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Yi Hu,Shinong Pan,Xudong Zhao,Wenli Guo,Ming He,Qiyong Guo 대한영상의학회 2017 Korean Journal of Radiology Vol.18 No.3
Objective: To evaluate orthopedic metal artifact reduction algorithm (O-MAR) in CT orthopedic metal artifact reduction at different tube voltages, identify an appropriate low tube voltage for clinical practice, and investigate its clinical application. Materials and Methods: The institutional ethical committee approved all the animal procedures. A stainless-steel plate and four screws were implanted into the femurs of three Japanese white rabbits. Preoperative CT was performed at 120 kVp without O-MAR reconstruction, and postoperative CT was performed at 80–140 kVp with O-MAR. Muscular CT attenuation, artifact index (AI) and signal-to-noise ratio (SNR) were compared between preoperative and postoperative images (unpaired t test), between paired O-MAR and non-O-MAR images (paired Student t test) and among different kVp settings (repeated measures ANOVA). Artifacts’ severity, muscular homogeneity, visibility of inter-muscular space and definition of bony structures were subjectively evaluated and compared (Wilcoxon rank-sum test). In the clinical study, 20 patients undertook CT scan at low kVp with O-MAR with informed consent. The diagnostic satisfaction of clinical images was subjectively assessed. Results: Animal experiments showed that the use of O-MAR resulted in accurate CT attenuation, lower AI, better SNR, and higher subjective scores (p < 0.010) at all tube voltages. O-MAR images at 100 kVp had almost the same AI and SNR as non-O-MAR images at 140 kVp. All O-MAR images were scored ≥ 3. In addition, 95% of clinical CT images performed at 100 kVp were considered satisfactory. Conclusion: O-MAR can effectively reduce orthopedic metal artifacts at different tube voltages, and facilitates low-tube-voltage CT for patients with orthopedic metal implants.
Knockdown of LncRNA H19 Relieves LPS-Induced Damage by Modulating miR-130a in Osteoarthritis
Yi Hu,Sukai Li,Yonggen Zou 연세대학교의과대학 2019 Yonsei medical journal Vol.60 No.4
Purpose: Osteoarthritis (OA) is a commonly occurring illness without a definitive cure, at present. Long non-coding RNAs (lncRNAs)have been widely confirmed to be involved in the modulation of OA progression. This study aimed to investigate the roleand mechanism of lncRNA H19 in OA. Materials and Methods: Abundances of H19 and microRNA-130a (miR-130a) in lipopolysaccharide (LPS)-treated C28/I2 cellswere measured by reverse-transcription quantitative PCR (RT-qPCR). CCK-8 and flow cytometry analyses were carried out to assesscell viability and apoptosis. Starbase online software was used to predict the putative binding sites between H19 and miR-130a. Luciferase reporter, RNA pull down, and RT-qPCR were performed to analyze the true interaction between H19 and miR-130a. Results: A notably dose-dependent elevation of H19 levels was observed in LPS-treated C28/I2 cells. Knockdown of H19 amelioratedthe injury of LPS-induced C28/I2 cells, reflected by induced viability, decreased apoptosis, and reduced inflammatory factorsecretions. Moreover, H19 negatively regulated the expression of miR-130a via acting as a molecular sponge for miR-130a. Thestimulatory effects of H19 on cell damage were abolished following the restoration of miR-130a. Conclusion: LncRNA H19 aggravated the injury of LPS-induced C28/I2 cells by sponging miR-130a, hinting a novel regulatorymechanism and a potential therapeutic target for OA.
Yi Hu,Dae Sik Jang,Chang Woo Lee,Jeong Ho Park,Seong Ik Cho 한국전자통신연구원 2008 ETRI Journal Vol.30 No.2
In this letter, we propose a novel approach to detecting and tracking apartment buildings for the development of a video-based navigation system that provides augmented reality representation of guidance information on live video sequences. For this, we propose a building detector and tracker. The detector is based on the AdaBoost classifier followed by hierarchical clustering. The classifier uses modified Haar-like features as the primitives. The tracker is a motion-adjusted tracker based on pyramid implementation of the Lukas-Kanade tracker, which periodically confirms and consistently adjusts the tracking region. Experiments show that the proposed approach yields robust and reliable results and is far superior to conventional approaches.
Mechanism and Experimental Investigation of Ultra High Pressure Water Jet on Rubber Cutting
Yi Hu,Yong Kang,Xiao-Chuan Wang,Xiao-Hong Li,Xinping LONG,Guang-Yao Zhai,Man Huang 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
The recycle and reuse of rubber materials has become a global environment problem with the fast increasing amount of waste rubber. Compared to traditional recycle methods, ultra high pressure water jet, as a fast developing tool of cool cutting, can be used inrecycling rubber materials without damaging the internal organization structure of materials. This paper investigates ultra highpressure jet cutting rubber in mechanism and experiment. Different from metallic materials and brittle materials, rubber materialsare cut by the force of shear and tensile under the impinging of ultra high pressure water jet and the erosion of high speed waterflow with rubber powder. The overall structure of kerf is Y shape. The upper section of Y shape is caused by shear, the middle sectionis resulted from both shear and tensile, and the bottom section is a result of the erosion and the tensile. The results of experimentshow: (1) a significant linear correlation between cutting depth and pump pressure;(2) 2.0 mm/s is the optimal transverse velocityunder the current experiment condition;(3) the cutting depth has a decreasing tendency with the stand-off distance increased. It canbe concluded from orthogonal analysis that pump pressure has a signification effect on cutting depth, nozzle transverse velocity isnot remarkable, and the effect of stand-off distance is not obvious.
Influence of Methylcellulose on Properties of Wheat Gliadin Film Cast from Aqueous Ethanol
Yihu Song,Lingfang Li,Qiang Zheng 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.4
Present work was focused on the influence of methylcellulose (MC) on steady rheology of wheat gliadin solution and the properties of glycerol plasticized gliadin films. The presence of MC below 0.99 wt% improved viscosity and flow activation energy of the 10 wt% gliadin solution significantly. In the casting films containing 0.2 g glycerol/g dry protein, the MC component aggregated in the gliadin matrix. The blend films containing less than 7.7 wt% MC exhibited higher Young’s modulus (E) and tensile strength (σb) and lower elongation at break (εb) in comparison with the pure gliadin film, which was related to the intermolecular interaction between MC and gliadins, the brittle fracture of the aggregated MC component, and the increase in glass transition temperature (Tg) of the gliadin phase. Increasing MC content led to a slight increase in water vapor permeability (WVP) without significant influence on the moisture absorption (MA).
Huajie Cai,Yihu Zheng,Zhengde Wen,Yingnan Yang,Shouzhang Yang,Qiyu Zhang 대한약학회 2021 Archives of Pharmacal Research Vol.44 No.4
Long non-coding RNAs (LncRNAs) havebeen implicated in the pathogenesis of various human diseases. In this study, we probed into the role and potentialmechanisms of the antisense of IGF2R non-protein codingRNA (LncRNA AIRN) in the progression of hepatocellularcarcinoma (HCC). Using a quantitative real-timepolymerase chain reaction, we corroborated that LncRNAAIRN expression was raised in the HCC tissues and cells. The bioinformatic analysis revealed that a potential interactionbetween LncRNA AIRN and STAT1, which wasverifi ed by the RNA pull-down and RNA immunoprecipitation. In the cycloheximide-chase assay, the knockdown ofLncRNA AIRN enhanced the stability of STAT1 protein. Inthe immunoprecipitation assay, the knockdown of LncRNAAIRN restrained the cullin 4A (CUL4A)-mediated ubiquitinationof STAT1 protein. The cell transfection, MTT andfl ow cytometry assays expounded that the LncRNA AIRN/STAT1 axis was bound up with the regulation of the proliferationand apoptosis of HCC cells. The in vivo experimentscorroborated that the knockdown of LncRNA AIRNrestrained the tumor growth of HCC. Our data expoundedthat the knockdown of LncRNA AIRN restrained HCC cellproliferation and boosted cell apoptosis by restraining theCUL4A-mediated ubiquitination of STAT1 protein.
The Optimum Configuration of Vehicle Parking Guide System based on Ad Hoc Wireless Sensor Network
Lim, Myoung-Seob,Xu, Yihu,Lee, Chung-Hoon The Korea Institute of Convergence Signal Processi 2011 융합신호처리학회 논문지 (JISPS) Vol.12 No.3
The wireless sensor network (WSN) based on ad hoc network is applied to vehicle parking guide system without parking guide man at area or building with large scale of parking lots. The optimum number of cluster heads was derived for getting the minimum power consumption as well as time delay. Through the theoretical analysis of power consumption and time delay with the number of cluster heads in wireless sensor network, it was found that there exists the minimum point in the variation of power consumption and time delay according to the number of cluster heads.