Application of Signal Compression into Medical Surgery Robot with Cable-Pulley System

Yuan Long Wei,Yo Hwan Kang,Chi Yen Kim,Min Cheol Lee 제어로봇시스템학회 2010 제어로봇시스템학회 국제학술대회 논문집 Vol.2010 No.10

Robot Technology and Medical Surgery combination has already been implemented into the surgical operation, such as the laparoscopy surgery. For reduce the risk of the Invasive surgery, we use robotic surgery instead of surgeon motion, which can be operated by realizing haptic torque control. But the surgical instrument cannot attach any electric sensors because of the human body obligations. To enhance the haptic force feedback without the sensors, in our system, we use the Pre-tensioned cable beside the instrument torque framework. In this paper, we will generate the feedback impulse signal through linear element using Signal Compression and study the method to estimate the system structure dynamic equation for the whole controller design. We can estimate the unknown parameters from the comparing the Bode diagrams of its impulse response and model’s response.

The HCV-Associated Hepatocarcinogenesis in Intracellular Low Viral Load Cells

( Chia-yen Dai ),( Shu-chi Wang ),( Chung-feng Huang ),( Wang-long Chung ),( Ming-lung Yu ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: There are differential viral load distribution in HCV infected liver tissues. We conduct the present study aimed to dissect the different viral load cells to investigate the viral-host resistance on the HCV asssoicated hepatocarcinogenesis. Methods: The study was performed using a replicated in vitro HCV-fluorescence infection model to discuss HCV-high viral load (HVL) cells and the HCV-low viral load (LVL) cells by Flow sort system. The next generation RNA sequence and miRNA array were used to explore the gene profiles and miRNA expression on different HCV-viral load cell populations. Results: The ROS indicator shows that the ROS abundantly in low viral load cells. The RNA-Seq analysis showed that significant enrichment in Cancer (P=5.00E-02 - 2.76E-04; 40 molecules) and a network of the Cellular Movement, Immune Cell Trafficking, Inflammatory Response (Score: 18) by IPA analysis. Protein analysis results confirmed the GADD45A and iNOS overexpression in the LVL cells which verified the oxidative stress qPCR array data in LVL cells. We also found the up-regulated Src oncoprotein expression and down-regulated E-cadherin expression in LVL cells. The miRNA array showed that miR-194, miR-192/215 and miR-10a were preferentially expressed in low viral load cells. Conclusions: With our established cell sorting system, this study provided the gene network between viral and host cells resistance by different viral load cells. The findings show the activated oxidative stress related-gene expression in hepatocytes is associated with the HCV-infected epithelial-to-mesenchymal transition (EMT), providing an important link between HCV viral load and liver cancer. The miRNA-gene intergraded dada need further studies.

Influences of Ru-doping on the Magnetic Properties of Ca0.85Pr0.15Mn1−xRuxO3

The Long Phan,Y.D. Zhang,유성초,P. Q. Thanh,P. D. H. Yen 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.61 No.10

CaMnO<SUB>3</SUB> is an antiferromagnet, where the super-exchange interaction taking place between Mn<SUP>4+</SUP> ions plays an important role. The doping of a small amount of 15% Pr into the Ca site, Ca<SUB>0.85</SUB>Pr<SUB>0.15</SUB>MnO<SUB>3</SUB>, leads the appearance of Mn<SUP>3+</SUP> ions, and introduces the ferromagnetic double-exchange interaction between Mn<SUP>3+</SUP> and Mn<SUP>4+</SUP> ions dominant in a narrow temperature range of 90~115 K. The ferromagnetic interaction becomes strong as Ca<SUB>0.85</SUB>Pr<SUB>0.15</SUB>MnO<SUB>3</SUB> doped with 4 and 8 % Ru into the Mn site (<I>i.e.</I>, Ca<SUB>0.85</SUB>Pr<SUB>0.15</SUB>Mn<SUB>1-x</SUB>Ru<SUB>x</SUB>O<SUB>3</SUB> with <I>x</I> = 0.04 and 0.08). The Curie temperature obtained for <I>x</I> = 0.04 and 0.08 are about 135 and 180 K, respectively. While the FM interaction in the former is dominant due to Mn<SUP>3+</SUP>-Mn<SUP>4+</SUP> exchange pairs, the latter has the contribution of Ru ions. This results in the remarkable difference in the feature of their FM-paramagnetic phase transitions, and coercive field <I>H</I><SUB>c</SUB>.

The Different Expression of Gene Profiles on Hepatocellular Carcinoma Cells with Different Intracellular Hepatitis C Viral Load

( Chia-yen Dai ),( Shu-chi Wang ),( Meng-hsuan Hsieh ),( Cheng-fu Yang ),( Ching-i Huang ),( Chung-feng Huang ),( Ming-lun Yeh ),( Jee-fu Huang ),( Wang-long Chung ),( Ming-lung Yu ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: The different hepatitis C virus (HCV) replication has been reported among individual hepatocytes in chronic HCV infection by identifying hepatocytes with different HCV RNA levels. We have previously established a fluorescence-activated cell sorting (FACS) protocol to study the effects of different intracellular viral loads in HCV-infected cells. The present study aimed to further study the gene expression on different hepatocellular carcinoma (HCC) cells with different HCV viral load. Methods: The JFH1-EYFP viral florescence intensity was used to sort the high and low viral load cells after 5 days infection in vitro which has been shown in our previous study that infected cells efficiently and accurately discriminated between high- and low-viral load cell populations. The next generation sequence-RNA sequence was used to clarify the mRNA and miRNA gene network between HCV-high and HCV-low infected cells of the HCC cell line. Venn diagram summarizing the probe sets that were differentially expressingbetween the Huh7.5.1 versus each differential viral load cell population and miRDB and miRTar databases were used to predict HVL and LVL/S2 unique miRNA target genes. Results: By analyzing the NGS dataset and miRNA microarray dataset, of the significant transcripts, three miRNA were unique for the LVL/S2 cells and nine miRNA unique for the HVL. Twenty-three miRNA were common for all 3 viral load groups. We verified them by q-PCR and data confirmed the array data expression level. We found that high viral loads were associated with cell inflammation- and cell death-associated pathway; and the low viral loads were associated many stress response- and cell adhesion molecular (CAMs)-related genes. Conclusions: With the established cell sorting protocol, we have demonstrated that different gene network between HCV-high and HCV-low infected cells in JFH1-EYFP infectious cells exists. Our results may provide a boarder gene regulation map between high and low viral load cell populations.

A Novel Transcriptomic Biosignature for Tuberculosis Diagnosis, Treatment Monitoring and Outcome Prediction

( Nguyen Phuoc Long ),( Nguyen Ky Phat ),( Nguyen Thi Hai Yen ),( Seongoh Park ),( Yumi Park ),( Yong-soon Cho ),( Jae-gook Shin ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-

Background Transcriptomic biomarkers have been demonstrated as a promising tool for accurate diagnosis and differential diagnosis of tuberculosis (TB). However, little is known about their potential in TB treatment monitoring and outcome prediction. Methods We carried out a comprehensive search for available transcriptomics data. The data was used for the discovery of genes that show significant responses during the treatment of TB. Genes with consistent downtrend alterations were determined. Potential candidates were then subjected to external validation. The potential of the biomarker candidates in TB diagnosis and active TB progression risk evaluation was also evaluated. Results The transcriptome of the TB patients was significantly changed during the treatment. There were 371 significantly expressed genes with the monotonic downtrend alteration in the time series comparison. Among these genes, 10 genes were found to be associated with the TB treatment outcome. The 10-gene signature reflected well the downtrend kinetics of TB patients during the course of treatment. It had potential in predicting cured TB patients, when employed as covariates in a logistic regression model. In addition, biomarker candidates clearly differentiated TB patients from non-TB patients and people with latent infection. Conclusions The 10-gene biosignature had potential in TB diagnosis, treatment monitoring, and outcome prediction.

Large Magnetocaloric Effect Around Room Temperature in Amorphous Fe-Gd-Zr Alloy Ribbon with Short-Range Interactions

Thanh, Tran Dang,Yen, Nguyen Hai,Duc, Nguyen Huu,Phan, The-Long,Dan, Nguyen Huy,Yu, Seong-Cho Springer-Verlag 2016 Journal of electronic materials Vol.45 No.5

Cold chain time- and temperature-controlled transport of vaccines: a simulated experimental study

Chun Zheng Ng,Yen Loong Lean,Siang Fei Yeoh,Qi Ying Lean,Kah Seng Lee,Amal Khalil Suleiman,Kai Bin Liew,Yaman Walid Kassab,Yaser Mohammed Al-Worafi,Long Chiau Ming 대한백신학회 2020 Clinical and Experimental Vaccine Research Vol.9 No.1

Purpose: The objective of this research was to examine the cold chain temperature maintenance for the supply of vaccines and other biological products by pharmaceutical wholesaler. Materials and Methods: In this study, six configurations using cold vaccine boxes or bags made with different materials, with and without insulation, of different sizes, and number of coolant-packs were used to simulate the configuration used by the pharmaceutical wholesalers for transportation of vaccine. Model vaccines (vial, n=10) were packed using these six configurations which then stored in an incubator at 38ºC and monitored for 24 hours. Each configuration was tested repeatedly for 5 times. Results: In term of compliance to 2°C–8°C, four out of six tested configurations are effective in cold chain transportation. The effectiveness is highly dependent on the type of passive containers used, size of cold boxes, insulation, and number of coolant-packs. The configuration with a larger polystyrene foam box with five coolant-packs maintained the required temperature up to 23 hours. In contrast, configurations using a polystyrene foam box with four coolant-packs and a large vaccine cold box with two coolant-packs failed to reach below 8ºC throughout the 24 hours. Conclusion: Packaging method, the material and size of the container could have a direct impact on the effectiveness of cold chain temperature maintenance. Polystyrene foam box, cold box with polyethylene interior lining and polypropylene insulation, a cooler bag with proper number of ice packs could be effectively used for

ONYX-I: Efficacy of Ombitasvir/Paritaprevir/Ritonavir + Dasabuvir in South Korean and Taiwanese Patients with HCV Genotype 1b Infection and without Cirrhosis

( Jeong Heo ),( Wan-Long Chuang ),( Yan Luo ),( Mong Cho ),( Chi-Jen Chu ),( Kwang-Hyub Han ),( Jia-Horng Kao ),( Seung Woon Paik ),( Chun-Yen Lin ),( Jin-Woo Lee ),( Cheng-Yuan Peng ),( Young-Suk Lim 대한간학회 2016 춘·추계 학술대회 (KASL) Vol.2016 No.1

Background: Approximately 45-50% of Hepatitis C virus (HCV) infections in South Korea and Taiwan are genotype (GT) 1b. Previous phase 3 studies demonstrated that the direct-acting antiviral (DAA) regimen of ombitasvir (OBV), ritonavir-boosted paritaprevir (PTV/r; identified by Abbvie and Enanta) and dasabuvir (DSV) was well tolerated and achieved sustained virologic response at post-treatment week 12 (SVR12) in 99% of treatment-naive and 100% of treatment- experienced patients with HCV GT1b. ONYX-I (NCT02517515) was designed to evaluate efficacy and safety in Asian patients with HCV GT1b infection without cirrhosis. Methods: Treatment-naive and IFN-based therapy-experienced patients with HCV GT1b infection in South Korea, Taiwan, and China were randomized 1:1 to receive either OBV/PTV/r (25 mg/150 mg/100 mg once daily) and DSV (250 mg twice daily) or placebo for 12 weeks during the double-blind (DB) period. Patients in the placebo arm subsequently received OBV/PTV/r + DSV for 12 weeks during the open-label period. Patients will be followed for 48 weeks after last dose of study drugs. The primary objectives are to compare the SVR12 rates for the treatment-naive and -experienced patients to corresponding historical SVR rates of telaprevir + peg-interferon and ribavirin therapy, and assess the safety of the OBV/PTV/r + DSV regimen. Presented are results from the South Korean and Taiwanese populations. Results: In both South Korea and Taiwan, 120 patients were randomized and treated. Of South Korean patients, 45% were male, 33% were treatment-experienced and 89% had F0-F1 fibrosis. Of Taiwanese patients, 39% were male, 33% were treatment-experienced, and 87% had F0-F1 fibrosis. Safety data and SVR at post-treatment week 4 will be presented. Conclusions: The ONYX-I study is evaluating the safety and efficacy of DAA regimen, OBV/PTV/r + DSV, in Southeast Asian patients without cirrhosis infected with HCV GT1b. Resultant data may help inform treatment guidelines for HCV GT1b in this population.

Accuracy assessment of real-time hybrid testing for seismic control of an offshore wind turbine supporting structure with a TMD

Lyan-Ywan Lu,Ging-Long Lin,Kai-Ting Lei,Shih-Wei Yeh,Kuang-Yen Liu 국제구조공학회 2023 Smart Structures and Systems, An International Jou Vol.31 No.6

In this study, the accuracy of a real-time hybrid test (RTHT) employed for a performance test of a tuned mass damper (TMD) on an offshore wind turbine (OWT) with a complicated jacket-type supporting structure is quantified and evaluated by comparing the RTHT results with the experimental data obtained from a shaking table test (STT), in which a 1/25- scale model for a typical 5-MW OWT controlled by a TMD was tested. In the RTHT, the jacket-type OWT structure was modelled using both multiple-DOF (MDOF) and single-DOF (SDOF) numerical models. When compared with the STT test data, the test results of the RTHT show that while the SDOF model, which requires less control computational time, is able to well predict the peak responses of the nacelle and TMD only, the MDOF model is able to effectively predict both the peak and over-all time-history responses at multiple critical locations of an OWT structure. This also indicates that, depending on the type of structural responses considered, an RTHT with either an SDOF or a MDOF model may be a promising alternative to the STT to assess the effectiveness of a TMD for seismic mitigation in an OWT context.

The Characteristics of Acute Aortic Dissection among Young Chinese Patients: A Comparison between Marfan Syndrome and Non-Marfan Syndrome Patients

Shih-Hung Tsai,Yen-Yue Lin,Chin-Wang Hsu,Yu-Long Chen,Min-Tser Liao,Shi-Jye Chu 연세대학교의과대학 2009 Yonsei medical journal Vol.50 No.2

Purpose: Aortic dissection (AoD) is one of the most common catastrophes involving the aorta. Nevertheless, early diagnosis remains to be a challenge in the Emergency Department (ED), particularly in young individuals. In this study, we attempted to identify the characteristics of acute AoD among young individuals, particular in patients with Marfan syndrome. Materials and Methods: This was an retrospective chart-review study conducted in a tertiary referring hospital. The hospital database was queried for the combination of AoD and patients under age of 40 years. The medical charts were reviewed to obtain demographic data, clinical data and laboratory characteristics by using a standardized data collection sheet. A comparison between Marfan syndrome and non-Marfan syndrome patients was performed. Results: During the 10- years period, 18 of 344 patients with acute AoD were younger than 40 years-old. Patients with Marfan syndrome developed acute AoD at a younger age than patients without Marfan syndrome. The mean diastolic blood pressure was significantly lower in patients with Marfan syndrome upon presenting to the ED than those without. Patients with Marfan syndrome had trends toward higher risk of development of type A AoD, increased recurrence rate and higher mortality rate than those without. However, statistical significance was not present. Conclusion: ED physicians should have high alert to acute AoD in young patients presenting with severe unexplained chest and back pain, particularly in those patients with a history of heart diseases, hypertension, and Marfan syndrome or featuring Marfanoid habitus. Acute coronary syndrome, unexplained abdominal symptoms, and sudden cardiac arrest could be the initial manifestation of AoD in young patients. A low threshold to perform enhanced computed tomography may facilitate early diagnosis and timely treatment in this patient population. Purpose: Aortic dissection (AoD) is one of the most common catastrophes involving the aorta. Nevertheless, early diagnosis remains to be a challenge in the Emergency Department (ED), particularly in young individuals. In this study, we attempted to identify the characteristics of acute AoD among young individuals, particular in patients with Marfan syndrome. Materials and Methods: This was an retrospective chart-review study conducted in a tertiary referring hospital. The hospital database was queried for the combination of AoD and patients under age of 40 years. The medical charts were reviewed to obtain demographic data, clinical data and laboratory characteristics by using a standardized data collection sheet. A comparison between Marfan syndrome and non-Marfan syndrome patients was performed. Results: During the 10- years period, 18 of 344 patients with acute AoD were younger than 40 years-old. Patients with Marfan syndrome developed acute AoD at a younger age than patients without Marfan syndrome. The mean diastolic blood pressure was significantly lower in patients with Marfan syndrome upon presenting to the ED than those without. Patients with Marfan syndrome had trends toward higher risk of development of type A AoD, increased recurrence rate and higher mortality rate than those without. However, statistical significance was not present. Conclusion: ED physicians should have high alert to acute AoD in young patients presenting with severe unexplained chest and back pain, particularly in those patients with a history of heart diseases, hypertension, and Marfan syndrome or featuring Marfanoid habitus. Acute coronary syndrome, unexplained abdominal symptoms, and sudden cardiac arrest could be the initial manifestation of AoD in young patients. A low threshold to perform enhanced computed tomography may facilitate early diagnosis and timely treatment in this patient population.