in constructing different types of typologies based on different criteria such as health care decommodification, education decommodification, and defamilisation. The second response is the concern that East Asian countries are under-represented in the 18 OECD members studied by Esping- Andersen (1990). This article contributes to these two responses through the implementation of two analytical tasks. The first task is to expand the health care decommodification index developed by Bambra (2005a) to cover the 18 OECD members studied by Esping-Andersen (1990) and five additional East Asian countries. The second task is to demonstrate how the health care decommodification index can be used to contribute to the analysis of the view of Walker and Wong (2004, 2005) on the marginalisation of East Asian countries in comparative welfare studies.
The contributions of welfare typologies to international social work practices
Sam Wai Kam Yu 한국사회복지학회 2018 Asian Social Work and Policy Review Vol.12 No.2
This paper is concerned with the link between studies of welfare typologies and studies of international social work. Its objective is to show how welfare typologies could be used to strengthen the role of international social work practices to support international exchange of ideas on welfare issues. To meet this objective, three analytical tasks are implemented. The first task is to show that professional imperialism could weaken the potential of international social work practices to promote international exchange of ideas on welfare issues. The second task is to discuss the importance of welfare typologies in supporting the development of international social work by challenging professional imperialism. The third task is to discuss a research project on a defamilization typology. This project provides empirical evidence of the contributions made by welfare typologies to international social work practices.
Studying the Health Care Systems in Seven East Asian Countries by the Cluster Analysis
Sam Yu 서울대학교 사회발전연구소 2014 Journal of Asian Sociology Vol.43 No.1
Since Esping-Andersen (1990) presented the “three worlds of welfare capitalism” thesis based on his study of the OECD countries, there have been debates on whether East Asian countries form a separate world of welfare capitalism or not. The objective of this article is to demonstrate how the study of the health care systems in six East Asian countries (Hong Kong, Singapore, South Korea, Taiwan, Malaysia, and Thailand) plus Japan contributes to the debate on the existence of a distinct welfare regime in East Asia. This objective is met by mainly using the evidence provided by health care typologies to test two hypotheses: 1) There are significant similarities between some of the health care systems in eleven OECD countries and those in Hong Kong, Taiwan, Thailand, South Korea, Malaysia, and Singapore, and 2) there are significant differences in the health care systems between Hong Kong, Taiwan, Thailand, South Korea, Malaysia, and Singapore.