정신분열병 환각의 횡문화적 연구 : 상해와 서울의 비교 A Transcultural Study

金光日,長良棟,陸明康,朴康奎,朴容千,金大虎 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.5

연구목적 : 정신분열병의 환각이 문화사회의 특성에 따라 어떤 차이가 나는지를 확인하고 그 의미를 문화정신의 학적 견지에서 고찰해보고자 이 연구를 시행하였다. 방 법 : Shanghai와 서울의 정신분열병 환자를 대상으로 환각의 형태, 내용, 주제 등에 관한 비교문화적인 조사연구를 하였다. Shanghai Mental Health Center, 국립서울정신병원, 한양대학교병원에 입원하고 있는 환자중 DSM-Ⅳ 진단기준으로 정신분열병의 진단이 확정된 환자 가운데 입원한지 1개월에서 6개월 이내인 환자를 대상으로 사전에 성별, 연령, 교육연한, 발병기간 임상아형, 등 5개 변인을 통제하여 조사대상을 선정하였다. 조사대상이 된 환자는 396명(Shanghai 182명, 서울 214명)이었다. 이중 환각이 확인된 환자 231명(Shanghai101명, 서울 130명)을 최종 연구대상으로 하였다. 결 과 : 환각의 형태에서는 양 집단 차이가 없었으나 환각의 내용이 양 집단에서 차이를 보였다. 즉 Shanghai에서는 정치적인 내용이, 서울에서는 초자연적/종교적 내용이 많았다. 결 론 : 환각의 주제나 내용은 망상과 긴밀하게 연관이 되어 있다는 점, 그리고 사회문화적 상황의 영향을 다분히 받고 있음을 알 수 있었다. Objective : The types, contents and major themes of schizophrenic hallucinations in Shanghai and Seoul were compared for evaluating cultural differences and connotation. Methods : Among the schizophrenic inpatients of Shanghai Mental Health Center in Shanghai and National Seoul Mental Hospital and Hanyang University Hospital in Seoul, 396 cases(182 cases in Shanghai, 214 cases in Seoul) were selected by two ways: a) five staged stratified random sampling of sex, age, education, clinical subtype and onset year, b) cases who have admitted for one to six months in their last admission. Among them, 231 cases(55.39% in Shanghai, 60.83% in Seoul) confirmed to have hallucinations were the final subjects of study. Results : Frequencies in types of hallucination were not different between the two groups. However, contents and major themes were different: Political themes and related contents were dominant in Shanghai cases, and supernatural and religious themes and related contents were dominant in Seoul cases. Conclusion : It was concluded that contents and themes of hallucinations were closely related to the delusional contents and themes, and such patterns were considerably influenced by so-ciocultural characteristics.

Molecular characterization and expression analysis of putative odorant carrier proteins in Adelphocoris lineolatus

Yong Xiao,Liang Sun,Qi Wang,Qiang Zhang,Shao-Hua Gu,Adel Khashaveh,Ze-Wen Liu,Yong-Jun Zhang 한국응용곤충학회 2018 Journal of Asia-Pacific Entomology Vol.21 No.3

The alfalfa plant bug Adelphocoris lineolatus (Goeze) (Hemiptera: Miridae), a serious pest of several agricultural crops, is extremely attracted by flowering plants to perform season host switching. Generally, chemoreception of A. lineolatus plays a crucial role in detecting food sources, locating mates and oviposition sites. In addition, odorant carrier proteins are believed to participate in the initial chemical communication and perception in insects. In this work, we identified 31 putative odorant carrier protein genes from the antennal transcriptomes of A. lineolatus, including 17 new odorant binding proteins (OBPs), 10 new chemosensory proteins (CSPs) and four Niemann-Pick type C2 proteins (NPC2s). Phylogenetic analysis demonstrated that the OBP and CSP genes from four mirid bug species (A. lineolatus, Adelphocoris suturalis, Apolygus lucorum and Lygus lineolaris) had a relatively close evolutionary relationship. Regular patterns and key conserved motifs of OBPs and CSPs in Hemiptera insects are also identified by using Multiple EM for Motif Elicitation (MEME) tool. Tissue expression profiles analysis showed that nine of the 17 OBPs, 10 CSPs and two of the four NPC2s were primarily or uniquely expressed in the adult antennae suggesting their putative roles in chemoreception. Our study provides the first insight into the roles of odorant carrier proteins in chemoreception of A. lineolatus, which will help to facilitate biological functions of odorant carrier proteins and develop novel insect behavioral regulation strategy

Selective Radiotherapy after Distant Metastasis of Nasopharyngeal Carcinoma Treated with Dose-Dense Cisplatin plus Fluorouracil

Liang, Yong,Bu, Jun-Guo,Cheng, Jin-ling,Gao, Wei-Wei,Xu, Yao-Can,Feng, Jian,Chen, Bo-Yu,Liang, Wei-Chao,Chen, Ke-Quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.14

Purpose: To investigate the efficacy and safety of selective radiotherapy after distant metastasis of nasopharyngeal carcinoma (NPC) treated with dose-dense cisplatin plus fluorouracil. Materials and Methods: Eligible patients were randomly assigned to a study group treated with dose-dense cisplatin plus fluorouracil following selective radiotherapy and a control group receiving traditional cisplatin plus fluorouracil following selective radiotherapy according to a 1:1 distribution using a digital random table method. The primary endpoint was overall survival (OS). Secondary endpoints were progression-free survival (PFS), objective response rate, relapse or progression rate in the radiation field and treatment toxicity. Results: Of 52 patients in the study group, 20 cases underwent radiotherapy., while in the control group of 51 patients, 16 underwent radiotherapy. The median PFS, median OS, survival rates in 1, 2 and 3 years in study and control group were 20.9 vs 12.7months, 28.3 vs 18.8months, 85.2%vs 65.9%, 62.2% vs 18.3%, and 36.6%vs 5.2% (p values of 0.00, 0.00, 0.04, 0.00 and 0.00, respectively). Subgroup analysis showed that the median OS and survival rates of 1, 2, 3 years for patients undergoing radiotherapy in the study group better than that in control group( 43.2vs24.1 months, 94.1% vs 86.7%, 82.4% vs 43.3%, 64.7% vs 17.3%, (p=0.00, 0.57, 0.04 and 0.01, respectively). The complete response rate, objective response rate after chemotherapy and three months after radiotherapy, relapse or progression rate in radiation field in study group and in control group were 19.2% vs 3.9%, 86.5% vs 56.9%, 85% vs 50%, 95% vs 81.3% and 41.3% vs 66.7% (p =0.03, 0.00, 0.03,0.30, 0.01 respectively). The grade 3-4 acute adverse reactions in the study group were significantly higher than in the control group (53.8% vs 9.8%, p=0.00). Conclusions: The survival of patients benefits from selective radiotherapy after distant metastasis of NPC treated with dose-dense cisplatin plus fluorouracil.

The Optimization Model and Algorithm of Remanufacturing Supply Chain Logistics Network with Option Contracts

Liang Yong,Qiao Peili,Luo Zhiyong,Wang Jian 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.8

By the point of view of remanufacturing enterprise, the studies of supply chain logistics network optimization problem focused on network optimization and logistics distribution between manufacturing enterprise and customer area. The present business environment is full of uncertainties. To compete effectively in such an environment, remanufacturing enterprises need to develop the capability of responding flexibly to changing market conditions and optimize effectively logistics networks. The mechanism of option contracts has effectively coordinated the relationship of remanufacturing enterprise and retailer and hedged against the risks of over- and under-production. There is few papers considers the mechanism of option contracts although there are lots of studies on supply chain logistics networks optimization problem. Therefore, the mechanism of option contracts is led into the study of remanufacturing supply chain logistics networks optimization problem. Considering environmental pollution influence factors in the remanufacturing process, a multi-objective optimization model of supply chain is developed. Dual-layer genetic algorithm mechanism was brought up. The first layer is responsible for supply chain logistics network structure with genetic algorithm. The second layer answers for specific supply chain logistics distribution with adaptive immune genetic algorithm. Finally, numerical examples demonstrate the validity of the model and algorithm for the optimization problem.

MiR-454 Prompts Cell Proliferation of Human Colorectal Cancer Cells by Repressing CYLD Expression

Liang, Hong-Liang,Hu, Ai-Ping,Li, Sen-Lin,Xie, Jia-Ping,Ma, Qing-Zhu,Liu, Ji-Yong Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6

Previous studies have shown that miR-454 plays an important role in a variety of biological processes in various human cancer cells. However, the underlying mechanisms of this microRNA in colorectal cancer (CRC) cells remain largely unknown. In the present study, we investigated the miR-454 role in CRC cell proliferation. We found that miR-454 expression is markedly upregulated in CRC tissues and CRC cells compared with the matched tumor adjacent tissues and the FHC normal colonic cell line. Ectopic expression of miR-454 promoted the proliferation and anchorage-independent growth of CRC cells, whereas inhibition of miR-454 reduced this effect. Bioinformatics analysis further revealed cylindromatosis (CYLD), a putative tumor suppressor as a potential target of miR-454. Data from luciferase reporter assays showed that miR-454 directly binds to the 3'-untranslated region (3'-UTR) of CYLD mRNA and repressed expression at both transcriptional and translational levels. In functional assays, CYLD-silenced in miR-454-in-transfected SW480 cells have positive effect to promote cell proliferation, suggesting that direct CYLD downregulation is required for miR-454-induced CRC cell proliferation. In sum, our data provide compelling evidence that miR-454 functions as an onco-miRNA, playing a crucial role in the promoting cell proliferation in CRC, and its oncogenic effect is mediated chiefly through direct suppression of CYLD expression.

Error Estimation Method for Matrix Correlation-Based Wi-Fi Indoor Localization

( Yong-liang Sun ),( Yu-bin Xu ) 한국인터넷정보학회 2013 KSII Transactions on Internet and Information Syst Vol.7 No.11

A novel neighbor selection-based fingerprinting algorithm using matrix correlation (MC) for Wi-Fi localization is presented in this paper. Compared with classic fingerprinting algorithms that usually employ a single received signal strength (RSS) sample, the presented algorithm uses multiple on-line RSS samples in the form of a matrix and measures correlations between the on-line RSS matrix and RSS matrices in the radio-map. The algorithm makes efficient use of on-line RSS information and considers RSS variations of reference points (RPs) for localization, so it offers more accurate localization results than classic neighbor selection-based algorithms. Based on the MC algorithm, an error estimation method using artificial neural network is also presented to fuse available information that includes RSS samples and localization results computed by the MC algorithm and model the nonlinear relationship between the available information and localization errors. In the on-line phase, localization errors are estimated and then used to correct the localization results to reduce negative influences caused by a static radio-map and RP distribution. Experimental results demonstrate that the MC algorithm outperforms the other neighbor selection-based algorithms and the error estimation method can reduce the mean of localization errors by nearly half.

Multi-objective Remanufacturing Supply Chain Optimization Problem with Dual Stochastic Programming

Liang Yong,Qiao Peili,Luo Zhiyong,Zhu Suxia 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.9

The successful implementation of remanufacturing supply chain not only needs foundation engineering technology, but also needs the efficient supply chain model to support logistics network. But till now, the optimization problems of supply chain logistics network focus on the determination for the number and location of facilities and logistics distribution between the various facilities. Except for the decisive factors, the optimization problem of remanufacturing supply chain logistics network considers the environmental pollution factors the waste product returns and transportation. The market demand and waste product returns are actually uncertain in remanufacturing supply chain. There is few papers focus on dual uncertain factors although there are lots of studies on the problems. Therefore, based on dual stochastic programming, the optimization model of multi-phase multi-objective remanufacturing supply chain is established with maximum profit in the remanufacturing supply chain, maximum rapid response customer satisfaction and minimum environmental pollution. Dual-layer genetic algorithm mechanism was brought up. The first layer algorithm is responsible for supply chain logistics network structure. The second layer algorithm determines specific distributions for remanufacturing supply chain, based on optimized logistics network structure mechanism in the first layer algorithm. Finally, numerical examples demonstrate the validity of the model and algorithm for the optimization problem.

Fast Thresholding Based on Improved Minimum Cross Entropy

Yong-Liang Zhang,Wen Zhang,Gang Xiao,Jia-Fa Mao,Shan-Shan Huang,Xiao-Wei Zheng 제어로봇시스템학회 2012 제어로봇시스템학회 국제학술대회 논문집 Vol.2012 No.10

Image segmentation is an important and classic problem in image processing and computer vision. Thresholding is applied to many fields, because of its less computation and stable performance. The key of thresholding method is to determine the adaptive threshold. In order to segment biological image effectively, a new adaptive thresholding method is proposed. First, two dimension minimum entropy is computed based on gray-gradient co-occurrence matrix; and then the genetic algorithm is applied to encode the two-dimension threshold vector; Finally, the optimum threshold is calculated based on fitness function and uniformity measurement(UM). Experimental results show that this method has three advantages: 1) improve computational efficiency so that it can run in real time; 2) retain more object and edge information so that it can meet the practical requirement; 3) robust to the uneven distribution of light.

Perimeter Intrusion Detection Based on Intelligent Video Analysis

Yong-Liang ZHANG,Zhi-Qin ZHANG,Gang XIAO,Rui-Dong WANG,Xia HE 제어로봇시스템학회 2015 제어로봇시스템학회 국제학술대회 논문집 Vol.2015 No.10

Monitoring system has become one of the most important means for perimeter intrusion prevention. But most of existing monitoring systems are passive surveillance. In this paper, we propose a method to implement active perimeter intrusion detection by identifying human targets in video images captured by monitoring system. In order to enhance the robustness of detecting postures of human targets, this paper introduces Fourier Descriptor (FD) and Histogram of Oriented Gradients (HOG) to realize an effective detection of human bodies with multiple postures captured by fixed cameras. The experiment results confirm that the proposed algorithm has higher recognition rate for detecting human targets with walking, climbing, and jumping postures, and sufficiently meets the requirements of perimeter intrusion detection.

Dosimetric Verification for Primary Focal Hypermetabolism of Nasopharyngeal Carcinoma Patients Treated with Dynamic Intensity-modulated Radiation Therapy

Xin, Yong,Wang, Jia-Yang,Li, Liang,Tang, Tian-You,Liu, Gui-Hong,Wang, Jian-She,Xu, Yu-Mei,Chen, Yong,Zhang, Long-Zhen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.3

Objective: To make sure the feasibility with $^{18F}FDG$ PET/CT to guided dynamic intensity-modulated radiation therapy (IMRT) for nasopharyngeal carcinoma patients, by dosimetric verification before treatment. Methods: Chose 11 patients in III~IVA nasopharyngeal carcinoma treated with functional image-guided IMRT and absolute and relative dosimetric verification by Varian 23EX LA, ionization chamber, 2DICA of I'mRT Matrixx and IBA detachable phantom. Drawing outline and making treatment plan were by different imaging techniques (CT and $^{18F}FDG$ PET/CT). The dose distributions of the various regional were realized by SMART. Results: The absolute mean errors of interest area were $2.39%{\pm}0.66$ using 0.6cc ice chamber. Results using DTA method, the average relative dose measurements within our protocol (3%, 3 mm) were 87.64% at 300 MU/min in all filed. Conclusions: Dosimetric verification before IMRT is obligatory and necessary. Ionization chamber and 2DICA of I'mRT Matrixx was the effective dosimetric verification tool for primary focal hyper metabolism in functional image-guided dynamic IMRT for nasopharyngeal carcinoma. Our preliminary evidence indicates that functional image-guided dynamic IMRT is feasible.