양극성 정동장애와 혈청 Inositol-1-phosphatase 활성도 변화

조현주,김영철,우행원,연규월,조기승 대한생물치료정신의학회 1998 생물치료정신의학 Vol.4 No.2

Objects : Several lines of possibilites have been oroposed about the etiology of bipolar attective disorder in biological, genetic and psychosocial aspect. The purpose of this study is to inspect the etiology of bipolar affective disorder in biological aspect by measuring the changes of serum inositol-1-phosphatase activity and investing a causal relationship between clinical symptoms and serum inositol-1-phosphatase activities in patients with bipolar affective disorder. Methods : The subjects were 18 inpatients who met DSM-IV diagnostic criteria for bipolar I affective disorder, manic episode and 15 normal controls. Inositol-1-phosphatase activities were measured in serum by using spectrophotometer. Clinical symptoms of patients were assessed by YMRS at admission day and after 2 weeks lithium treatment. Results : 1) Inositol-1-phosphatase activities of the patients were increased to about 2 times as compared with those of normal controls. And the activity levels were decreased gradually to the normal at 14 days. 2) Young's Mania Rating Scale(YMRS) scores were decreased significantly by lithium treatment. 3) Statistical significance could not be found between the change of YMRS scores and the levels of inositol-1-phosphatase activity. Conclusion : In this study, statistical significance could not be found between clinical improvement and inositol-1-phosphatase activities, but the fact that lithium treatment improve the clinical manifestation shown by YMRS score changes, and reverse the increased inositol-1-phosphatase activities suggests the strong association between pathophysiology of bipolar affective disorders and inositide metabolism.

미세유화약물송달시스템을 이용한 로바스타틴의 생체이용률 향상

윤복영,강복기,정상영,이영원,이시범,황성주,육순홍,강길선,이해방,조선행 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.4

A self-microemulsifying drug delivery system (SMEDDS) was developed to increase the dissolution rate, solubility, and ultimately bioavailability of a poorly water soluble drug, lovastatin. SMEDDS was the mixtures of oils, surfactants, and cosurfactants, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal (GI) tract. Various types of self-emulsifying formulations were prepared using four types of oil (Capryol 90, Lauroglycol 90, Labrafil M 1944 CS and Labrafil M 2125), two surfactants (Cremophor EL and Tween 80), and three cosurfactants (Carbitol, PEG 400 and propylene glycol). The efficiency of emulsification was studied using a laser diffraction size analyzer to determine particle size distributions of the resultant emulsions. Optimized formulations selected for bioavailability assessment were Carpryol 90 (40%), Cremophor EL (30%) and Carbitol (30%). SMEDDS containing lovastatin (20 mg and 5 mg) were compared to a conventional lovastatin tablet (Mevacor^? , 20 mg/tab) by the oral administration as prefilled hard gelatin capsules to fasted beagle dogs for in vivo study. The area under the serum concentration-time curve from time zero to the last measured time in serum, AUC_0→24h, was significantly greater in SMEDDS, suggesting that bioavailability increase 130% and 192% by the SMEDDS, respectively. The self-emulsifying formulations of lovastatin afforded the improvement in absolute oral bioavailability relative to previous data of lovastatin tablet formulation. These data indicate the utility of dispersed self-emulsifying formulations for the oral delivery of lovastatin and potentially other poorly absorbed drugs.

만선신부전 환자에서 관상동맥조영술 소견에 관한 연구

한대희,김성구,박상호,김성한,조원영,방덕원,조윤행,정의룡,은영근,권영구 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.1

Background : Patients with chronic renal fialure have a substantially elevated risk of death from cardiovascular diseases than do the general population. the patients with chronic renal failure are at significantly increased freqeuncy of hypertension, hyperlipidemia, and diabetes mellitus which are known to the risk factors of the coronary artery diseases, and the prevalence of the coronary artery diseases in chronic renal failure patients is highly associated with the hemodynamic disorder and metabolic abnormalities. therefore we expected that the coronary angiographic findings in patients with chronic renal failure should be different from the general population (control groups) and investigated the risk factors contributing to coronary artery diseases. Method : we have retrospectively compared the coronary angiographic findings of 44 patients with chronic renal failure on hemodialysis with that of 88 patients in the general population and investigated the factors contributing to the development and acceleration of coronary artery diseases in patients with chronic renal failure Result : Hypertension and diabetes mellitus which is risk factors for coronary artery disease is significantly increased in patients with chronic renal failure, in coronary angiographic finding the severity of the lesion is worse. the incidence of PCI or CABG of patients with chronic renal failure is more than that of control group but statistically no difference between patients with chronic renal failure and control group. the sex, the duration of disease, the duration of dialysis, serum creatinine in patients with chronic renal failure have no correlation to the prevalence of coronary artery disease and severity of lesion. hyperglycemic patients with chronic renal failure have high incidence of coronary artery disease and are worse in the severity of lesion Conclusions : There is significantly increased the pevalence and severity of involving multiple coronary artery diseses in hyperglycemic patients with CRF.

餘暇社會化 參與에 寄與하는 要因體系

千英一,具本行 중앙대학교 스포츠과학연구소 2000 體育硏究 Vol.- No.13

Ther are childhood and the period of adult on leisure socialization participation, and various factors such a family, school, attitude have an influence on it. The purpose of this research is to establish education of leisure socialization participation and valuable leisure outlook by organizing these factors. 1. Leisure socialization participation is divided into life habit, basic knowledge, attitude, value, behavioral psychology of childhood and the period of adult. 2. Leisure activity is experienced through childhood, adolescence, and a period of adult; however, leisure behavior in childhood is not a decisive factor of leisure behavior in the period of adult. 3. Family and school are the best superintendents, and they have an interactive effect. Many following researches are required. 4. Factors of perceived leisure aptitude reflect on differences quantitatively and qualitatively according to development stage, and these changes are represented to perceived ability limits of individuals. 5. When attitude to leisure is measured at the same level of intention, it can be a good predictive material about the intention of leisure activity participation.

마우스에 있어서 Isoniazid와 Rifampicin의 免疫毒性에 對한 酒精 및 高麗人蔘의 影響

안영근,김정훈,유항묵,강영세 圓光大學校 1988 論文集 Vol.22 No.2

結核의 一般的인 藥物療法으로 利用되고 있는 Isonicotinic acid hydrazide(INAH)와 Rifampicin의 倂用投與는 結核의 治療效果를 改善시킬 수 있는 反面에 INAH와 Rifampicin의 長期 倂用投與가 肝毒性과 免疫抑制作用을 出現시킨다고 報告된 바 있다. 한편 酒精의 長期間 暴露는 肝毒性과 T-lymphocyte 機能抑制 및 體液性 免疫에 손상을 가져 온다고 알려진 바 있고 高麗人蔘은 細胞性 및 體液性 免疫 修飾作用이 있으며 特히 石油 ether 分劃은 그 作用이 强하여 細胞性 및 體液性 免疫 macrophage의 活性 등을 현저하게 亢進시킨다고 本人 等이 밝힌 바 있다. 本 硏究의 結果 INAH와 Rifampicin 倂用投與時 이들 藥物에 의한 免疫 毒性에 對하여 酒精및 高麗人蔘을 倂用하였을 때 INAH와 Rifampicin은 細胞性 및 體液性 免疫을 低下시켰으며 酒精의 倂用投與는 免疫 毒性을 增加하였으나 高麗人蔘의 倂用投與는 細胞性 및 體液性 免疫과 大食細胞의 活性을 增加시킴을 밝혔다. 1. Rifampicin and INAH exposure decreased relative spleen weight, humoral and cellular immune responses and macrophage activity. 2. Alcohol combined administration significantly increased the cellular immunotoxicity of Rifampicin and INAH. Especially, 4% alcohol combined administration significantly suppressed the cellular immune response and macrophage activity. 3. Generally, Korean ginseng extracts reduced or removed the decline of humoral and cellular immune responses and macrophage activity by immunotoxicity of Rifampicin and INAH.

우리나라 지역 직업성질환 감시체계의 현황과 전망

임종한,장성실,김성아,문재동,채창호,홍윤철,김수영,김진석,김영욱,한상환,이혜숙,원종욱,송동빈,하은희,강성규 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

기존의 특수건강진단과 작업환경측정을 통한 직업병 관리가 진폐증, 소음성난청 등의 소수 특정질환에 국한되고 실제 직업병 발생 규모 파악이나 신종 직업병의 발견에 한계를 보인다는 사실은 산업의학전문가들 사이에서도 공감을 이루고 있다. 미국과 영국 등에서의 직업성질환 감시체계에 대한 경험은 우리 나라의 직업성질환 감시체계 구축에도 새로운 자극제가 되면서, 1998년이후 인천, 대전, 여천, 구미, 부울경 지역에서 지역 직업성질환감시체계를 산업보건관리의 중요한 시스템으로 구축하려는 노력이 확산되고 있다. 새로이 구축되어지는 이들 지역 직업성질환 감시체계는 감시하고자 하는 대상질환, 활용 가능한 인적자원 및 자료원, 지역 의료체계의 특수성 등에 따라서 목적과 방법을 달리하면서 독특한 형태로 발전을 하고 있다. 각 지역단위 감시체계들이 그 상황에 맞게 독특한 목적과 전략들을 발전 시키면서도, 향후 발전할 국가적인 차원의 직업성질환 감시체계 구축을 위하여 직업성질환 감시의 기본 전략 등을 공유하는 등의 노력이 필요하다. 환례 정의 및 기본적인 등록 서식의 공유, 직업성질환 감시 자료원의 발굴, 공동의 정보 네트워크 및 직업성질환 감시 데이터베이스 구축 등 직업성질환 감시활동을 지원하기 위한 여러 기초 인프라 구축에 힘을 모아야 할 것이다. 우리 나라에서 직업성질환 감시체계를 성공적으로 구축하기 위해서는 수집된 자료의 질 관리를 위한 직업성질환 감시의 원칙 제정과 감시 전략의 공유 등이 필요하며, 전국적인 직업성질환 감시체계의 하부구조라고 할 수 있는 지역감시체계의 기초 토대 마련과 강화작업이 절실하게 필요하다.

古代 中國에 있어서 女性의 婚姻生活에 關한 硏究

金龍興 대구효성가톨릭대학교 1989 연구논문집 Vol.39 No.1

교량의 실시간 거동 모니터링을 위한 GPS의 적용

박운용,정성모,곽두호,이흥규 東亞大學校 大學院 1999 大學院論文集 Vol.24 No.-

Real Time Kinematic GPS will allow a multitude of monitoring, navigation and engineering applications. Applications inclued real time deformation and movement monitoring and real time automated plant control. In a low dynamic environment, with a short baseline length, it is possible to position a roving receiver to an approximate accuracy of less than 5mm within a few seconds of thestart of the ambiguity. One Engineering application is the monitoring of the movement of cable suspension bridges. Such structures are capable of movements of up to a few meters under adverse wind conditions or heavy traffic loads. The use of relative OTF positioing at strategic points upon the bridge would allow close monitoring of the bridge's movements and calculate deformation and long-term deterioration factors for the bridge. Future bridge designs and traffic management schemes could also benefit from the monitoring system.

DS/CDMA 시스템에서 핸드오프 방식에 따른 얼랑용량과 링크마진 계산에 의한 셀 커버리지

권영수,김항래,한태영,김남 충북대학교 컴퓨터정보통신 연구소 2002 컴퓨터정보통신연구 Vol.10 No.2

PCS CDMA 시스템의 역방향 링크에서 핸드오프 기법에 따라 얼랑용량과 링크마진을 구하는 각각의 차단확률을 유도하였다. 동일한 시스템 파라메터로 그 값을 계산해서 COST-231 전파모델을 적용한 전파손실을 구할 때 적용하였으며, 현실적인 셀 최대용량으로 얼랑용량을 계산해 여러 지역에서 셀 커버리지와의 관계를 새로운 관점에서 분석하였다. 소프트핸드오프를 하는 상황에서 E_(b)/N_(o)=5 dB에서 차단확률을 5 %에서 2 %로 낮출 경우 링크마진은 0.88 dB 더 높여야하고 용량이 20 얼랑에서 2 얼랑 감소함에 따라 도시지역의 셀 커버리지도 0.1 km 줄어들지만 신뢰성과 서비스품질을 높일 수 있었다. 차단확률 5 % 이내에서 E_(b)/N_(o)=7 dB에서 5 dB로 낮게 적용할 경우 마진은 똑같이 2.8 dB로 적용해도 용량은 11 얼랑에서 9 얼랑 증가와 함께 커버리지도 1.5 km에서 0.2 km 증가하였다. 이때 하드핸드오프에 비하면 2.16 dB의 마진을 더 줄일 수 있어 10 얼랑 증가와 함께 0.22 km 늘어나는 소프트핸드오프 이득이 발생하였다. 또한 핸드오프를 하지 않는 단일 셀 경우에 비해서는 용량은 10 얼랑 이상 감소하지만 1.31 dB의 마진을 줄일 수 있어 셀 커버리지도 0.17 km 증가하였다. We derive the outage probability for the Erlang capacity and link margin according to handoffs in the reverse link of a PCS CDMA system, calculate them with the same parameters, and then analyze newly the cell coverage with the maximum realizable Erlang capacity in different areas by the COST-231 model. If it decreases from 5 % to 2 % in case of E_(b)/N_(o)=5 dB, the result shows a very reliable link on the additional increase of 0.88 dB in the margin and a high quality of service within coverage decrease of 0.1 km from 1.5 km in city area on the decrease of 2 Erlang from 20 Erlang in the capacity. When the E_(b)/N_(o) decreases from 7 dB to 5 dB within the outage probability of 5 % under a soft handoff, it shows the increase of 9 Erlang from 11 Erlang and of 0.2 km in it on the same margin of 2.8 dB. Then, comparing it with a hard handoff, it shows the soft handoff gain of the decrease of 2.16 dB in the margin, the increase of 10 Erlang, and of 0.22 km in it. Also, comparing it with a single cell, the decrease of more than 10 Erlang, but the enlargement of 0.17 km on the decrease of 1.31 dB.

편마비 환자의 건측에 적용한 고유수용성 신경근 촉진법이 환측 근 긴장도에 미치는 영향

우영근,조규행,유은영 한국전문물리치료학회 2002 한국전문물리치료학회지 Vol.9 No.2

The purpose of this study was to investigate the effect of proprioceptive neuromuscular facilitation (PNF) approach on the spasticity of affected side in patients with hemiplegia, Three subjects with hemiplegia participated in this study. In single-subject research design (a multiple baseline across individuals) was employed in this study. The intervention program including PNF to the unaffected side was introduced for 30 minutes each day during each intervention phase. Muscle tone of affected side was measured with Tone Assessment Scale, and active hip abduction distance of affected side was taken with the subject supine. And then the muscle tone and the hip abduction distance were measured again 30 minutes later following the intervention. The results showed that the PNF application had some beneficial effects on both muscle tone and active hip abduction. This results suggests that PNF application to non-paretic limb can be effective in reducing muscle tone and improving hip abduction range on paretic limb in persons with hemiplegia. However, further research is needed to prove the effect of PNF application on functional improvement.