몇 가지 항균제가 시험관내에서 내독소와 TNF-α, IL-6 분비에 미치는 영향

최정현,문건웅,김명훈,이동건,박윤희,김상일,김태연,유진홍,김양리,신완식,강문원 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2

To evaluate antibiotic-induced endotoxin release(AIER) and its correlation with some cytokines, we measured endotoxin level and tumor necrosis factor alpha(TNF-α) and interleukin6(IL-6) production in mononuclear cells in vitro after exposure of Pseudomonas aeruginosa to antibiotics belonging to different class with two extreme concentrations. The tested concetration of antibiotics were set up according to peak serum level. The low concetration of ceftazidirne and low concentration of imiperiem increased AIER, but high concentration of ceftazideme, high concentration of ciprofloxacin, high concentration of cefoperazone/sulbactam, high concentration of amikacin, and high concentration of meropenem reduced AIER.Interestingly, combined treatment of these antibiotics markedly reduced AIER, But the major cyotkines, TNF-α and IL-6 were not affect by type and concettration of antibiotics, combined treatment of antibiotics, and level of endotoxin released by antiboitics. In this study, we observed AIER was different according to type of antibiotics, concentration of antibiotics, and combination of antibiotics, But AIER had poor correlation with TNF-α and IL-6 in Pseudomonas aeruginosa. It suggests that cytokine release is not solely dependent to endotoxin, but more complex cascade is needed. More invesfigations, such as endotoxin induced cytokine mRNA expression, relationship with penicillin-binding proteins and endotoxin-neutralizing effect of antibiotic itself, must be performed.

Invariant NKT cells regulate experimental autoimmune uveitis through inhibition of Th17 differentiation

Oh, Keunhee,Byoun, Ok‐,Jin,Ham, Don‐,Il,Kim, Yon Su,Lee, Dong‐,Sup WILEY‐VCH Verlag 2011 European journal of immunology Vol.41 No.2

<P><B>Abstract</B></P><P>Although NKT cells have been implicated in diverse immunomodulatory responses, the effector mechanisms underlying the NKT cell‐mediated regulation of pathogenic T helper cells are not well understood. Here, we show that invariant NKT cells inhibited the differentiation of CD4<SUP>+</SUP> T cells into Th17 cells both in vitro and in vivo. The number of IL‐17‐producing CD4<SUP>+</SUP> T cells was reduced following co‐culture with purified NK1.1<SUP>+</SUP>TCR<SUP>+</SUP> cells from WT, but not from CD1d<SUP>−/−</SUP> or Jα18<SUP>−/−</SUP>, mice. Co‐cultured NKT cells from either cytokine‐deficient (IL‐4<SUP>−/−</SUP>, IL‐10<SUP>−/−</SUP>, or IFN‐γ<SUP>−/−</SUP>) or WT mice efficiently inhibited Th17 differentiation. The contact‐dependent mechanisms of NKT cell‐mediated regulation of Th17 differentiation were confirmed using transwell co‐culture experiments. On the contrary, the suppression of Th1 differentiation was dependent on IL‐4 derived from the NKT cells. The in vivo regulatory capacity of NKT cells on Th17 cells was confirmed using an experimental autoimmune uveitis model induced with human IRBP<SUB>1–20</SUB> (IRBP, interphotoreceptor retinoid‐binding protein) peptide. NKT cell‐deficient mice (CD1d<SUP>−/−</SUP> or Jα18<SUP>−/−</SUP>) demonstrated an increased disease severity, which was reversed by the transfer of WT or cytokine‐deficient (IL‐4<SUP>−/−</SUP>, IL‐10<SUP>−/−</SUP>, or IFN‐γ<SUP>−/−</SUP>) NKT cells. Our results indicate that invariant NKT cells inhibited autoimmune uveitis predominantly through the cytokine‐independent inhibition of Th17 differentiation.</P>

퇴행성 요추 질환의 후방 수술시 발생한 경막 손상

신병준,이재철,조영일,최원기,허일,김경제,김연일 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

컨버루션 코드를 利用한 通信系統의 에러 訂正

최상일,정연호,강창언 연세대학교 산업기술연구소 1984 논문집 Vol.16 No.1

A decorder is developed for correcting the single burst of errors. The convolutional code of Type-B2 is used for this purpose. This decoder has the ability to correct all bursts confined to m-l or fewer consecutive blocks with a guard space of the(m-1) consecutive error free blocks. A simple logical circuitry, having the same order of complexity as a pairity check circuit for a block code, is implemented to correct the errors in a communication system. The decoder used the (18,12) convolational code is designed and tested. Experimental results confirm the error-correcting ability.

X.509 프로토콜을 적용한 Kerberos 인증 메카니즘의 설계

배용근,정일용 조선대학교 전자정보통신연구소 2000 電子情報通信硏究所論文誌 Vol.3 No.1

본 논문에서는 X.509와 DNS를 연관하여 새로운 Kerberos 인증 메카니즘을 제안한다. Kerberos에서는 영역간의 서비스에 대하여 언급을 하지 않았기 때문에 영역간 인증은 X.509와 Domain Name System(DNS)를 사용하여 얻을 수 있는 체인에 의해서 수행하는 PKINIT를 통하여 이루어진다. 두 개의 프로토콜은 상이한 키관리 방식을 갖고 있는데 Kerberos는 공동키에 기반을 두고 있는 반면에 X.509는 공개키 방식에 기반을 두고 있으므로 이들을 상호 연동시키기 위해 연결 섹션은 Directory Service(DS)를 이용하였고, 실제적인 인증을 위해서는 Kerberos를 적용하였다. 새로운 프로토콜은 통신복잡도의 관점에서 고찰하면 IETF CAT Working Group에서 제안한 인증 메커니즘보다 개선하였다. In this paper, a new kerberos authentication mechanism associated with X.509 and Domain Name system(DNS) is presented Since any suggestion to regional services are not described in kerberos, authentication between regions is performed via PKINIT, which can be accomplished by the connected chain obtained from X 509 and DNS. These two protocols have distinguished key managment systems X 509 is designed using an asymmetric method, while Kerberos using a symmetric method In order to provide regional services, Directory Service(DS) is employed on connection part and Kerberos on actual authentication part The new protocol is better than the authentication mechanism proposed by IETF CAT Working group in terms of communication complexity

協商理論을 適用한 都市 嫌惡施設 立地政策에 관한 硏究

이용연,염일열 서강정보대학 1998 論文集 Vol.17 No.-

In hopes of nation's new reform, let alone regional development and local communities transformation, the first era of public local self-government, starting in 1995, had gotten its curtain dropped in the wake of the local election on June 4, followed by the second era of its kind teeing off on July 1. The mechanism of local self-government had went through rise and fall for the past three years. The lack of sufficient preparation for the prerequisites of successful localization such as the proper share of power with the central government, the reshuffle of administrative organization, the procurment of local governments' good finance, the ironing-out of various conflicts, etc., is asking for the price now. One of the most serious is the problem of regional conflicts. The completion of national policies has been postponed because of local opposition. The difference of private mutual interests has prevented public works from moving. Without resolving those regional conflicts, it is a great distance to catch up with international comparativeness and enhance the standard of living. Unaccustomed to negotiation culture each party concerned with its negotiation are prone to indignation. Taking its own stubborn stance in a haste is preferred to taking a cool picture of a situation and trying to solve the problem involved. Regional conflicts are those all of the people stand together to solve. This study, rested upon these kinds problems, is intended to search for cooperative alternatives between local governments and their inhabitants, by applying negotiation theory to the process of city planning, on the ground that systematic negotiation theory doesn't almost exist yet although the operation of local self-government must try to seek ways to reflect taxpayers's interests on the actual city planning.

Carboxymethyl chitosan의 항균성과 항곰팡이성

선우양일,박현숙,탁연수,최윤정,김광 동아대학교 환경문제연구소 1997 硏究報告 Vol.20 No.1

Chitin was converted to chitosan by deacetylation, and then carboxymethyl chitosan(CM-chitosan)was obtained by carboxymethlation of chitosan. The antibacterial activity was estimated using the miminum inhibitory concentration (MICwt%) assay. MICwt% of Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, candida albican and Staphylococcus aureus were 0.5, 0.5, 0.25, 0.25, 0.75 respectively. CM-chitosan was tested for antifungal antivity which is measured the inhibition of hyphal extension of the fungi. MIC_(50)wt% of CM-chitosan was shown half growth of the experimental over control group. MIC_(50)wt% of Penicillium citrinum, Myrothecium verrucaria and Verticillium albo-atrum were 0.5, and Gliocladium virens was 0.75, respectively. These results showed that CM-chitosan had the high inhibitory effect on the growth of the bacteria and fungi.

가축과 실험 동물의 생리자료(7) : 제7장 돼지 The swine

정순동,권해병,양일석,김용근 진주농과대학 1971 진주농과대학 연구논문집 Vol.- No.10

위 점막하 종양으로 발현된 동정맥 기형 1예

백순구,조미연,김준명,권상옥,이동기,김윤미,최윤종,김일회 대한소화기내시경학회 1999 Clinical Endoscopy Vol.19 No.4

Arteriovenous malformations (AVM) are an unusual cause of gastrointestinal (GI) bleeding. But most GI AVM can occur with GI bleeding. When conventional diagnostic studies have failed to reveal the source of GI bleeding, AVM have been one of the most common causes. But the incidence of AVM presented as bleeding of a gastric submucosal tumor is very low. A case of gastric submucosal tumor was experienced and reported as an AVM. This case is herein discussed with review of corresponding literature.

수술적으로 치료한 통증을 동반한 흉추부의 후외상성 Schmorl씨 결절 : 2례 보고 Report of Two Cases

신병준,이재철,송화용,정석봉,권계원,조영일,김연일 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

Study Design : Two patients who had painful Schmorl's node at thoracic level from acute trauma were adopted and taken operation for its treatment Objectives : To document the effect of operation for the treatment of painful Schmorl's node at thoracic level summary of background data : Schrmorl's nodes are common spinal lesion generally believed to be asymptomatic, but in some cases there were painful symptom by Schmorl's node. This case report is to explain the effect of operative treatment for the painful Schmorl's node. Methods : Two patients were adopted who had traumatic painful Schmorl's node at thoracic level for our case report. They were treated conservative methods at first but it's effect were poor, so they were taken anterior decompression and fusion, and checked back pain symptom. Result : In all two patients, the symptom of back pain by Schmorl's nodes at thoracic level was almost subsided. conclusion : For the treatment of traumatic painful Schmorl's node, most of surgeon says that conservative treatments were treatment of choice, but operative treatments are also benefit to subsidence of back pain by Schmorl's node.