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Functional Roles of Long Non-coding RNA in Human Breast Cancer
Ye, Ni,Wang, Bin,Quan, Zi-Fang,Cao, San-Jie,Wen, Xin-Tian,Huang, Yong,Huang, Xiao-Bo,Wu, Rui,Ma, Xiao-Ping,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.15
The discovery of long noncoding RNA (LncRNA) changes our view of transcriptional and posttranscriptional regulation of gene expression. With application of new research techniques such as high-throughput sequencing, the biological functions of LncRNAs are gradually becoming to be understood. Multiple studies have shown that LncRNAs serve as carcinogenic factors or tumor suppressors in breast cancer with abnormal expression, prompts the question of whether they have potential value in predicting the stages and survival rate of breast cancer patients, and also as therapeutic targets. Focusing on the latest research data, this review mainly summarizes the tumorigenic mechanisms of certain LncRNAs in breast cancer, in order to provide a theoretical basis for finding safer, more effective treatment of breast cancer at the LncRNA molecular level.
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Ye, Ni,Wang, Bin,Quan, Zi-Fang,Pan, Hai-Bo,Zhang, Man-Li,Yan, Qi-Gui Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
MicroRNA expression is a research focus in studies of tumors. This article concentrates attention on potential links between tumors caused by mouse mammary tumor virus (MMTV) and human breast cancer, in order to provide theoretical basis for using mouse model to search for miRNA effects mediated by Wnt/beta-catenin signaling in human breast cancer. By analyzing interactions between miRNAs and the Wnt/beta-catenin signaling pathway in breast cancer, we hope to casts light on more biological functions of miRNAs in the process of tumor formation and growth and to explore their potential value in cancer diagnosis, prognosis and treatment. Our endeavor aimed at providing theoretical basis for finding safer, more effective methods for treatment of human breast cancer at the miRNA molecular level.
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Falakaloğlu Seda,Yeniçeri Özata Merve,Güneş Betül,Silva Emmanuel João Nogueira Leal,Gündoğar Mustafa,Güçyetmez Topal Burcu 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.3
Objectives The purpose of this study was to evaluate the influence of endodontic access cavities design on the removal of calcium hydroxide medication of the apical third of mandibular incisor root canal walls and dentinal tubules with different cleaning protocols: EDDY sonic activation, Er,Cr:YSGG laser-activated irrigation, or conventional irrigation with IrriFlex. Materials and Methods Seventy-eight extracted human mandibular incisors were assigned to 6 experimental groups (n = 13) according to the endodontic access cavity and cleaning protocol for calcium hydroxide removal: traditional access cavity (TradAC)/EDDY; ultraconservative access cavity performed in the incisal edge (UltraAC.Inc)/EDDY; TradAC/Er,Cr:YSGG; UltraAC.Inc/Er,Cr:YSGG; TradAC/IrriFlex; or UltraAC.Inc/IrriFlex. Confocal laser scanning microscopy images were used to measure the non-penetration percentage, maximum residual calcium hydroxide penetration depth, and penetration area at 2 and 4 mm from the apex. Data were statistically analyzed using Shapiro-Wilk and WRS2 package for 2-way comparison of non-normally distributed parameters (depth of penetration, area of penetration, and percentage of non-penetration) according to cavity and cleaning protocol with the significance level set at 5%. Results The effect of cavity and cleaning protocol interactions on penetration depth, penetration area and non-penetration percentage was not found statistically significant at 2 and 4 mm levels (p > 0.05). Conclusions The present study demonstrated that TradAC or UltraAC.Inc preparations with different cleaning protocols in extracted mandibular incisors did not influence the remaining calcium hydroxide at 2 and 4 mm from the apex. Objectives The purpose of this study was to evaluate the influence of endodontic access cavities design on the removal of calcium hydroxide medication of the apical third of mandibular incisor root canal walls and dentinal tubules with different cleaning protocols: EDDY sonic activation, Er,Cr:YSGG laser-activated irrigation, or conventional irrigation with IrriFlex. Materials and Methods Seventy-eight extracted human mandibular incisors were assigned to 6 experimental groups (n = 13) according to the endodontic access cavity and cleaning protocol for calcium hydroxide removal: traditional access cavity (TradAC)/EDDY; ultraconservative access cavity performed in the incisal edge (UltraAC.Inc)/EDDY; TradAC/Er,Cr:YSGG; UltraAC.Inc/Er,Cr:YSGG; TradAC/IrriFlex; or UltraAC.Inc/IrriFlex. Confocal laser scanning microscopy images were used to measure the non-penetration percentage, maximum residual calcium hydroxide penetration depth, and penetration area at 2 and 4 mm from the apex. Data were statistically analyzed using Shapiro-Wilk and WRS2 package for 2-way comparison of non-normally distributed parameters (depth of penetration, area of penetration, and percentage of non-penetration) according to cavity and cleaning protocol with the significance level set at 5%. Results The effect of cavity and cleaning protocol interactions on penetration depth, penetration area and non-penetration percentage was not found statistically significant at 2 and 4 mm levels (p > 0.05). Conclusions The present study demonstrated that TradAC or UltraAC.Inc preparations with different cleaning protocols in extracted mandibular incisors did not influence the remaining calcium hydroxide at 2 and 4 mm from the apex.
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Eskibağlar Mehmet,Özata Merve Yeniçeri,Ocak Mevlüt Sinan,Öztekin Faruk 대한치과보존학회 2023 Restorative Dentistry & Endodontics Vol.48 No.4
Objectives The aim of this study was to examine the use of hand or rotary files by pre-graduation (fourth- and fifth-year) and postgraduate students in endodontic treatments and to determine the incidence of file fracture and the management of cases with broken instruments. Materials and Methods A total of 2,168 teeth undergoing primary endodontic treatment were included in this study. It was determined that 79 of these teeth resulted in broken tools. In the case of broken tools, the education level of the treating clinician, the tooth that was being treated, the canal and fracture level, the curvature of the tooth and the management of the broken instrument were recorded. Periapical radiographs of the patients were used to calculate curvature following the Schneider method. Results There was no significant difference in the incidence of broken tools according to education level (p > 0.05). The incidence of file fracture in molar teeth (73.4%) was higher than in other teeth (p < 0.05). More files were broken in the mandibular molar MB canal (20.25%) and in the apical third of the canals (72.1%). The risk of instrument fracture was high in teeth with moderate (44.3%) and severe (38%) curvature canals. The management of apically broken (80%) files mostly involved lefting (p < 0.05). Conclusions There was no statistically significant difference between fourth-year students, fifth-year students and postgraduate students in terms of instrument fracture.
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Nursing Home Residents’ Level of Knowledge About Urinary Incontinence
İlkim Çıtak Karakaya,Semiha Yenişehir,Mehmet Gürhan Karakaya 대한노인병학회 2019 Annals of geriatric medicine and research Vol.23 No.1
Background: A common problem in nursing home residents, urinary incontinence (UI) can lead to hygiene and skin problems, sleep disturbance, and decreased quality of life. This study evaluated the level of knowledge regarding UI among nursing home residents in Muğla, Turkey. Methods: This study included 64 (19 females, 45 males) nursing home resi-dent volunteers. Their physical and sociodemographic characteristics; daily living activities (Barthel Index); and the presence, frequency, severity, and type of UI as well as its impact on daily living were evaluated (International Consultation on Incontinence Questionnaire-Short Form) and history of treatment was queried. An Incontinence Quiz was used to as-sess the residents’ knowledge of incontinence. Results: The participants were living in nursing homes for 34.48±33.16 months. Their educational level was low and most were single. The mean Barthel Index score was 89.75±13.00. Twenty-five participants had UI (18.8% urge, 4.7% stress, 15.6% mixed/other type), and the mean International Consulta-tion on Incontinence Questionnaire-Short Form score was 8.08±4.24. Forty-four percent of the participants had no treatment and none had physiotherapy for incontinence. The mean Incontinence Quiz score was 4.88±1.96, indicating a low level of knowledge. The items with the highest ratio of incorrect responses (second and 14th) were related to the causes of incontinence and care seeking. Conclusion: These findings underscore the ne-cessity of increasing knowledge among nursing home residents about the reasons and health care options for UI. Further studies on appropriate strategies to improve UI knowl-edge in this population will be of great value.
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Civil society organizations and participatory local governance in Pakistan: An exploratory study
Yeni Rosilawati,Zain Rafique,Bala Raju Nikku,Shahid Habib 한국사회복지학회 2018 Asian Social Work and Policy Review Vol.12 No.3
This paper analyses the extent to which the civil society organizations (CSOs) have influenced the decision‐making of the local government toward the needs and priorities of citizens. In development discourse, civil society organizations hold a significant importance as they are deemed to provide holistic and new ways to ensure participatory local governance. Therefore, their role against the backdrop of their involvement in mobilizing citizens’ involvement and influencing decision‐making in Pakistan calls for further research. This paper aims to fill this gap. Using qualitative research methods, the current paper appraises the role of CSOs in mobilizing public involvement in the decision‐making process of local government institutions of Punjab, Pakistan. The paper finds that the effectiveness of CSOs is very low due to various institutional and political constraints. Motivations for CSOs seeking citizen involvement have been instrumental in nature rather than motivated by participatory principles.
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Yeni Kim,Songhee Jeon,Ha Jin Jeong,Seong Mi Lee,Ike dela Peña,Hee Jin Kim,Doug Hyun Han,Bung-Nyun Kim,Jae Hoon Cheong 대한신경정신의학회 2019 PSYCHIATRY INVESTIGATION Vol.16 No.7
Objective Synaptic vesicle mobilization and neurite outgrowth regulation molecules were examined in modulation of effects of methylphenidate (MPH) in Spontaneous Hypertensive Rats (SHRs), a model for attention-deficit hyperactivity disorder (ADHD). Methods We compared the changes in the protein expression level of Cyclin dependent kinase 5 (Cdk5) and molecular substrates of Cdk5; tropomyosin receptor kinase B (TrkB), syntaxin 1A (STX1A) and synaptosomal-associated protein 25 (SNAP25). Comparisons were made in prefrontal cortex of vehicle (distilled water i.p. for 7 days)-treated SHRs, vehicle-treated Wistar Kyoto Rats (WKYs) and MPH (2 mg/kg i.p. for 7 days) treated SHRs. Results The Cdk5 level of vehicle-treated SHRs was significantly decreased compared to the Cdk5 level of vehicle-treated WKY rats, but was restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. The ratio of p25/p35 was significantly decreased in MPH-treated SHR compared to vehicle-treated SHR. Moreover, TrkB, STX1A and SNAP25 of vehicle-treated SHRs were significantly decreased compared to vehicle-treated WKY rats, but were restored to the expression level of vehicle-treated WKYs in MPH-treated SHR. Conclusion The results show that Cdk5, TrkB, STX1A, and SNAP25 were involved in the modulation of MPH effects in prefrontal cortex of SHRs and play important role in treatment of ADHD.
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Yeni Stiadi,Tio Putra Wendari,Zilfa,Zulhadjri,Rahmayeni 대한환경공학회 2023 Environmental Engineering Research Vol.28 No.3
The magnetic nanocomposites of ZnO/NiFe2O4 were synthesized using a hydrothermal method in organic solvent-free media for application as a heterojunction photocatalyst. XRD measurements confirmed the formation of the required phases of nanocomposites with no impurity phases observed. The SEM and TEM analysis confirmed the morphology and shape of composite as being spherical and square-like grain. The magnetic properties of composites measured using vibrating sampler magnetometer (VSM) under an applied field of ±2 T showed a soft ferromagnetism. Band gap energy of the ZnO/NiFe2O4 sample was found to be lower than the pure ZnO nanoparticles. The photocatalytic activity of samples was evaluated by monitoring the simultaneous degradation of the mixed dye model of Rhodamine B and Methylene Blue under visible-light irradiation. Compared with pure ZnO, the nanocomposites exhibited a better photocatalytic performance with a degradation percentage of 98% for Rhodamine B and 97% for Methylene Blue in mix solution after 3 h of irradiation.
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