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Risa Yamada(Risa Yamada ),Takeshi Fujii(Takeshi Fujii ),Kotaro Hattori(Kotaro Hattori ),Hiroaki Hori(Hiroaki Hori ),Ryo Matsumura(Ryo Matsumura ),Tomoko Kurashimo(Tomoko Kurashimo ),Naoko Ishihara(Nao 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.2
Objective: This study aimed to determine if the discrepancy between depression severity rated by clinicians and that reported by patients depends on key behavioral/psychological features in patients with mood disorders. Methods: Participants included 100 patients with mood disorders. First, we examined correlations and regressions between scores on the Hamilton Depression Rating Scale (HAMD) and Beck Depression Inventory (BDI). Second, we divided the participants into those who provided 1) greater ratings for the BDI compared with the HAMD (BDI relative- overrating, BO) group, 2) comparable ratings for the BDI and HAMD (BDI relatively concordant, BC) group, or 3) less ratings for the BDI (BDI relative-underrating, BU) group. Adverse childhood experiences, autistic-like traits, and coping styles were evaluated with a six-item short version of the Childhood Trauma Questionnaire (CTQ-6), the Social Responsiveness Scale for Adults (SRS-A), and the Ways of Coping Checklist (WCCL), respectively. Results: A significant correlation was found between HAMD and BDI scores. Total and emotional abuse subscale scores from the CTQ-6, and the self-blame subscale scores from the WCCL were significantly higher for the BO group compared with the BU group. The BO group also elicited significantly higher SRS-A total scores than did the other groups. Conclusion: These findings suggest that patients with adverse emotional experiences, autistic-like traits, and self-blame coping styles perceive greater distress than that evaluated objectively by clinicians. The results indicate the need for inclusion of subjective assessments to effectively evaluate depressive symptoms in patients deemed to have these psycho- behavioral concerns.
Evaluation of 131I (monoiodide) BSP for Clinical Studies
Ueda, Hideo,Iro, Masahiro,Kurata, Kunio,Yamada, Hideo,Iwase, Tohru,Migita, Tohru,Kameda, Haruo,Kato, Sadatake,Sato, Noboru,Ide, Kazuko,Wakebayashi, Takao 대한핵의학회 1971 핵의학 분자영상 Vol.5 No.1
"In 1925 Rosenthal and White introduced a bromosulfophthalein (BSP) dye retention test as a sensitive indicator of liver function. Even now it is regared as one of the most sensitive agents for the detection of non-icteric liver disease (liver cirrhosis, early stage of acute-hepatitis and hepatic tumor). BSP accumulates in the liver cells, conjugates with glutathione and is excreted into the bile. Therefore, a disorder in its excretion is due to a disturbance of one of these processes. Since bilirubin and BSP compete for uptake by the liver and increased serum bilirubin interferes with the colorimetric determination of BSP, it has been considered that BSP test is inappropriate for the differential diagnosis of jaundice conditions. It has been generally said that when jaundice is present, the BSP test is useless and should not be performed. In 1955, Taplin et al. labeled rose bengal, a dye similarly metabolized in the liver as BSP, with 131I and measured the hepatic excretion of this dye by external monitoring. Laster, Blahd et al. applied this method to the determination of the peripheral pool, succeeding in the diagnosis of chronic and subacute hepatic diseases without colorimetry. In 1968, Yamada, Taplin et al. suggested the possibility of differentiating so-called medical jaundice from surgical jaundice by scanning the subjects during 24 to 48 hours following intravenous injection of 131I-labeled rose bengal. As mentioned before, many authorities hold the opinion that BSP is not proper for the differential diagnosis of jaundice states. Some have tried to diagnose biliary tract obstruction by a malignant tumor by measuring BSP excretion into duodenal fluid and others by quantitating changes in serum levels of conjugated and free BSP. Furthermore, Burton et al. reported that in patients with extrahepatic obstructive jaundice, BSP retention was observed for 24 days after its administration. From a consideration of all these finding we came to a conclusion that the differential diagnosis of various jaundice states, (medical, surgical and constitutional) is possible by sequential scanning with radioisotope-labeled BSP, as with rose bengal, in accordance with procedures described by Yamada, Taplin et al. The evidence suggested that labeled BSP might make a more important contribution than rose bengal. "
THE RICCI CURVATURE ON DIRECTED GRAPHS
Yamada, Taiki Korean Mathematical Society 2019 대한수학회지 Vol.56 No.1
In this paper, we consider the Ricci curvature of a directed graph, based on Lin-Lu-Yau's definition. We give some properties of the Ricci curvature, including conditions for a directed regular graph to be Ricci-flat. Moreover, we calculate the Ricci curvature of the cartesian product of directed graphs.
Animal models of Alzheimer's disease and evaluation of anti-dementia drugs
Yamada, Kiyofumi,Nabeshima, Toshitaka 한림대학교 환경·생명과학연구소 2002 [일송 국제심포지엄] 노화와 만성퇴행성 신경질환 Vol.- No.4
Alzheimer's disease(AD) is the most common cause of progressive decline of cognitive function in aged humans, and is characterized by the presence of numerous senile plaques and neurofibrillary tangles accompanied by neuronal loss. Some, but not all, of the neuropathological alterations and cognitive impairment in AD can be reproduced genetically and pharmacologically in animals. It should be possible to discover novel drugs that slow the progress or alleviate the clinical symptoms of AD by using these animal models. We review the recent progress in the development of animal models of AD and discuss how to use these model animals to evaluate novel anti-dementia drugs.
THE SOCIAL AUTHORITY OF JAPANESE SCHOOLS
YAMADA, C.L.S. EAST WEST EDUCATION RESEARCH INSTITUTE EWHA WOMANS 1987 East west education Vol.8 No.2
Mass education has become a universal feature of advanced countries. With parents legally obliged to send their children to school for a prescribed number of years, the school has divested the older generation, the traditional transmitters of knowledge and the cultural heritage, of their formal educational responsibilities. As a result, a sharp division of labour is evident between the school and the parents in the transmission of formal knowledge.
Yamada, Yusuke,Yano, Kentaro,Fukuzumi, Shunichi The Royal Society of Chemistry 2012 ENERGY AND ENVIRONMENTAL SCIENCE Vol.5 No.1
<p>Cu<SUB>2</SUB>O particles are active catalysts for hydrogen evolution from ammonia borane (AB) by hydrolysis, however, Cu<SUB>2</SUB>O particles easily form agglomerates as a result of highly reduced conditions during the reaction. In order to suppress agglomerate formation, capping of Cu<SUB>2</SUB>O with organic reagents or inorganic materials was performed and the catalytic reactivity in AB hydrolysis was examined. Among the examined methods, capping of Cu<SUB>2</SUB>O particles with Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles was the most effective to avoid agglomerate formation of Cu<SUB>2</SUB>O particles. The finding enabled us to examine the shape effect of Cu<SUB>2</SUB>O particles on the catalytic reactivity in AB hydrolysis in the presence of Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles. Comparisons of turnover frequencies for hydrogen evolution of Cu<SUB>2</SUB>O–Co<SUB>3</SUB>O<SUB>4</SUB> composites, in which Cu<SUB>2</SUB>O particles were in the shape of 50-facets, cube, octahedron or rhombicuboctahedron, indicated that the composite with Cu<SUB>2</SUB>O with the shape of 50-facets showed more than 7-fold higher hydrogen evolution rate normalized by surface area than the composite with Cu<SUB>2</SUB>O with the octahedral shape. The size and shape effects of Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles were also investigated on their ability to protect Cu<SUB>2</SUB>O from agglomeration. Comparisons of the catalytic reactivity of Cu<SUB>2</SUB>O particles decorated with Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles of different sizes and shapes in terms of amounts and rates of hydrogen evolved by AB hydrolysis indicated that the size of Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles is more important than the shape to exhibit high catalytic reactivity.</p> <P>Graphic Abstract</P><P>Hydrogen evolution from ammonia borane by hydrolysis has been conducted with Cu<SUB>2</SUB>O particles covered with Co<SUB>3</SUB>O<SUB>4</SUB> nanoparticles. <img src='http://pubs.rsc.org/ej/EE/2012/c1ee02639a/c1ee02639a-ga.gif'> </P>