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이재일,이채문,정융호,이득우 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-
Mechanical micro-engineering is an easy and cheap way to fabricate micro-structures. If the application of the conventional machining method using flat-end mill becomes available for the micro-manufacturing process, it will be advanced as an extension of the conventional machining process. In this study, micro-grooves cutting using flat-end mill(φ8) was performed. The characteristics on flat-end milling was investigated to improve machinability of micro-grooves. The experiments were performed according to variations of spindle revolution, depth of cut, and feed rate. Machinability through various cutting conditions was evaluated by surface geometry, tool wear, and cutting force. The results show that micro V-grooves of width(pitch) 297/μm were acquired by flat-end milling. The maximum and minimum roughness of the wall of grooves was 438 and 67 nm, respectively.
초음파 진동절삭을 이용한 평면 광도파로와 유리의 미세 홈 가공특성에 관한 연구
이준석,김병국,정융호,이득우 한국공작기계학회 2002 한국공작기계학회 춘계학술대회논문집 Vol.2002 No.-
Recent years, optical components' are widely used in optical communication industry for high speed and mass storage data processing. Micro grooving of planar lightwave circuit and glass, those are widely used in optical component, are realized by polycrystalline diamond tool with ultrasonic vibration. To know the characteristics of brittle materials cutting, ultrasonic vibration cutting tool and machining system are built for the experiment. Grooving on planar lightwave circuit and glass experiments are performed and their shape are measured by photograph with microscope. It reveals that better groove shape with low chipping of planar lightwave circuit and glass are obtained by micro grooving machining with ultrasonic vibration. These experiments are considered as a possibility to the micro grooving of optical communication components.
권동희,박진효,김정석,김병민,정융호,강명창 한국공작기계학회 2007 한국공작기계학회 추계학술대회논문집 Vol.2007 No.-
As demands for micro parts are on the increase in recent industries such as aerospace, biomedical, electronics, environment, information technology and display, the need for manufacturing such parts is also increasing. Major methods of manufacturing micro parts are based on semiconductor process technology such as lithography and etching and non-traditional machining using lasers, ultrasonic, ion-beams or electrical discharge. However, these methods require lots of time, workpiece materials are limited, and such methods are only applicable to the machining of two-dimensional shapes. Therefore, mechanical machining methods are required for the manufacturing of micro parts with complex shapes. This paper presents an investigation on the characteristics for micro groove machining by using the ultrahigh-speed air turbine spindle, and verifies the properties of mechanical method in fabricating molds for micro barrier ribs. As a result, the optimal machining condition could be found from the investigation of surface roughness according to the kinds of burr shapes in the fabricating of iron mold by using micro endmill.
(Yoong Ho Lim),(Mi Na Oh),(K . Hun Mok) 한국응용생명화학회 1998 Applied Biological Chemistry (Appl Biol Chem) Vol.41 No.8
The conformations of human insulin precursors, proinsulin and preproinsulin, are described in terms of molecular dynamics simulations. Despite the presence of the C-peptide and/or the signal peptide, molecular dynamics calculations utilizing the hydration shell model over a period of 500 ps indicate that the native conformations of the A and B chains are well conserved in both cases. These results further support the NMR spectroscopy results that the C-peptide is relatively disordered and does not influence the overall conformation of the native structure. The robustness of the native structure as demonstrated by experiment and simulation will permit future protein engineering applications, whereby the expression or purification yields can be improved upon sequence modification of the C-peptide and/or the signal peptide.
(Yoong Ho Lim),(Mi Na Oh),(Su Il Kim) 한국응용생명화학회 1998 Applied Biological Chemistry (Appl Biol Chem) Vol.41 No.8
Computer aided molecular modeling can help to predict the three dimensional structure of the polypeptide without the sample. The study on soybean Bowman-Birk protease inhibitor (SBI) is valuable, because it has been recently known that SBI possesses anticarcinogenic activities and immune-stimulating properties. SBI has several isoinhibitors, whose isolation and characterization were reported in 1990. Among these, DII inhibits trypsin only. The different inhibitory specificities cannot be explained only by their different primary sequences, but is possible with further assistance by the study on their different three dimensional structures. The study on the three dimensional structure of DII using homology method is reported in this paper.
A Comparison of Three Dimensional Structures of Biosynthesized Preproinsulin and Insulin Using NMR
(Yoong Ho Lim),(Mi Na Oh),(K . Hun Mok) 한국응용생명화학회 1998 Applied Biological Chemistry (Appl Biol Chem) Vol.41 No.8
The solution conformation of the human insulin precursor, preproinsulin, is described in terms of NMR spectral data. NMR experiments were performed on preproinsulin, whose structure was compared with the NMR structure of native human insulin. Despite the presence of the C-peptide and/or the signal peptide, secondary structure analyses indicate that the native structures of the A and B chains are well conserved even in preproinsulin. The observed relative robustness of the native structure in precursor forms permits further protein engineering experiments where the C-peptide or N-terminal signal sequence can be altered for the purpose of increasing expression or purification yields when producing recombinant human insulin.