뇌전이 융모암 : 증례 보고 Case Report

현용인,강재규,도종웅,김기욱,김상진 최신의학사 1990 最新醫學 Vol.33 No.12

법랑아세포종의 임상병리학적 연구

성일용,류성호,신상훈,김욱규,김종렬,정인교,변기정 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.1

The authors analyzed retrospectively the 60 patients with ameloblastoma who were treated at Department of Oral and Maxillofacial Surgery, Pusan National University Hospital from MArch, 1990 to December, 1995. The results obtained were as follows: There were 26 males (43.3%) and 34 females (56.7%). The peak age of patients was the third decade (41.7%). The majority of cases occurred in the mandible 93.3%, especially in the angle region (91.1%). Eighteen of 60 patients (30.0%) were associated with an impacted tooth, by impacted 3rd molar teeth (16.6%), molar (10.0%), and premolar and canine (3.4%) in order., Fifteen of 60 patients (25%) were associated with an odontogenic cyst, by dentigenous cyst(13.3%), odontogenic keratocyst(8.4%), and radicular cyst(3.3%) in order. Radiographically, there were 32 unilocular types(54.2%) with average age of 24.9±10.8 years, 14 multilocular types(23.7%) with average age of 35.7±17.7 and 13 mixed types(22.0%) with average age of 41.4±15.8. Histopathologically, there were 42 follicular types(70.0%) with average age of 33.7±15.1 years and 18 plexiform types(30.0%) with average age of 26±14.6. Conservertive treatment was performed in the 33 patients(55.0%) and their average age was 25.2±13.9 years and radical treatment in the 27 patients(45.0%) and their average age was 39.3±41.8. Overall recurrence rate was 10%. A consistent correlation between the age of the patient and the radiographic or histologic type of mandibular ameloblastoma was observed. There was a tendency for ameloblastomas of the follicular type to show a multilocular or mixed appearance and for those of the plexiform type to show a unilocular appearance.

음경의 Mondor씨 병 1례

김욱현,문기혁,송윤섭,박영호 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Superficial venous thrombosis of the chest wall was first described by Mondor in 1939. Braun-Falco reported in 1955 superficial penile vein involvement in diffuse thrombophlebitis of the abdominal wall and in 1958 Helm and Hodge first described isolated superficial dorsal penile vein thrombosis. Since then, fewer than 50 cases have been reported. The clinical presentation is usually redness and swelling of the dorsum of the penis, accompanied by a palpable, tender thrombotic vein. This acute and painful disease frightens the patients, who is concerned about his fertility and sexual function. The main cause of this disease is frequent sexual intercourse. Diagnosis is based upon anamnesis, physical examination and penile sonography with color Doppler imaging. It is usually a benign disease which resolves quickly under appropriate medical therapy. We present a man who was visited for this condition and was conservatively treated.

구강내 악성흑색종에 대한 임상연구

김욱규,허진호,황대석,김용덕,신상훈,김종렬,정인교 부산대학교 병원 암연구소 2008 부산대병원학술지 Vol.- No.23

The prognosis of oral malignant melanoma is poor compared with cutaneous melanoma. It may be related to the difficulty of wide enough resection, the early hematogenous matastases, higher stage at initial diagnosis, tendency to growth vertically. In the view of histological differences between oral mucosa and skin, it is impossible use Clark’s and Breslow’s classifications for prognosis. The great problem is that there is still no consensus on the treatment due to rarity. Because data collection from case reports is considered to be the best source of information and should be pooled to anlalyze key determinants of outcome, We reported on 6 cases of primary malignant melanoma of the oral cavity which were diagnosed and treated in Pusan National University Hospital recently and reviewed the literature. Immunohistochemical study on S100 Protein, GP 100 (HMB-45) with biopsy was usable to confirm the melanoma. Neck dissection including wide excision is recommended if lymph node involvement is suspected. Additionally, adjuvant chemotherapy could be supporting therapy.

구내신연장치를 이용한 치조골증대술 후 임프란트 매식 : 치험 5예 REPORT OF 5 CASES

이용욱,박충열,송종운,박홍주,김영운,오희균,유선열 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.2

Successful alveolar ridge augmentation by distraction osteogenesis method has been reported previously. There are several types of devices for alveolar ridge augmentation. In this paper, a new intraoral distraction device was used on the severe atrophic mandible in order to distract an alveolar ridge vertically in 5 patients. Mean amount of distracted alveolar ridge was 7.4㎜ (5∼9.5㎜). Dental implants were placed in the distracted alveolar bone and good osseointegration was obtained in all patients. Mean follow up period is 2years 6months (7months∼4years 9months). No complications, such as infection or resorption was observed in all patients. Alveolar ridge augmentation by gradual distraction seems to be a safe, simple and reliable procedure.

초내식성 스테인리스강의 교정용 브라켓에의 적용

추성욱,김경남,김광만,이원유,박용수,이상배 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.3

Esthetic has become an indispensable factors to consider when choosing a orthodontic fixed appliances. However, most of the brackets used on orthodontics are made of metallic materials because those esthetic alternatives showed several controversies like brittleness, deformation and discoloration. The AISI austenitic classes, 303, 304, 316 and 317 type of stainless steels are frequently used for orthodontic metallic brackets fabrication. The composition of this type of alloy is 18 wt% of chrome, 8 wt% of nickel, 2 to 3 wt% of molybdenum and low carbon contents. They seemed to show relatively good characteristics to fabricate the orthodontic brackets in previous study. But in hostile condition such as low pH containing chlorine ion like saliva they might to be attacked by localized corrosion. The purposes of this study were to evaluate the microstructure, microhardness, corrosion resistance, frictional resistance and cytotoxocity of 316L(MD), AISI 304(AC) and experimentally produced super stainless stell bracket(SS). The results from this study were as follows; 1. MD and AC showed (Cr, Fe)23C6 precipitating in austenite matrix. SS showed small ferrite island forming in matrix. 2. SS showed the highest polarization resistance(Rp). SS seemed to have the highest corrosion resistance since SS showed 0.9 ×10-3 MPY, MD showed 3.7 ×10-3 MPY and AC showed 7.4×10-3 MPY. 3. The friction resistance decreased from 3 days to 4 weeks for SS(p<0.05). MD showed significant differences for the measurement of 3 days, 2 weeks and 4 weeks. AD did not showed significant differences to 3 days but increased at 2 weeks(p<0.05). 4. SS seemed to have the best biocompatibility since SS showed response index of 0/1 (mild), AC showed 1/2 (mild+) at cytotoxicity test. According to these results, SS seemed to have sufficient characteristics to fabricate the orthodontic brackets and superior corrosion resistance compare to AISI 300 type stainless steel which could lower the chance of nickel allergic reaction.

전사촉진인자 GCN4 단백질의 대량생산과 HIS5 promoter와 결합기능 해석

하정욱,황용일 慶南大學校 附設 基礎科學硏究所 1997 硏究論文集 Vol.11 No.-

The GCN4 gene is required for the general control dereperssion of amino acid biosynthetic gene group in Saccharomyces cerevisiae. In vitro translated GCN4 protein binds to the consensus sequence(5'-TGACTC-3') region of HIS3. HIS4. ILVI and ILV2 subject to general control. We constructed a expression system of GCN4 protein with λPL promoter in Escherichia coli and produced partially purified 44 kDa GCN4 protein. 5'-untranslated HIS5 region was able to bind with purified GCN4 protein and showed various binding patterns in proportion to concentrations of GCN4 protein. This result means that GCN4 protein directly involved in HIS5 expression and the expression level of HIS5 was influenced by GCN4 protein in yeast cell.

효과적인 수학교육의 교수 : 학습 방법에 대한 고찰

조용욱 신라대학교 교육과학연구소 2000 교육과학연구 Vol.- No.5

韓國産 漁類骨格에 關한 硏究(I) : Comparative osteology of the family Sciaenidae 민어科 魚類의 骨格比較

金容億,金仁培 釜山水産大學校 1965 釜山水産大學 硏究報告 Vol.6 No.2

韓國産 민언科 魚類 中 5屬 6種(Table I)에 對하여 骨格解剖學的 面에서 比較 觀察하고 이것을 屬 또는 種間의 分類 形質로서 比較 檢討하였다. 이들 魚類의 形質 中 鼻骨과 第二 服下骨 및 翼耳骨의 狀態가 가장 代表的인 分類形質이 된다. 1.鼻骨이 膜質로서 三軸型으로 되어 있는 것(Pseudosciaena, Collichthys)과 骨質로서 四角形을 하고 그 骨緣에 있는 棘이 하나이며 上向하는 것(Miichthys)과 下向하는 것(Nibea)및 背緣棘이 二個로서 하나는 上向하고 다른 하나는 下向하는 것 (Argyrosomus)으로 分類되며, 2.第二 眼下骨에는 膜質이며 內向 突起가 없는것(Pseudosciaena, Collichthys)과 骨質이며 內向 突起가 있는 것(Argyrosomus, Nibea, Miichthys)이 있고, 3.翼耳骨의 狀態에서는 그 外表面이 三個의 棘만 남긴 긴 三角形인 것(Pseudosciaena, Collichthys)과 外表面의 隆起緣이 前後로 向한 完全한 梯形을 이루는 것 (Nibea, Miichthys) 및 앞쪽이 넓어진 不完全한 梯形을 이루는 것(Argyrosomus)으로 나누어 진다. 4.이 外에 第三椎骨의 腹面 突起, 後翼狀骨, 鋤骨, 額骨, 關節骨, 基底楔骨의 中央突起, 副楔骨, 上後頭骨, 基底後頭骨, 中央突起 等 여러 骨格 形質에 있어서 Pseudosciaena와 Collichthys 二屬과 Argyrosomus, Nibea 및 Miichthys의 三屬 사이에 顯著한 差異点을 볼 수 있었다. 그러나 Argyrosomus 屬은 여러가지 点에서 어느 程度 兩群사이의 中間形質로서 나타나기도 한다. 그리고 Pseudosciaena와 Collichthys의 形質間에는 다른 餘他 屬間의 形質差異에 比하면 共通点이 大端히 많고 따라서 그 類緣關係의 가까움을 暗示한다. 또한 以上 五屬中 Collichthys가 가장 原始的이거나 또는 退化型으로 認定된다. Among the fishes of Sciaenidae of Korea we have collected seven species (five genera) of them, and have made a comparative observation about the osteological aspect. Of the osteological characters of these fishes, the nasal, the second suborbital, and the pterotic bones were the most characterized bones for each genus or species of the fishes. 1.Nasal bone is membranous and of triaxon in the genera Pseudosciaena and Collichthys, and is essified and tetrangular in others, but with one upward spine in Miichthys, one downward spine in Nibea, and with two spines, of which one is upward and the other is downward in Argyrosomus. 2.The second suborbital bone is membranous and with an inward spine in Pseudosciaena and Collichthys, and is ossified without spine in Argyrosomus, Nibea and Miichthys. 3.The Pterotic bone is triangular with three spines on its outer surface in Pseudosciaena and Collichthys, is incomplete ladder shaped with broader anterior portion in Argyrosomus, and is complete ladder shaped in Nibea and Miichthys. The spines in the first group is apparently the degenerated remainings of the ladder shaped commissure of the other groups. 4.Many other bones such as the ventral process of the third vertebra, metapterygoid, vomer, frontal, articular, the median process of basisphenoid, parasphenoid, supraoccipital, the median process of basioccipital, etc. have also pronounced distinctions between two groups: one being comprized of Pseudosciaena and Collichthys,and the other being comprized of Argyrosomus, Nibea and Miichthys. Argyrosomus, howeverm has many intermediate characters between the former and the latter. ANd Collichthys appears as the most primitive (or perhaps degenerated) genus of the fishes observed this time.

TFSCAN 검색 프로그램 TFSCAN의 개발

이병욱,박기정,김기봉,박완,박용하 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

TFD는 기능이 알려진 짧은 DNA sequence(signal)들과 그와 연관된 저널 자료로 구성된 데이타베이스이다. 임의의 DNA에서 이 데이타베이스의 sequence들을 검색하여 signal을 찾는 프로그램으로 Dan S. Prestridge가 개발한 SIGNAL SCAN이라는 프로그램이 사용되고 있는데, 이는 간단한 문자열 비교 알고리즘을 사용한다. 본 연구에서는 계산상 보다 효율적인 검색을 위해서, TFD의 sequence를 검색하기 위한 automata를 구성하는 프로그램과, 이 automata에 따라 signal을 검색하도록 하는 TFSCAN이라는 프로그램을 개발하였다. 검색된 signal에 대한 관련 문헌의 검색에서도 인덱싱 방법을 이용하여 계산 속도를 향상시켰다. 프로그램의 사용을 단순화시켰고, 결과 내용을 signal과 관련된 모든 정보를 일목요연하게 보여줄 수 있도록 구성하였다. 이 프로그램을 Web을 통해서도 사용할 수 있도록, GINet Web 서버에 TFSCAN 입력용 form과 CGI 프로그램을 개발·설치하였다. 본 연구의 특정 Motif 패턴으로 구성된 데이타베이스 검색에서, automata를 응용한 알고리즘을 이용하여 계산상 급격히 향상된 결과를 얻을 수 있음을 알 수 있었는데, 이는 생물학의 여러 패턴 검색에 응용될 수 있을 것이다. 더욱 민감한(sensitive) signal 검색을 위해서, 이와 같이 automata를 활용하고, 이 automata를 최적화하는 알고리즘 연구를 계속하고 있다. TFD is a transcription factor database which consists of short functional DNA sequences called as signals and their references. SIGNAL SCAN, developed by Dan S. Prestridge, is used to determine what signals of TFD may exist in a DNA sequence. This program searches TFD database by using a simple algorithm for character string comparison. We developed TFSCAN that aims at searching for signals in an input DNA sequence more efficently than SIGNAL SCAN. Our algorithms consist of two parts, one constructs an automata by scanning sequences of TFD, the other searches for signals through this automata. Searching for signal-related references is radically improved in time by using an indexing method. Usage of TFSCAN is very simple and its output is obvious. We developed and installed a TFSCAN input form and a CGI program in GINet Web server, to use TFSCAN. The algorithm applying automata showed drastical results in improvement of computing time. This approach may apply to recognizing several biological patterns. We have been developing our algorithm to optimize the automata and to search more sensitively for signals.