정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

가마미 해수욕장(전남 영광) 갯벌의 미세조류의 분포에 관한 연구

이학영 한국환경과학회 2003 한국환경과학회지 Vol.12 No.7

Distributional patterns of microalgae were studied in the tidal flats of Gamami Beach(Young-Gwang, Korea) from November 1999 to 2000 July. The tidal flats of Gamami Beach was composed mainly of sandy sediment. The concentrations of nutrients were low compared with other tidal flats. In the present study, 68 species of microalgal flora were identified. These were comprised of 25 species of benthic microalgae and 59 species of planktonic microalgae. Diatoms predominated the benthic microalgae with 96.0% of total species occurred. Dominant species were Amphora sp., Cocconeis sp., Coscinodiscus asteromphalus, Coscinodiscus sp., Nit=schia sigma var. intermedia, Nitsschia distans, Navicula spp., Paralia sulcata, Pleurosigma sp. Skeletonema coastatum, and Surirella sp. Among them, Amphora sp., Paralia sulcata, and species of Pleurosigma and Nitzschia were observed throughout the studied period. Planktonic microalgae of Gamami Beach was also predominated by diatoms. They occupied 88.1% of total planktonic microalgae. The density of microalgal population was higher in silty sediment than in sandy sediment. The population density of microalgae was higher in high tide zone than that in low tide zone. The density of the benthic microalgae in the surface layer of tidal flats showed increasing tendency for 2 hours after the beginning of ebb tide. On the contrary, benthic microalgal density of subsurface layer was decreased during the period. Concentrations of chlorophyll a from sediment and water were not synchronized during the study period. Therefore, the distributional patterns of the benthic microalgae and planktonic algae seemed not to be related. Chlorophyll a of water was highly related with the concentration of NH₄-N, whereas, chlorophyll a of sediment was related with NO₃-N concentration.

융모성림프구를 보이는 비장변연부 림프종 1예

진한영,손창학,주영돈,박정하,이재익,조영완,이원식 인제대학교 2006 仁濟醫學 Vol.27 No.-

Splenic marginal zone lymphoma is very rare B-cell lymphoma, characterized by an indolent clinical course. Clinical features are moderate-to severe splenomegaly, absolute lymphocytosis, and bone marrow intrasinusoidal infiltration of lymphocyte. We report the case of a 37-year-old male with SMZL. He complained of LUQ pain, who had a massive splenomegaly and moderate lymphocytosis in peripheral blood. Immunophenotyping findings and morphologic findings were consistent with SMZL. He underwent splenectomy and received chemotherapy with cyclophosphamide for eight months. Now, one year later after surgery he has a nearly normal blood count with no treatment.

Multiple myeloma 환자에서 Bortezomib치료 후 발생한 마비성 장폐색증 1례

김준영,이원식,손창학,박성길,진한영,박석주,조영완,정은욱,강명주,박정하,주영돈 인제대학교 2006 仁濟醫學 Vol.27 No.-

Bortezomib is the first clinically available proteasome inhibitor that is clinically effective in the treatment of multiple myeloma. A proteasome inhibitor acts through multiple mechanisms to arrest tumor growth, tumor spread, and angiogenesis. The main adverse effects of bortezomib are gastrointestinal symptoms, cytopenia, fatigue, and peripheral neuropathy. To date, severe paralytic ileus has not been reported as a toxic effect of bortezomib treatment in multiple myeloma. Bortezomib is a novel agent that has only been used clinically for 30 months, so a need exists to further evaluate its toxicity. We report a case of grade Ⅲ (NCI CTCAE v3.0) or grade Ⅳ(SWOG toxicity criteria) paralytic ileus in a 65-year-old man with relapsed multiple myeloma who underwent one cycle of single-agent bortezomib treatment scheduled in a 21-day cycle (1.3 mg/㎥ as a single i.v. bolus on days 1, 4, 8, and 11).

성인 IgA 신병증의 임상적 고찰

김영학,권용은,허경무,윤채중,김종인,김건영,배학연,정종훈 조선의대 1998 The Medical Journal of Chosun University Vol.23 No.1

금 박막의 기계적 물성에 끼치는 두께와 미세조직의 영향

전영선(Young-Sun Jeon),이상주(Sang-Joo Lee),현승민(Seung-Min Hyun),이학주(Hak-Joo Lee) 대한기계학회 2007 대한기계학회 춘추학술대회 Vol.2007 No.10

We have used Visual Image Tracing(VIT) strain measurement system coupled with a micro tensile testing unit to test thickness and microstructure dependent mechanical behavior of Au film. The advantage using this method is to monitor the real time images of specimen during the test in order to determine its Young’s modulus, yield strength and tensile strength. 0.5, 1 and 2 ㎛ thick films were deposited by sputtering system. Free standing films were prepared through lithography and etching processes. Au films were annealed at 300℃ and 350℃ to achieve microstructure evolution and Focus ion beam (FIB SEM) and transmission electron microscopy (TEM) were employed to characterize grain sizes of films. Thickness and grain sizes dependent mechanical behavior such as stress-strain curve, Young’s modulus and yield strength of Au thin film will be presented.

Rat의 복강내에 투여한 5-fluorouracil-polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

강대영,송규상,최정목,노승무,정경수,오정연,김진향,양준묵,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

For more effective intraperitoneal chemotherapy, the authers made 5-fluorouracil-polyglycolic acid composite disks(FU-PGA disks) with 5-fluorouracil and polyglycolic acid, a biodegradable polymer. We inserted the FU-PGA disk into the peritoneal cavites of Sprague-Dawley male rats, the control and three experimental groups; one FU-PGA disk insert group(300mg/kg), two FU-PGA disk insert group(600mg/kg), and three FU-PGA disk insert group(900mg/kg). The control group received a similar number of PGA disk inserts. A pharmacokinetic study was performed to measure the 5-fluorouracil concentration in the peritoneal fluid, blood, and tissues(liver, kidney and heart) at 24 hours, 72hours and 168 hours after insertion of the FU-PGA disk. Light and electron microscopic studies were done. The results were as follows: 1) The number of white blood cells and platelets decreased after FU-PGA insertion. The degree was proportional to the duration and amounts inserted. The change in the number of red blood cells varied slightly. 2) Light microscopically, slight changes were noted at 168 hours in the 3 disk insert group (900mg/kg). Mild fatty change and hepatocyte degeneration around the central veins of the liver were noted, with vacuolar degeneration in the proximal convoluted tubules of the kidney. 3) Electron microscopically,the liver showed focal increases of lipid droplets in the hepatocytes, and irregular nuclear membrane with focal nucleolar segregation of the fibrillar and granular elements. Also the double membranous structure of the hepatocytes and Kupffer cells was widened with bleb formation. The kidney showed wide separation of the nuclear double membrane in the proximal convoluted tubular cells and mesangial cells, with vacuolation and myelin figure formation in the mitochondria of the proximal convoluted tubular cells, at 72 hours and 168 hours in the 2 to 3 FU-PGA insert groups. The heart showed focal loss of cristae,vacuolation and myelin figure formation in the mitochondria of the 2 to 3 FU-PGA insert groups. In conclusion, despite the large amont of FU-PGA inserted, the histopathological changes in the liver, kidney and heart were slight, and consonant with the very low amount of 5-fluorouracil concentrations detected in the liver, kidney and heart. The above results suggest that the FU-PGA composite can serve as a new device for releasing drugs in a controlled manner and easily targeted to intraperitoneal organs. This device can improve the efficacy of intraperitoneal chemotherapy for gastric cancer.

대통령기록관리제도 시행의 의의와 과제

이영학(Lee, Young-Hak) 한국외국어대학교 역사문화연구소 2009 역사문화연구 Vol.33 No.-

이 연구는 2007년 4월 27일 「대통령기록물 관리에 관한 법률」(이하「대통령기록법」으로 약칭함)이 제정되고, 2008년 4월에 대통령기록관이 개관하면서, 대통령기록관리제도가 시행되게 된 과정과 그 의의 및 과제를 살펴본 글이다. 2007년 4월에 「대통령기록법」이 제정되고, 이 법률에 의거하여 11월 30일 대통령기록관 직제를 신설하고, 2008년 4월에 대통령기록관을 개관하게 되었다. 「대통령기록법」이 시행됨으로써 대한민국 역사에서 대통령기록물을 관리하는 법적인 토대가 처음으로 마련되었으며, 대통령기록관리의 체계가 자리잡기 시작하였다. 「대통령기록법」의 제정과 대통령기록관의 설립은 대통령기록관리의 중요성을 명문화하고 대통령기록관리의 제도화를 시작하였다는 점에 큰 의의가 있다. 1948년 대한민국 정부 수립 이후 1998년 김영삼 정부 때까지 50년 동안 정부기록보존소에 이관한 대통령기록물은 총 13만여건이었으며, 1999년「공공기관의 기록물관리에 관한 법률」을 제정한 김대중 정부에서는 20만건의 대통령기록물을 이관하였다. 반면에 2007년에 「대통령기록법」을 제정한 노무현정부는 280 여만건의 대통령기록물과 530 여만건의 웹기록을 이관하였다.대한민국사에서 대통령기록물 이관의 신기원을 연 것이다.2007년에 「대통령기록법」이 제정되고, 그 다음 해에 대통령기록관을 개관하면서 대통령기록관리제도를 시행하게 되었지만, 1년 동안 많은 시행착오를 겪게 되었다. 대통령기록관리제도의 첫 발을 디뎠을 뿐이지, 그 제도를 정착시키기 위해서는 많은 노력이 기울여져야 할 것이다. 대통령기록관리제도를 시행하면서 나타난 주요 쟁점은 대통령지정기록물보호제도 문제,전직 대통령의 대통령기록물 열람권 문제, 대통령기록관의 독립성과 전문성의 문제 등이다. 이를 바탕으로 대통령기록관리제도를 정착시키기 위해서는 다음의 과제들이 완수되도록 노력해야 한다. 먼저 대통령기록관의 독립성과 전문성을 강화해가야 한다. 아울러 대통령기록관리위원회를 시급히 구성하여 대통령기록관의 운영을 컨설팅해야 한다. 기록관리전문인력의 배치와 전문가 양성에 노력을 기울여야 한다. 또한 대통령기록관은 대통령기록물을 제대로 이관받거나 수집해야 하며, 관리하고 있는 기록물을 국민 및 연구자들이 편리하게 이용할 수 있도록 서비스해야 할 것이다. On April 27th, 2007 there were enacted laws about 「Presidential Records Management Act」, and in April, 2008 presidential archives was opened. As these incidents happened, this paper is to see the process of how it established and to look into significance and task of 「Presidential Records Management」. As 「Presidential Records Management Act」 was enacted in April 2007, Government made the organization of an office in Presidential Archives. In April 2008, Government opened Presidential Archives. As 「Presidential Records Management Act」 took effect, there was the first legal ground to manage presidential archives in Korean history. Also, presidential Archives management system was settled from that time. The enactment of Presidential Records Management Act」 and establishment of presidential archives give big significance in two points, which are stipulation of the importance in presidential records management and systematization of presidential archives management. From 1948 (Formation of Korean government) to 1998 (Government of Young-Sam Kim), presidential records had been transferred about 130,000 in Government Archives and Records Service(政府記錄保存所). Also, government of Dae-Jung Kim, which established 「Records Management of public instituition Act(공공기 관의 기록물관리에 관한 법률)」 transferred 200,000 presidential archive. On the other hand, government of Moo-Hyun Roh, which enacted 「Presidential Records Management Law」, transferred about 2,800,000 presidential rchives and 5,300,000 web records. It means a new epoch in transferal of presidential records in Korea history. 「Presidential Records Management Act」was enacted in 2007,and Presidential Archives was opened in 2008. We operated the Presidential Records Management System, butwe suffered the trial and error for one year. Nowadays we only made the first step in Presidential Records Management System, we must exert all possible efforts to settle down it. In operating of Presidential Records Management System, the issue in dispute is the protection of Presidential Records, the former President's Access about Presidential Records, Independence and speciality of Presidential Archives. we must accomplishment the follow task. First, we must strengthen the Independence and speciality of Presidential Archives. We must consitute Presidential Records Committee and consult the Presidential Archives' administration. We must station the Archivist and educate them in Presidential Archives. After the Presidential Records must be transferred and be collected in Presidential Archives, they must be opened and serviced to the researcher and people.

백서의 복강내에 투여한 Mitomycin-C-Polyglycolic acid 제형이 장기에 미치는 영향에 관한 연구

송규상,강대영,최정목,노승무,정경수,오정연,김진향,양준목,최선웅,이진호,조준식,민병무,김용백,김창식,박근성,김승영,김학용,인현빈 충남대학교 의과대학 지역사회의학연구소 1998 충남의대잡지 Vol.25 No.1

To evaluate the in-vivo effects of mitomycin-C-polyglycolic acid composite(MMC-PGA) the disk: shaped composite were implanted into the peritoneal cavity of the Sprague-Dawley rats. The pathologic changes were examined at various time points up to 12 weeks. Initially the soft tissue around the inserted disks showed capillary congestion at 3 days. Inflammatory infiltrates with foreign body giant cells appeared from the 2nd week and reached peak response at 6-8 weeks. These reaction diminished prominently at 12 weeks. No specific pathologic change was found in the liver, the kidneys, and the heart. The above results suggest that the MMC-PGA composite can serve as a new device for intraperitoneal chemotherapy of various types of cancers.

전통누룩 진균류를 이용한 입국의 제조 및 입국곰팡이의 동정

김재호 ( Jae Ho Kim ),권영희 ( Young Hee Kwon ),이애란 ( Ae Ran Lee ),김혜련 ( Hye Ryun Kim ),안병학 ( Byung Hak Ahn ) 한국균학회 2012 韓國菌學會誌 Vol.40 No.4

다양한 향미를 가진 막걸리의 개발을 위해 전통누룩으로부터 분리한 곰팡이로 입국을 제조한 후 품질특성을 분석하여 입국의 규격에 적합하며 이취가 없고 관능이 우수한 9균주를 입국 제조용 우수균주로 최종 선발하였다. 선발된 균주는 Aspergillus oryzae(C1-5-2-2, C20-7-3, CN1.3.1-4, CN16.19.1-1, N152-1, N220-1), Mycocladus corymbiferus (N162-2), Rhizopus oryzae(N20), Lichtheimia corymbifera (N21)로 동정되었으며, 제조한 입국의 산도는 5.0~6.8, 당화력은 128~241sp이었다. Various koji were prepared by fungi isolated from traditional nuruk and their quality characteristics were investigated. Acidity and saccharification power of their koji were ranged in 5.0~6.8 and 128sp~241sp. Nine fungi which were showed good quality and sensory evaluation were identified by analysis of their nucleotide sequences with PCR-amplified 18S rDNA internal transcribed spacer-1(ITS-1) and ITS-4 genes. Among them, six strains were identified as Aspergillus oryzae and the other strains were identified as Mycocladus corymbiferus, Rhizopus oryzae, Lichtheimia corymbifera.