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Yoshiki Kimura,Yoshiki Matsui,TomokiYamaguchi 한국방사성폐기물학회 2022 한국방사성폐기물학회 학술논문요약집 Vol.20 No.1
Nuclear security event involving nuclear and other radioactive materials outside of regulatory control (MORC) has the potential to cause severe consequences for public health, the environment, the economy and society. Each state has a responsibility to develop national nuclear security measures including nuclear forensics to respond to such events. In Japan, national nuclear forensics capability building efforts mainly based on research and development (R&D) have been conducted since 2010, in accordance with national statement of Japan at the Nuclear Security Summit in Washington DC. Most of that work is undertaken at the Integrated Support Center for Nuclear Non-proliferation and Nuclear Security (ISCN) of the Japan Atmic Energy Agency (JAEA) in close cooperation with other competent authorities. The ISCN has made increased contributions to the enhancement of international nuclear security by establishing technical capabilities in nuclear forensics and sharing the achievements with the international community. The ISCN has mainly engaged in R&Ds for establishing and enhancing nuclear forensics technical capability. As for the laboratory capability, several new pieces of analytical equipment have been introduced for nuclear forensics R&D purposes. High-precise measurement techniques validated in the past nuclear forensics incidents have been established, and novel techniques that can contribute to the more timely and confident nuclear forensics signature analysis have been developed. The ISCN has been also developed a proto-type nuclear forensics library based on the data of nuclear materials possessed for past nuclear fuel cycle research in JAEA. These technical capability developments have been conducted based on the cooperation with international partners such as the U.S. Department of Energy and EC Joint Research Center, as well as participation in exercises organized by Nuclear Forensics International Technical Working Group (NF-ITWG). Recent R&D works have been mainly based on the needs of domestic competent authorities, such as first responders and investigators, and aim to develop technologies covering the entire spectrum of nuclear forensics processes from crime scene investigation to laboratory analysis and interpretation. One important key issue is the enhancement of technical capability for post-dispersion nuclear forensics. For instance, the ISCN has carried out the development of radiation measurement equipment coupled with the low-cost and mobile radiation detectors that uses machine-learning algorithms for quick and autonomous radioisotope identification to support first responders during crime scene investigations. Laboratory measurement techniques for samples collected at a post-dispersion crime scene are also among the important technical issues studied at the ISCN. The application of emerging technologies to nuclear forensics has also been studied. This includes the application of deep leaning models to nuclear forensics signature interpretation that could provide more confident results, as well as the development of contamination imaging technology that could contribute to the analytical planning on the samples in collaboration with conventional forensics. Many analytical techniques have been developed and the capability to analyze nuclear and other radioactive materials for nuclear forensics purposes has been considerably matured over the past decade. The challenges of post-dispersion samples, collaboration with conventional forensics and the development of novel signatures will be more important in the near future. Therefore, the ISCN will promote the R&Ds to further enhance the technical capabilities solving these issues. In addition, the ISCN is also promoting to expand the nuclear forensics research into universities and other research institutes in Japan. This is expected to contribute to the establishment of a domestic nuclear forensics network that enables to respond timely and flexibly to the MORC incidents, and to the maturation of nuclear forensics as a new academic field.
Yoshiki Itoh,Yasuharu Izumisawa,Seiya Maehara,Kazuto Yamashita,Norihiko Itoh 대한수의학회 2013 JOURNAL OF VETERINARY SCIENCE Vol.14 No.1
Electroretinography (ERG) is a well-established diagnostic procedure for objectively evaluating retinal function. In this study, ERG in beagle dogs, which are a popular experimental animal, was performed to determine the normal range of ERG variables and assess differences between the left and right eyes. ERG findings including rod, combined rod-cone,single-flash cone, and 30-Hz flicker responses were recorded with an LED-electrode in 43 sedated beagle dogs. The subjects were divided into young (< 1 year old), adult (1∼5years old), and senile animals (≥ 6 years old). Normal ERG ranges were obtained. Significant differences in b-wave amplitude along with b/a ratio of the combined rod-cone response were found between the young and adult animals as well as young and senile dogs. No significant differences were observed between the left and right eyes. ERG variables in beagle dogs differed by age due to age-related retinal changes. Thus, we propose that normal ERG ranges should be determined according to age in each clinic and laboratory using its own equipment because each institution usually has different systems or protocols for ERG testing.