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Enhanced Effect of Losartan and Rosuvastatin on Neointima Hyperplasia
Yi, In-Seon,Lee, Jung-Jin,Park, Jeong-Sook,Zhang, Wei Yun,Kim, In-Su,Kim, Yo-Han,Shin, Chang-Yong,Kim, Hyung-Sik,Myung, Chang-Seon 대한약학회 2010 Archives of Pharmacal Research Vol.33 No.4
The beneficial effects of losartan and rosuvastatin on neointimal formation have been well characterized, but little is known about the combined treatment benefit of these two drugs. This study was designed to investigate the synergistic effect of losartan combined with rosuvastatin on the magnitude of protective action in vascular injury mediated by cuff-induced neointimal formation model in vivo. Losartan at 20 mg/kg or rosuvastatin at 40 mg/kg significantly decreased both the neointimal formation and BrdU-positive cells in neointima, indicating the inhibition of cell proliferation including a progress of DNA synthesis. The combination treatment used lower doses of losartan with rosuvastatin (10 + 20 & 5 + 10 mg/kg, respectively) that proved to be significant in decreasing the neointimal formation and BrdU incorporation. These results were comparable to the diminution attained with monotherapy of either drug in higher doses. Interaction index measured by isobolar method indicated drug synergism in these two combinations of both drugs at lower doses. Therefore, the administration of losartan and rosuvastatin in combination with low doses synergistically decreased in cuffinduced neointimal formation by reducing cell proliferation, suggesting that this drug synergism may be fully effective with, lower adverse effects, for the treatment of vascular remodeling such as restenosis.
Perioperative Management of Sudden Tachycardia and Fever during Partial Sialoadenectomy
( Yo-seob Lee ),( Min-tak Oh ),( Jae-woo Yi ),( Jun-young Chung ) 경희대학교 경희의료원 2023 慶熙醫學 Vol.38 No.1
There are many medical conditions that can cause tachycardia and fever during surgery. Indeed, tachycardia and fever may occur in a patient through infection, medication use, or other inflammatory diseases. As in the case of our patient, a thyroid storm can also cause the onset of tachycardia and fever. A thyroid storm is not very common, however, when it occurs during general anesthesia, it can result in medical emergencies and mortality rates of up to 20%-30% if left untreated [1]. This is a case report of 21-year-old female with no specific past medical history who showed tachycardia and fever during a partial sialoadenectomy. Perioperative tachycardia and fever characteristically lasted in the patient, leading us to suspect malignant hyperthermia, thyroid storm or pheochromocytoma. Finally, thyroid storm could be inferred through patient’s clinical findings and intraoperative thyroid function test.