고관절 치환술후 무균성 해리와 골용해 조직에서 세포사멸

김신윤,인주철,손윤경,김정완,신홍인,구경회 경북대학교 병원 2003 경북대학교병원의학연구소논문집 Vol.7 No.1

목적 : 인공 고관절 치환술 후 실패의 가장 중요한 원인이 되는 무균성 해리및 골용해와 nitric oxide(NO)에 의한 염증세포 사멸의 연관성을 규명하기 위해 본 연구를 시행하였다. 대상 및 방법 : 무균성 해리와 골용해로 인해 재치환술을 받은 18명의 환자의 조직에서 세포들의 사멸을 Terminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick End Labeing (TUNEL) 방법을 이용하여 검사하였으며, inducible nitric oxide synthase(iNOS)와 미토콘드리아 관련 세포사멸 경로를 p53, Bax, Bcl2, Ki67 항체를 이용해서 면역 염색하였다. 대조군으로 대퇴 경부 골절 환자 6명의 관절낭을 이용하였다. 결과 : 16명(89%)에서 iNOS, p53, Bax 항체에 양성 반응을 보였으며, 12명(67%)에서 Bcl2, Ki-67 항체에 양성반응을, 전례에서 TUNEL에 양성반응을 보였다. 대조군에서는 1명(17%)에서 iNOS와 Bax에, 3명(50%)에서 TUNEL에 양성반응을 보였다. 무균성 해리와 골용해 조직의 세포사멸에 대한 양성반응의 발현빈도가 대조 조직에서 보다 유의하게 높았다. 결론 : Nitric oxide에 의한 염증세포의 사멸이 인공고관절 치환술 후 생기는 무균성 해리와 골용해에 작용함을 알수 있었다. 이 결과는 해리 및 골용해의 예방과 치료방법을 개발하는데 도움을 줄 수 있다. Purpose : To evaluate the relationships between the apoptosis induced by nitric oxide(NO), aseptic loosening and osteolysis, which are the most serious causes of failure after total hip arthroplasty. Materials and Methods : Apoptosis of the inflammatory cells of interface tissues from 18 patients who underwent revision hip arthroplasty was identified by Teminal Deoxyribonucleotidyl Transferase-Mediated dUTP Nick End Labeling(TUNEL). The reaction to immunostaining of inducible nitric oxide synthase(iNOS), p59, Bax, Bcl2, and Ki-67 were evaluated. Six joint capsules obtained from six patients of femoral neck fracture were studied as controls. Results : Sixteen(89%) of 18 interface tissues were positive for iNOS, p53, and Bax monoclonal antibody and twelve(67%) for Bcl2 and Ki-67 monoclonal antibody. All tissues were positive for TUNEL. In the control group of six joint capsules, only one(17%) was positive for iNOS and Bax, and three(50%) were positive for TUNEL. The incidences of apoptiotic signals at the interfacial tissue of aseptic loosening and osteolysis were significantly greater than those of the control. Conclusion : The current study suggested that the apoptosis of inflammatory cells, due to oxidative stress by NO, might be involved in the development of implant loosening and osteolysis after total hip arthroplasty. This information might be crucial for the treatment and prevention of periprosthetic osteolysis and subsequent loosening.

A case of lichen amyloidosis in an adult

( Jee Yon Shin ),( Myeong Heon Chae ),( Ji Yeoun Lee ),( Tae Young Yoon ) 대한피부과학회 2019 대한피부과학회 학술발표대회집 Vol.71 No.1

Lichen amyloidosis is a type of primary localized cutaneous amyloidosis clinically characterized by persistent pruritic, hyperkeratotic papules commonly distributed on the shins. Histopathologically, amyloid deposition in the papillary dermis is the characteristic finding. It appears to be more common in males and most often occurs in people 50-60 years of age. A 49-year-old woman presented with brownish papuloplaques on the both lower legs. Itching sense was severe and the lesion was occurred 2 years ago. Histopatholgic findings showed amyloid deposit in the papillary dermis. D-PAS staining was negative. Based on these findings, a diagnosis of lichen amyloidosis was made. We think this case has typical chracteristics of lichen amyloidosis. Therefore we report a case of lichen amyloidosis for educational purposes.

Edward Ⅳ 의 羊毛정책 : 英國 重商主義 起源問題로서 As Origin Problems of Mercantilism in England

申允吉 中央大學校 史學硏究會 1987 중앙사론 Vol.5 No.-

정맥내 통증자가조절법을 이용한 Nalbuphine-Ketorolac과 Butorphanol-Ketorolac의 술후 진통효과 비교

윤석화,이원형,손수창,신용섭,김윤희,양신영 충남대학교 의과대학 의학연구소 2003 충남의대잡지 Vol.30 No.1

This study aimed to compare analgegic efficacy, satisfaction score and side effect of nalbuphine-ketorolac and butorphanol-ketorolac by using intravenous patient controlled analgesia(IV-PCA) for postoperative anlgesia following a gastrectomy for stomach cancer. Ninety patients who had undergone gastrectomy for stomach cancer under general anesthesia were randomly divided into two groups. Each group recieived nalbuphine 50mg with ketorolac 150mg(Group 1, n=45) and butorphanol 5mg with ketorolac 150mg(Group 2, n=45) by using IV-PCA during postoperative 48hrs. Assessments for pain with numerical rating scale(NRS), and side effects were evaluated at 2hr, 6hr, 12hr, 24hr, 36hr and 48hr after the operation. There were no significant difference in NRS for pain during rest, but Group 2 requested significantly greater amount of supplementary diclofenac during first 24 hours. Side effects were higher Group 1 in pruritus, nausea and vomiting and Group 2 in sedation, nausea and vomiting. This study suggests that adding ketorolac with intravenous nalbuphine or butrophanol in using an intravenous PCA can decrease analgesics requirement and improve analgesic property without the major morbidity like respiratory depression, but needs for the careful observation and treatment on the side effects like nausea. vomiting, pruritis and sedation...

만성 화농성 중이염의 세균학적 고찰

윤신의,문문만,김승찬,박희완,나한조,최봉남 朝鮮大學校 附設 醫學硏究所 1991 The Medical Journal of Chosun University Vol.16 No.1

The chronic suppurative otitis media is one of the most common disease in the otologic field. And the works on bacterial distribution of chronic suppurative otitis media were studied by many otologist, but there is some difference. The bacteriologic study was done on 126 cases of chronic suppurative otitis media who visited the Department of Otolaryngology, Chosun University Hospital between January 1989 and December 1989 and the following conclusions were obtained. 1) In sex distribution, the male had higher incidence rate than female (M: 56.3%, F:43.7%). 2) In age distribution, 3rd decade (34.1%), 2nd decade (34.1%), were most prevalent. 3) In duration of the disease, the hightest frequence was below 5 years duration 4) Among 126 cases, 98 cases(77.8%) were unilateral (right ear was 47 cases(37.3%) and left ear was 51 cases(40.5%))and 28 cases(22.2%) were bilateral. 5) The 136 cases(88.3%) showed the positive results under culture, but 18 cases(11.7%) didn't growthed. Among 136 cases 95 cases(61.7%) had single infection and the 41 cases(26.6%) had mixed infection. 6) The most frequently isolated bacteria was staphylococcus(38 strains, 27.9%) and next were proteus(27 strains, 19.9%) and pseudomonas (22 strains, 16.2%). 7) The Staphylococcus was sensitive to cephalothin(94.7%), amikacin(78.9%) and resistant to penicaIin(63.2%). 8) The Proteus was sensitive to amikacin(92.6%), cephalothin(88.9%) and resistant to minocycline(81.5%) and gentamicin(70.4%). 9) The Pseudomonas was sensitive to amikadn(86.4%), gemtamicin(59.1%) and resistant to minocycline(90.9%), ampicillin(86.4%) and cephalothin(86.4%).

TV媒體가 兒童의 攻擊性 發達에 미치는 影響

申允澈,裵珍洙 진주교육대학교 1986 論文集 Vol.30 No.1

Few tropics have attracted as much theoretical and empirical attention over the past score as the development and regulation of aggressive behavior permeated by the TV viloence viewing. In this pacer we intended to overview the ambivalent effects of TV-media, the relationship between TV violence viewing and aggressive behavior development of the children through the literatures according to the types of research, and after that suggest some implipications to decrease and prevention of aggression. In light of the review we draw the following conclusions. 1) Research has demonstrated that TV plays a role in the positive effect and negative effect as well according to the TV programs, 2) Although multiple theories have been explored to explain the development of aggression derived from the TV violence viewing, only one theory can't be done it completely. 3) Though the results gained from the laboratory experiments about the effects of TV violence viewing and the viewer's aggression are inconsistent, they have helped to identify the range of circumstamces under which it is possible to find an effect on viewer aggression. 4) While field experiments haute found either no effect or awn effect of less aggression in the group that viewed violence compared to a group that viewed neutral films, the remaining majority of these studies has provided qualified evidence that viewing of violence leads to an increase in viewer aggression. 5) Most of the correlational study have not reached the conclusion that there is a consistent or, small positive correlation between viewing TV violence and aggression. But there is little evidence that in natural settings viewing TV violence cause people to be more aggressive. 6) There are many intervening variables in determining the TV violence viewing and aggressive behavior, that is, age, sex-typing, identification and fantasy wish the TV characters, viewer's predisposition, parents influence, etc.

학교불소용액 양치사업 평가에 관한 조사연구

윤신종,신승철 단국대학교 치의학연구소 1991 논문집 Vol.3 No.-

The author have surveyed 1634 school children for experimental group and 886, for control, through the oral examination and questionaires, the school based fluoride mouth rinsing program that had been done for several years at some elementary schools for pilot projects. Questionaires were proposed to parents of students, teachers and school nurses also. The obtained results were as follows. 1. It was estimated that the fluoride mouth rinsing program were well performed for several years in the initial periods of the projects as about 30% of caries reduction effect. But there were less efforts as years progresses and now only 40% of schools were continued at the program. 2. The most school children and parents of students were in favor for fluoride mouth rinsing program on the other hands, teachers and school nurses disliked or were indifferences. So comprehensive readjustment were needed to promote the school based fluoride mouth rinsing program. 3. In order to pormote and to spread to all over the Korea, the authorities of the Ministry of Health and Welfare and the Ministry of Education as well as dentists and school teachers should be take part in the program. And it should be needed that the department of oral health wer established to control the school based fluoride mouth rinsing program, in Korea.

정보통신기술의 전략적 활용에 관한 연구 : An Empirical Study

尹信一 강남대학교 사회과학연구소 1997 사회과학논총 Vol.3 No.-

배드민턴 선수의 멘토링 경험이 스포츠 자신감에 미치는 영향

신용업,정훈,박윤미 龍仁大學校 體育科學硏究所 2011 體育科學硏究論叢 Vol.21 No.1

The purpose of this survey was the effect of mentoring experience on sports confidence of badminton players, and hypothetical models, then after, I examined the cause-effect relationship between variables through means of structural equation model. To test this, 143 participants were sampled from the position badminton players using stratified cluster random sampling, and then frequency analysis, exploratory factor analysis, t-test, one-way ANOVA, Scheffé analysis, correlation analysis, regression analysis, and path analysis of the resulting data were conducted using SPSS 15.0 program. Results revealed from these research methods and analyses of data are as follows: First, there were significant differences in career function and psychosocial function according to individual characteristics in gender, age, exercise career, education level and monthly income. Second, there were significant differences in trait sport-confidence according to individual characteristics in age, exercise career and education level. And there were significant differences in state sport-confidence according to individual characteristics in gender, age, exercise career, education level and monthly income. Third, psychosocial function had significant influences on trait sport-confidence, and explains 23.8%(R²=.238) of the physical self-concept. And career function and psychosocial function had significant influences on state sport-confidence, and explains 26.4%(R²=.264) of the physical self-concept.

저먼 세퍼드에서 발생한 내측 갈고리돌기 유합부전을 컴퓨터 단층촬영술을 이용하여 진단한 증례

황윤태,안지영,신희승,최호정,이영원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2009 動物醫科學硏究誌 Vol.16 No.1

A 4-year-old male German shepherd dog with reluctance to exercise, swelling of bilateral elbow joint and general depression was referred to the Veterinary Medical Teaching Hospital of Chungnam National University. Swelling, alopecia and lichenification of bilateral elbow joint were observed on physical examination. Osteophytes, sclerosis and joint mouse of bilateral elbow joint were found on radiography. Deformation of medical coronoid process and soft tissue density swelling at caudal part of bilateral elbow joint were also observed on radiography. Computed tomography revealed fragmented medial coronoid process and osteophytes of bilateral elbow joint. Therefore this case was diagnosed as fragmented medical coronois process and degenerative joint disease.