The ERCC1 C118T Polymorphism Predicts Clinical Outcomes of Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Meta-analysis Based on 22 Studies

Qian, Ying-Ying,Liu, Xin-You,Wu, Qian,Song, Xian,Chen, Xiao-Feng,Liu, Yi-Qian,Pei, Dong,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.19

Background: Although the predictive value of the excision repair cross-complementing group 1 (ERCC1) C118T polymorphism in clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, the conclusions are conflicting. Therefore, we performed the present meta-analysis to determine the precise role of the ERCC1 C118T polymorphism in this clinical situation and help optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs) and their 95% confidence intervals (CIs) were used to estimate objective response and oxaliplatin-induced toxicity, with hazard ratios (HRs) with 95%CIs for progression-free survival (PFS) and overall survival (OS). Results: A total of 22 studies including 2,846 CRC patients were eligible in the analysis. Overall, no significant correlation was found between the ERCC1 C118T polymorphism and objective response to oxaliplatin-based chemotherapy, in all patients or in the Asian and Caucasian subgroups. However, the pooled analysis showed that the PFS and OS were significantly shorter in patients who carried T/T or T/C genotypes of ERCC1 C118T as compared to the C/C genotype. On stratified analysis by ethnicity, the ERCC1 118T allele was associated with a favorable prognosis in Caucasians (PFS, HR=0.58, 95%CI: 0.24-1.44; OS, HR=0.38, 95%CI: 0.22-0.64) but an unfavorable prognosis in Asians (PFS, HR=2.49, 95%CI: 1.87-3.33; OS, HR=2.63, 95%CI: 1.87-3.69) based on a dominant model. In addition, we failed to find a statistically significant impact of ERCC1 C118T polymorphism on oxaliplatin-induced toxicity. Conclusions: The ERCC1 C118T polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

The XPD Lys751Gln Polymorphism has Predictive Value in Colorectal Cancer Patients Receiving Oxaliplatin-Based Chemotherapy: a Systemic Review and Meta-analysis

Qian, Ying-Ying,Liu, Xin-You,Pei, Dong,Xu, Jia-Li,Shen, Hua,Chen, Xiao-Feng,Liu, Yi-Qian,Shen, Li-Zong,Shu, Yong-Qian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.22

Background: The predictive value of the xeroderma pigmentosum group D (XPD) Lys751Gln polymorphism regarding clinical outcomes of patients with colorectal cancer (CRC) receiving oxaliplatin-based chemotherapy has been evaluated in numerous published studies, but the results remain inconclusive. Therefore, we performed a meta-analysis to determine the precise role of the XPD Lys751Gln polymorphism in this clinical situation and optimize individual chemotherapy. Materials and Methods: A multiple search strategy was used to identify eligible studies. Pooled odds ratios (ORs), generalized odds ratio (ORG) and their 95% confidence intervals (CIs) were used to estimate the objective response, while hazard ratios (HRs) with 95%CIs were used for progression-free survival (PFS) and overall survival (OS). Results: A total of 17 studies including 2,286 patients met the inclusion criteria. Overall, the XPD 751Gln allele was associated with a non-significant reduced objective response to oxaliplatin-based chemotherapy in all patients or in the Asian and Caucasian subgroups. However, poor PFS and OS of CRC patients treated with oxaliplatin-based regimens were significantly related to the XPD 751Gln allele in the dominant model (PFS: HR=2.10, 95%CI: 1.65-2.67; OS: HR=3.18, 95%CI: 1.57-6.47). On stratified analysis by ethnicity, these relationships were more pronounced in Asians (PFS: HR=2.49, 95%CI: 1.79-3.47; OS: HR=5.25, 95%CI: 3.46-7.94) than in Caucasians (PFS: HR=1.73, 95%CI: 1.22-2.46; OS: HR=1.78, 95%CI: 1.06-2.99). Conclusions: The XPD Lys751Gln polymorphism may have prognostic value in patients with CRC undergoing oxaliplatin-based chemotherapy.

Aqueous Synthesis of Luminescent CdSe Quantum Dots from Selenium Tetrachloride

Qian, Shu-Ying,Su, An-Mei,Huang, Feng-Hua,Li, Huai-Mei,Wang, Yi-Lin Korean Chemical Society 2014 Bulletin of the Korean Chemical Society Vol.35 No.6

Aqueous Synthesis of Luminescent CdSe Quantum Dots from Selenium Tetrachloride

Shu-Ying Qian,An-Mei Su,Feng-Hua Huang,Huai-Mei Li,Yilin Wang 대한화학회 2014 Bulletin of the Korean Chemical Society Vol.35 No.6

旅行社質量管理內容及其體系的建立

전정영 ( Zheng Ying Qian ) 세계문화관광학회 2012 International Journal of Culture and tourism Resea Vol.5 No.2

With the development of the national economy, improve people’s living standards, tourism has gradually become a part of people’s life, travel as people travel is important rely on carrier, its service and management quality for people’s life has an important influence on tourism. This article mainly from the three aspects of the topic spreads out discuss, first studied the travel service quality management content, from the hardware management and software management combination of two levels is discussed, then on the basis of the travel agency establishing quality management system, from the four aspects of the process, the last around travel cooperative quality management approach to such problems in many aspects. In this paper, starting from theoretical analysis, through a systematic study and analysis for the travel service quality management to provide some reference to the study, at the same time as the consumers’ choice of a travel agency to provide efficient quality judgment.

논문 : 한국학 전공자를 위한 한국 사회,문화 교재 개발 방향

이해영 ( Hai Ying Li ),최수진 ( Su Jin Choi ),임명걸 ( Ming Jie Ren ),왕청청 ( Qian Qian Wang ),필신연 ( Xin Yan Bi ),정란 ( Lan Ding ) 국제한국어교육학회 2006 한국어 교육 Vol.17 No.3

This study aims at presenting the development direction of Korean social and cultural teaching materials for Koreanology majors according to the necessity of the Korean language teaching materials and the needs of Korean language education in China for Koreanology majors. We had found that investigating the characteristics and needs of students must precede all others to enhance the effectiveness in all classes, and so we questioned Koreanology professors and majors in Chinese universities on that. According to the survey results, we decided to set the development direction of the materials as follows. In the aspects of form, first, due to the materials will be for the Koreanology major students, we are to write them in Korean language. Second, according to analyzing the needs of students, they require the lecture and discussion be together, and so we present the subject for discussion or meditation in the closing parts of the materials. Third, we will put special corner and internet web site in the material for them to be practical sources. On the other hand, in the aspects of contents, under the educational goal of training integrated men of ability well-grounded in Korean language, society and culture, we try to reflect the characteristics of Korean social and cultural aspects inclusively. Finally, this study will consider the proportion of tradition and the present day, simultaneously represent the difference between Chinese culture and Korean culture. (Ocean University of China·University of International Business and Economics)

Utilization of Potato Starch Processing Wastes to Produce Animal Feed with High Lysine Content

( Ying Li ),( Bing Nan Liu ),( Jin Zhu Song ),( Cheng Jiang ),( Qian Yang ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.2

This work aims to utilize wastes from the potato starch industry to produce single-cell protein (SCP) with high lysine content as animal feed. In this work, S-(2-aminoethyl)-L-cysteine hydrochloride-resistant Bacillus pumilus E1 was used to produce SCP with high lysine content, whereas Aspergillus niger was used to degrade cellulose biomass and Candida utilis was used to improve the smell and palatability of the feed. An orthogonal design was used to optimize the process of fermentation for maximal lysine content. The optimum fermentation conditions were as follows: temperature of 40°C, substrate concentration of 3%, and natural pH of about 7.0. For unsterilized potato starch wastes, the microbial communities in the fermentation process were determined by terminal restriction fragment length polymorphism analysis of bacterial 16S rRNA genes. Results showed that the dominant population was Bacillus sp. The protein quality as well as the amino acid profile of the final product was found to be significantly higher compared with the untreated waste product at day 0. Additionally, acute toxicity test showed that the SCP product was non-toxic, indicating that it can be used for commercial processing.

Sepsis induces variation of intestinal barrier function in different phase through nuclear factor kappa B signaling

Ying-Ya Cao,Zhong-Han Wang,Qian-Cheng Xu,Qun Chen,Zhen Wang,Wei-Hua Lu 대한생리학회-대한약리학회 2021 The Korean Journal of Physiology & Pharmacology Vol.25 No.4

The intestinal barrier function disrupted in sepsis, while little is known about the variation in different phases of sepsis. In this study, mouse models of sepsis were established by caecal ligation and puncture (CLP). The H&E staining of sections and serum diamine oxidase concentration were evaluated at different timepoint af-ter CLP. TUNEL assay and EdU staining were performed to evaluate the apoptosis and proliferation of intestinal epithelium. Relative protein expression was assessed by Western blotting and serum concentrations of pro-inflammatory cytokines was mea-sured by ELISA. The disruption of intestinal barrier worsened in the first 24 h after the onset of sepsis and gradually recovered over the next 24 h. The percentage of apop-totic cell increased in the first 24 h and dropped at 48 h, accompanied with the prolif-erative rate of intestinal epithelium inhibited in the first 6 h and regained in the later period. Furthermore, the activity of nuclear factor kappa B (NF-κB) presented similar trend with the intestinal barrier function, shared positive correction with apoptosis of intestinal epithelium. These findings reveal the conversion process of intestinal barrier function in sepsis and this process is closely correlated with the activity of NF-κB signaling.

Achieving Improved/Reversed Tension–Compression Asymmetry by Tailoring Extrusion Processing for Mg–Sn(–Y) Alloy

Ying Zeng,Xunfei Xiong,Xiaoying Qian,Dabiao Xia,Xin Shang,Bin Jiang,Dongdi Yin 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.7

Significant tension-compression (T–C) yield asymmetry in common wrought Mg alloys hinders their widespread applications. A double extrusion process with variable speed and partially substituted yttrium (Y) (2 wt%) for Sn was proposed to improvethe T–C asymmetry of Mg–2.5Sn (wt%) alloy, and then to explore the critical grain size parameter for T–C symmetry. Theresult showed that the individual double extrusion or partial substitution of Sn by Y slightly refined the grains of Mg–2.5Snalloy (from ~ 42.5 μm to 35.5 μm and 31.2 μm, respectively), along with the improved T–C asymmetry (CYS/TYS) from0.44 to 0.51 and 0.75, respectively. When combining the above two factors, the double-extruded Mg–Sn–Y alloys obtainedfine grains with ~ 8.8 μm and gained a T–C yield symmetry (CYS/TYS = 1.01). By tailoring the extrusion speed from theprevious 1.2 mm/s to 2 mm/s, the grain size of double-extruded Mg–Sn–Y further deduced to ~ 5.6 μm and turned to be areversed T–C asymmetry (CYS/TYS) of 1.37. The refined grain size combined with weakened texture led to a decreasedactivation or even inhibition of tension twinning and increased activation of non-basal slip, which might be the main reasonfor the improved or even reversed T–C asymmetry in double-extruded Mg–0.5Sn–2Y.

Evaluating Pharmacological Effects of Two Major Components of Shuangdan Oral Liquid: Role of Danshensu and Paeonol in Diabetic Nephropathy Rat

( Ying Chen ),( Zhuying Liu ),( Fuxing Zhou ),( Hang Zhao ),( Qian Yang ),( Hua Li ),( Jiyuan Sun ),( Siwang Wang ) 한국응용약물학회 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.5

Shuangdan oral liquid (SDO) containing radix Salviae miltiorrhizae (Chinese name Danshen) and cortex moutan (Chinese name Mudanpi) is a traditional Chinese medicine using for treating vascular diseases. Danshensu (DSS) is a main effective monomer composition derived from radix Salviae miltiorrhizae and paeonol (Pae) from cortex moutan. Although the two herbs are widely used in traditional Chinese medicine, the pharmacological functions of their active compositions were not reported. Therefore, the research of DSS and Pae in mechanisms and pharmacodynamics interaction can provide scientific evidence to support clinical application. The diabetic nephropathy (DN) rats which were induced by streptozotocin (STZ) were treated with SDO, DSS, Pae, and DSS+Pae for eight weeks. The positive effects on DN animal models were investigated by detection of physiological and biochemical indexes and oxidative stress markers, within five treatments: SDO, DSS, Pae, DSS+Pae and insulin group. Compared with the model group, the DSS+Pae group improved the renal function, blood lipid metabolism and blood viscosity, increased the vitality of T-SOD or T-AOC and decreased the level of MDA or NO after the treatment. The study was successfully showed that the DSS+Pae group could delay the process of DN, especially in the renal injury part of histopathology changes. Our results suggest that the co-administration of DSS and Pae significantly may play a protective role in DN rats through decreasing the oxidative stress and improving the blood lipid metabolism mechanisms.