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Yan‑Li Li,Xi‑Qian Xing,Yi Xiao,Yan‑Hong Liu,Yu‑Shan Zhou,Min Zhuang,Chao‑Qian Li 한국유전학회 2020 Genes & Genomics Vol.42 No.12
Background: The overexpression of TSLP and DNA methylation in asthma were both risk factors the relationship was not clear. Objective: This study aimed to investigate the relationship between methylation status of TSLP promoter and mRNA/protein expression in asthmatic airway epithelial cells. Methods: Human bronchial epithelial cells were cultured in vitro and divided into: Control group, treated with PBS, model group, sensitized with LPS (10 μg/mL) for 12 h (37 °C, 5% CO2). Other groups were cultured with the pCMV3 plasmid (M + NC/pCMV), pGPH1 plasmid (M + NC/pGPH), DNMT1/pCMV3 plasmid (M + DNMT1/pCMV), and DNMT1/pGPH1 plasmid (M + DNMT1/pGPH) for 48 h. The expression of DNA methyltransferase 1 and TSLP were measured using real-time PCR and western blotting. Results: Compared with the control group, TSLP mRNA (1.00 ± 0.00 vs. 2.82 ± 0.81 vs. 1, P < 0.001) and protein (1.07 ± 0.04 vs. 1.46 ± 0.11, P < 0.01) were significantly greater, and the methylation of promoter was lower (92.75 ± 1.26 vs. 58.57 ± 3.34, P < 0.05) in the model group. Compared with the model group, TSLP mRNA (2.82 ± 0.81 vs. 1.17 ± 0.10, P < 0.001) decreased, but TSLP promoter methylation increased (58.57 ± 3.34 vs. 92.58 ± 7.30, P < 0.05) in M + DNMT1/pCMV. TSLP mRNA and protein were higher (2.82 ± 0.81 vs. 5.32 ± 0.21, P < 0.001; 1.46 ± 0.11 vs. 1.94 ± 0.11, respectively, P < 0.01), TSLP promoter methylation was lower (58.57 ± 3.34 vs. 33.57 ± 4.29, P < 0.05) in M + DNMT1/pGPH. Conclusions: Overexpression of TSLP in asthmatic airway epithelial cells may be regulated by DNA demethylation.
Axial behavior of RC columns strengthened with SCC filled square steel tubes
Yi-Yan Lu,Hong-Jun Liang,Shan Li,Na Li 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.3
Self-compacting Concrete (SCC) Filled Square steel Tubes (SCFST) was used to strengthen square RC columns. To establish the efficiency of this strengthening method, 17 columns were tested under axial compression loading including 3 RC columns without any strengthening (WRC), 1 RC column strengthened with concrete jacket (CRC), 13 RC columns strengthened with self-compacting concrete filled square steel tubes (SRC). The experimental results showed that the use of SCFST is interesting since the ductility and the bearing capacity of the RC columns are greatly improved. The improvement ratio is significantly affected by the nominal wall thickness of steel tubes (<i>t</i>), the strength grade of strengthening concrete (C), and the length-to-width ratio (L /B) of the specimens. In order to quantitatively analyze the effect of these test parameters on axial loading behavior of the SRC columns, three performance indices, enhancement ratio (ER), ductility index (DI), and confinement ratio (CR), were used. The strength of the SRC columns obtained from the experiments was then employed to verify the proposed mode referring to the relevant codes. It was found that codes DBJ13-51 could relatively predict the strength of the SRC columns accurately, and codes AIJ and BS5400 were relatively conservative.
The Study of Influencing Factors of Mobile E-commerce Software Use Intention-based on TAM and TRA
Yan Zhao,Ya-Ru Xue,Yan-Fei Jin,Jun-Wei Li,Yi He 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.8
With the wide popularity of mobile devices, e-commerce software in the mobile client forms a larger consumer market, which makes the volume of e-commerce transactions having a wide range of growth. As the consumers have a frequent contact with mobile devices, which makes consumers pay more attention to security and entertainment of the e-commerce software. Past mobile e-business research typically focus on the related factors about transaction process, like interface design, services and user experience, but seldom study the factors about consumers. On the basis of the TAM, this paper not only added perceived security and perceived entertainment, but also the consumers’ personality factors like subjective norm in TRA, into the model. The study shows that PU, PEU, PS and PE all will have direct or indirect effects on use attitude and use intention, and subjective norms and use attitude will directly affect the consumers' use intention. Through the empirical analysis we found that e-commerce operators not only make the consumers experience more of usefulness and ease of use, security, and entertainment in the technology and services, but also improve the popularity with the aid of the mainstream media propaganda and star power to enhance the public's normative beliefs, which will ultimately affect the user behavior of the consumers.
Hydrogels with diffusion-facilitated porous network for improved adsorption performance
Yan-yan Pei,Dong-mei Guo,Qing-da An,Zuo-yi Xiao,Shangru Zhai,Bin Zhai 한국화학공학회 2018 Korean Journal of Chemical Engineering Vol.35 No.12
Porous alginate-based hydrogel beads (porous ABH) have been prepared through a facile and sustainable template-assisted method using nano-calcium carbonate and nano-CaCO3 as pore-directing agent for the efficient capture of methylene blue (MB). The materials were characterized by various techniques. The sorption capacities of ABH towards MB were compared with pure sodium alginate (ABH-1:0) in batch and fixed-bed column adsorption studies. The obtained adsorbent (ABH-1:3) has a higher BET surface area and a smaller average pore diameter. The maximum adsorption capacity of ABH-1:3 obtained from Langmuir model was as high as 1,426.0mg g1. The kinetics strictly followed pseudo-second order rate equation and the adsorption reaction was effectively facilitated, approximately 50minutes to achieve adsorption equilibrium, which was significantly shorter than that of ABH-1:0. The thermodynamic parameters revealed that the adsorption was spontaneous and exothermic. Thomas model fitted well with the breakthrough curves and could describe the dynamic behavior of the column. More significantly, the uptake capacity of ABH-1:3 was still higher than 75% of the maximum adsorption capacity even after ten cycles, indicating that this novel adsorbent can be a promising adsorptive material for removal of MB from aqueous solution under batch and continuous systems.
Eccentric strength and design of RC columns strengthened with SCC filled steel tubes
Yi-Yan Lu,Hong-Jun Liang,Shan Li,Na Li 국제구조공학회 2015 Steel and Composite Structures, An International J Vol.18 No.4
Self-compacting Concrete Filled steel Tubes (SCFT), which combines the advantages of steel and concrete materials, can be applied to strengthen the RC columns. In order to investigate the eccentric loading behavior of the strengthened columns, this paper presents an experimental and numerical investigation on them. The experimental results showed that the use of SCFT is interesting since the ductility and the bearing capacity of the RC columns are greatly improved. And the performance of strengthened columns is significantly affected by four parameters: column section type (circular and square), wall thickness of the steel tube, designed strength grade of strengthening concrete and initial eccentricity. In the numerical program, a generic fiber element model which takes in account the effect of confinement is developed to predict the behavior of the strengthened columns subjected to eccentric loading. After the fiber element analysis was verified against experimental results, a simple design formula based on the model is proposed to calculate the ultimate eccentric strength. Calibration of the calculated results against the test results shows that the design formula closely estimates the ultimate capacities of the eccentrically compressed strengthened columns by 5%.
Yi Qin,Zhao-hui Jin,Zhen-ying Zhang,Ke-ke Chen,Xin Yu,Hong-jiao Yan,Rui-dan Wang,Yuan Su,Ai-xian Liu,Jia-ning Xi,Bo-yan Fang 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.1
Background and Purpose Orthostatic hypotension (OH) is common in patients with Parkinson’s disease (PD). Early recognition OH is required with sensitive assessments. The purpose of this study was to determine whether blood pressure (BP) changes during exercise can predict the occurrence of OH in PD. Methods This prospective cohort study included 80 consecutive patients with PD. All patients agreed to participate in a baseline evaluation and cardiopulmonary exercise test (CPET). According to the initial active standing test (AST), those without OH (PD-nonOH) at baseline had their AST results followed up for 6 months. The main outcome was defined as whether patients without OH at baseline would develop OH after 6 months. Logistic regression analysis was applied to identify the relevant variables. A nomogram was constructed based on clinical features and identified variables. The concordance index (C-index) and area under the receiver operating characteristic curve (AUC) were used to evaluate the accuracy and predictive ability of the nomogram, respectively. Results CPET results indicated that peak load, peak heart rate, heart rate recovery at 1 min, and systolic BP change (ΔSBP) were lower in those with OH than in the PD-nonOH group (p<0.05) at baseline. Logistic regression analysis indicated that peak load and ΔSBP during CPET had significant effects on OH (p<0.05). Age, sex, peak load, and ΔSBP were used to construct the nomogram model (C-index=0.761). The prediction model had an AUC of 0.782 (95% confidence interval=0.649–0.889) and a specificity and sensitivity of 70.0% and 81.8%, respectively. Conclusions This study has identified predictive factors for OH development in patients with PD. CPET could be used as a complementary examination to identify patients at a high risk of OH.