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Yirong Zhu,Lihua Huang,Zhijun Zhang,Behzad Bayrami 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.3
Recycling concrete construction waste is an encouraging step toward green and sustainable building. A lot of research has been done on recycled aggregate concretes ( s), but not nearly as much has been done on concrete made with recycled aggregate. Recycled aggregate concrete, on the other hand, has been found to have a lower mechanical productivity compared to conventional one. Accurately estimating the mechanical behavior of the concrete samples is a most important scientific topic in civil, structural, and construction engineering. This may prevent the need for excess time and effort and lead to economic considerations because experimental studies are often time-consuming, costly, and troublous. This study presents a comprehensive data-mining-based model for predicting the splitting tensile strength of recycled aggregate concrete modified with glass fiber and silica fume. For this purpose, first, 168 splitting tensile strength tests under different conditions have been performed in the laboratory, then based on the different conditions of each experiment, some variables are considered as input parameters to predict the splitting tensile strength. Then, three hybrid models as GWO-RF, GWO-MLP, and GWO-SVR, were utilized for this purpose. The results showed that all developed GWO-based hybrid predicting models have good agreement with measured experimental results. Significantly, the GWO-RF model has the best accuracy based on the model performance assessment criteria for training and testing data.
Patterning of CVD Diamond Films For MEMS Application
Wang, Xiaodong,Yang, Yirong,Ren, Congxin,Mao, Minyao,Wang, Weiyuan The Korean Vacuum Society 1998 Applied Science and Convergence Technology Vol.7 No.1
To apply diamond films in microelectromechanical systems(MEMS), it is necessary to develop the patterning technologies of diamond films in the micrometer scale. In this paper, three different kinds of technologies for patterning CVD diamond films carried out by us were demonstrated: selective growth by improved diamond nucleation in DC bias-enhanced microwave plasma chemical vapor deposition (MPCVD) system, selective growth of seeding using diamond-particle-mixed photoresist, and selective etching of oxygen ion beam using Al as the mask. It was show that high selectivity and precise patterns had been achieved, and all the processes were compatible with IC process.
Correlation analysis between the karyotypes and phenotypic traits of Chinese cymbidium cultivars
Huijuan Ning,Suyan Ao,Yirong Fan,Jianxin Fu,Chuanmei Xu 한국원예학회 2018 Horticulture, Environment, and Biotechnology Vol.59 No.1
Chinese cymbidium are a group of valuable ornamental plants that is formed by genetically distinct species. Currently, arobust Chinese cymbidium classification system, such as that based on cytotaxonomy, is lacking. To investigate the geneticvariation within Chinese cymbidium, we selected 28 individual Chinese cymbidium cultivars as experimental materialto perform karyotype analysis. The results showed that chromosome number among these 28 cultivars was constant anddiploid (i.e., 2n = 40). In addition, no satellite chromosomes were observed. The karyotypes were more symmetrical andconsisted mainly of 1B and 2B types with a small number of 2A and 2C types. Based on principal component analysis, thefive karyotype parameters with the highest classification values were screened, which revealed that the mean of long to shortarm ratio, the mean relative length of long arms, and the asymmetry coefficient of karyotypes (As.K.) were reliable parametersfor use in Chinese cymbidium cytotaxonomy. Cluster analysis of karyotype parameters successfully identified cultivarsof the bamboo petal, narcissus petal, and plum petal types, thus confirming the accuracy of the cytological classificationsystem. Furthermore, flower traits of Chinese cymbidium were strongly correlated with karyotype parameters. Overall, weconclude that karyotype parameters can provide valuable information for studies on the classification, identification, andgenetic diversity of Chinese cymbidium.
Zhiqiang Dong,Yamei Dang,Yirong Chen 연세대학교의과대학 2014 Yonsei medical journal Vol.55 No.2
Purpose: This study was conducted to investigate the small double-stranded RNA (dsRNA) mediated anti-tumor effects of p21WAF1/ClP1 (p21) transcriptional activation in vitro in the human glioma SHG-44 cell line. Materials and Methods: Human glioma SHG-44 cells were transfected with dsRNA using LipofectAMINE 2000 transfection reagent. Real-time PCR and Western blot analysis were conducted to detect p21 and survivin mRNA and protein levels, respectively. Cell proliferation was examined by MTT assay. Cell cycle distribution and apoptosis were detected by flow-cytometric analysis. Results: We found that dsRNA targeting p21 promoter (dsP21) significantly induced the expression of p21 at transcription and protein levels,and reduced the expression of survivin. AS well, dsP21 transcription significantlyinhibited human glioma SHG-44 cell proliferation. Analysis of cell cycle distributionrevealed that dsP21 transfection increased accumulation of cells in the G0/G1 phase and reduced accumulation of cells in the S phase. Further analysis revealed that dsP21 transcription led to an increase in both early and late stages of apoptosis in human glioma SHG-44 cells. Conclusion: In the present study, P21 activation by RNA-induced gene activation (RNAa) induced anti-tumor activity in vitro in a humanglioma SHG-44 cell line. The results suggested that RNAa could be used for human glioma treatment by targeted activation of tumor suppressor genes.
Lihua Huang,Wei Jiang,Yuling Wang,Yirong Zhu,Mansour Afzal 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.3
Concrete is a most utilized material in the construction industry that have main components. The strength of concrete can be improved by adding some admixtures. Evaluating the impact of fly ash (FA) and silica fume (SF) on the longterm compressive strength (CS) of concrete provokes to find the significant parameters in predicting the CS, which could be useful in the practical works and would be extensible in the future analysis. In this study, to evaluate the effective parameters in predicting the CS of concrete containing admixtures in the long-term and present a fitted equation, the multivariate adaptive regression splines (MARS) method has been used, which could find a relationship between independent and dependent variables. Next, for optimizing the output equation, biogeography-based optimization (BBO), particle swarm optimization (PSO), and hybrid PSOBBO methods have been utilized to find the most optimal conclusions. It could be concluded that for CS predictions in the long-term, all proposed models have the coefficient of determination (R<sup>2</sup>) larger than 0.9243. Furthermore, MARS-PSOBBO could be offered as the best model to predict CS between three hybrid algorithms accurately.
DNMT1 mediates chemosensitivity by reducing methylation of miRNA-20a promoter in glioma cells
Daoyang Zhou,Yingfeng Wan,Dajiang Xie,Yirong Wang,Junhua Wei,Qingfeng Yan,Peng Lu,Lianjie Mo,Jixi Xie,Shuxu Yang,Xuchen Qi 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
Although methyltransferase has been recognized as a major element that governs the epigenetic regulation of the genome during temozolomide (TMZ) chemotherapy in glioblastoma multiforme (GBM) patients, its regulatory effect on glioblastoma chemoresistance has not been well defined. This study investigated whether DNA methyltransferase (DNMT) expression was associated with TMZ sensitivity in glioma cells and elucidated the underlying mechanism. DNMT expression was analyzed by western blotting. miR-20a promoter methylation was evaluated by methylation-specific PCR. Cell viability and apoptosis were assessed using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) and TdT-mediated dUTP-biotin nick end labeling assays, respectively. The results showed that compared with parental U251 cells, DNMT1 expression was downregulated, miR-20a promoter methylation was attenuated and miR-20a levels were elevated in TMZ-resistant U251 cells. Methyltransferase inhibition by 5-aza-2′-deoxycytidine treatment reduced TMZ sensitivity in U251 cells. In U251/TM cells, DNMT1 expression was negatively correlated with miR-20a expression and positively correlated with TMZ sensitivity and leucine-rich repeats and immunoglobulin-like domains 1 expression; these effects were reversed by changes in miR-20a expression. DNMT1 overexpression induced an increase in U251/TM cell apoptosis that was inhibited by the miR-20a mimic, whereas DNMT1 silencing attenuated U251/TM cell apoptosis in a manner that was abrogated by miR-20a inhibitor treatment. Tumor growth of the U251/TM xenograft was inhibited by pcDNA-DNMT1 pretreatment and boosted by DNMT1-small hairpin RNA pretreatment. In summary, DNMT1 mediated chemosensitivity by reducing methylation of the microRNA-20a promoter in glioma cells.