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Low Gate Leakage Current HFET Structure Fabricated by Using a Step-free Airbridge Gate Process
Feng-Tso Chien,Chien-Liang Chan,Chi-Ling Wang,Chien-Nan Liao,Yao-Tsung Tsai,Hsien-Chin Chiu 한국물리학회 2010 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.56 No.3
Conventional heterostructure field-effect transistors (HFETs) have a high gate leakage current due to the gate electrode being in contact with the exposed channel layer and with the carrier-providing layer on the mesa sidewall. In this study, we use a new step-free (SF) air-bridge gate structure to reduce the gate leakage and improve the breakdown voltage. The proposed structure does not increase any MASKs as compared with the conventional process. In addition, this new structure promises a gate-source capacitance smaller than those of conventional heterostructure FET devices. Consequently, the high-frequency performance of the HFETs using the proposed structure can be improved.
Yao-Chun Yang,Min-Hong Hsieh,Jui-Teng Chien,Keng-Chang Liu,Chang-Chen Yang 대한골다공증학회 2023 Osteoporosis and Sarcopenia Vol.9 No.1
Objectives: Sacral insufficiency fracture (SIF) is not an uncommon osteoporosis fracture among the elderly. Aside from traditional treatments, sacroplasty and teriparatide (TPTD) injection have been introduced. This report aims to compare the effects of sacroplasty and teriparatide on clinical outcomes of SIF. Methods: Thirty-one elderly patients with SIF were enrolled in this retrospective observational study. Four male patients were excluded. Fourteen patients who received TPTD for 6 months were classified into the TPTD group (TT), and 13 who underwent sacroplasty were classified into the sacroplasty group (SS). All patients in both groups were instructed to take calcium and vitamin D supplements daily. Their symptoms and signs, visual analog score (VAS), Oswestry disability index (ODI), and radiographic studies were retrospectively reviewed. Results: The TT group showed significantly lower VAS than SS group after 3 (P < 0.001) and 6 months of treatment (P < 0.001). The TT group also has significant lower ODI than SS group after 1 (P = 0.010), 3 (P = 0.005) and 6 months (P < 0.001) of treatment. Upon generalized estimating equations (GEE) analysis, the TT group showed significantly more reduction in both VAS and ODI compared to the SS group at 1 month (P = 0.022, P = 0.001), 3 months (P < 0.001, P < 0.001), and 6 months (P < 0.001, P < 0.001) post-treatment. Conclusions: Postmenoposal woman with SIF who received TPTD healed better than those who underwent sacroplasty after 1 month treatment.
Chien-Ning Hsu,Ya-Ting Lin,Yu-Hsu Chen,Tsung-Yu Tseng,Hsing-Fen Tsai,Shinn-Gwo Hong,Chao-Ling Yao 한국생물공학회 2023 Biotechnology and Bioprocess Engineering Vol.28 No.3
Repair and regeneration of vascular tissue is a crucial current research focus in the fields of biomedical engineering and regenerative medicine. Numerous studies revealed that cells are required to grow on an appropriate extracellular matrix to maintain or enhance functionality. In the present study, various surface modification methods were evaluated to fix fibronectin on the surface of a bio-based and aligned poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) film for vascular tissue engineering. After chemical modification, the properties of the fibronectin-fixed PHBV films were examined and compared with the original films, including -NH2 group expression, contact angle, mechanical properties, and fibronectin binding amount. Then, cytotoxicity and biocompatibility were measured by culture with L929 cells and endothelial progenitor cells (EPCs) of the fibronectinfixed PHBV films. In addition, cell morphology, cell growth kinetics, acetylated low-density lipoprotein uptake ability, lectin binding ability and specific gene expressions of cultured EPCs on fibronectin-fixed PHBV films were also analyzed. Taken together, our data demonstrated that the surface of the aligned PHBV films could be successfully modified to immobilize fibronectin. Importantly, EPCs cultured on the fibronectin-fixed PHBV films showed excellent cell biocompatibility, a rapid proliferation rate, an aligned growth direction and correct cell functions. We believed that fibronectin-fixed PHBV films can serve as a potential scaffold for vascular tissue engineering.
Equifield line simulation and ion migration prediction for concrete under 2-D electric field
Chih-Chien Liu,Chun-Yao Huang,Wen-Ten Kuo 사단법인 한국계산역학회 2013 Computers and Concrete, An International Journal Vol.12 No.4
This study attempted to find a proper method applicable to simulating practical equifield lines of two-dimensional Accelerate Lithium Migration Technique (ALMT), and evaluate the feasibility of using the theoretical ion migration model of one-dimensional ALMT to predict the ion migration behavior of two-dimensional ALMT. The result showed that the electrolyte or carbon plate can be used as matrix to draw equifield line graph similar to that by using mortar as matrix. Using electrolyte electrode module for simulation has advantages of simple production, easy measurement, rapidness, and economy. The electrolyte module can be used to simulate the equifield line distribution diagram in practical two-dimensional electrode configuration firstly. Then, several equifield line zones were marked, and several subzones under one-dimensional ALMT were separated from various equifield line zones. The theoretical free content distribution of alkali in concrete under two-dimensional electric field effect could be obtained from duration analysis.
( Nai-chien Huan ),( Inn Shih Khor ),( Hema Yamini Ramarmuty ),( Ming Yao Lim ),( Kai Choon Ng ),( Alfieyanto Syaripuddin ),( Qin Zhi Lee ),( Wee Jing Teo ),( Kunji Kannan Sivaraman Kannan ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Introduction Pleural fluid adenosine deaminase (pfADA) is a simple, rapid and inexpensive surrogate marker for tuberculous pleural effusion (TPE). A nationwide cut-off of 40U/L is currently used based on overseas data. There is a need to optimise the diagnostic utility of pfADA by establishing a local cut-off value. In this study, we aimed to: describe the demographics and clinical characteristics of patients with TPE and non-TPE; to determine the sensitivity and specificity of current pfADA of 40U/L; and to establish a new local pfADA cut-off for TPE. Methods We conducted a single centre, observational, prospective study of patients with exudative pleural effusion and pfADA measured from 1st October 2019 to 30th April 2020 at Queen Elizabeth Hospital, Malaysia. Results The diagnosis of analysed patients (n=93) included TPE (n=41), malignancy (n=28), parapneumonic effusion (n=12) and other causes (n=12) (figurer 1). The mean pfADA was 51.15 (SD=13.77)U/L among TPE group and 18.86 (SD=12.33)U/L among non- TPE. When analysis was restricted to TPE patients, the local pfADA cut-off is 29.6U/L, with sensitivity of 97.6% and specificity of 90.4% (figure 2). The current pfADA of 40U/L has a sensitivity of 87.8% and specificity of 92.3%. Conclusion We established a local pfADA cut-off of 29.6U/L for TPE. Optimising the utility of pfADA helps to enhance clinicians’ treatment confidence of TPE when initial work-up were inconclusive.