STAR-FORMING REGION Sh 2-233IR. I. DEEP NEAR-INFRARED OBSERVATIONS TOWARD THE EMBEDDED STELLAR CLUSTERS

Yan, Chi-Hung,Minh, Y. C.,Wang, Shiang-Yu,Su, Yu-Nang,Ginsburg, Adam IOP Publishing 2010 The Astrophysical journal Vol.720 No.1

Y-90 radioembolisation for large unresectable hepatocellular carcinoma as a bridge to surgery - A 5-year single institute’s experience in Hong Kong

Yan Lilian CHAN,Wai Hung CHEUNG,Chung Yan Justin CHAN,Tak Wing LAI 한국간담췌외과학회 2022 Annals of hepato-biliary-pancreatic surgery Vol.26 No.-

Serum fibrosis index-based risk score predicts hepatocellular carcinoma in untreated patients with chronic hepatitis B

( Lilian Yan Liang ),( Hye Won Lee ),( Vincent Wai-sun Wong ),( Terry Cheuk-fung Yip ),( Yee-kit Tse ),( Vicki Wing-ki Hui ),( Grace Chung-yan Lui ),( Henry Lik-yuen Chan ),( Grace Lai-hung Wong ) 대한간학회 2021 Clinical and Molecular Hepatology(대한간학회지) Vol.27 No.3

Background/Aims: Serum fibrosis scores comprised of common laboratory tests have high utility to assess severity of liver fibrosis. We aimed to derive and validate a hepatocellular carcinoma (HCC) risk score based on serum fibrosis scores to predict HCC in treatment-naive chronic hepatitis B (CHB) patients. Methods: Fifteen thousand one hundred eighty-seven treatment-naive adult CHB patients were identified to form the training cohort in this retrospective study. Individual fibrosis score was included to construct a new HCC prediction score. The score was externally validated in an independent treatment-naive Korean CHB cohort. Results: 180/15,187 patients (1.2%) in training cohort and 47/4,286 patients (1.1%) in validation cohort developed HCC during a mean follow-up of 52 and 50 months, respectively. The newly developed HCC risk score, Liang score, is composed of gender, age, hepatitis B virus DNA, fibrosis-4 (FIB-4) index, and ranges from 0 to 22. Area under the time-dependent receiver operating characteristic curve of Liang score was 0.79 (95% confidence interval, 0.70-0.89). A cutoff value of nine provided an extremely high negative predictive value of 99.9% and high sensitivity of 90.0% at 5 years in the validation cohort. Patients with Liang score ≤9 had HCC incidence <0.2% per year in both training and validation cohorts, in whom HCC surveillance might be exempted. Conclusion: A novel HCC risk score, Liang score, based on FIB-4 index, is applicable and accurate to identify treatment-naive CHB patients with very low risk of HCC to be exempted from HCC surveillance. (Clin Mol Hepatol 2021;27:499-509)

“仁心仁術”의 서방 사유 주도 하에서의 현대 의학 - 唐 孫思邈의 <大醫精誠>의 현대적 해석 -

蕭宏恩(Siu, Hung-Yan) 새한철학회 2020 哲學論叢 Vol.100 No.2

“인심인술(仁心仁術)”은 줄곧 중국 전통 아래 의학 방법이었지만, 오늘날 보기에 과연 그렇게 신빙성이 있을까? 이러한 의문의 연유는 한 편으로는 의술인의 “마음이 바르지 못함(心術不正)을 제거하는 것을 보장하지 못하는 데에 있고, 또 다른 한 편으로는 마음(心)과 술(術)을 서로 나누었기 때문에 그 양자의 필연적 결합을 보장하지 못하는 데에 있다. 사실상, 이것은 오늘날 의학의 관점으로부터 보면, 중국 전통 의학의 일원적 사유는 결코 양분된 문제가 아니다. 전통 의학은 어진 마음(仁心)이 없으면 곧 어진 의술(仁術)이 없다고 보았으며, 이러하다면 설령 최고의 의술을 가지고 있다 할지라도, 또한 의술에 깊지 않은 것이었다. 이러한 의술의 극치는 당대(唐代) 명의 손사막(孫思邈)이 저술한 <대의정성(大醫精誠)>에 잘 표현되어 있다. 이 서적은 오랜 세월을 거쳐 지금에 이르기까지, 분명 그 시대적 의의와 가치를 가지고 있다. 오늘날 우리는 손사막과 1300여 년의 시간적 차이를 두고 있고, 의료환경에 있어서도 또한 자연과학과 기술을 모범으로 삼는 현대의학(의학과학)의 발전 때문에, 완전히 그의 시대와 다른 거대한 전환이 있었지만, <대의정성>은 우리들이 처한 사회문화 배경에 있어서도 우리들에게 이해하기 쉬울 뿐만 아니라 또한 깨달음을 주는 바가 있다. 현대 생리, 병리, 치료관계, 생명윤리 등 난해한 의제에 대하여, 관념적으로 반드시 시대적 전환에 부합하는 바가 있어야만, 비로소 문제 해결의 방도를 열 수 있을 것이며, 관념의 전환은 또한 반드시 그 과거의 시대적 의의와 가치에 대한 해석이 필요하다. 본문은 곧 이러한 의도에 기초하여, 당 손사막의 <대의정성>에 현대적 해석을 시도함으로써 관념의 전체적 전환에 보탬을 기할 것이다. The art of benevolence and benevolence has always been the traditional practice of Chinese medicine, but today it seems so unreliable! The reason for this is that on the one hand, there is no guarantee that the doctor will be able to avoid "psychological irregularities" and on the other, that the mind and art will be separated from each other, and that the inevitable combination of "two" is not guaranteed.In fact, this view is based on today"s medical science, and there is no such thing as the unitary thinking of traditional Chinese medicine as to be unsympathetic, or benevolent, which makes it impossible to become a doctor even if it has any superior skill.In this way, Sun Si-miao, a famous doctor of the Tang Dynasty, wrote The Great Doctor"s Essence.Today, 1300 years after Sun Ssu-miao, the medical environment is completely different from other times, and even though the "Prosperity of Great Medicine" is a social and cultural background, it is easy for me to understand and understand the meaning and value of today"s physical problems, and it is necessary to solve the problems of today"s life.Based on such an intention, this paper makes a modern interpretation of Tang Ssu-mang"s Essence of Great Medicine in order to facilitate the transformation of the whole concept.

Lycopene Synthesis Activity with Culture Duration of Carrot (Daucus carota CV.) Cell Suspension System

Yan Liang,Ming Wang,Hang Chen,Daming Chen 한국원예학회 2008 한국원예학회 기타간행물 Vol.- No.-

Optimization of EDM parameters for ZrO2 and Al2O3 ceramics using Taguchi method

Yan-Cherng Lin,Jung-Chou Hung,Han-Ming Chow,A-Cheng Wang 한양대학교 세라믹연구소 2015 Journal of Ceramic Processing Research Vol.16 No.2

Electrical Discharge Machining (EDM) is the most commonly used technique in mold and die manufacturing. The purpose of this investigation was to optimize the machining parameters of EDM on zirconium dioxide (ZrO2) and aluminum oxide (Al2O3). During the EDM process, the surface of electrically nonconductive ceramic was covered with adhesive conductive copper (Cu) and aluminum (Al) foils to attain the threshold of electrical conductivity for the EDM process. The machining characteristics associated with the EDM process such as material removal rate (MRR) and surface roughness (SR) were explored through the experimental study according to an L18 orthogonal array using the Taguchi method. The analysis of variance (ANOVA) was conducted to examine the significant machining parameters which affect the machining characteristics. As the experimental results show, peak current and pulse duration significantly affected MRR and SR. In addition, the optimal combination levels of machining parameters were also determined from the response graph of signal-to-noise (S/N) ratios for each level of machining parameters. A practical and convenient process for shaping the electrically nonconductive ceramics was developed which featured high efficiency, high precision, and high-quality of surface integrity.

Effect of rice bran and deep flooding on weed suppression in transplanted rice field

Yan Yong-Feng,Fu Jin-Dong,Nguyen Hung T.,Lee Byun-Woo 한국작물학회 2005 한국작물학회 학술발표대회 논문집 Vol.2005 No.-

Measurement of the Modulation Transfer Function of Infrared Imaging System by Modified Slant Edge Method

Hang Li,Changxiang Yan,Jianbing Shao 한국광학회 2016 Current Optics and Photonics Vol.20 No.3

The performance of a staring infrared imaging system can be characterized based on estimating themodulation transfer function (MTF). The slant edge method is a widely used MTF estimation method,which can effectively solve the aliasing problem caused by the discrete undersampling of the infrared focalplane array. However, the traditional slant edge method has some limitations such as the low precisionof the edge angle extraction and using the approximate function to fit the edge spread function (ESF),which affects the accuracy of the MTF estimation. In this paper, we propose a modified slant edge method,including an edge angle extraction method that can improve the precision of the edge angle extractionand an ESF fitting algorithm which is based on the transfer function model of the imaging system, toenhance the accuracy of the MTF estimation. This modified slant edge method presents higher estimationaccuracy and better immunity to noise and edge angle than other traditional methods, which is demonstratedby the simulation and application experiments operated in our study.

Using Chlorophyll (SPAD) Meter Reading and Shoot Fresh Weight for Recommending Nitrogen Topdressing Rate at Panicle Initiation Stage of Rice

Hung The Nguyen,이변우,Lan The Nguyen,Yong-Feng Yan,Kyu-Jong Lee 한국작물학회 2007 Journal of crop science and biotechnology Vol.10 No.1

Nitrogen management at the panicle initiation stage (PI) should be fine-tuned for securing a concurrent high yield and high quality rice production. For calibration and testing of the recommendation models of N topdressing rates at PI for target grain yield and protein content of rice, three split-split-plot design experiments including five rice cultivars and various N rates were conducted at the experimental farm of Seoul National University, Korea from 2003 to 2005. Data from the first two years of experiments were used to calibrate models to predict grain yield and milled-rice protein content using shoot fresh weight (FW), chlorophyll meter value (SPAD), and the N topdressing rate (Npi) at PI by stepwise multiple regression. The calibrated models explained 85 and 87% of the variation in grain yield and protein content, respectively. The calibrated models were used to recommend Npi for the target protein content of 6.8%, with FW and SPAD measured for each plot in 2005. The recommended N rate treatment was characterized by an average protein content of 6.74% (similar to the target protein content), reduced the coefficient of variation in protein content to 2.5% (compared to 4.6% of the fixed rate treatment), and increased grain yield. In the recommended N rate treatments for the target protein content of 6.8%, grain yield was highly dependent on FW and SPAD at PI. In conclusion, the models for N topdressing rate recommendation at PI were successful under present experimental conditions. However, additional testing under more variable environmental conditions should be performed before universal application of such models. Nitrogen management at the panicle initiation stage (PI) should be fine-tuned for securing a concurrent high yield and high quality rice production. For calibration and testing of the recommendation models of N topdressing rates at PI for target grain yield and protein content of rice, three split-split-plot design experiments including five rice cultivars and various N rates were conducted at the experimental farm of Seoul National University, Korea from 2003 to 2005. Data from the first two years of experiments were used to calibrate models to predict grain yield and milled-rice protein content using shoot fresh weight (FW), chlorophyll meter value (SPAD), and the N topdressing rate (Npi) at PI by stepwise multiple regression. The calibrated models explained 85 and 87% of the variation in grain yield and protein content, respectively. The calibrated models were used to recommend Npi for the target protein content of 6.8%, with FW and SPAD measured for each plot in 2005. The recommended N rate treatment was characterized by an average protein content of 6.74% (similar to the target protein content), reduced the coefficient of variation in protein content to 2.5% (compared to 4.6% of the fixed rate treatment), and increased grain yield. In the recommended N rate treatments for the target protein content of 6.8%, grain yield was highly dependent on FW and SPAD at PI. In conclusion, the models for N topdressing rate recommendation at PI were successful under present experimental conditions. However, additional testing under more variable environmental conditions should be performed before universal application of such models.

Metabolism of dl-Praeruptorin A in Rat Liver Microsomes using HPLC-Electrospray Ionization Tandem Mass Spectrometry

Hang Ruan,Xuan Zhu,Zhen Zhang,Xin-fang Liang,Yan Fu,Mei-qin Su,Qi-lin Liu,Xiu-min Wang 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.8

dl-Praeruptorin A (Pd-Ia) is the major active constituent of the traditional Chinese medicine Peucedanum praeruptorum Dunn. Recently it has been identified as a novel agent in the treatment and prevention of cardiovascular diseases. Accordingly, we investigated the metabolism of Pd-Ia in rat liver microsomes. The involvement of cytochrome P450 (CYP) and CYP isoforms were identified using a CYP-specific inhibitor (SKF-525A), CYP-selective inhibitors (α-naphthoflavone, metyrapone, fluvastatin, quinidine, disulfiram, ketoconazole and ticlopidine) and CYP-selective inducers (phenobarbital, dexamethasone and β-naphthoflavone). Residual concentrations of the substrate and metabolites were determined by HPLC, and further identified by their mass spectra and chromatographic behavior. These experiments showed that CYP450 is involved in Pd-Ia metabolism, and that the major CYP isoform responsible is CYP3A1/2, which acts in a concentration-dependent manner. Four Pd-Ia metabolites (M1, M2, M3, and M4) were detected after incubation with rat liver microsomes. Hydroxylation was the primary metabolic pathway of Pd-Ia, and possible chemical structures of the metabolites were identified. Further research is now needed to link the metabolism of Pd-Ia to its drug-drug interactions.