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마우스 대장암 모델 구축 및 항암제 활성 평가를 위한 예비 연구
김예솔,강봉석,이상은,이은주,이경록,정상헌,박정숙 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract – Aberrant crypt foci (ACF) are early imorphological changes observed in rodents after administration of colon-specific carcinogen such as azoxymethane (AOM). ACF are considered to be putative preneoplastic lesions and are widely used as a surrogate biomarker to rapidly evaluate chemopreventive potential of compounds. The size of colorectal cancer was evaluated after administration of three anticancer drugs, 1 parent drug and 2 prodrugs. The body weights of mice were measured daily and considered as a surrogate for evaluation of general wellbeing. Colons were removed, cut along the longitudinal axis and flushed with phosphate-buffered saline. Each colon was cut into three equal lengths and fixed flat between filter papers. The fixed colon sections were stained with methylene blue. The number of ACF per colon, the number of aberrant crypts observed in each focus and the location of each focus were recorded. After single administration of AOM and multiple doses of anticancer drugs, no significant changes in the body weights of the mice was observed which was recorded for 52 days. However, an expected ACF was not observed in any treated groups. These findings suggest the induction of ACF in mice requires the promotion by dextran sulfate sodium as well as the initiation by AOM.
사무직 근로자의 수면의 질 및 직무스트레스와 우울과의 관련성
강미나,강수영,권수정,김현주,배재원,이보연,이예진,임의롬,정다영,조한솔 이화여자대학교 간호과학대학 2013 이화간호학회지 Vol.- No.47
Purpose: The purpose of this study was to understand the degree of depression, sleep quality, job stress and their association among office workers. Method: A self-administered questionnaire was distributed to 147 workers employed in 5 big enterprises, and 5 small and medium enterprises from October 21 to November 21, 2012. The questionnaires included socio-demographic and health-related characteristics, job-related characteristics, sleep quality, job stress (KOSS) and depression (CES-D). Result: Among all subjects, 23.1% was in the depression group (21 points and over in the CES-D score). Depressive level was positively correlated with job stress and quality of sleep. The adjusted odd ratio for the effects of sleep quality and job stress on depression significantly increased in the depression group compared to that of the normal group. Multiple regression analysis revealed that the following factors of influence had combined explanatory powers on depression: BMI, life satisfaction, quality of sleep, and job stress. Conclusion: The study revealed that complicated influences were exerted on the level of depression by variable factors, as well as socio-demographic characteristics, health-related characteristics, quality of sleep, and job stress. Specifically, the level of depression was influenced by the quality of sleep and job stress.
Dielectric and structural properties of (Ca0.7Sr0.3)(Zr0.8Ti0.2)O3 ceramics
Ye-Sol Yun 한양대학교 세라믹연구소 2014 Journal of Ceramic Processing Research Vol.15 No.4
(Ca0.7Sr0.3)(Zr0.8Ti0.2)O3 ceramics were fabricated on conventional mixed oxides method. The experimental results show that sintering temperature strongly affects the microstructure and dielectric properties of CSZT ceramics. The optimum sintering temperature was 1450 o C, exhibiting relatively high dielectric constants and quality factors in wide frequency ranges (51.7 and 1379) (at 1 MHz), (50.1 and 1328) (at 3.5 GHz). Also, CSZT ceramics sintered at 1450 o C meets C0G characteristic (± 30 ppm/ o C, -55o C ~ 125 o C). These results indicated that CSZT ceramics can be applied to materials for microwave ceramics.
Tooth loss in aggressive periodontitis patients: retrospective study with follow-up of 3 to 8 years
Ye-Sol Park,Young-Mi Chung,정성념 조선대학교 치의학연구원 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.4
The purpose of this study was to assess the clinical outcomes of active periodontal therapy (APT) and supportive periodontal therapy(SPT) through loss of teeth in the Korean patients with aggressive periodontitis. The number of missing and residual teeth, probingpocket depth were examined in 33 patients diagnosed with aggressive periodontitis at the baseline and who had participated in APTand SPT for 3 years or more. A 20 and 3 teeth were lost during the APT and SPT, respectively. The mean tooth loss rate of 0.13 perpatient and year. There was no significant statistical difference in clinical improvement between the smoker and non-smoker groups. Within the limitation of this study, APT combined with supportive therapy could decrease the risk of tooth loss in patients sufferingfrom aggressive periodontitis.
( Ye Sol Bak ),( Sun Young Ham ),( Baatartsogt O ),( Seung Hyun Jung ),( Kang Duk Choi ),( Tae Young Han ),( Il Young Han ),( Do Young Yoon ) 한국응용생명화학회(구 한국농화학회) 2014 Journal of Applied Biological Chemistry (J. Appl. Vol.57 No.2
A5E is complex of several medicinal herb ethanol extracts. The aim of this study is investigating the anticancer effect for non-small cell lung cancer. The antitumor effects of A5E on NCI-H460 were examined by regulation of cell proliferation, apoptosis, cell cycle arrest, mitochondrial membrane potential (Δψm), and apoptosis-related protein. Cell proliferation was measured by MTS assay. Apoptosis induced by A5E was confirmed by Annexin V-fluorescein isothiocyanate (FITC)/Propidium Iodide (PI) staining, and cell cycle arrest was measured by PI staining. NF-κB translocation was detected by immunofluorescence and MMP (Δψm) was measured by JC-1 staining. The expression of extrinsic pathway molecules such as FasL and FADD were elevated, and procaspase-8 was processed by A5E. In addition, intrinsic pathway related molecules were altered. The Bcl-2 and Bcl-xl levels decreased, Bax increased, and cytochrome C was released. In addition, the mitochondrial membrane potential collapsed, and caspase-3 and poly-(ADP-ribose) polymerase were processed by A5E. Moreover, A5E affected the cellular survival pathway involving phosphatidylinositol 3-kinase (PI3K)/Akt and NF-κB. PI3K and Akt were downregulated, also NF-κB expression was decreased, and nuclear translocalization was inhibited by A5E. These results suggested that A5E delays proliferation, inhibit cell cycle progression and induce apoptosis in human lung cancer cell. We conclude that A5E is a potential anticancer agent for human lung carcinoma.
Treatment of the cemental tear
Ye-Sol Park,이재홍,정성념 조선대학교 치의학연구원 2018 Oral Biology Research (Oral Biol Res) Vol.42 No.4
Cemental tears are uncommon form of root fracture that can lead to rapid localized periodontal attachment loss. Studies havedescribed periodontal breakdown as being associated with the separation of the cementum from the underlying tooth structure. The aim of this case report is to assess the outcome of treatment of cemental tear with several surgical treatment regimens. Threepatients with cemental tear were treated with different surgical method. In all three cases, the cemental tear occurred on maxillaryright central incisors. In each case, the root fragment were removed, the localized defect was treated using different surgical methodsincluding guided tissue regeneration and bone graft followed by scaling and root planting. In all three cases, symptoms subsided afterthe treatment and clinical attachment level was improved up to 2 mm at 3 month after surgery. Both conventional and regenerativeperiodontal surgery could achieve successful outcomes.