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Bing-You Liu 제어·로봇·시스템학회 2020 International Journal of Control, Automation, and Vol.18 No.9
This paper proposes the theoretical framework and the experimental application of an improved active disturbance rejection controller (ADRC) to speed control for the pitching axis of a remote sensing camera. Mechanical model of the pitching axis, mechatronics model of the speed control system for the pitching axis, and speed algorithm model of a permanent magnet synchronous motor are established. Control rates of the extended state observer (ESO) and the nonlinear state error feedback (NSEF) of the traditional ADRC are improved using a new nonlinear function. The nonlinear dynamics, model uncertainty, and external disturbances of the speed control system are extended to a new state, and the improved ESO is implemented to observe this state. The overtime variation of the speed control system is predicted and compensated for in real time using the improved ESO. The nonlinear integration method is adopted to nonlinearly combine the differential and the error differential by the improved NSEF. Subsequently, high-quality control is provided to the system. Simulation and experimental verification for the speed control system for the pitching axis of a remote sensing camera are conducted. Results show the effectiveness of the proposed controller.
Baimantuoluosides D-G, Four New Withanolide Glucosides from the Flower of Datura metel L.
Bing-you Yang,Yong-gang Xia,Qiu-hong Wang,De-qiang Dou,Hai-xue Kuang 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.8
In our search for bioactive anti-psoriasis compounds from the flower of Datura metel L, we isolated four new withanolide glucosides, baimantuoluosides D, E, F and G (1-4). The structures of the new compounds are (5α,6α,7β,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (1), (5α,6β,7α,22R)-5,6,7,27-tetrahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (2), (5α,6β,7α,12β,22R)-5,6,7,12,27-pentahydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (3), and (5α,6β,22R)-5,6,27-trihydroxy-1-oxowitha-2,24-dien-27-O-β-D-glucopyranoside (4) on the basis of chemical and physicochemical evidence.
Viability of C2C12 Mouse Myoblast Cells Under Chemical Hypoxic Condition
( You Bing Yang ),( Kyoung Mi Park ),( In Ho Hwang ) 전북대학교 농업과학기술연구소 2011 농업생명과학연구 Vol.42 No.1
The present study was to use the MTT assay in evaluating the viability of C2C12 cells under the chemical hypoxia which mimics muscle cells death process in anoxia after animal bleeding. C2C12 cells were seeded at the density of 0.5×10(4), 1×10(4), 1.5×10(4), 2.5×10(4) per well of 96-well plates to test correlation between MTT assay and direct cell counting and cells were seeded at the density of 5000 cells per well of 96-well plates to construct cells growth curve. C2C12 cells were treated with DMEM (serum withdraw), 1 mM, 10 mM and 50 mM sodium azide (NaN3 in DMEM) and returned to the incubator for 12 hours, 24 hours, 48 hours and 72 hours. MTT assays were performed using cells harvested from the time points indicated and the responses of C2C12 cells to serum deprivation and sodium azide-mediated (NaN3) chemical hypoxia were determined by optical density at 490 nm. Our results demonstrate that there is a linear correlation between directly counted C2C12 cell number and MTT absorbence. The cells growth curve showed that the period of before 24 hours is the lag phase and the period of after 24 hours is the exponential phase. The present in vitro model with 1 mM sodium azide (NaN3) or serum deprivation is well applicable to mimic the hypoxia-induced apoptosis.
Zheng, You-Bing,Zhao, Wei,Liu, Bing,Lu, Li-Gong,He, Xu,Huang, Jian-Wen,Li, Yong,Hu, Bao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9
Background and Aim: Increasing evidence correlates the presence of systemic inflammation with poor survival in patients with hepatocellular carcinoma (HCC). The aim of this study was to investigate the prognostic significance of the blood neutrophil-to-lymphocyte ratio (NLR) in patients with advanced HCC who received sorafenib monotherapy. Methods: A total of sixty-five patients with advanced HCC, not eligible for locoregional therapy, treated with sorafenib were enrolled. Potential prognostic factors such as age, gender, tumoral characteristics, performance status and NLR were analyzed. Results: Median OS and TTP for the entire cohort were 10.0 months (95%CI, 7.6-12.3 months) and 4.5 months (95% CI, 4.0-4.9 months). The mean NLR at baseline was 2.89. The median OS of patients with a high NLR (>4) was 6.5 months (95%CI, 5.2-7.7 months) compared with 12.5 months (95%CI, 9.9-15.0) for patients with a normal NLR (${\leq}4$) (P=0.01). Age ${\leq}65$, NLR>4, extrahepatic metastases and vascular invasion were all predictors of poorer overall survival. Multivariate analysis showed that NLR > 4, vascular invasion and extrahepatic metastases were independent predictors of poorer overall survival. The median TTP of patients with a high NLR was 2.5 months (95%CI, 1.4-3.6 months) compared with 4.5 months (95%CI, 3.9-5.1 months) for patients with a normal NLR (P=0.012). Conclusions: High baseline NLR was associated with worse OS and TTP for patients with advanced HCC treated with sorafenib.
Yang, You Bing,Pandurangan, Muthuraman,Hwang, InHo Published for the International Federation for Cel 2012 Cell biology international Vol.36 No.9
<P>The calpains play an important role in cell death and cell signalling. Caspases catalyse wholesale destruction of cellular proteins which is a major cause of cellular death. The current study looks at the function of μ-calpain and caspase 9, using RNAi (RNA interference)-mediated silencing, and to observe the mRNA expression level of caspase genes during satellite cell growth. The satellite cells were treated with siRNA (small interfering RNA) of μ-calpain and caspase 9 separately. There was reduction of 16 and 24% in CAPN1 (calpain1)-siRNA2 and CAPN1-siRNA3 transfected cells respectively, whereas it was 60 and 56% in CAPN1-siRNA1 and CAPN1-siRNA4 transfected cells respectively. CAPN1-siRNA4 and CAPN1-siRNA1 treated cells showed more reduction in caspase 3 and 7 gene expression. CARD9 (caspase recruitment domain 9)-siRNA1 and CARD9-siRNA2-treated cells showed reduction of 40 and 49% respectively. CARD9-siRNA1 and CARD9-siRNA2 showed an increase in caspase 3 gene expression, whereas CARD9-siRNA2 showed reduction in caspase 7 gene expression. These results suggest a strong cross-talk between μ-calpain and the caspase enzyme systems. Suppression of target genes, such as μ-calpain and caspase 9, might have genuine potential in the treatment of skeletal muscle atrophy.</P>
Genetic Diversity for Rice Blast Management
(You Yong Zhu),(Hai Ru Chen),(Yun Yue Wang),(Zuos Hea Li),(Yan Li),(Jing Hua Fan),(Jian Bing Chen),(Jin Xiang Fan),(Shi Sheng Yang),(Guang Liang Ma),(Ling Ping Hu),(Jin Yu Zou),(Christopher C . Mundt) 한국균학회 2001 Proceedings of the Fifth Korea-China Joint Symposi Vol.- No.-
Association Between the Ku70-1310C/G Promoter Polymorphism and Cancer Risk: a Meta-analysis
Xu, Lu,Ju, Xiao-Bing,Li, Pu,Wang, Jue,Shi, Zhu-Mei,Zheng, Ming-Jie,Xue, Dan-Dan,Xu, Yan-Jie,Yin, Yong-Mei,Wang, Shui,You, Yong-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Ku70 plays an important role in DNA double-strand break repair. Studies revealing conflicting results on the role of the Ku70-1310C/G promoter polymorphism on cancer risk led us to perform a meta-analysis to investigate this relationship. Ten case-control studies with 2566 cases and 3058 controls were identified. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to assess the strength of associations. The overall results suggested no association between the Ku70-1310C/G promoter polymorphism and total cancer risk. However, on stratified analysis, significantly increased risks were observed among the Asian population (GG vs. CC: OR=1.50, 95%CI=1.10-2.06; GG vs. CC/CG: OR=1.47, 95%CI=1.07-2.01) and population-based case-control studies (GG vs. CC: OR=1.57, 95%CI=1.12-2.22; CG vs. CC: OR=1.35, 95%CI=1.11-1.64; CG/GG vs. CC: OR=1.37, 95%CI=1.14-1.65). Additionally, variant genotypes were associated with a significantly increased breast cancer risk (GG vs. CC: OR=1.80, 95%CI=1.26-2.56; GG vs. CC/CG: OR=1.40, 95%CI=1.01-1.95).