아급성 Ethanol 중독시 고뇨산혈증에 미치는 Pyrazinamide의 영향

장윤경,강우규,김동훈,최종원 慶星大學校 環境問題硏究所 1992 環境硏報 Vol.2 No.1

Ethanol 투여후 pyrazinamide 처리로 유도되어지는고 뇨산혈증의 발생 기전과 규명하고자 ethanol을 rat에 아급성적으로 투여하고 pyrazinoic acid의 대사 과정, 뇨산의 혈증 농도, 뇨산의 생합성 및 분해과정에 관여하는 효소의 활성 변화를 비교검토하였을 때 pyrazina-mide의 대사산물인 pyazinoic acid의 생성과정은 증가되었으나 pyrazinoic acid의 분해과정은 영향이 없었다. Ethanol 아급성 중독상태에 pyrazinamide를 투여하였을 때 혈액중의 뇨산 농도는 대조군에 비해 약 123% 정도현저히 증가되었다. 뇨산의 분해 효소인 urixase의 활성변화와 생합성에 관여하는 adenosine deaminase, purine nucleoside phos-phorylase 및 guanine deaminase의 활성변화에는 별다른 관련성이 없었으며 선책적으로 xanthine oxidase 활성만이 유도되어 나타나는 결과였다. In the present work, the purpose was to onbserve the effect of subacute ethanol intoxication on the changes of purine metabnolic pathway after pyraxzinamide administration in rats. In vitro test, it was observed that pyrazinamide deaminasing-enzyme activity was significantly increased and pyrazinoic acid oxidizing-enzyme activity was not affected by ethanol-administrated rat's cytosolic liver. When uric acid level in blood was estimated after pyrazinamide treatment, the blood level was increased in comparison to control group of subacute ethanol intoxication. Ethanol administration did not affect activities of guanine deaminase, adenosine deaminase, purine nucleoside phosphorylase and uricase, on the other hand, xanthing oxidase activity was significantly increased as compared with control. These results suggest that hyperuricemia incuced by the administration of pyrazinamide after subacute ethanol intoxication may be result from the selective increase of xanthine oxidase activity.

유도선수의 체중감량 전후 및 운동후의 혈액 성분 변화에 관한 연구

全允秀,노석규 대구효성 가톨릭 대학교 1990 연구논문집 Vol.40 No.1

The purpose of the study was to investigate the changes of blood components in before and after bodyweight reduction and after exercise of judoists. The subjects were 10ma1e national caliber judoists, and they reduced 3∼5% of bodyweight for three days. The tested items were WBC, Hemoglobin, Glucose, Lactic acid, pH. These items were compared in each three phase. The followings are conclusion : 1. It was shown a significant increase of WBC after bodyweight reduction and exercise than before bodyweight reduction. (p <.001) 2. The hemoglobin level was increased but not a shown significant level after exercise and bodyweight reduction than bodyweight reduction. 3. The blood lactate level was significantly increased after bodyweight reduction and exorcise than before bodyweight reduction. (p < .001) 4. The concentration of pH was increased after bodyweight reduction than before bodyweight reduction but significantly decreased after exercise. (p <. 01)

미곡 산지 건조ㆍ저장시설의 확충방안

최윤상,박동규 한국농업정책학회, 한국축산경영학회 2001 농업경영정책연구 Vol.28 No.3

This study evaluates the efficient plans to extend a dry and storage center (DSC), the division in a rice processing complex, which is in need of extension. The results imply that its extension should be designed in the direction of building DSC's in size larger than 10,000 ton/year rather than building many small-scale DSC's. They also show that the current drying fee is far below the optimal level and the government supports to the DSC's should consider the regional differences.

가변 부하를 위한 RF 전원 공급기 설계

金允溟,朴圭喆,崔鍾云,朴宰煥 단국대학교 1992 論文集 Vol.26 No.-

In the RF gas discharge system the load varies frequently by the operational environment. And it is often necessary to change the matching network to provide the maximum possible power transfer from the oscillator to the RF load. An Rf oscillator whose variable operating frequency is between 20 and 30 MHz and whose output RF power is about 200 watts was designed to solve this problem. The conversion efficiency from the DC power was about 80% It is found that the output oscillating frequency which gives minimum RF reflections from the loads follows automatically to the changes of the load or of the operating conditions. It is also found that the output frequency decreases with the larger load shunt capacitance.

전자토모그래피의 정량적 분석에서 대물렌즈 조리개의 영향

김진규,이상희,권희석,정종만,정원구,이수정,주형태,김윤중 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.4

Electron tomography의 정량적 분석을 위해서 대물렌즈 조리개가 투과빔의 강도에 미치는 영향을 평가하였다. Electron tomography에 도입되는 Beer’s law의 올바른 적용을 위해서는 투과빔은 시료의 기울기에 따른 mass thickness의 변화에 의한 효과만을 반영해야 한다. 그러므로 빔 경로상의 대물렌즈 조리개, 홀더 등에 의한 다른 효과는 제거되어야 한다. 본 연구에서는 대물렌즈 조리개의 cut-off 효과를 120 kV TEM과 Quantifoil holey 카본 시료를 이용하여 상세히 평가하였다. 대물렌즈 조리개를 사용하지 않은 경우와 비교할 때, 30 μm 크기의 대물렌즈 조리개를 통과한 투과전자빔의 강도는 약 16.7%의 감소가 일어난다. 또한 55˚이상의 고경사각 기울기에서는 대물렌즈 조리개의 cut-off 효과에 의해 14.2%의 강도 감소가 추가적으로 발생함을 알 수 있었다. Electron tomography에서 정량적 분석을 위해서는 이러한 대물렌즈 조리개의 영향을 고려해야만 한다. 또한 Beer’s law의 올바른 적용을 위해서는 일련의 기울기에 따른 2차원적 영상은 가능하면 대물렌즈 조리개를 사용하지 않은 상태에서 획득하는 것이 바람직하다. We have evaluated the effects of experimental factors on transmitted electron beam intensities for quantitative analysis in electron tomography. For the correct application of Beer’s law in electron tomography, the transmitted beam intensity should reflect the net effect of mass properties on beam path. So, the any other effects of the objective aperture and the specimen holder on beam path should be removed. The cut-off effects of objective aperture were examined using Quantifoil holey carbon film and a transmission electron microscope operated at 120 kV. The transmitted beam intensities with 30 μm objective aperture dropped about 16.7% compared to electron beam intensities without the objective aperture. Also, the additional losses of about 14.2% at high tilt angles were occurred by cut-off effects of the objective apertures. For the precise quantitative analysis in electron tomography, the effect of the objective aperture on transmitted electron beam intensities should be considered. It is desirable that 2-D tilt series images are obtained without the objective aperture for correct application of Bee’s law.

처분장근처에서 침식에의한 Sr 화학종의 평형

조윤정,김성현,이인화,김시욱,고문주,박성규,이범규 조선대학교 환경연구소 2000 環境硏究 Vol.16 No.1

Leaching and adsorption equilibria of Sr Chemical Species from the near field of a repository has been studied in solidified cement with Fe and oxidized Fe. The absorption percent, Ads %, and distribution coefficient, K_d were calculated using equilibrium concentration to predict the extent of leaching and adsorption. In the mixed aqueous solutions the Ads % increase as Cement(C)/Water(W) ratios increase and K_d was decreased for Sr. These behaviors were discussed by adsorption and equilibrium of spiked ions. Oxides Fe promoted adsorption of spiked ions, but pure Fe had no effect. E_h values were also estimated and discussed to elucidate oxidation-reduction environment of experimental system.

2,4-Dinitrophenol을 처리한 호밀(Secale cereale L.) 유식물의 질산염 환원에 관한 연구 : Ⅰ. 호밀 유식물 묘조의 질산염 환원요소 활량에 대한 2, 4-Dinitrophenol의 영향 Ⅰ. Effect of 2, 4-Dinitrophenol on in vivo Nitrate Reductase Activity in the Shoots of Rye Seedlings

曺圭燐,李相淑,權五溶 충남대학교 1991 忠南科學硏究誌 Vol.18 No.1

This work was accomplished to determine the effect of 2,4-dinitrophenol (DNP) on in vivo nitrate reductase activities(NRA) in the shoots of 6 day old rye(Secale cereale L.) seedlings. The NRA in the shoots of rye seedlings pretreated with 0.5mM DNP was higher than that of the control group in all the experimental conditions as below. The optimal concentration of KNO_3 for maximum NRA was 10mM in both the control and treated group. The NRA accumulated with the treatment of 10mM KNO_3 was gradually increased for 4 hours in both groups, and then maintained constantly. On the other hand, the NRA occurred per hour was highest at 1 hour in both groups, while it was declined subsequently. The optimal pH for NRA was 7.5 in both groups. The daily pattern of NRA was markedly decreased for 4 days in both groups, and decreased slowly to 7 days. The NRA was greatly inhibited in the solutions of 200mM KCI and NaCl. According to the treatment time with the solutions of 200mM KCI and NaCl, the NRA was extremely inhibited at 2 hours, thereafter recovered slowly from its inhibition effects.

정상 관동맥을 가진 심장 점액종 환자에서 발생한 급성 심근 경색증 1예

이정민,이현승,전은정,윤호중,정욱성,오용석,김철민,김재형,최규보,홍순조,이교영,심상인 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.9

산소분압열처리를 이용한 폐기물산화철로부터의 단상 및 복합상 산화철의 제조

임희대,이찬규,허석환,박연준 國立 昌原大學校 産業技術硏究所 1998 産技硏論文集 Vol.12 No.-

Oxygen pressure heat-treatment with CO-CO2 gas mixture was introduced to purify the waste oxidized iron in shortblast process. To determine the temperture and oxygen partial pressure, Fe-O phase diagrams was used. single phase FeO, Fe₃O₄and composite phase FeO-Fe₃O₄, Fe-FeO could be obtained sucessfully in the range of 10(-17)∼10(-19) in Po₂at 800℃.

투과전자현미경 내 직접 가열 실험에서의 실험적 문제들

김영민,김진규,김양수,오상호,김윤중 韓國電子顯微鏡學會 2008 Applied microscopy Vol.38 No.4

In performing in situ heating transmission electron microscopy (TEM) for materials characterizations, arising concerns such as specimen drifts and unintentional Cu contamination are discussed. In particular, we analysed the thermal and mechanical characteristics of in situ heating holders to estimate thermal drift phenomena. From the experimental results, we suggest an empirical model to describe the thermal drift behavior so that we can design an effective plan for in situ heating experiment. Practical approaches to minimize several hindrances arisen from the experiment are proposed. We believe that our experimental recommendations will be useful for a microscopist fascinated with the powerful potential of in situ heating TEM.