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Yeongjin Baek,Jinwook Lee,Dukwon Lee,Yongbin Xu,Nam-Chul Ha 한국구조생물학회 2023 Biodesign Vol.11 No.2
The HlyBD-TolC complex, belonging to the type I secretion system (T1SS), is found in many pathogenic Gram-negative bacteria. This complex comprises three components: the ABC-type inner membrane transporter HlyB, the periplasmic adaptor HlyD, and the outer membrane channel TolC. Recent crystal and cryo-EM structures have shed light on the stoichiometry of the HlyB hexamer and HlyD hexamer in the functional complex. In this study, we performed a modeling study using the AI-based structure prediction program Alphafold-multimer to gain a deeper understanding of the assembly of the T1SS system. The program predicted a funnel-like hexameric model of the HlyD, which was stable in a molecular dynamics simulation, and the HlyD hexamer would intermesh with the TolC trimer in a cogwheel structure. Combining the modeled and docked structures, we built an assembly model of HlyBD-TolC, showing a central channel spanning the complex. These observations suggest a mechanism reminiscent of the DNA helicase.
Application of genetically engineered Salmonella typhimurium as tumor targeting agents
Yeongjin Hong,Seung-Hwan Park,Seong Young Kwon,Jung-Joon Min 제어로봇시스템학회 2013 제어로봇시스템학회 국제학술대회 논문집 Vol.2013 No.10
Some attenuated bacteria have been studied as viable tumor-targeting agents. Among them, Salmonella typhimurium carrying many advantages such as growth in both of aerobic and anaerobic conditions, various attenuated virulent strains, universal genetic engineering tools, and the clarified full genome sequences has been studied the most up to now. In this paper, we review recent progresses of tumor treatment using this bacterium.
Rare earth metal-doped Zintl phase thermoelectric materials:The Yb5xRExAl2Sb6(RE=Pr, Nd, Sm) system
Yeongjin Hong,Tae-Soo You,Seongbeom Yeon,Jiwon Jeong,Dohyun Moon 대한화학회 2022 Bulletin of the Korean Chemical Society Vol.43 No.10
Three Zintl phase solid solutions in the Yb5xRExAl2Sb6(RE=Pr, Nd, Sm)system have successfully been synthesized by arc melting followed by anneal-ing. The isotypic crystal structure of these compounds was characterized byPXRD and SXRD analyses, and their Ca5Al2Bi6-type structure (space groupPbam,Z=2) was described as a combination of (1) the 3-dimensional anionic[Al2(Sb4Sb4/2)] frameworks and (2) the space-filling cations Yb2+and RE3+located in between the anionic frameworks. In particular, the anionic frame-works were originally built from the two neighboring tetrahedral [AlSb4] moie-ties via the Sb1-Sb1 bridges. The site-preference of RE3+for the Yb3/RE-sitewith the mixed occupation ratio between ca. 9% and 16% of RE3+was eluci-dated by the size-factor criterion based on the size match between the cationicsize and the site volume. The band structures, density of states, and crystalorbital Hamilton population curve analyses were conducted by the tight-binding linear muffin-tin orbital method, and the results proved that the RE3+-doping increased the band degeneracies and the number of resonance peaksnear the Fermi level resulting in the improved Seebeck coefficients. The electri-cal transport property measurements proved that despite the successful addi-tion ofn-type RE3+dopants in the title Yb5xRExAl2Sb6system, the electricalconductivity decreased due to the canceling off of the newly addedn-type car-riers by the already existingp-type carriers resulting in still thep-type character.However, the enhanced Seebeck coefficients predicted by the increased effec-tive mass from the DFT calculations eventually improved the overall power fac-tor of the RE3+-doped title compounds.
Secure Integrated Circuit with Physical Attack Detection based on Reconfigurable Top Metal Shield
Yeongjin Mun,Hyungseup Kim,Byeoncheol Lee,Kwonsang Han,Jae-SungKim,Ji-Hoon Kim,Byong-Deok Choi,Dong Kyue Kim,Hyoungho Ko 대한전자공학회 2019 Journal of semiconductor technology and science Vol.19 No.3
Invasive physical attacks on integrated circuits (ICs), such as de-packaging, focused ion beam (FIB) chip editing, and micro-probing attempts, constitute security threats for chips with potentially valuable information, such as smart cards. Using a state-of-the-art circuit-editing technique, an attacker can remove an IC’s top metal layer, leaving its secure information exposed to micro-probing attacks. Security ICs can be seriously threatened by such attacks and thus require on-chip countermeasures. Conventional active shields, however, have difficulty coping with physical attacks based on FIB chip editing (i.e., bypassing the top metal shield). This study presents a novel countermeasure against physical attacks based on the use of a reconfigurable metal shield for both top metal removal and micro-probing attack detection. This shield consists of two circuits: an FIB chip editing detection circuit consisting of a random number generator and a micro-probing attempt detection circuit consisting of two conditionally synchronized ring oscillators. Both circuits share a randomly reconfigured top metal shield, which represents a promising solution for security against state-of-the-art invasive attacks.
Dynamic Pricing, Scheduling, and Energy Management for Profit Maximization in PHEV Charging Stations
Kim, Yeongjin,Kwak, Jeongho,Chong, Song IEEE 2017 IEEE TRANSACTIONS ON VEHICULAR TECHNOLOGY Vol.66 No.2
<P>Recently, as plug-in hybrid electric vehicles (PHEVs) take center stage for the eco-friendly and cost-effective transportation, commercial PHEV charging stations will be widely prevalent in the future. However, previous studies in the fields of the management of PHEV charging stations have not synthetically taken practical charging systems into account. In this paper, we study the profit-optimal management of a PHEV charging station under the realistic environment addressing not only various types of vehicles but waiting time guarantee for PHEV customers as well. This paper is first to jointly take into account pricing for charging services, scheduling of reserved vehicles to PHEV chargers, dropping of reserved vehicles, and management of the energy storage in a unified framework that contains key features of a practical PHEV charging station. Based on this framework, we develop an algorithm to find the parameters required for charging management by invoking the 'Lyapunov drift-plus-penalty' technique. Through theoretical analysis, we prove that the proposed algorithm achieves close-to-optimal performance under particular conditions by exploiting opportunism of time-varying arrival of charging vehicles, price of electricity, and renewable energy generation, but it requires no probabilistic future information. Finally, we find several significant messages via trace-driven simulation of the proposed algorithm.</P>