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Yangki Jung(정양기) 대한기계학회 2005 대한기계학회 춘추학술대회 Vol.2005 No.5
In this work, way to improve the performance of the MJA is investigated using computer modeling. Finite-difference method is used to analyze and better understand the heat transfer in the MEMS based air micro-jet array (MJA) impinging cooling device. The three-dimensional Navier-Stokes (NS) equations using the compressible flow are solved. The computed temperature distribution at the bottom of the MJA is in good agreement with the experimental measurement data.
TGFBI Promoter Methylation is Associated with Poor Prognosis in Lung Adenocarcinoma Patients
Seok, Yangki,Lee, Won Kee,Park, Jae Yong,Kim, Dong Sun Korean Society for Molecular and Cellular Biology 2019 Molecules and cells Vol.42 No.2
Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related deaths worldwide and has high rates of metastasis. Transforming growth factor beta-inducible protein (TGFBI) is an extracellular matrix component involved in tumour growth and metastasis. However, the exact role of TGFBI in NSCLC remains controversial. Gene silencing via DNA methylation of the promoter region is common in lung tumorigenesis and could thus be used for the development of molecular biomarkers. We analysed the methylation status of the TGFBI promoter in 138 NSCLC specimens via methylation-specific PCR and evaluated the correlation between TGFBI methylation and patient survival. TGFBI promoter methylation was detected in 25 (18.1%) of the tumours and was demonstrated to be associated with gene silencing. We observed no statistical correlation between TGFBI methylation and clinicopathological characteristics. Univariate and multivariate analyses showed that TGFBI methylation is significantly associated with poor survival outcomes in adenocarcinoma cases (adjusted hazard ratio = 2.88, 95% confidence interval = 1.19-6.99, P = 0.019), but not in squamous cell cases. Our findings suggest that methylation in the TGFBI promoter may be associated with pathogenesis of NSCLC and can be used as a predictive marker for lung adenocarcinoma prognosis. Further large-scale studies are needed to confirm these findings.
면방전 AC PDP에서 콘트라스트 개선을 위한 구동 파형과 회로설계
안양기,윤동한,김태형 國立金烏工科大學校 産業技術開發硏究院 2002 産業技術開發硏究 Vol.18 No.-
This paper proposes a method to drive an AC plasma display panel(PDP) with a significantly improved contrast ratio. In the proposed method, during the first sub-field of one frame, all PDP cells are reset by the ramp waveform, and during the other sub-fields, only the cells turned on in the previous sub-field are reset. No light is emitted during the reset period of every sub-field except the first sub-field. For a 10-bit picture, the luminance of the dark level for the proposed method is 10 times lower than that for the conventional method, in which the ramp waveform for the reset is used in every sub-field. Accordingly, the contrast ratio for the proposed method is 10 times higher than that for the conventional method. For the 10-bit picture, the measured contrast ratio was about 3080:1 for the proposed method and about 185:1 for the conventional method, resulting in 10.8 times increase in the contrast ratio. This result shows that the proposed method can realize an image with high contrast ratio.
崔壹,吳洋基 木浦大學校 工業技術硏究所 1992 工業技術硏究誌 Vol.2 No.-
In 1980’s, Korean universities have experienced a rapid growth especially in their population. But, as for their physical settings, there only be paid attentions to the spaces for lecture. This means a strict suffice to the “Ordinance for University Installation Standards”. But the purpose for the ordinance is not there, giving a legal validity for a minimum facility. The ordinance should be a creative guideline for the physical settings for a better university education. In these basis mentioned above, this study aims to analyze the ordinance, to make a new concept for the university education facilities, and to propose some amendments for suitable campus settings.
( Soo-taek Uh ),( So My Koo ),( Yangki Kim ),( Kiup Kim ),( Sungwoo Park ),( An Soo Jang ),( Dojin Kim ),( Yong Hoon Kim ),( Choon-sik Park ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5
Background/Aims: Diesel exhaust particles (DEPs) lead to elevation of reac-tive oxygen species, which can activate the nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain 3 (NLRP<sub>3</sub>)-inflammasome. In this study, we elucidated whether NLRP<sub>3</sub> -inflam-masome is activated by DEPs and whether antioxidants (N-acetylcysteine [NAC]) could inhibit such activation. Methods: RAW 264.7 cells and ex vivo lung tissues explants obtained from elas-tase-induced emphysema animal models were stimulated with cigarette smoking extract (CSE), DEPs, and lipopolysaccharide, and levels of interleukin-1β (IL-1β), caspase-1 and nucleotide-binding oligomerization domain-like receptor (NLR) family members containing the pyrin domain (NLRP<sub>3</sub>)-inflammasome were as-sessed by Western blotting and immunohistochemistry. Results: NAC and caspase-1 inhibitor suppressed CSE- and DEP-induced secretion of IL-1β in RAW 264.7 cells. The expression levels of the NLRP3-inflammasome and caspase-1 were upregulated in RAW 264.7 cells by stimulation with CSE and DEPs and were inhibited by NAC. CSE and DEPs increased the secretion of IL-1β in lung tissues from both the normal and elastase-induced emphysema groups. The secretion of IL-1β by CSE and DEPs was increased in the elastin-induced em-physema group more than that in the normal group (CSE: 309 ± 19 pg/mL vs. 151 ± 13 pg/mL, respectively, p < 0.05; DEP: 350 ± 24 pg/mL vs. 281 ± 15 pg/mL, respective-ly, p < 0.05). NAC inhibited CSE- and DEP-induced IL-1β secretion in both the nor-mal and elastase-induced emphysema groups. NLRP<sub>3</sub>-inflammasome expression as determined by immunohistochemistry was increased by CSE and DEPs in both the normal and elastin-induced emphysema groups, and was suppressed by NAC. Conclusions: The NLRP<sub>3</sub>-inflammasome is activated by DEPs in ex vivo tissue explants from elastase-induced emphysema animal model, and this activation is inhibited by NAC.
The Effect of Mental Rotation on Surgical Pathological Diagnosis
Park, Heejung,Kim, Hyun-Soo,Cha, Yoon Jin,Choi, Junjeong,Minn, Yangki,Kim, Kyung Sik,Kim, Se Hoon Yonsei University College of Medicine 2018 Yonsei medical journal Vol.59 No.3
<P><B>Purpose</B></P><P>Pathological diagnosis involves very delicate and complex consequent processing that is conducted by a pathologist. The recognition of false patterns might be an important cause of misdiagnosis in the field of surgical pathology. In this study, we evaluated the influence of visual and cognitive bias in surgical pathologic diagnosis, focusing on the influence of “mental rotation.”</P><P><B>Materials and Methods</B></P><P>We designed three sets of the same images of uterine cervix biopsied specimens (original, left to right mirror images, and 180-degree rotated images), and recruited 32 pathologists to diagnose the 3 set items individually.</P><P><B>Results</B></P><P>First, the items found to be adequate for analysis by classical test theory, Generalizability theory, and item response theory. The results showed statistically no differences in difficulty, discrimination indices, and response duration time between the image sets.</P><P><B>Conclusion</B></P><P>Mental rotation did not influence the pathologists' diagnosis in practice. Interestingly, outliers were more frequent in rotated image sets, suggesting that the mental rotation process may influence the pathological diagnoses of a few individual pathologists.</P>