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Transient simulation and experiment validation on the opening and closing process of a ball valve
Yong Han,Ling Zhou,Ling Bai,Peng Xue,Wanning Lv,Weidong Shi,Gaoyang Huang 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.5
The ball valve is an important device in the pipeline transportation system of nuclear power plants. Itsoperational stability and safety directly affect the normal working of nuclear power plants. In this study,the transient numerical simulation of the opening and closing process of a ball valve was conducted onthe basis of the flow interruption capability experiment of the ball valve by using the moving meshmethod and inlet and outlet variable boundary conditions. The flow rate and pressure difference withtime of the opening and closing process of the ball valve were studied. The internal flow characteristics ofthe ball valve under different relative openings were analyzed in conjunction with the typical back-stepflow structure. Results show that the transient numerical results agree well with the experimental results. The internal flow characteristics of the ball valve are similar at the same opening during openingand closing process. At small opening, the spool and outlet channels easily form a back-step flowstructure. The disappearance and generation of backflow vortices during opening and closing occur at85% opening and 75% opening, respectively. With the decrease in opening degree, the difference invortex core area in the flow channel of the ball valve spool in the opening and closing process graduallyappears. The research results provide some reference value for the design and optimization of ball valves.
Yong-Gui Chen,Yong He,Wei-min Ye,Ling-Yan Jia 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.26 No.-
The competitive adsorption of Na(I)/Cr(III) and Cr(III)/Cu(II) on GMZ bentonite was studied by batch experiments. The results show that the bentonite has larger total adsorption amount of Cu(II) and Cr(III) in binary ions solution compared to that of single ion solution. Increasing of Na(I) concentration reduces the adsorption capacity of Cr(III) in their binary solution. The phenomenon Cr(III) has a lager adsorption than Cu(II) indicate that the adsorption capacity of Cu(II) is inhibited in their binary solution. The sequence of distribution coefficients (Kd) in the solution as follow: Kd binary (Cr) > Kd single (Cu) > Kd single (Cr) > Kd binary (Cu).
Yong Luo,Ling Lan,Yong-Guang Jiang,Jia-Hui Zhao,Ming-Chuan Li,Neng-Bao Wei,Yun-Hua Lin 한국분자세포생물학회 2013 Molecules and cells Vol.36 No.2
Although cancer stem cells (CSCs) play a crucial role in seeding the initiation of tumor progression, they do not always possess the same potent ability as tumor metastasis. Thus, precisely how migrating CSCs occur, still remains unclear. In the present study, we first comparatively analyzed a series of prostate CSCs, which exhibited a dynamically increasing and disseminating ability in nude mice. We observed that the transcriptional activity of HIF-1 and -catenin became gradually elevated in these stem cells and their epithelial-mesenchymal transition (EMT) characteristic altered from an epithelial type to a mesenchymal type. Next, we further used cancer-associated fibroblasts (CAFs), which were cultured from surgically re-sected tissues of prostate cancer (PCa) to stimulate prostate CSCs. Similar results were reconfirmed and showed that the protein levels of both HIF-1 and -catenin were markedly improved. In addition, the EMT phenotype displayed a homogenous mesenchymal type, accompanied with increased aggressive potency in vitro. Most importantly, the aforementioned promoting effect of CAFs on prostate CSCs was completely repressed after “silencing” the activity of -catenin by transfection of stem cells with ShRNA. Taken together, our observations suggest that prostate migrating CSCs, with a mesenchymal phenotype, could be triggered by CAFs in a HIF-1alpha/beta-catenin-depen-dent signaling pathway.
Two New Diterpenoid Alkaloids from Aconitum brachypodum
Yong Shen,Ai-Xue Zuo,Zhi-Yong Jiang,Xue-Mei Zhang,Hong-Ling Wang,Ji-Jun Chen 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
Two new diterpenoid alkaloids, N(19)-en-denudatine (1) and N(4)-butanone-flavaconitine (2), were isolated from Aconitum brachypodum Diels.. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D- and 2D-NMR.
Yi-Ling Du,Shi-Fei Chen,Liang-Ying Cheng,Xue-Ling Shen,Yuan Tian,Yong-Quan Li 한국미생물학회 2009 The journal of microbiology Vol.47 No.4
A novel Streptomyces strain, L10, which is capable of producing natamycin, was isolated from a soil sample collected from Zhejiang province, China. On the basis of phylogenetic analysis of rpoB gene and 16S rDNA sequences, as well as phenotypic comparison, strain L10 (CGMCC 2644) is proposed to be a previously uncharacterized strain of S. chattanoogensis. By screening a cosmid library of strain L10 and primer walking, a partial sequence of scnRI and the entire sequence of scnRII were obtained, which are orthologues to the pathway-specific positive regulator genes of natamycin biosynthesis in S. natalensis. The engineered S. chattanoogensis D1, generated by inserting an additional copy of scnRII into the chromosome of strain L10, increased its natamycin production by 3.3 fold in YSG medium and 4.6 fold in YEME medium without sucrose.
Cat fertilization by mouse sperm injection
Jin, Yong-Xun,Cui, Xiang-Shun,Yu, Xian-Feng,Lee, Sung-Hyun,Wang, Qing-Ling,Gao, Wei-Wei,Xu, Yong-Nan,Sun, Shao-Chen,Kong, IL-Keun,Kim, Nam-Hyung Cambridge University Press 2012 Zygote Vol.20 No.4
<B>Summary</B><P>Interspecies intracytoplasmic sperm injection has been carried out to understand species-specific differences in oocyte environments and sperm components during fertilization. While sperm aster organization during cat fertilization requires a paternally derived centriole, mouse and hamster fertilization occur within the maternal centrosomal components. To address the questions of where sperm aster assembly occurs and whether complete fertilization is achieved in cat oocytes by interspecies sperm, we studied the fertilization processes of cat oocytes following the injection of cat, mouse, or hamster sperm. Male and female pronuclear formations were not different in the cat oocytes at 6 h following cat, mouse or hamster sperm injection. Microtubule asters were seen in all oocytes following intracytoplasmic injection of cat, mouse or hamster sperm. Immunocytochemical staining with a histone H3-m2K9 antibody revealed that mouse sperm chromatin is incorporated normally with cat egg chromatin, and that the cat eggs fertilized with mouse sperm enter metaphase and become normal 2-cell stage embryos. These results suggest that sperm aster formation is maternally dependent, and that fertilization processes and cleavage occur in a non-species specific manner in cat oocytes.</P>
Establishment and Clinical Application of an Electronic Database for Breast Cancer in China
Lv, Yong-Gang,Huang, Mei-Ling,Xiao, Jing-Jing,Ling, Rui Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.2
Purpose: To establish a database for breast cancer patients to save and manage clinical data and to preliminarily investigate its clinical application. Materials and Methods: Information on breast cancer patients hospitalized in our department from 2008.01 to 2013.01 were input into our breast cancer management system. SPSS 16.0 software was used as a convenient reference to evaluate the accuracy of the newly built database. Results: A database of 2403 breast cancer patients was successfully established. Information in the database clearly displayed capabilities of storage, addition, retrieval, statistical analysis and other functions. As the continuously updated database showed, the distribution of age, sex, nationality, allergy history, pausimenia and marriage of patients was identical to that achieved by SPSS analysis, indicating reliable and accurate data analysis. Conclusions: The described database is easy and convenient to operate and manage, and should prove suitable for application in clinical research and treatment.
Two New Diterpenoid Alkaloids from Aconitum brachypodum
Shen, Yong,Zuo, Ai-Xue,Jiang, Zhi-Yong,Zhang, Xue-Mei,Wang, Hong-Ling,Chen, Ji-Jun Korean Chemical Society 2010 Bulletin of the Korean Chemical Society Vol.31 No.11
Two new diterpenoid alkaloids, N(19)-en-denudatine (1) and N(4)-butanone-flavaconitine (2), were isolated from Aconitum brachypodum Diels.. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D- and 2D-NMR.
Wen Zhong-Ling,Yang Min-Kai,Fazal Aliya,Liao Yong-Hui,Cheng Lin-Run,Hua Xiao-Mei,Hu Dong-Qing,Shi Ji-Sen,Yang Rong-Wu,Lu Gui-Hua,Qi Jin-Liang,Zhi Hong,Qian Qiu-Ping,Yang Yong-Hua 한국미생물·생명공학회 2020 Journal of microbiology and biotechnology Vol.30 No.8
In this study, two soybean genotypes, i.e., aluminum-tolerant Baxi 10 (BX10) and aluminumsensitive Bendi 2 (BD2), were used as plant materials and acidic red soil was used as growth medium. The soil layers from the inside to the outside of the root are: rhizospheric soil after washing (WRH), rhizospheric soil after brushing (BRH) and rhizospheric soil at two sides (SRH), respectively. The rhizosphere bacterial communities were analyzed by high-throughput sequencing of V4 hypervariable regions of 16S rRNA gene amplicons via Illumina MiSeq. The results of alpha diversity analysis showed that the BRH and SRH of BX10 were significantly lower in community richness than that of BD2, while the WRH exhibited no significant difference between BX10 and BD2. Among the three sampling compartments of the same soybean genotype, WRH had the lowest community richness and diversity while showing the highest coverage. Beta diversity analysis results displayed no significant difference for any compartment between the two genotypes, or among the three different sampling compartments for any same soybean genotype. However, the relative abundance of major bacterial taxa, specifically nitrogen-fixing and/or aluminum-tolerant bacteria, was significantly different in the compartments of the BRH and/or SRH at phylum and genus levels, indicating genotype-dependent variations in rhizosphere bacterial communities. Strikingly, as compared with BRH and SRH, the WRH within the same genotype (BX10 or BD2) always had an enrichment effect on rhizosphere bacteria associated with nitrogen fixation