18–30세 사이에 발생하는 뇌경색의 특징, 다기관 레지스트리 연구

장윤경,송태진,김용재,허지회,이경열,김영은,장민욱,조수진,강석윤 이화여자대학교 의과학연구소 2017 EMJ (Ewha medical journal) Vol.40 No.3

Objectives: Although there have been several reports that described characteristics for young age stroke, information regarding very young age (18–30 years old) has been limited. We aimed to analyze demographic factors, stroke subtype, and 3-month outcome in acute ischemic stroke patient who have relatively very young age in multicenter stroke registry. Methods: We evaluated all 122 (7.1%) consecutive acute ischemic stroke (within 7 days after symptom onset) patients aged 18 to 30 from 17,144 patients who registered in multicenter prospective stroke registry, 1997 to 2012. Etiology was classified by Trial of Org 10172 in Acute Stroke Treatment criteria. Stroke severity was defined as National Institutes of Health Stroke Scale (NIHSS) and stroke outcome was defined by modified Rankin scale (mRS) at 3 months after index stroke. Results: The mean age of all included patients was 25.1±3.7 years and 76 patients (62.2%) were male. The median NIHSS at admission was 4. Considering stroke subtype, 37 patients (30.3%) had stroke of other determined etiology (SOD), 37 (30.3%) had undetermined negative evaluation (UN) and 31 (25.4%) had cardioembolism (CE) were frequently noted. After adjusting age, sex and variables which had P<0.1 in univariable analysis (NIHSS and stroke subtype), CE stroke subtype (odds ratio, 4.68; 95% confidence interval, 1.42–15.48; P=0.011) were significantly associated with poor functional outcome (mRS≥3). Conclusion: In very young age ischemic stroke patients, SOD and UN stroke subtype were most common and CE stroke subtype was independently associated with poor discharge outcome.

Preparation and Characterization of Surface Energy of BPDA-BAPP Polyimide

Kim, Kyung-Hoe,Kim, Yong-Gwon,Kwon, Young-Hwan The Polymer Society of Korea 2009 Macromolecular Research Vol.17 No.6

The surface properties (water sorption and repellency, adhesion) are closely related to the surface tension of polymer solids. The critical surface tension (${\gamma}_c$) and surface tension (${\gamma}_s$) of a polymer solid were estimated by the contact angle method by our quantitative imaging system. BPDA (3,3',4,4'-biphenyl tetracarboxylic dianhydride)-BAPP (1,3-Bis(4-aminophenoxy) propane) polyimide was successfully synthesized. The ${\gamma}_c$ values were analyzed by a Zisman plot, a Young-$Dupr\acute{e}$-Good-Girifalco plot, and a log ($1+cos{\theta}$) vs log ${\gamma}_L$ plot. The ${\gamma}_s$ value of BPDA-BAPE polyimide was evaluated using the geometric mean equation and our multiple regression analysis. The calculated values of ${{\gamma}_s^d$ (a dispersion component), ${{\gamma}_s^p$ (a polar component), ${{\gamma}_s^h$ (a hydrogen bonding component), and ${\gamma}_s$ were 30.79, 9.32, 0.20, and 40.31 $mN{\cdot}m^{-1}$, respectively. The ${\gamma}_s$ of BPDA-BAPP polyimide containing both a methylene group and an ether group was larger than that of the polyimide containing only a methylene group.

중국시장 확보를 위한 셀룰러폰의 전략적 디자인 개발

김영춘,박신균,신호균 한국의사결정학회 2004 경영과학연구 Vol.12 No.-

This paper os to strategically develop the of the cellular phone, aiming at the Chinese market, considering that the overall and in-depth research & analysis is insufficient for the mobile telecommunication of China. To achieve the objective, a field study has been on the conducted using the unstructured questionaires for the consumers and the interviews with the representatives of the distributers in china. The design of this study is developed based on the details, such as, documents research, statistics, data made by the partners, Chinese mobile telecommunication market condition, and the preference analysis of the users. The result of the study is considered to be used as basic data, which can be available for domestic terminal companies to secure the beachhead of Chinese market. Furthermore, it is expected to be used to preempt the market share for the cellular phone in China.

최근 3개월 동안 원광의대 병원에서 분리된 주요 세균의 분리양상과 항균제 감수성

문영희,이영진,조지현 圓光大學校 醫科學硏究所 1996 圓光醫科學 Vol.12 No.2

For the statistical evaluation and timely report of frequency and antimicrobial susceptibility patterns of microorganisms, we have tried to develop computer program. Using that program, we evaluated microorganisms isolated in Wonkwang University Hospital from Aug. 16 to Nov. 30 in 1996. The results were as follows: 1. Total number of isolated microorganisms was 1,778 and the most frequently isolated organisms were P aeruginosa(16.4%), E coli/(13.3%), S aureus(10.0%), CNS(8.8%), viridans streptococci(7.0%), B cepacia(5.5%) and E cloacae(5.0%), in order. 2. According to specimen types, the most frequently isolated organisms were P aeruginosa(31.5%) in respiratory tract. E coli(22.0%) in urine. S aureus(22.7%) in pus, P aeruginosa(15.0%) in fluid and E coli/(29.7%) in blood. 3. According to requested wards, the most frequently isolated organisms were P aeruginosa in ICU(28.0%), neurosurgery(30.4%), general surgery(35.3%) and orthopedic surgery(22.2%), and pseudomonas species in urology(23.8%), E coli in pediatrics(12.6%) and medicine(26.8%) and E cloacae(14.1%) in neonatal ICU. 4. Antimicrobial susceptibility patterns were similar to other reports in Korea, but antimicrobial resistance rate of P aeruginosa was higher to gentamicin(72.6%), tobramycin(72.3%), amikacin(57.3%), piperacillin(51.5%), imipenem(39.2%), aztreo-nam(43.6%), and ciprofloxacine(70.3%). Methicillin resistance rate of S aureus and CNS were 69.6% and 74.6% respectively. Resistance to icoplanin or vancomycin among gram-postive cocci was not found.

강자성체에서 상전이의 수치적 모의실험

유대영,양해정,양회룡,정진,최승평,장차익 조선대학교 기초과학연구소 2001 自然科學硏究 Vol.24 No.-

It is difficult to explain the magnetic phase transition with classical physics in Curie temperature. We studied qualitatively with the well known Ising model in statistical mechanics. We simulated systems of finite size by Monte Carlo methods with Metropolis algorithm. Thus we could estimate the values of quantities such as the magnetization(m) per spin the specific heat(c) per spin the magnetic susceptibility(χ) per spin, and the mean energy per spin compare with the numerical values in infinitive size. The quantities of c, m, χ, e varied rapidly within 2.3∼2.4 temperature at J/k units. Those values show that the critical temperature can be within the range. The hysteresis loop was obtained with this model.

알레르기 환자에서 면역요법에 따른 면역학적 지표의 변화

최영환,허영구,김항재,김능수 慶北大學校 醫科大學 1991 慶北醫大誌 Vol.32 No.2

혼합 항원추출액으로 면역요법시 경과 관찰에 도움이 되는 객관적인 지표를 설정하기 위하여 D. farinae 또는 D. pteronyssinus를 포함한 2내지 6가지 복수의 기인 항원을 갖고 면역요법을 6∼12개월 받은 환자(제Ⅱ군)와 2년 이상 받은 환자(제Ⅲ군)를 대상으로 말초혈액 호산구수, 혈청총IgE치, RAST score, 피부반응도, 말초혈액 IgE수용체보유림프구, 말초혈액 T, B림프구 및 T림프구 아형을 측정하여 면역요법을 받지 않은 알레르기 환자(제Ⅰ군)들에서의 성적과 비교 검토하였다. 혈청총IgE치는 6∼12개월 면역요법군 및 2년이상 면역요법군에서 면역요법을 받지 않은 군보다 유의하게 낮았다. (각각 P<0.05) 면역요법전혈청총IgE치가 400IU/㎖이상인 환자에서는 면역요법후 그 감소가 뚜렷하였으나 300IU/㎖이하인 경우는 유의한 감소를 볼 수 있다. 면역요법을 받지 않았는 군에서의 피부반응도지수의 평균은 1.80±1.79였고 6∼12개월 면역요법을 받은 제Ⅱ군 및 2년이상 면역요법을 받은 제Ⅲ군의 피부반응도지수는 제Ⅰ군보다 각각 유의하게 낮았다. 말초혈액 FcεR(+)림프구는 면역요법을 받지 않았는 Ⅰ군보다 Ⅱ군 및 Ⅲ군에서 유의하게 낮았으나 여전히 정상치 이상이었다. 그러나 혈중 호산구수, RAST score, 말초혈액림프구 및 그 아형은 면역요법 전후 유의한 변화를 나타내지 않았다. 이상의 성적에서 혈청총 IgE치, 피부반응도지수, 말초혈액FcεR(+)림프구는 면역치료의 경과를 대체로 추적할 수 있는 지표가 될 수 있을 것으로 생각된다. To determine the reliable parameters for assessing the efficacy of immunotherapy in multi-allergen sensitive allergy patients, we observed the changes of peripheral blood eosinophil counts, total and specific IgE levels, skin-test reactivity index, Fcε receptor-bearing lymphocytes, T/B lymphocytes and T-subsets in peripheral blood in the three groups of allergic asthma or rhinitis patients, the first group(group Ⅰ) of 102 patients who were not on immunotherapy, the second group(group Ⅱ) of 28 patients who received 6-12 months immunotherapy, and the third one(group Ⅲ) of 24 patients who received 2 years immunotherapy. Those patients were sensitive to 2-6 aeroallergens including D. farinae or D. pteronyssinus and all the patients in group Ⅱ and group Ⅲ had been immunized with the specific desensitization vaccine (SDV, Bencard®), resulting good response on symptoms. Total serum IgE levels were significantly decreased in the groups of Ⅱ and Ⅲ, compared with groupⅠand the decrease in IgE was more prominent in the patients of high IgE level over 400IU/㎖ prior to immunotherapy. The mean of skin-test reactivity index was 1.80±0.79 in group Ⅰ and this index was significantly lowered in group Ⅱ and Ⅲ. Significant decrease in Fcε receptor-bearing lymphocytes in peripheral blood was developed in immunotherapy-received groups(Ⅱ and Ⅲ). However, the patients still had higher levels of Fcε receptor-bearing lymphocytes in peripheral blood than normal controls, even after more than 2 years of immunotherapy. The differences of peripheral blood eosinophil counts, RAST score, T/B lymphocytes and T-subsets were not significant between before and after immunotherapy. These findings suggest that serum IgE, skin-test reactivity index and Fcε receptor-bearing lymphocytes in peripheral blood could be useful parameters in assessing the efficacy of immunotherapy with extracts of multi-allergens.

비선형 편미분방정식의 수치 해석에 관한 연구

하회영 인제대학교 1985 仁濟論叢 Vol.1 No.1

A Numeric analysis of one-dimensional parabolic partial differential equation has been developed using finite difference method (both explicit and implicit). This proposal method Includes the following results. 1.Some of the nonlinear equations are linearized by replacing nonlinear expressions by new variable (modified scale function). 2.Tearing of the linear subset of equation is carried out by using Gauss elimination in this subset to express all the variables as explicit linear functions of the fear variables.

인삼 및 코티손계투여가 정상집토끼의 경구 당부하시 혈당치, 인슐린농도 및 유리지방산에 미치는 영향 : preliminary report

문영희 최신의학사 1971 最新醫學 Vol.14 No.2

This work was carried out in order to study whether Korean Ginseng (Panax C. A. Mey) could compete hyperglycemia. Three groups of healthy rabbits weighing about 1. 5kg were fed same food as the first control group, but the second group was given 1.Ogm of ginseng mixed with food, and the third group was given ginseng-mixed and injected 0. 25mg of cortisone everyday for 10 days. Serum glucose, free fatty acids, insulin, potassium and sodium were checked after 8 hour's fasting. And all the animals were fed 1.0gm/ (kg body weight) of glucose orally. Then serum glucose was checked at 30, 60 and 120 minutes after oral glucose-loading. From my serum chemistry and some other author's reports, the possible role of ginseng competing hyperglycemia or the action of cortisone were discussed. That is; Ginseng supposed to accelerate the metabolism of glucose from absorption, glycogenesis, glyco?lysis to the utilization by tissue cells, and seemed to suppress glyconeogenesis. Therefore author expect ginseng could control the diabetes resulted from the malutilization of glucose in tissue cells or overwhelming of glyconeogenesis

계층적 구조에서 분산 성분의 Bayesian 추정

하회영 인제대학교 1994 仁濟論叢 Vol.10 No.1

The EM algorithm, in a particular form, can be reading applied to a ierarchy to yield a comceptually straightforward. We are concerned with speeding up the convergence of the EM algorithm for Bayesian stimation of variance components in hierarchical structures by SEM algorithm.

상추種子 活力의 生化學的 評價硏究 : Ⅰ. Ethylene生成 Ⅰ. Ethylene Evolution

禹永澮,朴大榮,李政明 경희대학교 부설 식량자원개발연구소 1992 硏究論文集 Vol.13 No.-

Studies were conducted to find out relationship between the vigor of lettuce and the production of ethylene from germinating seeds of i5 cultivars and lines at 3 different temperatures. The effect of red light illumination and the effect of ACC (1-aminocyclopropane-1-carboxylic acid) and red light on seed germination and ethylene production were also investigated. major results can be summarized a s follows. 1. The lettuce seeds with greater ability of producing ethylene germinated better at high temperatures (25 and 30℃). Highly significant, positive correlations were found between the ethylene evolution and the germination rate at both tested temperatures. 2. Red light treatment significantly increased ethylene evolution and the seed germination rate at 25℃. Treatment of ACC in addition to the red light illumination further increased the germination rate as compared to the red light treatment alone. 3. Red light treatment a t high temperatures was found to be effective in releasing the thermodormancy induced by high temperatures, but the effectiveness varied considerably depending upon the cultivars.