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정염성,방승규 大韓神經精神醫學會 1982 신경정신의학 Vol.21 No.2
저자들은 1977년 1월 1일부터 1980년 12월 31일까지 카톨릭의과대학 부속 여의도 성모병원 신경정신과 입원환자중 전기충격요법을 받은 272명을 대상으로 임상적 고찰을 하여 다음과 같은 결과를 얻었다. 1. 총 입원환자 1,709명중 272명(15.9%)이 전기충격요법을 받았으며 정신분열증이 75.7%, 주요정동장애가 15.5%, 기타질환이 8.8%이었다. 2. 진단별로 보면 정신분열증의 30.4%, 주요정동장애의 22.5%, 기타질환의 2.8%가 전기충격요법을 받았다. 3. 전기충격요법의 시행횟수는 1인당 평균 8.3회(정신분열증, 8.9회;주요정동장애, 6.3회;기타질환, 7회)이었다. 4. 치료의 대상이 되었던 증상은 정신분열증의 경우 피해망상(20.3%)이 가장 많았으며 주요정동장애의 경우 정신운동성지체 혹은 초조(23.0%)가 가장 많았다. The authors performed this preliminary study to investigate the effect of ECT. The 272 psychiatric inpatients who received ECT atthe Department of Neuropsychiatry of Catholic Medical College from 1977 to 1980 were evaluated for clinical features. The results were as follows; 1. ECT was performed in 15.9% of a total of 1,709 inpatients who were admitted during the study period. Of them, 75.7% were diagnosed as schizophrenia, 15.5% as major affective disorder and 8.8% as others. 2. ECT was performed in 30.4% of the schizophrenics, 22.5% of those with major affective disorder and 2.8% of others. 3. Mean number of ECT was 8.3 times a patient. 4. The most common target symptom was persecutory delusion in schizophrenia and psychomotor retardation or agitation in major affective disorder.
초등 실과 바느질 단원의 모듈 수업이 학업 성취도에 미치는 영향
최염숙 韓國實科敎育硏究學會 1999 實科敎育硏究 Vol.5 No.2
For this study to determine the effect of modules instruction of sewing in elementary schools, two fifth-grade classes were selected: one as the experimental group receiving modular sewing lessons, and the other as the control group receiving conventional sewing lessons, for a period of four weeks. The cognitive, functional, and definitive aptitudes of each student from both groups wee assessed right before and after the experiment. The result showed that functional and definitive achievements were higher in the experimental group while cognitive achievement did not indicate any significant difference. In conclusion, a modular sewing lesson, coping with difference in individual learning abilities, was found to be a better educational method in functional and definitive areas, but not in cognitive area.
고 아밀라아제 혈증을 보인 급성 Lithium Carbonate 중독증 1례
홍현상,박흥수,정염성,노왕구 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.2
Lithium carbonate is a widely used and invaluable drug in the treatment and prevention of manic-depressive illness. However, lithium cardonate may induce multisystemic adverse effects and toxic effects that, when not recognized, may lead to severe, life-threatening complications. The authors experienced a manic patient who showed severe lithium toxic reactions with hyperamylasemia. The patient was 41-year-old woman who had received lithium carbonate treatment for 3 months. The patient's symptoms and signs of toxic reaction had disappeared after hydration, insulin therapy, and hemodialysis.
( Hyun Sik Youm ),( Hyun Sik Youm ),( Jong-ryeol Choi ),( Daesik Oh ),( Young Ho Rho ) 대한산부인과학회 2016 대한산부인과학회 학술대회 Vol.102 No.-
목적: To evaluate whether ectopic pregnancy rates differ between natural and hormone replacement endometrial preparation in frozen embryo transfer. 방법: Meta-analysis was performed on the 3 selected studies in the statistical framework R using ‘meta’ package (random effects model: DerSimonian-Laird estimator). The outcome considered in this study was the ectopic pregnancy rates. 결과: The ectopic pregnancy rates were not different between natural and hormone replacement endometrial preparation in frozen embryo transfer (odds ratio [OR] 0.91, 95% confidence interval [CI] 0.40-2.06). 결론: The data presented in this meta-analysis do not support a different risk in ectopic pregnancy between natural and hormone replacement endometrial preparation in frozen embryo transfer.
Youm, J-Y.,Woo, J-H.,Kim, T-H.,Bae, S-C.,Yoo, D-H. Informa Healthcare 2007 Scandinavian journal of rheumatology Vol.36 No.5
<P> Objective. Interleukin-1 (IL-1) has been implicated in the pathogenesis of several rheumatic inflammatory diseases, including adult-onset Still's disease (AOSD) and systemic-onset juvenile idiopathic arthritis (SoJIA). Several clinical trials also suggest that anakinra, a human recombinant interleukin-1 receptor antagonist (IL-1Ra), is effective in patients with AOSD and SoJIA. We have therefore investigated whether IL-1&bgr; and IL-1Ra gene polymorphisms are associated with the development and clinical features of AOSD. Methods. Genomic DNA was isolated from 83 AOSD patients and 144 healthy controls. Genotyping of the two IL-1&bgr; gene (IL-1B+3954 and IL-1B-511) polymorphisms was performed using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). Genotyping of the IL-1Ra gene (intron 2, VNTR) polymorphism was performed using PCR-based analysis. To compare genotype and allele frequencies, the &khgr;2-test or Fisher's exact test was used. Haplotype frequencies and pairwise linkage disequilibrium were also estimated. A p-value <0.05 was considered significant. Results. There were no significant differences in the genotype and allele frequencies of the IL-1&bgr; and IL-1Ra gene polymorphisms. No differences were also found in the IL-1 gene cluster haplotypes between both groups. IL-1 gene cluster polymorphisms had no effect on the clinical course and joint involvement pattern. Nevertheless, the IL-1B-511 and IL-1RN (VNTR) polymorphic sites were in linkage disequilibrium. Conclusion. These results suggest that IL-1&bgr; and IL-1Ra gene polymorphisms are not associated with the development and clinical features of AOSD in Korean patients.</P>
Youm, Jeong-A,Kim, Young-Gon The Microbiological Society of Korea 2003 The journal of microbiology Vol.41 No.1
Pycnogenol (PYC) is believed to have potential as a therapeutic agent against free radical-mediated oxidative stress. It is important, therefore, to understand the interactions between PYC and cellular defenses against oxidative stress. Toward this end, we analyzed the survival rates on the gene expression responses of E. coli sod katG mutants to PYC after pre-treatment of PQ or H$_2$O$_2$-mediated stress under aerobic conditions. We identified SOD induced by PYC, but not HP1 in sod hate mutants. A striking result was the PYC induction of SOD with antioxidant property in single katG mutant cells, particularly MnSOD and CuZnSOD. These inductions were further increased with oxidative stress, while HP1 was not induced in these conditions. The effects of pycnogenol treatment on these cells depend in part on its concentration on the stress response. Protective effects of PYC exposure which affected gene expression in cells were consistent with cell survival rates. Our results demonstrate that pycnogenol may alter the stress response gene expression in a specific manner such as SOXRS because PYC induction of single mutant only worked under increased PQ stress. All together our data indicate that SOD activity is essential for the cellular defense against PQ-mediated oxidative stress, suggesting that PYC may not be effective as an antioxidant in only oxidative stress conditions. On the other hand, it was expected that PYC may play a role as a pro-oxidant and if it is available for use, it should be evaluated carefully.