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최영묵(Young-Mook Choi) 한국언론정보학회 2012 한국언론정보학보 Vol.59 No.3
리영희 선생은 한국 현대사에서 가장 영향력이 있었던 지식인 중의 한사람이다. 리 선생은 지난 반세기 동안 한국사회에서 ‘사상의 은사’ 혹은 ‘의식화의 원흉’이라는 극단적 평가를 받았다. 리영희 철학과 언론사상의 핵심은 휴머니즘과 자유, 지식인의 사회적 책임이라고 정리할 수 있다. 리영희 선생은 평생 언론사 기자, 언론학 교수로 살았지만 리 선생의 언론활동, 언론실천, 언론사상 등에 대한 논의는 아직 초보 수준에 머물러 있다. 이 논문에서는 언론인, 언론학자로서 리영희 선생의 언론 사상과 실천 활동을 정리하고자 했다. 리 선생의 ‘언론인 50년’을 관통하는 핵심 의제는 사상의 자유를 위한 투쟁, 이론과 실천의 통일로서의 글쓰기, 언론과 언론인 비판이었다. Lee Yeung-Hi is one of the most influential intellectuals in the modern history of Korea. Lee Yeung-Hi was evaluated as “the Teacher of thought” or “Culprit of consciousness” over the past half century in Korea. At the core of Lee Young-Hi’s philosophy and idea is humanism, freedom of express and social responsibility of intellectuals. Lee Yeung-Hi lived lifelong journalists, journalism professors. But the study of Lee Yeung-Hi’s media activities and media practice, ‘Idea of Journalism’ are insufficient. This paper has deeply studied the ‘Idea of journalism’ and ‘Writing of social practise’ of professor Lee.
Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.
Lee, Sang-Mook,Lee, Young-Joo,Lee, Jae-Wook The Polymer Society of Korea 2007 Macromolecular Research Vol.15 No.1
This study investigated the effect of ultrasound irradiation on the blend of poly(lactic acid) (PLA) and poly(butylene adipate-co-terephthalate) (PBAT). The blends of PLA/PBAT(50/50) (PBAT50) were prepared in a melt mixer with an ultrasonic device attached. Thermal, rheological, and mechanical properties, morphology, and biodegradability of the sonicated blends were analysed. The viscosity of the sonicated blends was increased by the ultrasound irradiation owing to the strong interaction. The morphology of the sonicated blends was significantly dependent on the duration o the ultrasound irradiation. For PBAT50, the phase size reduction was maximized when the blends were ultrasonically irradiated for 30 sec. At longer duration of ultrasound irradiation, the PBAT phase underwent flocculation. Measurement of the tensile properties showed an increased breakage tensile stress and an enhanced Young's modulus when the blends were properly irradiated. This improvement was ascribed to better adhesion between the PLA matrix and the PBAT domain and to better dispersion of the PBAT phase. However, the tensile properties were maximized after excessive energy irradiation, which was ascribed to an emulsifying effect leading to coalescence of the PBAT phase. Impact strength was increased to reach a peak with the ultrasound irradiation, and was higher than the untreated sample for all sonicated samples due to the difference of failure mechanism between the tensile test and the impact test.
백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구
송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1
To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.
고광묵,김영일,양재헌 우석대학교 생명과학연구소 1998 생명과학연구소 논문집 Vol.2 No.-
We prepared alginate beads containing β-carotene which could be a gel at low pH and could be swell at weak alkali in order to protect the degradation of β-carotene in the stomach. β-carotene was incorporated into the beads up to 95 %. The release rate of β-carotene was affected by the concentration of Calcium chloride, contents of β-carotene and surfactants. When β-Carotene incorporated into alginate beads it could be delivered in the intestine.
Immunoturbidimetric assay를 이용한 철결핍 및 만성질환에 의한 빈형에서 가용성 트란스페린 수용체 측정의 진단적 유용성
박영진,박건,박상묵,최영화,장숙진,문대수 조선대학교 2001 The Medical Journal of Chosun University Vol.26 No.2
Background : Soluble transferrin receptor (sTfR) has been known to be a good marker for evaluating iron deficiency anemia (IDA) and anemia of chronic disease (ACD) without bone marrow aspiration. The sTfR has been measured with enzyme linked immunosorbent assay (ELISA). However, Immunoturbidimetric (IT) assay for measuring sTfR was recently introduced. Author try to use clinical application and measure sTfR using IT assay. Methods : IDA group (26 patients, ferritin < 12.0 μg/L), ACD group (20 patients, ferritin > 60.0 μg/L), Iron depletion and control group (30 normal persons) were classified. Hemoglobin, RBC indices, serum iron, serum transferrin, serum ferritin, total iron binding capacity were measured and calculated. Serum sTfR measured with IT assay using automated chemical analyzer. Those sTfR levels of each other group were compared. The correlations between iron parameters and sTfR were studied in other group. Results : The sTfR receptor levels were prominently higher in IDA group (5.2 ± 2.2 nmol/L) than in ACD group (1.1 ± 0.8 nmol/L), and normal control group (1.4 ± 0.3 nmol/L). The sTfR levels between ACD group and control group was not different. The correlations between sTfR and Hb levels in IDA group was in good inverse line. Other iron parameters and sTfR levels were not correlated in other groups. Conclusion : The results indicate that IDA can be differentiated efficiently from ACD with IT method to measure sTfR.