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Chun, Yoon-Keun,Ha, Joo-hun,Hong-Jung-Woo,Oh, Soo-Myung,Kim, Sung-Soo 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1
Yoon-Keun Chun¹,Joohun Ha□Hong-Jung Woo□, Soo Myung Oh□,Sung Soo Kim□ ¹Department of Molecular Biology, College of Medicine,²Department of Surgery, college of Medicine,³Department of Internal Medicine, College of Oriental Medicine,and ⁴East-Weat Medical Reserch Institute,Kyung Hee University, Seoul, Korea. The HBV DNA Amounts in Serum Have No relationship with ALT level and Hetergeneous Population Coexits in Chronic Hepatitis B Virus Infection. Proceedings of International Symposium on East-West Medicine, Seoul. 212-230, 1999. -Hepatitis B is caused by hepadnavirus. Hepatitis B virus replicates through 3.5kb pregenomic RNA intermediate which is regulated by core promoter. Pathogenesis of hepatitis B virus has been bilieved the result of host immune response. But recently many studies have reported that high level of viral replication caused by mutation in core promoter might result in severs hepatitis. But these studies were performed in vitro, not in vivo. So there is yet debate about which factor, viral of host factor, is more important in pathogenesis of hepatitis B virus. So we measured real viral replication level in 204 chronic hepatitis B patients by quantifying HBV DNA from sera by our novel PCR-based more sensitive method, and compared these results with ALT level measured from same sera, which indicates liver cell damage. Surprisingly there are no significant correlation between HBV DNA quantity and ALT level. Then we cloned core promoter region. In SSCP, we found that many viral mutants coexist in one patient. Base on SSCP result, we chose main viral core promoter type in each patients, which is thought to determine overall viral replication level in this patient. Main type of core promoter region of each 41 patients were directly sequenced. And with these we measured promoter activity by luciferase assay system and compared promoter activity with on another. We found tha there were some differences in promoter activity according to core promoter sequences. And we constructed replication-competent viral constructs with core promoter from 41 patients and Transfected these into HepG2 cell and measured HBV DNA by southern blot. There were also differences in HBV DNA quantity according to core promoter sequences. On these all results we investigated correlation between the effect of HBV core promoter on viral replication in vitro and HBN DNA quantity, ALT level from sera of each patients. We found there is no significant correlation among them. As a result, we concluded that in determining severity chronic hepatitis B patients, host factors of each patient is more important rather than replicative activity of virus itself.
저서성 (低棲性) 대형무척추동물에 의한 생물학적 수질평가 연구 (3) - 육안적 간이수질평가방법을 중심으로 -
윤일병,공동수,유재근 ( Il Byong Yoon,Dong Soo Kong,Jae Keun Ryu ) 한국환경생물학회 1992 환경생물 : 환경생물학회지 Vol.10 No.2
In this present paper, simple water quality evaluation method using Korean benthic macroinvertebrate 29 systematic groups was proposed from data matrix investigated by authors etc. at 613 sampling units in Korean streams and lakes since 1971. The evaluation of water quality criteria by this method showed identity of 63% in 378 sampling to chemical evaluation. Also we proposed the quantitative index named Yoon-Kong`s GPI (Group pollution index) and this index showed correlation coefficient over 0.9 to Pantle-Buck`s saprobic index S and Yoon-Kong`s Total Biotic Score, TBS.
디지털 위서 통신 채널의 비선형성 보상을 위한 신경회로망 등화기의 설계 및 평가
윤병문,김정희,임영선,진근식,신요안 崇實大學校 生産技術硏究所 1995 論文集 Vol.25 No.2
A digital satellite communication channel has a strong nonlinearity with memory due to saturation characteristics of the high power amplifier in the satellite and transmitter/receiver filters used in the overall system, and can be well modelled by a nonlinear Volterra series. In this paper, we design and evaluate neural network based adaptive equalizers for compensation of nonlinearities in digital satellite communication channels. We consider CMLP (complex multi-layered perception). CRBFN (complex radial basis function network) and complex ρth order Volterra filter as equalizers, and evaluate their performances in terms of symbol error rate under various noise conditions. In particular, a complex hybrid learning algorithm of k-means clustering and LMS (least mean squares) algorithm is proposed for the CRBFN. Computer simulation results show good performance for all the equalizers considered
자료표현 학습에서 자기조절 학습시스템이 학업성취도에 미치는 영향
윤정희,이은경,한건우,이영준 韓國敎員大學校 敎育硏究院 2007 敎員敎育 Vol.23 No.2
In order to understanding the principles of computer operation, students need to know data representations first. But most of students have difficulties in understanding it and their academic achievements are relatively low. Therefore, we developed a self-regulated learning system based on self-regulated learning strategies and implemented it in the high school. The experimental group was taught with the self-regulated learning system, while the control group was taught with a traditional teaching method. We found that teaching with the self-regulated learning system has more positive effects on academic achievement than teaching with a traditional method in data representation learning. 인문계 고등학교 ‘정보사회와 컴퓨터’ 과목의 ‘자료표현’ 영역은 컴퓨터의 작동원리를 이해할 수 있는 중요한 영역이지만 학생들은 이 영역 학습을 매우 어려워하며 성취도도 낮은 편이다. 따라서 학생들이 보다 쉽게 ‘자료표현’ 영역을 학습할 수 있는 지원시스템이 필요하며 본 연구에서는 개인의 능력에 따라 학습이 가능하고 실질적인 교수학습과정에 유용하도록 설계된 자가조절학습 프로그램을 적용한 자기조절학습시스템을 개발하였다. 개발된 시스템을 실제 교수 학습 현장에 적용하여 자기조절학습시스템을 활용한 수업이 학습자의 학업성취도에 긍정적인 영향을 끼쳤음을 확인하였다.
윤근수,이준원 安東大學校 工業技術硏究所 1999 공업기술연구논문집 Vol.6 No.1
국내 네트워크 장비 개발이 활발해짐에 따라 이들 장비들에 대한 검증이 중요하게 되어 네트워크 장비 시험센터가 설립되었다. 이 센터가 효율적으로 운용되기 위해서는 이용자들의 요구사항을 파악하여 반영하고 시험결과나 관련정보들을 효율적으로 수집하고 알려주는 시스템이 매우 중요하다. 따라서 본 논문은 웹 기반에 액티브 서버 페이지를 이용하여 언제 어디서나 누구든지 네트워크 장비 시험센터에 접속해서 설문조사를 통해 사용자의 요구 사항을 파악하여 반영하고, 네트웍 장비의 시험정보와 시험일정, 시험결과 및 관련정보를 데이터 베이스화하여 효율적으로 보여주고 관리 할 수 있는 시스템을 설계 및 구현하였다. The Network Equipment Test Center(NETC) was established and began to operate. To use the NETC effectively, the management system is required. The Network Equipment Test Center System is a system which retrieves and manages the informations related to the NETC. We design and implement the web based system.
물분쟁의 해소를 위한 기술적·제도적 측면과 사회적 장애 : 용담샘의 사례 Case Study of Yongdam Dam
윤근섭,宋正基 全北大學校 1996 論文集 Vol.42 No.-
The purpose of this research is to analyse conflict circumstances between the two regions (Chonbuk and Chungcheong) of Keum-Kang river basin and furthermore to suggest the ways of solving water-dispute from the viewpoint of technological and institutional aspects. In this study, I found the two regions' conflict is due to the probelm how to keep the appropriate amount of water in Keum-Kang river basin. I also suggest to develop a new coordinate procedure for solving this problem. Nevertheless, the best possible choice for this problem is to develop a way of integrating it with the consideration of social barriers accompanied by water-resource development projects.
충북 남부지역 중소 제조기업의 경쟁력 제고를 위한 경영 및 애로기술 실태조사 연구
윤상원,구경완,정성진,백기영,김선훈,서용성,이근복 호서대학교 반도체제조장비국산화연구센터 2001 반도체장비학술심포지움 Vol.2001 No.-
본 연구에서는 충북 남부 3개군 지역(옥천 · 보은 · 영동)의 중소 제조기업의 경영실태 및 애로기술을 대상으로 실증조사 되었다.·지역의 특정상황의 전제하에 지방 중소기업들의 실질적인 문제점들을 발견하고, 그 개선 방안을 탐색함은 물론 산 · 학 · 연 컨소시엄 사업의 성공적인 수행을 위해 시도되었다.세부적으로는 중소 제조기업의 경영 및 애로기술 특성을 일반적 사항, 경영애로요인, 경영전략, 현장개선기법, 정보화, 제품 및 공정 기술상의 애로기술 현황파악의 6개 영역으로 조사되었다. 조사결과들은 추후 산 · 학 · 연 공동기술개발 사업에 있어 창의적, 틈새적 과제발굴 및 신제품 기술개발의 토대마련이 될 뿐 아니라, 지역경제 발전을 위한 산 · 학 관의 지원 전략 수립에 적극 활용 될 것으로 판단된다.