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肺炎 誘發菌의 生育을 抑制하는 韓藥材 探索에 關한 硏究
정병운,서운교,정지천,한영환 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.7 No.2
韓藥材 중 肺炎의 치료효과가 기대되는 淸熱化痰, 止咳平喘藥을 중심으로 23種의 藥材를 사용하여 肺炎을 유발하는 K. pneumoniae, S. pyogenes 및 S. pneumoniae 세균의 생육을 억제하는 藥材를 탐색하고, 탐색된 藥材의 추출물에 대한 세균의 最小生育抑制濃度를 측정하였다. 韓藥材의 水溶性 추출물 중 黃連, 胡黃蓮, 敗醬, 黃芩이 K. pneumoniae에서, 黃連이 S. pyogenes에 대해서 생육억제 효과가 있었으며, S. pneumoniae에 대한 比較沮止環의 直徑은 黃連, 鳥梅, 五味子, 黃芩이 우수하였으나 黃連 추출물 사용시 병원균 모두에서 生育沮止環의 크기가 가장 크게 나타났으며 對照群로 사용된 大腸菌과 枯草菌에서도 어느 정도의 抗細菌 효과를 볼 수 있었다. 에탄올 추출물에서는 敗醬, 黃芩, 五味子, 鳥梅가 K. pneumoniae 세균의 생육을 억제하였으며, S. pyogenes 세균은 黃連, 五味子, 鳥梅, 馬兜鈴찾, 黃芩에 의하여 생육이 억제되어 黃連은 水溶性 및 에탄올 溶解性 주출물에서 모두 우수한 抗細菌 효과를 보여주고 있다. 각 세균에 대한 最小生育沮止濃度(MIC)는 K. pneumoniae 세균일 경우 黃連 및 黃芩의 水溶性 추출물과 鳥梅 및 敗醬의 에탄올 溶解性 추출물이 유의성을 보였으며, S. pyogenes 세균은 黃連의 水溶性 및 에탄올 溶解性 추출물과 鳥梅의 에탄올 溶解性 추출물, S. pneumoniae 세균은 黃連과 鳥梅의 水溶性 및 에탄올 溶解性 주출물에서 유의성이 나타났다. 이상의 결과를 통하여 黃連, 五味子, 鳥梅, 黃芩, 胡黃蓮, 敗醬의 水溶性 및 에탄올 溶解性 추출물이 肺炎 誘發菌f K. pneumoniae, S. pyogenes, S. pneumoniae에 對하여 우수한 生育抑制 作用을 나타냄을 알 수 있었다. The various oriental herbal medicines, which have usually been used for treatment of reducing fever, purging intense heat and detoxication, were screened to determine the antibacterial activity and the minimal inhibitory concentration against pulmonary disease-causing Klebsiella pneumoniae, Streptococcus pyogenes, and Streptococcus pneumoniae. The results obtained were as follows: 1. Among the 23 oriental medicines tested, the water-soluble extracts of Coptis japonica, Scutellaria baicalensis and Picrorrhiza kurroca showed the antibacterial activity against K. pneumoniae and that of C. japonica against S. pyogenes. The antibacterial activities of C. japonica, Prunus mume, Schizandra chinesis, Scutellaria baicalensis were also found against S. pyogenes. When C. japonica was used, the high antibacterial activity was shown against Bacillus subtilis and other extracts showed a little activity against B. subtilis and E. coli as a control. 2. The ethanol-soluble extracts of Patrinia scabriosaefolia, P. mume, S. baicalensis, S. chinensis showed the antibacterial activity against K. pneumoniae and those of S. baicalensis, C. japonica, S. chinensis P. mume against S. pyogenes and S. pneumoniae. However, those extract showed a little antibacterial activity against B. subttilis and E. coli except for that the extract of C. japonica showed comparatively high growth inhibition of B. subtilis. 3. Among the medicinal herbs tested, the water- and ethanol extracts of C. japonica showed very extcellent antibacterial activity against the pathogenic bacteria and controls. 4. When the water-soluble extracts of C. japonica and S. baicalensis, minimal inhibitory concentrations (MICs) against K. pneumoniae were 10 ㎎/㎖ and 22 ㎎/㎖, respectively. The MICs of the ethanol-soluble extracts of P. mume and P. scabriosaefolia were 5 ㎎/㎖ and 20 ㎎/㎖, respectively. 5. For the MICs against S. pyogenes, C. japonica showed 15 ㎎/㎖ with the water-soluble extract and P. mume and C. japonica with the ethanol-souble extract did 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. 6. For the MICs against S. pneumoniae, C. japonica and P. mume with the water- and ethanol-souble extract showed 5 ㎎/㎖ and 10 ㎎/㎖, respecitively. As a result, the highest antibacterial activity was found in the water- and ethanol-soluble extracts of C. Japonica against pulmonary disease-causing bacteria, K. pneumoniae, S. pyogenes, and S. pneumoniae. Also, the water- and ethanol-soluble extracts of S, chinensis, P. mume, S. baicalensis and P. kurrooa showed high antibacterial activities.
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근접 통신 단말의 무선 전력 전송 효율 향상을 위한 자기 공진코일 시스템
김영교(Yeong-gyo Gim),김시호(Shiho Kim) 大韓電子工學會 2011 電子工學會論文誌-SD (Semiconductor and devices) Vol.48 No.10
근접 통신 시스템(NFC)의 전력 전송 효율과 수동형 RFID의 동작 거리 향상을 위해 자기 공명 공진코일을 이용한 무선전력전송 방식을 근접 통신 단말에 적용하였다. 소스코일과 디바이스코일 사이에 공진코일을 배치시켜 시스템을 구성하였으며 효율을 13.56MHz 대역의 RFID 리더와 태그 시스템을 사용하여 측정하였고 3차원 시뮬레이터를 통하여 시뮬레이션 하였다. RFID 리더와 태그를 통해 측정한 결과 자기 공명 공진코일을 적용한 경우 신호의 송수신 최대 거리는 96.72% RFID 태그의 수신된 전압은 17.95% 증가함을 보였다. A magnetic resonant coil system for enhancement of wireless power transfer efficiency of NFC devices was proposed. The NFC system consists of resonant coils arrange between source coil and device coil. The effects of resonant coil was measured using a 13.56MHz RFID reader and tag system and simulated by 3D RF simulator. The measurement results from RFID reader and tag show that the maximum distance of signal transmission is increased by 96.72% and received voltage of RFID tag is grew by 17.95% thanks to the magnetic resonant coils.
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유방의 종괴로 발현된 항호중구세포질항체 음성 육아종 다발혈관염
김민교 ( Min Gyo Kim ),허재형 ( Jae Hyeong Huh ),천윤홍 ( Yun Hong Cheon ),조상영 ( Sang Yeong Cho ),고경혁 ( Gyung Hyuck Ko ),김현옥 ( Hyun Ok Kim ),김지은 ( Ji Eun Kim ),최혜영 ( Hye Yeong Choi ),이상일 ( Sang Il Lee ) 대한류마티스학회 2014 대한류마티스학회지 Vol.21 No.4
Granulomatosis with polyangiitis (GPA) is a disease characterized by a granulomatous necrotizing vasculitis of the small vessels, along with the presence of antineutrophil cytoplasmic antibody (ANCA), serologically. GPA is a multisystem disease, in which the diagnosis is frequently based on respiratory and renal manifestations, with rare breast invasion. To date, several cases of breast invasion by GPA have been published, and most cases have been positive for ANCA. However, ANCA-negative forms of breast invasion by GPA are extremely rare and have not been reported in Korea thus far. Therefore, we report a case of ANCA-negative GPA in a 70-year-old woman, who was initially presented with a localized palpable mass in the left breast.
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흰쥐에서 허혈성 재관류 손상에 대한 Amphetamine 전처치의 신보호 효과가 Heat Shock Protein에 의한 것인가?
조영일 ( Jo Yeong Il ),나흥식 ( Na Heung Sig ),백승근 ( Baeg Seung Geun ),조승제 ( Jo Seung Je ),김교순 ( Kim Gyo Sun ),최영숙 ( Choe Yeong Sug ),송종오 ( Song Jong O ) 대한신장학회 2004 Kidney Research and Clinical Practice Vol.23 No.1
목 적 : In vivo에서 heat shock protein (HSP)이 허혈성 재관류 손상 (I/R injury)에 대한 신보호 효과를 가지는지에 대해서는 상반된 연구 결과들이 보고되고 있다. 저자들은 발열작용을 하는 암페타민과 HSP의 발현을 억제하는 작용이 있는 quercetin을 이용하여 in vivo에서 열전처치가 신장의 I/R injury에 대해 어떤 효과를 나타내는지, 그리고 신보호 효과가 있다면 그것이 HSP의 발현에 의한 것인지를 규명하고자 하였다. 방 법 : Sprague-Dawley rat를 대상으로 암페타민 혹은 quercetin으로 전처치 후에 양측 신동맥을 30분 혹은 60분 동안 결찰하고 24시간 동안 재관류시킨 다음 희생시켜 BUN/Cr, histopathologic score 및 HSP70의 발현을 조사하기 위한 immunohistochemistry 검사를 시행하였다. 결 과 : 신동맥을 결찰하기 전에 암페타민 전처치를 시행한 군에서는 재관류 후의 BUN, Cr, histopathologic score가 대조군에 비해 유의하게 낮았다. 반면에, 암페타민 전처치 전에 quercetin을 투여한 군이나 quercetin만을 단독으로 투여한 군에서는 대조군과 유의한 차이를 나타내지 않았다. HSP70은 암페타민 전처치를 시행한 군에서 발현이 증가하였으나, 나머지 군에서는 HSP70이 발현되지 않거나 미미하였다. 결 론 : 흰쥐에서 암페타민 전처치는 신장의 I/R injury에 대해 신보호 효과를 나타내었고, 이러한 효과는 암페타민 전처치로 생성된 HSP70과 관련이 있었다. Background : Heat shock proteins (HSOs) induced by variable kinds of stress produce tolerance to a variety of adverse conditions. However, the protective effect of HSP on ischemia/reperfusion injury (I/R injury) of kidney in vivo remains unclear. The present study was designed to evaluate whether HSP70 induced by hyperthermic preconditioning had renoprotective effect on I/R injury of the kidney in vivo. Methods : 82 Sprague-Dawley male rats were esed. Animals in control group (n=24) were subjected to bilateral occlusion of renal pedicles for 30 or 60 minutes followed by 24-hour reperfusion. In amphetamine (Amp, n=18) and quercetin (Q, n=16) group, amphetamine sulfate, a sympathomimetic drug which can elevate the body temperature as a result of enhanced endogenous lipolysis, and quercetin, a biflavonoid which inhibit the expression of HSP, were injected 4 hours prior to renal ischemia, respectively. In quercetin-amphetamine (QAmp, n=7) group, quercetin was injected 1 hour before administration of amphetamine. AA (n=8) or QQ (n=9) group was identical to Amp or Q group except that sham operation was performed instead of ischemic insult. In all groups, animals were sacrificed prior to or 24 hours after I/R injury. HSP70 induction was confirmed by immunohistochemistry. To assess the I/R injury of kidney, BUN, Cr, histopathologic change of tubular cell and HSP70 expression were evaluated. Results : In Amp group, an increase of BUN and Cr were significantly lower than other groups and less severe renal tubular injury was also observed. In addition, HSP70 was strongly expressed in Amp group, whereas HSP70 was weakly expressed in control group and not expressed in QAmp and Q group. There were no differences in the functional and histologic injuries of kidney after I/R injury between AA, QQ and control group. Conclusion : These data demonstrate that the renoprotective effect by amphetamine preconditioning to I/R injury is linked with the expression of HSP70. (Korean J Nephrol 2004;23(1):12-21)
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이온빔 스퍼터링에 의해 제조된 (Ti,Al)N 박막의 미세구조 및 기계적 특성
오영교 ( O Yeong Gyo ),백창현 ( Baeg Chang Hyeon ),홍주화 ( Hong Ju Hwa ),위명용 ( Wi Myeong Yong ),강희재 ( Kang Hui Jae ) 한국열처리공학회 2003 熱處理工學會誌 Vol.16 No.6
N/A Microstructure and mechanical properties of (Ti_(1-x),Al_(x))N films, produced by the the Ion Beam Sputtering(lBS) method, were studied by changing the Ti, Al contents. The compositions of films determined by RBS were (Ti_(0.75)AI_0.25))N, (Ti_(0.61)AI_(0.39))N and (Ti_(0.5)AI_(0.5))N, and XPS binding energies of Ti2p, A12p and Nls shifted to higher energies than those of pure Ti, Al and N, which indicated that nitrides were formed. XRD results indicated that the NaCl structure for x≤0.39 changed into amorphous structure at x=0.5. For films with x≤0.39, the lattice parameter decreased in proportion to the Al content. Nanoindentation hardness value were above HV=3300 at Al content up to x=0.39. However, the hardness of films with x=0.5 abruptly decreased to HV=1800, and this lower hardness values were attributed to different crystal structure. Critical load(Lc) in scratch test showed 23N at x=0.25, 22N at x= 0.39 and 22N at x=0.5, which indicated that films with different Al contents showed similar adhesion behavior.
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