다발성 골수종에서 저용량 thalidomide, cyclophosphamide, dexamethasone (TCD) 요법의 효과

류충헌,정재현,고정해,장제혁,박영진,최규남,박봉수,이상민,주영돈 인제대학교 2008 仁濟醫學 Vol.29 No.-

Background and Objectives : The immunomodulatory drug thalidomide can inhibit angiogenesis and induce apoptosis in experimental models. It can also induce marked and durable response in newly diagnosed myeloma patients. Thalidomide has been used at doses ranging from 200 to 800 mg with significant toxicity. No data are available on the impact of low-dose thalidomide, cyclophosphamide and dexamethasone as initial therapy for myeloma patients. Design and Methods : To address this issue, newly diagnosed myeloma patients were treated with 50 mg/day thalidomide continuously and cyclophosphamide 150 mg/m², days 1-4 and dexamethasone 20 mg/m², days 1-5 and day 15-19, every month. Between October 2005 and October 2006, 14 patients (median age 54.5 years) were treated with low-dose thalidomide, cyclophosphamide and dexamethasone. Results : After a minimum of two cycles of treatment, 5 patients (55.5%) showed a partial remission. After four cycles of treatment, 10 patients (83.3%) showed a partial remission (n=6) and complete remission (n=4). After a median follow-up of 15.4 months, 1 year overall survival rate was 82.0%. Thalidomide was well tolerated without serious toxic effects. Conclusions : The combination of low-dose thalidomide, cyclophosphamide and dexamethasone demonstrates favorable response rate and 1 year overall survival rate in newly diagnosed myeloma. Severe toxicities were not seen with this combination.

일부 종합병원에 내원한 척추손상 환자에 대한 통계적 고찰

제영권,이동배,이영수 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.2

To find out the incidence and general characteristics of the spinal injury, this study was performed with analysis of 256 cases of spinal injured patients admitted in a general hospital in Tae jeon during the last 5 years, from January 1983 to December 1987, with the 9,077 total cases of injured patients including the spinal injury, admitted as the same period. We obtained the following results. 1. The incidence rate of the spinal injury among total injred patint was 2.8%, and among its causes, fall down was 10.7%, slip down was 4.1%, traffic accident was 2.4%, and direct blow and others was 0.7% in that order. The incidences of fall down, traffic accident, direct blow and others were increased anually. The seasonal incidence was 2.6% in Spring, 2.9% Summer and Autumn, and 3.0% in Winter. 2. The ratio between male and female was 2.1:1, and the most common cause of injury in female was slip down, but that in male was fall down, but traffic accident, direct blow and others were evenly distributed. 3. For the level of spinal injury, 46.1% was lumbar, 31.6% was thoracic, and 22.2% Was cervical vertebral injury. The injury to the cervical vertebrae was more frequent in traffic accident, but injury to the thoracic and lumbar vertebrae was more frequent in fall down cases. 4. For the nerve injury, 14.5% was complete paralysis, 9.7% was nerve root injury, and 7.0% was incomplete paralysis. Incomplete paralysis was more frequent in traffic accident cases, but complete paralysis and nerve root injury were frequent in fall down cases. 5. For the age distribution, the fifth decade was the most prevalent as 20.3%, but below the 19-year-old age group was the least as 3.9%. The incidence of third to sixth decade was higher. in male than female, but that of below the 19-year-old age group and over the 60-year-old age - group was reversed. 6. In the below the 19-year-old age group, the most frequent site of injury was cervical spine, but that was lumbar in third decade and that was thoracic in over the 60-year-old age group. The most frequent cause of injury in third, forth, and sixth decades was direct blow, but in fifth decade, that was fall down and in over the 60-year-old age group, that was slip down. 7. For the nerve injury, complete paralysis was frequent in sixth and fifth decade, incomplete paralysis was frequent in third and fourth decades, but nerve root injury was frequent in fifth decade. 8. For the comparison between male and female, cervical injury was more frequent in male, but lumbar injury was more frequent in female. Complete paralysis was more frequent in male than female. g, Most complete paralysis revealed in cervical and thoracic spinal injury, but most nerve root injury revealed in lumbar spinal injury. 10. There were 19.9% of spinal injured patients who had associated injury. The most frequent associated injury was extremity fracture as 58.7% and it was most frequent in traffic accident.

우심방과 우심실의 거대 심장 혈관종 1예

김제열,조상호,김건일,허경림,김현숙,조구영,최영진,이원용,임종윤 朝鮮大學校 附設 醫學硏究所 2007 The Medical Journal of Chosun University Vol.32 No.2

Cardiac tumors, especially the primary tumors involving any part of the heart are extremely rare and its relative incidence has been reported to be approximately 0.02%. We report a patient with huge cardiac hemangioma who complained of shortness of breath, general weakness, and dizziness, Imaging study by echocardiography and computed tomography of thorax revealed a huge lobulating mass like a bunch of grapes in the right chamber of heart. The surgical exploration of thorax was performed and a histological diagnosis of spindle cell hemangioma was obtained by microscopy. The patient was treated by surgical resection of the tumor and doing well after surgery. Our experience indicated that prompt diagnosis and treatment of cardiac hemangioma is imperative for patients' prognosis.

사람 비만세포주에서 Clozapine과 Fluoxetine에 의한 케모카인 및 케모카인 수용체의 상이한 발현

유영민,김종우,조정제,임강현 대한생물치료정신의학회 2001 생물치료정신의학 Vol.7 No.2

Objectives : It has been suggested that the immune system has a role in the pathophsiology of neuropsychiatric diseases. There are some reports that clozapine and fluoxetine affect on cytokine networks. Recently, it has been known that chemokines have chemotactic effect, and modulate a number of biological responses including the process of inflammation and the maintenance of CNS homeostasis. In the present study, we investigated the effect of clozapine or fluoxetine on the expression of chemokines and their receptors. Methods : Human mast cells(HMC-1) was incubated with phorbol myristate acetate(PMA, 100ng/㎖) and calcium ionophore A23187(350ng/㎖) for 3 hours. Colzapine(10^-7M) or fluoxetine(10^-7M) were pretreated for 1 hour. RT-PCR was performed for the detection of expression of various chemokines and chemokine receptors. Results : after treatment of clozapine, the expression of MCP-1, MIP-1β, CCR3,CXCR2, CXCR3 and CXCR4 were lower than the PMA/Ca ionophore-treated group, while the expression of MIP-1α, RANTES and IL-8 were not changed. However, fluoxetine was not affected the changes of expression of various chemokines and chemokine receptors. Conclusion : This result indicates that clozapine may affect on the expression of chemokines and chemokine receptors. Therefore, this study could, in part, provide the important basic data on the explanation of side effects of clozapine, such as fever and pancreatitis.

카본/페놀 복합재료의 제조와 그 전기전도성에 관한 연구

葛英淳,李才熙,陳省昊,張相熙,李馨植 慶一大學校 1997 論文集 Vol.14 No.2

The mechanical properties and electrical conductivity of spun carbon fiber/phenolic composites were tested and evaluated. The tensile and flexural strengths of carbon/phenolic composite specimens were 16.8 ksi and 25.0 ksi, respectively. The electrical conductivities of carbon/phenolic specimens were generally similar in the all range of test temperatre. The lowest electrical conductivity was observed at 150℃, which is originated from the morphology change due to the glass transition of cured phenolic matrix. The activation energy on the conductivity at the temperature range of 150∼190℃ was 0.196 eV.

X-線粉末廻折法에 의한 Cadmiun Sufide 試料의 定量定性分析

徐日煥,金永銓,鄭濟永 충남대학교 자연과학연구소 1983 忠南科學硏究誌 Vol.10 No.1

The 32 X-ray diffraction intensity peaks for the cadmium sulfide powder (99.999% purity),which is an industrially important semiconductor, were obtained rotating 2θh㎘ Bragg angle of X-ray diffractometer with Cu Kα radiation from 20 to 120 degrees by θ-2θ scan technique. Each reflecting plane identified by means of the graphical and analytical methods indicated that there are two different kinds of phases : hexagonal close-packed structure with a=4.13Å, c=6.75Å and face-centered cubic structure with a=5.82Å. In order to account for the result of two molecules per unit hexagonal cell and four molecules per unit cubic cell, they should have the wurtzite form and zinc blende form respectively. The quantitative analysis by the direct comparison method has shown that this sample contains approximately 86.3 percent wurtzite form and the rest 13.7 percent zinc blende form of CdS. The correct result has been proved by the good agreement between the experimental and theoretical integrated intensities.

膜分離에 의한 海水의 淡水化에 관한 硏究

申盛義,李性琪,崔炯一,申大允,金永範,李抵憲,姜永周 조선대학교 환경연구소 1989 環境公害硏究 Vol.6 No.-

In this study, we made investigation into water permeation, solute separation, concentration and Na^(+), K^(+), Mg^(2+), Ca^(2+), Cl^(-), SO^(2)_(4)-, HCO^(-)_(3) ions separation of seawater by the revers osmosis process using a suitable semipermeable membrane. The different thickness of membranes were prepared. On heat treatment, temperature was 80℃ and thier effects were also investigated. The flat single module system was made to be capable of treating feed solution at 200-2000cc/min and 120 atm. The experimental results can be summerized as follows: 1) As the effective operating pressure increased, permeability of pure water proportionally increased. 2) As the exposure period of the manufactured membrane in air increased, permeation rate increased, but as the thickness of the membrane increased, permeation rate decreased. 3) The capacity for being reproductive of the manufactured membrane (CA: 30wt%, Formamide: 45wt%, Acetone: 25wt%) in their performance was less than 10-30% and agreed with that reported in the literature. 4) We could separated about 85-95% of salt ion in seawater using a flat single module system.

The Evaluation and Optimization of Welding Qualities in the RSW (Resistance Spot Welding) Process Using the Servo Controlled Gun

Yeong Je Park,Hyung Suck Cho,Ji Hwan Park 제어로봇시스템학회 2001 제어로봇시스템학회 국제학술대회 논문집 Vol.2001 No.10

Interplay Between Primary Cilia and Autophagy and Its Controversial Roles in Cancer

( Je Yeong Ko ),( Eun Ji Lee ),( Jong Hoon Park ) 한국응용약물학회 2019 Biomolecules & Therapeutics(구 응용약물학회지) Vol.27 No.4

Primary cilia and autophagy are two distinct nutrient-sensing machineries required for maintaining intracellular energy homeostasis, either via signal transduction or recycling of macromolecules from cargo breakdown, respectively. Potential correlations between primary cilia and autophagy have been recently suggested and their relationship may increase our understanding of the pathogenesis of human diseases, including ciliopathies and cancer. In this review, we cover the current issues concerning the bidirectional interaction between primary cilia and autophagy and discuss its role in cancer with cilia defect.

Geometric and Wave Optic Features in the Optical Transmission Patterns of Injection-molded Mesoscale Pyramid Prism Patterned Plates

Je-Ryung Lee,Tae-Jin Je,Sangwon Woo,Yeong-Eun Yoo,Jun-Ho Jeong,Eun-chae Jeon,Hwi Kim 한국광학회 2018 Current Optics and Photonics Vol.2 No.2

In this paper, mesoscale optical surface structures are found to possess both geometric and wave optics features. The study reveals that geometric optic analysis cannot correctly predict the experimental results of light transmission or reflection by mesoscale optical structures, and that, for reliable analyses, a hybrid approach incorporating both geometric and wave optic theories should be employed. By analyzing the transmission patterns generated by the mesoscale periodic pyramid prism plates, we show that the wave optic feature is mainly ascribed to the edge diffraction effect and we estimate the relative contributions of the wave optic diffraction effect and the geometric refraction effect to the total scattering field distribution with respect to the relative dimension of the structures.