민머귀나무果皮의 Coumarin 成分硏究 (II)

李映鐘,林錫麟 大田大學校 1988 論文集 Vol.7 No.1

This experirnent was carried out to study the constituents of coumarin in the pericarpium of Zanthoxylum ailanthoides S.et.Z. inermis Nakai. Three substances (Ⅰ-Ⅲ) were obtained and identified by GLC, IR, NMR methods, The results showed that subs. I identified as sterol, subs. Ⅱ was bergapten (mp.187~188˚. ?? ) subs. Ⅲ was isopimpinellin (mp.108~109˚, ?? ).

고로슬래그를 굵은골재로 사용한 콘크리트강도에 관한 연구

김영인,고창옥,이채규,양승현 조선대학교 국토개발연구소 1994 국토개발연구 Vol.14 No.2

Blast furnace, by-product of iron industry has widely used as reclamation materials for pavement or harbour construction. The studies which make blast furnace slag use as aggregates for concrete have being actived owing to natural aggregates insufficiency. In order to use air cooled blast furnace slag as a coarse aggregate for concrete which was fixed to 440kg, 400kg, 360kg, 320kg, 280kg, 240kg of cement content were performed. This study is aimed to ascertain the feasibility of utilizing the concreate with crushed slag aggregates and to find specific properties such as slump air content, compresive strength, tensile strength, bending strength. The results of this study are summarised as follows; 1. On the base of 320kg of unit cement weight the strength according to each dry day are similar in the condition of 45% of w/c whereas in the condition of 50% of w/c the strength of 7-days are similar, but the strength of 28-days are different. 2. In the relation of δ25 - c/w, the strength of slag concrete is greater than that of crushed storn concrete in condition of epual c/w except 400kg/㎥. 3. Slag of concrete as aggregate is destoryed with mortar. 4. The relation of δ28 and tensile strength is very good(γ = 0.8), the equation of regression analysis is δt= 0.63+0.00598 × 28. 5. The reation of bend strength and w/c is liner(γ = 0.72) the equation of regression analysis is δb=80-0.69w/c. 6. It must be care to abtain equal workability to natual aggregate concrete because the change of water absorption is greate. The water content of slag concrete is more than that of crushed storn concrete to obtain the same workability. It must be careful to use blast furnace slag as a coarse aggregate for concrete. And after investgating the quality of demended concrete carefully, real mixing work must be done.

초등과학 탐구수업 지도자료의 활용 실태

신영준,장명덕,배진호,권난주,여상인,이희순,노석구 한국초등과학교육학회 2005 초등과학교육 Vol.24 No.2

In this study, we had tried to present a plan for improving the actual conditions of practical utilization of teaching material for 6th grade science developed by Ministry of Education & Human Resources Development and distributed to all elementary schools in Korea. Also we presented ways of better utilization of the teaching material after investigating the actual conditions of practical utilization. A survey was made to investigate and collect all data in the major metropolitan cities, the Kangwon, Chungcheong, Honam, and Kyeongsang area, respectively. We surveyed 316 6th grader teachers to investigate the actual conditions of distribution and utilization of teaching material as a general research. In addition, we surveyed 46 teachers to investigate the organization and content of teaching material as a particular research. The results are as follows. First, the teaching material was not approximately transmitted and kept to 6th grader teachers. Second, the utilization guide was not made. Third, it was reported that the thematic divisions of teaching material was a strong point, but the less detailed experiment manual was a weak point. Fourth, the consideration of content difficulties and simplicity was necessary to improve the material. Fifth, additional items should be included in the introductory presentation, convenience of reorganization, activity material causing learning interest, guidance of substitution experiment, and more concrete notice of experiment activity. Finally, there were positive responses of more than 4.0 point of Likert scale (1 to 5 point scale) in detail investigations of thematic items, which could have possibility that the teaching material was helpful to elementary school science field.

프로그램을 이용한 합성교량의 설계에 관한 연구

김영인,박길현,양승현 조선대학교 국토개발연구소 1996 국토개발연구 Vol.16 No.1

This study is experts system about design of composite bridge that brings a simple working system and an outstanding application. By knowledge base involved deep knowledge and surface knowledge, user can execute the design of floor span and main girder and investigation stress on the ground of composite precess. Opening the program, user can notice the minium number of input-data and the easy amendment at pertinent picture. The study is the object of uninitialed education and preservation efficiency of work while the expert has been absent.

초등과학영재의 성격특성과 협동학습에 대한 인식

여상인,김영신 이화여자대학교 사범대학 교육과학연구소 2005 교육과학연구 Vol.36 No.2

이 연구의 목적은 초등과학영재의 성격특성과 협동학습에 대한 인식을 조사하는 것이다. 이 연구를 위하여 대학부설 과학영재교육원의 초등학교 과학영재 17명을 대상으로 성격특성검사와 협동학습 태도검사를 실시하였고, 수업 중에 교사에 의한 관찰, 동료에 의한 상호평가를 실시하였다. 연구 결과 주요 성격특성에서 대부분의 초등과학영재는 정서적 안정성, 지적 성취성, 유순성, 외향성, 성실성에서 높은 특성을 나타내었다. 이러한 특성을 가진 영재 학생들은 협동학습을 긍정적으로 인식하는 경향이 있었고, 협동학습에서 구성원과 활발하게 상호작용하였다. 특히, 원격교육과 주말교육의 협동학습에서 활발하게 상호작용하는 과학영재는 세부적인 성격특성에서 탐구성, 성취성, 순응성에서는 점수가 높게 나타났고, 공격성, 불안수준, 자기주장, 자제력에서는 점수가 낮았다. 연구 결과를 토대로 대학부설 과학영재교육원에서의 초등과학 영재교육 프로그램 운영의 문제점 중의 하나인 시간과 공간의 한계를 극복할 수 있는 대안으로 이 연구에서 적용된 웹에서의 상호작용이 첨가된 협동학습을 제안하였다. The purpose of this study is to examine the perceptions of cooperative learning and personal characteristics of science-gifted elementary school students. To this study, a personality test, class observation, and peer evaluation were administered to 17 gifted students attending a science gifted education center attached to a university. As for the result, most of the gifted in science showed high levels of extroversion, sincerity, emotional stability, intellectual accomplishment, and agreeableness in the main personality characteristics. Also, they positively interacted with their peers during the cooperative learning. Especially, the gifted students with more active interaction in the distance and weekend education showed strong characteristics in terms of exploration, accomplishment, adaptation, while they showed weak characteristics in terms of aggressiveness, anxiety, self-assertive, self-control. It suggested the advantages to be acquired from cooperative learning added web-based distance education, as the alternative teaching method, to overcome the limits in the matter of time and space that existed in the current gifted education.

간선도로 돌발상황 검지기법 개발

이영인,황준환 서울시립대학교 도시과학연구원 2000 도시과학논총 Vol.26 No.1

In this research, a new incident detection algorithrn for urban streets is developed. Incidents, termporary events that reduce the capacity of roadway segments and cause delays, are a major cause of urban roadway congestion. The performance of the proposed algotithm, California algorithm, and Neural Network technique were evaluated on the basis of their operating characteristic curves. The evaluation results revealed that the proposed algorithm can identify incidents more effectively than other models. Detection rate(DR) and False alarm rate(FAR) of the proposed model are 92.1%, and 7.2% respectively, and at all levels of DR and FAR, the proposed algorithm is superior to the California algorithm and Neural Network. Test results with the proposed algorithm show that the area of uncertainty decreases when incident index is applied. The distribution curves of the proposed algorithm decreases when incident index is applied. The distrbution curves of the proposed algorithm are almost separated so that most of the incident could be detected accurately.

정신분열병과 N-Methyl-D-Aspartate 수용체 유전자와 연관된 VNTR 표지자인 D9S158 다형성의 연합

김종원,채영규,정은기,김길숙,박강규,이영호,최인근,양병환,한진희 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

정신분열병과 NMDA 수용체와 연관된 D9S158 유전적 표지자와의 연관성을 알아보기 위해 75명의 정신분열병 환자군과 87명의 정상대조군을 대상으로 중합효소연쇄반응을 이용하여 연합연구를 시행하여 다음과 같은 결론을 얻었다. D9S158 유전좌위에는 모두 8개의 대립유전자가 있었고, 각 대립유전자는 cytosine-adenine염기가 반복되는 217염기쌍에서 233염기쌍의 형태였다. 먼저 정신분열병 환자와 정상대조군의 대립유전자의 빈도를 비교해 본 결과 통계적으로 유의한 차이를 보이지 않았다(p〉.05). 환자군을 좀 더 동질적으로 만들기 위해 정신분열병의 가족력 유무, 음성 및 양성증상, 연성신경학적 징후, DSM-IV 임상아형에 따라 환자군을 나누어 대립유전자의 빈도를 비교해 본 결과, 특정 임상양상과 관련이 있는 대립유전자를 발견하지 못하였다. 결론적으로 본 연구에서는 D9S158 유전좌위와 정신분열병의 연관성을 입증하지 못하였으나 NMDA 수용체 유전자주위의 다른 표지자나 좀 더 유전적으로 동질한 환자군을 대상으로 한 추후연구가 필요할 것으로 생각된다. An association study with Korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D9S158 polymorphism and schizophrenia using polymerase chain reaction. Eight different alleles of a dinucleotide polymorphism on D9S158 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K) and DSM-IV diagnostic subtypes. Then we compared the frequencies of alleles among subgroups of clinical phenotypes, and there were no significant differences between subgroups(p〉.05). Although our findings fail to provide an evidence of association between schizophrenia and D9S158 locus, further investigation of other loci that are linked to NMDA receptor gene may be needed in genetically homogeneous subgroups of schizophrenia.

FREQ模型을 利用한 都市高速道路 램프미터링 技法의 效果分析方法論 定立 : 올림픽 都市高速道路를 中心으로 Case Study of Olympic Freeway

金永燦,李榮寅 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

Peak-period congestion is a frequent occurence on many freeways. This paper describes the testing, evaluatation, calibration of FREQ, the optimization and simulation program fo- freeway corridor, and its use for evaluating the effectiveness of urban freeway ramp-metering strategies Olympic Freeway in Seoul was selected as study site. Evaluatin and calibration were accomplished by comparing simulation results with actual field data of the study freeway. The testing and calibration process revealed that the program is reliable and can be effectively used for simulating ramp-metering strategies with reasonable accuracy. Study results showed that the travel-speed increase of 28 percents throughout the freeway corridor including parallel routes was expected by introducing freeway traffic control system. The reduction of fuel consumption and emmision was also gained as supplimentary effects. The evaluation process presented in this paper can also be used for evaluating various strategies for imporoving freeway traffic flow, such as ramp closures, HOV prior1ity lane, and geometric improvements.

정신분열병과 Neurotensin 수용체 유전자 다형성의 연합 연구

이유상,김형배,한진희,채영규,이정식,이혜순,주연호,김형섭,최인근,양병환 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.6

연구목적: Neurotensin(NT)은 NT수용체와 결합하여 그 효과를 나타내는 neuromodulator 혹은 neurotransmitter로서 대뇌에서 도파민의 분비를 조절하는데 중요한 역할을 한다. 근래의 연구에 의하면 NT와 그 수용체는 대뇌에서 항정신병 약물의 효과를 매개하는 것으로 생각되고 있으며 약물치료를 받지 않은 정신분열병 환자의 뇌척수액에서 NT의 양이 적으로 보고되고 있어 이들은 정신분열병과 깊은 관련을 가지고 있을 것으로 추정된다. 최근 NT수용체의 유전자의 3`인접영역에서 정보가치가 높은 4 염기반복 다형성이 발견되어 이를 유전 표지자로 하여 정신분열병과의 연합을 알아보았다. 방 법: 서로 혈연관계에 있지 않은 정신분열병 환자 120명(남자 91명, 여자 29명)과 정상 대조군 106명(남자 84명, 여자 22명)을 대상으로 하였다. PANSS를 사용하여 양성 및 음성을 알아보았다. 말초혈액에서 DNA를 분리한 후에 중합효소연쇄반응을 사용하여 3`인접영역에 있는 4 염기 반복 다형성을 증폭하였고 silver staining한 후에 유전자형을 관찰하였다. chi-square 검증과 Bonferroni`s correction을 사용하여 환자군과 정상 대조군간의 대립유전자 빈도의 차이를 알아보았다. 또한 양성 및 음성 환자군으로 나누어 차이를 알아보았다. 결 과: 총 23개의 대립유전자가 관찰되었으며, 399bp의 대립유전자(A10)의 빈도가 환자군보다 정상대조군에서 통계적으로 유의하게 높았다(χ²=16.49, df=1, p<0.001). 음성 정신분열병 환자군과 정상대조군 사이의 비교에서는 정상대조군의 A10의 빈도가 환자군보다 유의하게 높았다(χ²=21.33, df=1, p<0.001). 성별 비교에서 남자 정신분열병 환자군은 대조군에 비하여 A10의 분포가 유의하게 적었다. (χ²=13.71, df=1, p<0.001) 결 론: NT 수용체 유전자와 정신분열병사이에 음성연합이 관찰되었다. NT 수용체 유전자가 일부 정신분열병의 발병과정에서 확실하지는 않지만 어떤 종류의 보호기능을 할 수도 있다는 것을 암시한다. Objectives: Neurotensin(NT), of which functions are evoked by its interaction with neurotensin receptors(NTR), coexists with mesolimbic dopamine and regulates endogenous dopamine release. Recent studies have shown that NT with NTR exerts neuroleptic-like activity within the central nervous system and may play an important role in the pathogenesis and in the treatment of schizophrenia. We have examined the gentic association between schizophrenia and tetranucleotide repeat polymorphism in the 3-flanking region of the NTR gene to investigate the possible contribution of the NTR gene to the schizophrenia susceptibility. Methods: Among 23 alleles identified, the subjects were 120 patients(male 91, female 29)with schizophrenia and 106 normal healthy controls(male 84, female 22). They were unrelated native Korean. PANSS was used to determine positive or negative subgroup in the schizophrenic patients. Using polymerase chain reaction and polyacrylamide gel electrophoresis, tetranucleotide repeat polymorphism(CCTT and CTT) in the 3`-flanking region of NTR gene was observed. For a comparison of NTR gene`s allelic frequencies between patients with schizophrenia and normal healthy controls, chi-square test and Bonferroni`s correction was performed. Results: The frequency of A10 allele(base pair size=399)was significantly higher in normal healthy controls than schizophrenia(χ²=16.4902, df=1, p<.000). In the comparison between schizophrenic patients with negative symptoms and normal controls, the frequency of A10 allele was significantly higher in normal healthy control subjects than patients with schizophrenia(χ²=21.33, df=1, p<0.001). In the case of male, the frequency of A10 allele of schizophrenia was significantly higher than normal controls(χ²=13.71, df=1, p<0.001). Conclusions: NTR gene was negatively associated with schizophrenia. NTR gene`s tetranucleotide repeat polymorphism may provide some protective function against schizophrenia.

24주간 추적하는 임상 연구에서 한국인 남자 알코올 의존 환자의 비재발률

강철중,김성곤,남궁기,조동환,이병욱,최인근,최용성,박성봉,제영묘,김현경,김성연 大韓神經精神醫學會 2006 신경정신의학 Vol.45 No.1

Objetives : In order to provide useful data tbr the further clinical studies with Korean alcohol-dependent patients, enrollment and non-relapse rates were investigated while alcohol-dependent patients wcre followed up for 24 weeks. Methods : The subjects of this study were alcohol-dependent male patients who, for the first time, visited a hospital among 3 groups of hospitals, University Hospital, General Hospital or Mental Hospital, or those who needed to be followed up after discharge from those hospitals. After assigning 12 subjects to each hospital, we investigated enrollment and non-relapse rates while cognitive-behavioral therapy and pharmacotherapy were provided. Results : 1) Forty-eight patients were enrolled and the rate of enrollment was 36.4%. The enrollment rate in the University Hospital group was 52.1%, in the General Hospital group 50.0%. and in the Mental Hospital group 10.4%. 2) In 48 patients, non-relapse rate was 27.1% at 12 week and 18.8% at 24 weeks after starting follow-up. It was 24.4% and 20.0% at 12 and 24 weeks, repectively, in the University Hospital group while the General Hospital group showed 33.3% and 16.7%, respectively, and the Mental Hospital Group showed 20.0% at both 12 and 24 weeks. Conclusion : These results provide important data for further clinical studies of Korean alcohol-dependent patients.