Poster Session : Mechanism of Lysophosphatidylcholine in Upregulation of Endothelial Adhesion Molecules: involvement of GPR4

( Ya Ni Zou ),( Eun Kyung Go ),( Ji Young Kim ),( Hae Young Chung ) 한국생화학분자생물학회 (구 한국생화학회) 2006 생화학분자생물학회 춘계학술발표논문집 Vol.2006 No.-

In Search of a Helpmate

Ya Ni Yoo 한국기독교학회 2011 한국기독교신학논총 Vol.78 No.-

이 글은 창세기의 ``돕는 배필``(에제르 크넥도)이라는 말과 아담과 이브가 금단의 열매를 먹고 벌을 받는 이야기가 한국에서 어떻게 번역되고 해석되어왔는지를 페미니스트 시각에서 추적한다. 한국 개신교의 시작(1885)부터 20세기 중반까지, 20세기 중반부터 1980년까지, 1980년부터 현재까지 등 세 시기로 나누어 분석한다. 첫 시기에는 최병헌과 맥컬리 선교사가 소녀들의 교육, 당시의 축첩제도와 상반되는 일부일처제, 남녀의 동등성을 강조하였다. 둘째 시기의 학자들은 오히려 이브에 대해 가부장적인 해석을 보였다. 셋째 시기의 학자들은 시대정신의 영향을 받아 첫 두 사람의 관계를 묘사하는 데 상호성, 조화, 평등, 공동체와 같은 말을 많이 썼다. 이 글은 ``돕는 배필``에 대한 해석사에서 전반적으로 이성애 결혼제도와 일부일처제를 하나님이 창조하신 질서라고 너무 강조하는 경향이 있음을 지적한다.

글로벌시민 룻의 달콤살벌한 성공기

유연희(Ya Ni Yoo) 한국기독교학회 2009 한국기독교신학논총 Vol.62 No.-

마틴 루터의 해석적 성서번역

김야니(Ya Ni Kim) 한국독어독문학교육학회 2001 獨語敎育 Vol.21 No.-

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Performance Comparison of Surface-Inset Machines With Two Layer Equal/Unequal Magnet-Arc Halbach Magnets

Ni Youyuan,Zhang Xin,Chen Qiuming,Huang Ya,Wang Qunjing 대한전기학회 2024 Journal of Electrical Engineering & Technology Vol.19 No.3

The electromagnetic performances of surface-inset machines with two layer equal/unequal magnet-arc Halbach magnets are compared. The magnetic feld distribution is analytically obtained by analyzing the outer/inner layer Halbach magnets separately. Through presented analytical technique, the magnetization angles of each layer Halbach magnets are analytically optimized. Considering the practical application of relatively large usage of magnets, the larger the outer layer magnet-arc ratio, the better the performances. The analytical predictions show that the optimal two layer unequal magnet-arc Halbach machine has a much higher sine degree of both the airgap fux density and the back-electromotive force and a much lower torque ripple than the optimal two layer equal magnet-arc Halbach machine. The fnite element analysis and analytical prediction results are compared.

Effects of Myogenin on Expression of Late Muscle Genes through MyoD-Dependent Chromatin Remodeling Ability of Myogenin

Chao Du,Ju-Hua Ni,Ya-Qiong Jin,Jun-Juan Qi,Zhen-Xing Ji,Shu-Yan Li,Guo-Shun An,Hong-Ti Jia 한국분자세포생물학회 2012 Molecules and cells Vol.34 No.2

MyoD and myogenin (Myog) recognize sets of distinct but overlapping target genes and play different roles in skeletal muscle differentiation. MyoD is sufficient for near-full expression of early targets, while Myog can only partially enhance expression of MyoD-initiated late muscle genes. However, the way in which Myog enhances the expression of MyoD-initiated late muscle genes remains unclear. Here, we examine the effects of Myog on chromatin remodeling at late muscle gene promoters and their activation within chromatin environment. Chromatin immunoprecipitation (ChIP) assay showed that Myog selectively bound to the regulatory sequences of late muscle genes. Overexpres-sion of Myog was found to overcome sodium butyrate-inhibited chromatin at late muscle genes in differ-entiating C2C12 myoblasts, shifting the transcriptional activation of these genes to an earlier time period. Furthermore, overexpression of Myog led to increased hyperacetylation of core histone H4 in differentiating C2C12 myoblasts but not NIH3T3 fibroblasts, and hyperacetylated H4 was associated directly with the late muscle genes in differentiating C2C12, indicating that Myog can induce chromatin remodeling in the presence of MyoD. In addition, co-immunopre-cipitation (CoIP) revealed that Myog was associated with the nuclear protein Brd4 in differentiating C2C12 myoblasts. Together, these results suggest that Myog enhances the expression of MyoD-initiated late muscle genes through MyoD-dependent ability of Myog to induce chromatin remodeling, in which Myog-Brd4 interaction may be involved.

Spirodiclofen Analogues as Potential Lipid Biosynthesis Inhibitors: A Convenient Synthesis, Biological Evaluation, and Structure-Activity Relationship

Shaoyong Ke,Tingting Sun,Zhigang Zhang,Ya-Ni Zhang,Ying Liang,Kaimei Wang,Ziwen Yang 대한화학회 2010 Bulletin of the Korean Chemical Society Vol.31 No.8

Twenty spirodiclofen analogues have been designed and conveniently synthesized via three steps including esterification,one-pot heterocyclization, and acylation reactions. The target molecules have been identified on the basis of analytical spectra (1H NMR, 13C NMR and ESI-MS) data. All newly synthesized compounds have been screened for their potential insecticidal and herbicidal activity by standard method. The preliminary assays indicated that some of analogues displayed moderate to good insecticidal activity against Plutella xylostella compared with spirodiclofen,and some compounds showed obvious activity against Brassica chinensis. Structure-activity relationship (SAR) is also discussed based on the experimental data.

Parametric Study of Water Inrush in a Tunnel Crossing a Fault based on the “Three Zones” fault structure

Jing Wu,Xintong Wang,Li Wu,Ya-ni Lu,Yanhua Han 대한토목학회 2022 KSCE Journal of Civil Engineering Vol.26 No.8

As tunnelling progresses into the complex geological environment such as fault zones, water inrush has become one of the main geological hazards during tunnel construction. Consequently, understanding the evolution of pore pressure and flow velocity when a tunnel is excavated in a fault zone is crucial to ensure safe working conditions and reduce construction risks. In this work, based on the concept of “Three Zones” fault structure, we simulate the nonlinear water inrush process by solving the Darcy-Brinkman flow equation for the host rock and the fault zone. We examine the impacts of 1) the angle between the tunnelling direction and the fault and 2) the relative position from the tunnel face to the fault on the evolution of pore pressure and flow velocity near the tunnel face. The results show that within 5 m to 20 m ahead of the working face, pore pressure, flow velocity, and water inrush rate are the smallest when the angle is 90°. As the angle decreases, both pore pressure and flow velocity ahead of the working face increase. The pore pressure is larger when the tunnel has not reached the fault zone than when the tunnel has crossed the fault zone. Flow velocity also exhibits similar behaviour as pore pressure. With different relative positions from the tunnel working face to the fault, the closer the tunnel face to the fault, the lower the pore pressure and the larger the flow velocity ahead of the tunnel face. The largest water inrush rate occurs when the tunnel face is excavated to the center of the fault core, and the water inrush rate declines as the distance away from the fault increases. The simulation results provided a new method for simulating water inrush when a tunnel crosses a fault and could provide valuable references for the prediction of water inrush for underground projects.

Clinical Characteristics and Survival Analysis of Breast Cancer Molecular Subtypes with Hepatic Metastases

Ge, Qi-Dong,Lv, Ning,Kong, Ya-Nan,Xie, Xin-Hua,He, Ni,Xie, Xiao-Ming,Wei, Wei-Dong Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.10

Background: The liver is one of the most common metastatic sites of breast cancer, hepatic metastases developing in 6%-25% of patients with breast cancer and being associated with a poor prognosis. The aim of this study was to analyze the survival and clinical characteristics of patients with hepatic metastases from breast cancer of different molecular subtypes and to investigate the prognostic and predictive factors that effect clinical outcome. Methods: We retrospectively studied the charts of 104 patients with breast cancer hepatic metastases diagnosed at Sun Yat-sen University Cancer Center from December 1990 to June 2009. Subtypes were defined as luminal A, luminal B, human epidermal growth factor receptor 2 (HER2) enriched, triple-negative (TN). Prognostic factor correlations with clinical features and treatment approaches were assessed at the diagnosis of hepatic metastases. Results: The median survival time was 16.0 months, and the one-, two- three-, four-, five-year survival rates were 63.5%, 31.7%, 15.6%, 10.8%, and 5.4%, respectively. Median survival periods after hepatic metastases were 19.3 months (luminal A), 13.3 months (luminal B), 18.9 months (HER2-enriched), and 16.1 months (TN, P=0.11). In multivariate analysis, a 2 year-interval from initial diagnosis to hepatic metastasis, treatment with endocrine therapy, and surgery were independent prognostic factors. Endocrine therapy could improve the survival of luminal subtypes (P=0.004) and was a favorable prognostic factor (median survival 23.4 months vs. 13.8 months, respectively, P=0.011). Luminal A group of patients treated with endocrine therapy did significantly better than the Luminal A group of patients treated without endocrine therapy (median survival of 48.9 vs. 13.8 months, P=0.003). Conclusions: Breast cancer subtypes were not associated with survival after hepatic metastases. Endocrine therapy was a significantly favorable treatment for patients with luminal subtype.

Multidetector CT Characteristics of Fumarate Hydratase-Deficient Renal Cell Carcinoma and Papillary Type II Renal Cell Carcinoma

Yang Ling,Li Xue-Ming,Hu Ya-Jun,Zhang Meng-Ni,Yao Jin,Song Bin 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.12

Objective: To investigate the multidetector computed tomography (MDCT) features of fumarate hydratase-deficient renal cell carcinoma (FH-deficient RCC) with germline or somatic mutations, and compare them with those of papillary type II RCC (pRCC type II). Materials and Methods: A total of 24 patients (mean ± standard deviation, 40.4 ± 14.7 years) with pathologically confirmed FH-deficient RCC (15 with germline and 9 with somatic mutations) and 54 patients (58.6 ± 12.6 years) with pRCC type II were enrolled. The MDCT features were retrospectively reviewed and compared between the two entities and mutation subgroups, and were correlated with the clinicopathological findings. Results: All the lesions were unilateral and single. Compared with pRCC type II, FH-deficient RCC was more prevalent among younger patients (40.4 ± 14.7 vs. 58.6 ± 12.6, p < 0.001) and tended to be larger (8.1 ± 4.1 vs. 5.4 ± 3.2, p = 0.002). Cystic solid patterns were more common in FH-deficient RCC (20/24 vs. 16/54, p < 0.001), with 16 of the 20 (80.0%) cystic solid tumors having showed typical polycystic and thin smooth walls and/or septa, with an eccentric solid component. Lymph node (16/24 vs. 16/54, p = 0.003) and distant (11/24 vs. 3/54, p < 0.001) metastases were more frequent in FH-deficient RCC. FHdeficient RCC and pRCC type II showed similar attenuation in the unenhanced phase. The attenuation in the corticomedullary phase (CMP) (76.3% ± 25.0% vs. 60.2 ± 23.6, p = 0.008) and nephrographic phase (NP) (87.7 ± 20.5, vs. 71.2 ± 23.9, p = 0.004), absolute enhancement in CMP (39.0 ± 24.8 vs. 27.1 ± 22.7, p = 0.001) and NP (50.5 ± 20.5 vs. 38.2 ± 21.9, p = 0.001), and relative enhancement ratio to the renal cortex in CMP (0.35 ± 0.26 vs. 0.24 ± 0.19, p = 0.001) and NP (0.43 ± 0.24 vs. 0.29 ± 0.19, p < 0.001) were significantly higher in FH-deficient RCC. No significant difference was found between the FH germline and somatic mutation subgroups in any of the parameters. Conclusion: The MDCT features of FH-deficient RCC were different from those of pRCC type II, whereas there was no statistical difference between the germline and somatic mutation subgroups. A kidney mass with a cystic solid pattern and metastatic tendency, especially in young patients, should be considered for FH-deficient RCC.