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        Constituents from Senecio scandens and Their Antioxidant Bioactivity

        Yann-Lii Leu,Chih-Lung Lin,Ping-Chung Kuo 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.3

        Forty-one compounds including two new constituents, senecainin A (1) and 3-methoxyisonicotinic acid (2), were characterized from the methanol extracts of the whole plant of Senecio scandens. The structures of the new compounds were comprehensively established with the aid of 1D and 2D NMR spectroscopic and mass spectrometric analyses. The chemical structures of known compounds were identified by comparison of their spectroscopic and physical data with those reported in the literature. In addition, the antioxidant activity of some of the isolates was examined in the DPPH free radical scavenging assay. Among the tested compounds, (–)-monoepoxylignanolide, (–)-pinoresinol and (–)-epi-pinoresinol displayed significant antioxidant bioactivity.

      • KCI등재

        Chemical Constituents from Lobelia chinensis and Their Anti-virus and Anti-inflammatory Bioactivities

        Ping-Chung Kuo,Yann-Lii Leu,Tsong-Long Hwang,Ying-Ting Lin,Yuh-Chi Kuo 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.5

        In total, forty six compounds, including the novel compound lobechine (1), were characterized from the methanol extracts of Lobelia chinensis. The chemical structures of known metabolites were identified by comparing their spectroscopic and physical data with compounds reported in the literature. The structure of lobechine (1) was comprehensively established with the aid of 1D and 2D NMR spectroscopic analyses. In addition, selected isolates were screened for their inhibition of HSV-1 replication, superoxide anion generation, and elastase release. Among the tested compounds, scoparone (10) exhibited significant inhibition of superoxide anion generation with IC_50 of 6.14 ± 1.97 μM and lobechine (1) exhibited moderate inhibition of elastase release with IC_50 of 25.01 ± 6.95 μM, respectively.

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