헬리코박터 파이로리 균 진단용 ^13C-요소 캅셀의 개발

용철순,김용일,김지만,강성훈,권기철,이종달,김종국,사홍기,최한곤 영남대학교 약품개발연구소 2002 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-

The purpose of this study was to develop a new ^13C-urea-containing capsule for diagnosis of H.pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystaline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG,[^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG (38/1.9/1.9 mg/cap)] had the maximum DOB value. about 16 at 20 min, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable perparation for diagnosis of H. pylori.

폴록사머를 이용한 디클로페낙 고형 좌제의 개발

용철순,오유경,김정애,김용일,박상만,양준호,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.2

To develop a poloxamer-based solid suppository with poloxamer mixtures, the melting points of various formulations composed of P 124 and P 188 were investigated. To investigate the effect of poloxamer to the dissolution and dissolution mechanism of diclofenac sodium from the suppository the dissolution of diclofenac sodium delivered by the poloxamer-based suppository was performed. Furthermore, to investigate the mucoadhesive property of the poloxamer-based solid suppository, the identification test in the rectum was carried out after its rectal administration in rats. The poloxamer mixtures composed of P 124 and P 188 were homogeneous. Very small amounts of P 188 affected the melting points of poloxamer mixtures. In particular, the poloxamer mixture [P 124/P 188 (97/3%)] with the melting point of about 32℃ was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, very small amounts of P 188 in the poloxamer-based suppository hardly affected the dissolution rates of diclofenac sodium from the suppository. Dissolution mechanism analysis showed the dissolution of diclofenac sodium was proportional to the time. At 4 h after administration, the blue color of poloxamer-based suppository [diclofenac sodium/poloxamer mixture (2.5/97.5%)] with the P 124/P 188 ratio of (97/3%) and blue lake in the rectum was faded. However, the position of suppository in the rectum did not significantly change with time. Thus, it retained in the rectum for at least 4 h. Our results indicated that the poloxamer-based solid suppository with P 124 and P 188 would be a candidate of rectal dosage from for diclofenac sodium.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.

프레탈정 (실로스타졸 100mg)에 대한 실로스탄정 (한국유나이티드 제약)의 생물학적 동등성

용철순,이경희,최진석,박병주,정세현,김용일,박상만,유봉규,이종달,최한곤 한국병원약사회 2003 병원약사회지 Vol.20 No.2

Bioequivalence of one cilostazol tablets, the Pletaal^(R)(Korea Otsuka Pharmaceutical Co., Ltd.) and Cilostan^(R)(Korea united Pharmaceutical Co., Ltd.), was evaluated according to the guideline of KFDA. Sixteen normal male volunteers(age 20~30 years old)were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 100㎎ of cilostazol were orally administered, blood was taken at predetermined time intervals and the concentration of cilostazol in plasma was determined with an HPLC method using UV detector. The pharmacokinetic parameters(C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameter. The results showed that the differences in C_(max), T_(max) and AUC_(t) between one tablet were 16.08%, 18.88% and 17.57%, respectively. The powers (1-β) for C_(max), T_(max) and AUC_(t) were 85.03%, 83.92% and 80.12%, respectively. Detectable differences(Δ) and confidence intervals were all less than 20%, and confidence interval of all the parameters were also less than 20% at the significance level(α) of 0.05. All of these parameters met the criteria of KFDA for bioequivalence, indicating that Cilostan^(R) tablet is bioequivalent to Pletaal^(R) tablet.

헬리코박터 파이로리 균 진단용 ^13C-요소 캅셀의 개발

용철순,김용일,김지만,강성훈,권기철,이종달,김종국,사홍기,최한곤 한국약제학회 2002 Journal of Pharmaceutical Investigation Vol.32 No.1

The purpose of this study was to develop a new ^13C-urea- containing capsule for diagnosis of H. pylori. The urea-containing capsules were prepared with various diluents such as polyethylene glycol (PEG), microcrystalline cellulose, sodium lauryl sulfate and citric acid. The dissolution test, ^13C-urea breath test and stability test were then performed on the capsules. Microcrystalline cellulose and sodium lauryl sulfate retarded the initial dissolution rates of urea. However, PEG increased the initial dissolution rates of urea. Furthermore, two formulae composed of PEG, [^13C-urea/PEG (38/1.9 mg/cap)] and [^13C-urea/PEG/citric acid (38/1.9/1.9 mg/cap)] had the maximum DOB value, about 16 at 20 mim, while the formula composed of only 38 mg ^13C-urea had the maximum DOB value at 30 min. The results indicated that PEG improved the sensitivity of ^13C-urea in the human volunteers. The capsule [^13C-urea/PEG (38/1.9 mg/cap)] was stable for at least six months in 25 and 37℃. Thus, a PEG-containing capsule, [^13C-urea/PEG (38/1.9 mg/cap)] would be a more economical, sensitive and stable preparation for diagnosis of H. pylori.

에폭시 수지 복합재료의 트래킹열화에 미치는 충전제와 자외선의 영향

박용관,조한구,김희곤 成均館大學校 科學技術硏究所 1994 論文集 Vol.45 No.1

This paper studies on the effect of ultraviolet light and filler on the tracking characteristics of epoxy resin which is widely used to enhance the insulation capability of materials. The specimens employed in the study were bisphenol and cycloaliphatic epoxy resins filled with Si0_2. A low-pressure mercury lamp was used as the source of UV light. In order to see the phenomena of tracking of the specimen, the expoerimentation is performed to the tracking apparatus(IEC, Publication 587) which mainly used under severe ambient conditions.

부울함수의 논리곱의 배타적 합 논리로의 간략화

이상곤,이진흥,서용수 東西大學校 1998 동서논문집 Vol.4 No.-

In this paper, a Boolean function minimization algorithm in the form of exclusive-or sum of products(ESOP) is proposed Since Boolean furctions expressed as the ESOP are convenient to determine the structural equivalence among functions, they may be used in developing Boolean functions for hash function.

GIS를 활용한 도시소공원 지형해석의 적성적 연구

김순곤,김용백 서강전문대학 2000 산업과학연구 Vol.2 No.-

The object of urban planning is to induce us to develop consistent public facilities. The desire for a resting place in city is increasing lately. It is important to ensure green zones and parks in urban planning(design), so many studies have been progressing. Most of studies about city parks aim at minimization and accessibility of park by the policy of high density population. The park with under area of 500m2 in the whole park of YEOSU city is selected and studied by the following course in this study topography analysis the present condition.

琴湖江 隣近 部落 地下水의 理化學的 所見

蔡龍坤,張鳳基,金斗熙 慶北大學校 醫科大學 1987 慶北醫大誌 Vol.28 No.2

This study was carried out to investigate of physico-chemical status of drinking ground water near by the Gum-ho river basin, from February, 20 to March, 20, 1986. The ground water for testing was sampled 26 sites which are eleven wells, twelve electric pumps, and three simple piped water. Out of 23 kinds of phsico-chemical factors investigated, hydrogen ion, alkalinity, nitrate nitrogen, sulfate, copper, zinc, hexavalent chromium, arsenic, mercury, and lead were within allowable values for drinking. However, total hardness (sites Ⅴ-1 and Ⅵ-1), turbidity(site Ⅴ-2), ammonia nitrogen(site Ⅲ-2), chlorine(sites Ⅲ-2, Ⅲ-4, Ⅳ-1, Ⅴ-1 and Ⅵ-6) iron (site Ⅳ-2), manganese(sites Ⅱ-1 and Ⅲ-2) cadmium(sites Ⅰ-1 and Ⅲ-2), were higher than allowable value. The shorter straight distance from Gum-ho river side to sampling points, the higher concentration of alkalinity, carbon dioxide and sulfate(p<0.05). The concentration of sulfate, arsenic, and lead were negatively correlated with depth of ground water (p<0.05). In comparision of water supplying style and chemical contents; ammonia nitrogen, sulfate, lead, arsenic and mercury were higher in the well water than in the simple piped water(p<0.05). The pollution of ground water was high negative correlation with the distance of contamination sources such as toilet, cattle shed, rice field, etc.

보-기둥 접합부의 이력거동을 고려한 RC 평면골조의 내진해석

조용부,김영곤,우종열,윤정배 慶尙大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.15 No.-

The analytical studies from the test results are presented. From experimental envelope curve, hysteretic behaviors under cyclic loading are modeled for beam-column subassemblages. Modelled curves show relatively good reproduction for experimental curves. Finally, seismic performances are investigated for 7 story plain framed structure by nonlinear dynamic analysis. The resulting responses are different by each beam-column joint design.