정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

급성 뇌졸중 환자의 경동맥 죽상경화반 표면 불균일성과 뇌졸중 예후 인자 및 기능적 예후의 연관성 평가: 예비 보고

박영태, 이혜림, 여민주, 김지선, 이성현, 이상수, 신동익 충북대학교 의학연구소 2016 忠北醫大學術誌 Vol.26 No.2

본문참고

Mn-nodule의 선광에 관한 연구(제1보)

김익수,박동기,성일용,김승혁,엄제현 三陟大學校 2000 論文集 Vol.33 No.1

For the purpose of reserching the floatability of Managanese-nodule, the test was proformed by means of Zeta potential measuring and the flotation experiment for 10Å Manganite. The flotation condition in the flotation experiment were as follow. sample : Todorokite (0.3gr) sample size : 65 mesh ~ 200 mesh condition size : 10 min flotation time : 4 min air amount : 20 ㎖/min promoter : D.A.cl, S.D.S. PH regular : Hcl, CaO From the test the flotation result were summerized as follow. 1. The isoelectric point of 10Å Manganite in the Zeta potential measuring was pH 4.3. 2. The floatability of 10Å Manganite was 80% as a function of pH5 using 10mg/ℓ of D.A.cl. 3. The recovery of 10Å Manganite was best when the floatability of 10Å Manganite was 90% as using D.A.cl 80mg/ℓat PH 2.7.

아파트 거주의향 및 선호경향에 관한 연구 : 구미시 중·소형 아파트 구매예정자를 대상으로

신소영,박세문,김익환 금오공과대학교 2005 論文集 Vol.26 No.-

This paper analyzes the living intention and preference tendency of the potential buyers for small and medium sized apartment houses in Gumi. The analysis results are summarized as follows; 1) About 90% of pollees have intention to move into apartment houses, and prefer a subcenter of Gumi city as residence area, which provides convenient living environment and great nature environment. 2) Most of them want to buy aparbnent houses in ordre to own their houses. Thus, they have a strong desire to have their own houses. When buying apartment houses, they consider economic points first such as price and the merits of investment. 3) Most pollees say they think indoor space is more important than outdoor space. Especially, they want storing spaces and a large balcony. 4) Majority of the pollees like a housing complex consisting of around 300 to 1000 houses and high-rise apartment buildings of 11 to 15 stories.

도시근린공원의 이미지와 이용만족도에 관한 연구

하영철,정수일,곽윤근,신현익,하헌정,김익환,김석만 金烏工科大學校 1999 論文集 Vol.20 No.-

This paper presents the future direction of the development and maintenance of the urban park of the Kumi city. The direction was obtained by analyzing the evaluation results on the satisfaction level of park use and the park image of the park users. The analysis results are as follows. 1) It turns out that the rest and accommodation facilities are the major facilities that uplifts the total image of the park. 2) Among the park images, the image on the pleasantness was the major image, related with the satisfaction on the park equipments. 3) The social class, who gave a bad score on the above equipments and images, is a low-aged class, who is a white class with high income as well. Therefore, it is suggested that the park maintenance plan, with emphasis on the class, is an important task.

닭고기의 부위별 영양 성분 분석 : 아미노산 및 무기질 Amino acid and minerals

고하영,유익종 우석대학교 자연과학연구소 1997 自然科學硏究論文集 Vol.1 No.-

닭고기를 가슴살, 넓적다리살, 다리살의 3부위 살코기와 껍질을 포함한 날개 가식부를 취하여 단백질 함유량, 아미노산의 조성 및 무기질 조성을 분석하였다. 단백질 함량은 가슴살이 22.9%로 가장 높았으며, 넓적다리살 19.7%, 다리살 18.8%, 그리고 날개 17.6%로 비슷하였다. 닭고기에서 가장 많은 아미노산은 글루탐산, 아스파르트산, 리신, 로이신의 순서이었다. 필수아미노산 중 아르기닌과 히스티딘을 함유한 10종 필수아미노산의 경우 닭고기 가슴살이 11,860㎎/100g당으로 가장 높았으며, 다리살의 경우에는 돼지고기, 쇠고기 등심과 유사하였다. 총아미노산 중 필수아미노산 함량은 닭고기가 41 ∼ 44%, 돼지고기가 40 ∼ 45%, 쇠고기 41 ∼ 45%로서 3종류의 육류가 대개 유사한 결과를 보여주었다. 함황아미노산은 닭고기의 경우 100g당 725 ∼ 759㎎이었으며, 돼지고기는 680 ∼ 820㎎, 쇠고기는 660 - 830㎎의 함량을 나타내었다. 방향족 아미노산의 경우 닭고기는 100g당 1,602 ∼ 1,667㎎으로 조사되었으며, 돼지고기는 1,150 ∼ 1,520㎎, 쇠고기는 1,230 ∼ 1,610㎎이 함유된 것으로 나타났다. 무기질은 다리살이 가슴살에 비해 철분과 아연의 함량이 많아 각각 1.0㎎%와 4.0㎎%이었으며, 가슴살에는 인(220.2㎎%)과 칼륨(390.5㎎%)이 많았다. Protein contents, amino acid compositions, and minerals of chicken which parted by chests and legs without skin, and wings with skin were analyzed. Protein contents of chicken were 22.9% in chests, 19.7% in legs, and 17.6%. Major amino acids were glutamic acid, aspartic acid, lysine, and leucine, 10 essential amino acid contents were 11,860㎎% in chests and 10,454㎎% in legs. Ratio of essential amino acids were 41.7 ∼ 44.1%. Sulfur containing amino acids and aromatic amino acid contents were 725 ∼ 759㎎% and 1,602 ∼ 1,667㎎%, respectively, K, P and Na contents as major minerals were 390.5㎎%, 220.2㎎%, and 81.5㎎% in chests and 308.4㎎%, 170.8㎎%, and 109.7㎎% in legs, Ca, Fe and Zn contents were 2.9㎎%, 0.5㎎%, and 0.5㎎% in chests and 7.0㎎%, 1.0㎎%, and 4.0㎎% in legs.

패턴 인식 적용을 위한 가스센서 어레이의 임피던스 특성 측정

홍영호,장익훈,김인수 경운대학교 산업기술연구소 2001 産業技術硏究論文誌 Vol.3 No.2(C)

The response of semiconductor gas sensor is usually showed as variation of resistance when the sensing material is reacted on gas. Also it can be showed as variation of impedance of sensing material. The variation of impedance is separated into two parts. One is the variation of capacitance. The other is the variation of resistance. The former is dependent on the type and the concentration of gases. The latter is dependent on change of rising time and falling time that was determined by capacitance. The important factors considered are the selectivity and the stability of various sensor characteristics. But, sensors generally exhibit non-stability and non-linearity in dynamic properties. This problem can be solved using pattern recognition. The system was implemented using back propagation algorithm and showed good pattern recognition for each gas pattern. Also, the measuring output was proportional to concentration of each gas approximately. Therefore the system could be adapted implementation of measurement system with multi channel sensor array for various gases.

장애인의 성 향유에 영향을 미치는 요인연구 : 20대 미혼 장애인을 중심으로

이익섭,이영미 연세대학교 사회복지연구소 2003 연세사회복지연구 Vol.9 No.-

본 연구는 장애인의 성 문제에 관한 최초의 전국 조사로서 성을 보다 다차원적이고 포괄적인 개념으로 보아 장애인의 성이 타인과의 상호작용이자 자신의 존재의미와 자아존중감과도 연결되는 근원적인 힘으로 작용한다고 보고 결혼한 장애인들이 아닌 미혼의 청장년 장애인들을 연구대상으로 하여 이들이 포괄적인 의미에서의 성을 얼마만큼 향유하고 있는지 그리고 성향유에 영향을 주는 요인들은 무엇인지를 밝힘으로서 통합적이고 전인적인 기능을 하는 성을 향유하도록 돕고자 하였다. 그리고 이 연구를 통해 향후 장애인의 성 향유를 촉진할 수 있는 정책의 방향설정에 토대가 될 수 있는 함의를 도출하고자 하였다. 조사 결과 우리나라 장애인은 비교적 긍정적인 성에 대한 태도를 보이고 있음에도 불구하고 성과 관련된 사생활이 보장되지 않고 성문제를 상담할 수 있는 기회가 제한되어 있으며 이성과의 접촉이 어려움으로 인해 성을 향유하지 못하고 있었다. 성의 향유에는 이성과의 접촉정도, 사생활 보장, 성에 대한 대화정도가 영향을 미치며 그 외에 장애유형이나 교육수준, 성별도 영향을 미치고 있음을 알 수 있었다. 장애인의 성문제를 해결하기 위해 성 상담프로그램이나 이동권 보장, 체계적인 성교육강화 등의 정책적 접근이 이루어져야 하며 장애인의 성에 대한 부정적 선입견을 해소하기 위한 다양한 방법이 모색되어야 할 것이다. The Purpose of Study is to examine degree of sexuality enjoyment of the disabled in holistic perspective and to find factors affecting sexuality of the disabled in Korea. Reasearch was conducted on the people with visual disabilities and physical disabilities. Telephone survey was used for the persons with visual disabilities whereas mailing survey was used for persons with physical disabilities. The final sample was consisted of 353 respondents. The major findings of this study were as follows: First, although persons with disabilities have positive attitudes about their sexuality, they don't have the privacy nor the opportunity to talk openly about their sexuality. Second, the factors affecting sexuality of the disabled were the opportunity to meet the opposit sex, the degree of privacy and the extent of open discussion. The current findings suggest that intervention and policy aimed at improving sexuality enjoyment of the people with disabilities such as enhanced availability, sexuality education, sexuality counselling, and inclusive education.

1989學年度 新入生 實態調査 結果分析

朴榮哲,朴鍾翼 충남대학교 1990 學生生活硏究 Vol.17 No.-

우울증 환자에서 Cortisol 일일변화 검사의 의의

채영래,한상익,백인호 大韓神經精神醫學會 1988 신경정신의학 Vol.27 No.4

This study was designed to investigate whether depressed patient showed increased plasma contisol level compared with nondepressed patients and to examine whether diurnal variation is preserved or flattened in depressed patients and whether diurnal variation itself could be a useful diagnostic procedure in depression. We studied also the possible relationship between the diurnal variation of cortisol secretion and the degree of symptomatic improvement with antidepressant administration in major depression patients. The results were as follows : 1) The value of serum cortisol levels checked before antidepressant administration were 8.44±4.89㎍/dl, 5.74±3.19㎍/dl, 3.18±3.54㎍/dl, 10.75±5.23㎍/dl at 12AM, 4PM, 11PM and 8AM respectively in endogenous depression group, and 6.39±3.29㎍/dl, 6.25±3.75㎍/dl, 2.74±1.85㎍/dl, 10.79±4.77㎍/dl respectively in control group. There were no significant differences in serum cortisol levels between both groups(Table 2). 2) In 31 endogenous depressives, 18(58.1%) maintained diurnal variation of cortisol level and 13(41.9%) showed flattened variation. However, of 16 control group(schizophrenics and dysthymic disorder patients), 11(68.8%) maintained diurnal variation of cortisol secretion and5(31.2%) showed flattened variation. As a result, the sensitivity, specificity and predictive value of diurnal cortisol test for endogenous depression were 42%, 67%, and 72% respectively 3) In 26 major depression patients, 11 patients who showed flattened diurnal variation of cortisol secretion had significantly high "agitative depression" factors of Hamiltion Rating Scale for Depression compared with 15 patients who maintained diurnal variation. 4) Among 15 major depression patients whose diurnal variation was preserved, 12(80.0%) showed marked improvement of depressive symptoms with antidepressant administration and 3(20.0%) did not. Among 11 major depression patients whose diurnal variation was disturbed, 6(54.5%) improved and 5(45.5%) did not. There were no significant differences in symptomatic improvement between two groups.