P-Selectin-mediated Acute Inflammation Can Be Blocked by Chemically Modified Heparin, RO-Heparin

Yanguang Gao,Na Li,Rui Fei,Zhihong Chen,Sheng Zheng,Xianlu Zeng 한국분자세포생물학회 2005 Molecules and cells Vol.19 No.3

Selectins are carbohydrate-binding cell adhesion molecules that play a major role in the initiation of inflammatory responses. Heparin can bind to P-selectin, and its anti-inflammatory property is mainly due to inhibition of P-selectin. However, the strong anticoagulant activity of heparin limits its clinical use. We prepared periodate-oxidized, borohydride-reduced heparin (ROheparin) by chemical modification and tested its anticoagulant and anti-inflammatory activities. Activated partial thromboplastin time (aPTT) assays showed that, compared with heparin, RO-heparin had greatly reduced anticoagulant activity. Intravenous administration of this compound led to reduction in the peritonealinfiltration of neutrophils in a mouse acute inflammation model. In vitro cell adhesion experiments demonstrated that the effect of RO-heparin on inflammatory responses was mainly due to inhibiting the interaction of P-selectin with its ligands. These results indicate that RO-heparin may be a safer treatment for inflammation than heparin, especially when selectin is targeted.

The Causes of China's Abnormal Sex Ratio and Improved Approaches

Yanguang Wang EWHA INSTITUTE FOR BIOMEDICAL LAW & ETHICS 2008 BIOMEDICAL LAW & ETHICS Vol.2 No.2

This article tries to show that the causes of China' s abnormal sex ratio are the traditional cause of China's shortage of females and the underlying cause of the son preference in Chinese culture and; China's Ultrasound technology abuse also should be blamed; China's economic system retonnation and discrimination against women are reasons on the shortage of daughters; China's one or two-child policy is not the main cause of abnormal sex ratio, but was related to the couples' sons fever and shortage of girls. The laws and regulations of prohibiting the sex-selection failed to balance the male and female sex ratio, Its failure and female infanticide are the causes abnormal sex ratio. This article also discussed the approaches to prevent further losses of daughters, It is stressed that the major requirements are to ultimately overcome the deep preference for sons and reform the social insurance structures related to women. In the end, this article shows that bioethics education can cause a rational decision from the parents who are making a choice to use prenatal tests, Compared with Ultrasound diagnosis for a later abnormal abortion and selective female fetus abortion, the preimplantadon genetic diagnosis has the advantage of being used before the pregnancy. The study found preimplantation genetic diagnosis was more readily accepted in some Chinese couples after they accepted the bioethics views that fetus has moral status although they are not a person, and abortion much more harm to fetus and mother. So the better way is using preimplantation genetic diagnosis to prevent both abnormal or female fetus abortion and infanticide within the son preference culture.

Eu3+-site occupation in CaTiO3 perovskite material at low temperature

Fengfeng Chi,Yanguang Qin,Shaoshuai Zhou,Xiantao Wei,Yonghu Chen,Changkui Duan,Min Yin 한국물리학회 2017 Current Applied Physics Vol.17 No.1

In order to clarify the site occupancy of rare-earth ions in rare-earth doped perovskite materials, the undoped pure CaTiO3 and Eu3þ-doped CaTiO3 samples with a series of Ca/Ti ratio were synthesized via high-temperature solid-state reaction method. X-ray diffraction (XRD) powder patterns confirm that the crystal structure keeps invariant at various Ca/Ti ratios. Measurement results of unit-cell parameters and X-ray photoelectron spectroscopy (XPS) indicate that Eu3þ ions enter into the Ca2þ site. The highresolution photoluminescence spectra of Eu3þ ions at 20 K in all samples did not witness a significant change under the excitation at different wavelength, implying that Eu3þ ions occupy only one type of site. Considering the small spectral splitting range of 5D0/7F2 transition and the large intensity ratio of 5D0 / 7F2/5D0 / 7F1, it can be concluded that Eu3þ occupies Ca2þ site with larger coordinate numbers rather than Ti4þ site.

Study on microstructure wear reduction performance and life prediction of unfolding wheel

Chengyi Pan,Jiahao Chang,Chuan Wang,Yanguang Gu 대한기계학회 2022 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.36 No.3

The unfolding wheel for testing steel ball is apt to wear. Manufacturing microstructure at its surface is a method to reduce wear. Firstly, friction and wear experiments were conducted with load and microstructure area as variables. The friction coefficients and wear mass of the specimens were measured. The friction and wear performance of the microstructure surface is studied by analyzing the data trend of friction coefficient and wear mass. Then, the mechanism on wear resistance of microstructure surface is analyzed. The mathematical model of wear is deduced based on the Archard wear model. The finite element simulations of wear of microstructure surface and smooth surface were conducted through ANSYS software respectively. Finally, the equation relationship between the unfolding wheel life and the number of wear is established by fitting the data from the simulation results using MATLAB. The predicted result shows that the unfolding wheel life of the microstructure surface is about 26.5 % longer than that of the smooth surface.

Size control of Co-doped ZnO rods by changing the solvent

Zhao, Jing,Yan, Xiaoqin,Lei, Yang,Zhao, Yanguang,Huang, Yunhua,Zhang, Yue Techno-Press 2012 Advances in materials research Vol.1 No.1

In this work, the Co-doped ZnO rods were prepared by the hydrothermal method. The size of these rods can be changed from micro-size to nano-size by using different solutions during the preparation. The results of transmission electron microscopy (TEM) and selected area electron diffraction (SAED) showed that the as-prepared nano-sized Co-doped rods have single-crystal structure. The polarized Raman experiments were presented on an individual micro-sized Co-doped ZnO rod in the $X(YY)\vec{X}$, $X(ZY)\vec{X}$ and $X(ZZ)\vec{X}$ configurations, the results of polarized Raman indicated that these rods are crystallized and their growth direction is parallel to c-axis.

Effects of Hardener Type on Cure Behavior and Physical Properties of TMP Modified UF Resin and Its Composites with Bamboo Powder

Yun-fei Zhang,Man-geng Lu,Hui Liu,Yanguang Wu 한국고분자학회 2017 폴리머 Vol.41 No.2

In this study, effects of mixed hardeners (ammonium chloride mixed with ammonium persulfate, oxalate and phosphoric acid) on the properties of 2,4,6-trimethylolphenate modified UF resin (TMPUF) were studied, and the potlife, gel time and curing temperature of TMPUF/hardeners were characterized. The results indicated that the hardeners used have critical influence on the pH value of TMPUF and some proton donor can be used to lower the pH value of TMPUF with low formaldehyde content. Besides, bamboo particleboards were made with TMPUF/hardeners, and tensile properties, water absorption ratio and the swelling ratio of bamboo particleboards were characterized. The study demonstrated that the tensile strength of bamboo particleboards increased when partial ammonium chloride was replaced by ammonium persulfate to cure the TMPUF adhesives in our experiment.

Vibration Reduction Control of In-Pipe Intelligent Isolation Plugging Tool Based on Deep Reinforcement Learning

Xingyuan Miao,Hong Zhao,Boxuan Gao,Tingting Wu,Yanguang Hou 한국정밀공학회 2022 International Journal of Precision Engineering and Vol.9 No.6

Compared with traditional plugging methods, the in-pipe intelligent isolation plugging tool (IPT) is advantageous in safety and work efficiency. However, during the plugging process, the flow field around the IPT changes drastically, resulting in vortex-induced vibration and potential failure of the plugging operation. In this study, three foldable spoilers were designed at the tail of the IPT to optimize the flow field. The vibration of the IPT can be alleviated by adjusting the angles of the spoilers. A vibration reduction control system of the IPT was designed based on deep reinforcement learning. First, we conducted an experiment for vibration reduction system. Second, a nonlinear model of the pressure difference based on experimental data was established. Then, a multi-agent self-learning system based on the deep Q-network (DQN) was designed, and the optimal actions were selected in each agent to adjust the spoiler angles during the plugging process. Finally, a controller based on fuzzy reinforcement learning was proposed to flip the spoilers to the optimized angles. The results show that the vibration reduction control system of the IPT reduced the pressure difference by an average of 28.32%, which indicates the stability of the plugging process and a successful reduction of the IPT vibration.

Modeling the Yellow River sediment flux and its deposition patterns under climatological conditions

Lu, Jing,Qiao, Fangli,Wang, Xiaohua,Teng, Yong,Jung, Kyung Tae,Liu, Yanguang Springer-Verlag 2013 Ocean dynamics Vol.63 No.6

FACTORS CONTROLLING THE STRONGEST SIZES IN THE INVERSE HALL-PETCH RELATIONSHIP

YONG PAN,ZHAO FENG ZHOU,SHAO-YUN FU,YANGUANG NIE,CHANG Q SUN 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2008 NANO Vol.3 No.3

Incorporating the bond-order-length-strength correlation mechanism [Sun CQ, Prog Solid State Chem 35, 1 (2007)] and Born’s criterion for melting [J. Chem. Phys. 7, 591 (1939)] into the conventional Hall-Petch relationship has turned out an analytical expression for the size and temperature dependence of the mechanical strength of nanograins, known as the inverse Hall-Petch relationship (IHPR). Reproduction of the measured IHPR of Ni, NiP and TiO2 nanocrystals revealed that: (i) the competition between the size-induced energy-density gain and atomic cohesive energy loss in the surface skins of nanograins originate the IHPR; (ii) the competition between the activation and inhibition of atomic dislocations motion activate the entire IHPR behavior; (iii) the bond nature involved and the T/Tm ratio between the temperature of operating and the temperature of melting dictate the measured strongest sizes of a given specimen; (iv) a quasimolten phase presenting before melting determines the size-induced softening and the superplasticity of nanostructures.

A new red-emitting phosphor of Eu3+-doped Sr2MgMoxW1−xO6 for solid state lighting

Shuo Li,Xiantao Wei,Kaimo Deng,Xiuna Tian,Yanguang Qin,Yonghu Chen,Min Yin 한국물리학회 2013 Current Applied Physics Vol.13 No.7

The white light-emitting diode has recently attracted great attention as a promising candidate for next generation lighting. The solid solution of Sr1.80Eu0.10Li0.10MgMoxW1-xO6 was synthesized via hightemperature solid-state reaction and this solid solution is treated as a promising red emitting phosphor for white light-emitting diodes. In our cases, the X-ray diffraction, excitation spectra, emission spectra and decay curves of these solid solutions were measured as a function of the Mo/W ratio to characterize the structural and luminescent properties. The excitation bands of the series of phosphors are consistent well with the region of near ultraviolet light, and the phosphors present better color purity than the commercial phosphor Y2O2S:Eu3þ in current use. Taking these properties into consideration,this kind of material may find a great potential application as a red phosphor for near-ultraviolet excited white light-emitting diodes.