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Isoindolin-1-ones from the stems of Nicotiana tabacum and their antiviral activities
Guang-Yu Yang,Jia-Meng Dai,Zhen-Jie Li,Jin Wang,Feng-Xian Yang,Xin Liu,Jing Li,Qian Gao,Xue-Mei Li,Yin-Ke Li,Wei-Guang Wang,Min Zhou,Qiu-Fen Hu 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.8
In previous studies, several isoindolin-1-oneanalogs that exhibited signifi cant anti-tobacco mosaic virus(anti-TMV) activities were isolated from Nicotiana tabacum . Since gene-editing mutants provide a new sample for thediscovery of active metabolites, we focused on the stems ofYN-18–23 (a mutant N. tabacum for gene editing with thealkaloid metabolic pathway cultivated by Yunnan TobaccoCompany), which led to the isolation of four new ( 1–4 )and four known ( 5–8 ) isoindolin-1-ones. To the best of ourknowledge, nicindole C ( 3 ) is the fi rst subclass of isoindolin-1-one bearing a pentacyclic ketone, while nicindole D ( 4 )is the fi rst example of isoindolin-1-one bearing a methylpyridin-2-(1 H )-one moiety. Compounds 1–4 were testedfor their anti-TMV activities, and the results revealed thatcompounds 1 , 3 , and 4 exhibited high anti-TMV activities atconcentrations of 20 μM with inhibition rates of 48.6, 42.8,and 71.5%, respectively. These rates are higher than the inhibitionrate of the positive control (33.2%). The mechanisticstudy of compound 4 , which had the highest anti-TMV activityrevealed that increased potentiation of defense-related enzyme activities and downregulation of expression of theNtHsp70 protein may induce resistance in tobacco againstthe viral pathogen TMV. Molecular docking studies alsorevealed that the isoindolin-1-one substructure is fundamentalfor anti-TMV activity. The methyl-pyridin-2-(1 H )-onemoiety in compound 4 and the 2-oxopropyl groups in compounds1 and 3 at the N -2 position may increase inhibitoryactivities. This study of the structure–activity relationshipis helpful for fi nding new anti-TMV activity inhibitors. Tostudy whether the isoindolin-1-ones have broader antiviralactivities, compounds 1–4 were also tested for their antirotavirusactivities. Compound 4 exhibited high anti-rotavirusactivity with a therapeutic index (TI) value of 20.7. This TI value is close to that of the positive control (20.2).
Xue Guang Li,In-Su Park,Byung Hyune Choi,Ung-Jin Kim,민병현 한국조직공학과 재생의학회 2020 조직공학과 재생의학 Vol.17 No.2
BACKGROUND: To regenerate tissue-engineered cartilage as a source of material for the restoration of cartilage defects, we used a human fetal cartilage progenitor cell pellet to improve chondrogenesis and modulation of the immune response in an in vivo bioreactor (IVB) system. METHODS: IVB was buried subcutaneously in the host and then implanted into a cartilage defect. The IVB was composed of a silicone tube and a cellulose nano pore-sized membrane. First, fetal cartilage progenitor cell pellets were cultured in vitro for 3 days, then cultured in vitro, subcutaneously, and in an IVB for 3 weeks. First, the components and liquidity of IVB fluid were evaluated, then the chondrogenesis and immunogenicity of the pellets were evaluated using gross observation, cell viability assays, histology, biochemical analysis, RT-PCR, and Western blots. Finally, cartilage repair and synovial inflammation were evaluated histologically. RESULTS: The fluid color and transparency of the IVB were similar to synovial fluid (SF) and the components were closer to SF than serum. The IVB system not only promoted the synthesis of cartilage matrix and maintained the cartilage phenotype, it also delayed calcification compared to the subcutaneously implanted pellets. CONCLUSION: The IVB adopted to study cell differentiation was effective in preventing host immune rejection.
Niederreiter Cascade Combination Cryptosystem Based on the Double Public Keys
Zhou Xue Guang,Li Zhong Yuan,Wang HaoTian,Qv ChengQin 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.7
This paper firstly briefed the basic concepts of N public key cryptosystem, RS code and QC-LDPC code, and then put forward the cascade cryptosystem with the RS code being the outer code and QC-LDPC code being the internal code. At last, the writer analyzed in detail the security and performance of the N cryptosystem based on double public key, and thus proved its better security and performance than the traditional public key cryptosystem based on error correcting code. In addition, it is also endowed with higher practicability in complex environment.
Molecular classification of hepatocellular adenoma: A single-center experience
Xue-Yin Shen,Xu-Guang Hu,Young-Bae Kim,Mi-Na Kim,Sung-Yeon Hong,Bong-Wan Kim,Hee-Jung Wang 한국간담췌외과학회 2019 Annals of hepato-biliary-pancreatic surgery Vol.23 No.2
Backgrounds/Aims: Hepatocellular adenoma (HCA) is a rare benign tumor that has a risk of malignant transformation into hepatocellular carcinoma (HCC) and bleeding. The aim of this study was to analyze the characteristics of HCA by performing molecular classification. Methods: We retrospectively collected data from nine patients who were diagnosed with HCA from 1995 to 2016. The patients underwent liver surgery due to the existence of clinical symptoms. Immunohistochemical (IHC) staining was performed to classify the subgroups of HCA. Results: Four patients with both β-catenin and inflammation were classified as β-IHCA. Two patients were defined as β-HCA. Two patients were classified as HHCA. Only one patient was defined as IHCA. None of the patients had unclassified HCA. Seven of nine patients had a malignant transformation. By comparing the characteristics of HCA between two groups, we found the mean tumor size in the malignant transformation group was greater than the non-malignant transformation group. Conclusions: Taken together, the mean tumor size and activation of catenin β1 mutation status might be the risk factors for the malignant transformation of HCA into HCC. Moreover, IHCA without the catenin β1 mutation could also have a possibility of malignant transformation into HCC.
( Xue-yin Shen ),( Xu-guang Hu ),( Sung-yeon Hong ),( Bong-wan Kim ),( Hee-jung Wang ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Right trisectionectomy was the most effective curative treatment with massive tumor located in the right lobe especially central location of liver. Due to the compressing or even invasion from huge tumor to main branches of portal vein, hepatic vein and bile duct, adequate consideration of inflow and outflow reconstruction during surgery was needed and vessels acquired from cadaveric donor or artificial should be prepared preoperatively. Methods: We present the case of a 59-year-old man who found a 10 cm malignant mass in the right lobe with the invasion of right anterior portal vein, right hepatic vein and middle hepatic vein. By performing right portal vein embolization, left lateral section volume was increased from 26.5% to 37.3%, satisfy the condition of right trisectionectomy. Outflow reconstruction was performed using pericardium, which was acquired from previous cadaveric donor. Results: The recovery process was smooth, patient was discharged in POD 58 without any complication, Conclusions: Preoperatively, sufficient consideration of using allograft to perform inflow or outflow reconstruction is needed in patient with vascular invasion. Postoperatively, regular hepatic mesenteric doppler F/U is needed. Usage of allograft is limited in the hospital where cadaveric donor liver transplantation is feasible. Thus, artificial graft should be prepared in the vascular invasion cases.
Can we delineate preoperatively the right and ventral margins of caudate lobe of the liver?
Xue-Yin Shen,Hee-Jung Wang,Bong-Wan Kim,Sung-Yeon Hong,Mi-Na Kim,Xu-Guang Hu 대한외과학회 2019 Annals of Surgical Treatment and Research(ASRT) Vol.97 No.3
Purpose: Complete removal of the caudate lobe, which is sometimes necessary, is accomplished via isolated caudate lobectomy or hepatectomy that includes the caudate lobe. It is impossible, however, to confirm the right and ventral margins of the caudate lobe by preoperative imaging. This study was undertaken to determine whether we could identify the right and ventral margins of the caudate lobe preoperatively using Synapse 3D visualization software. Methods: Ninety-four preoperative 3-dimensional (3D) computed tomographic images (1-mm slices) of the liver from candidate donors were examined. The images of the caudate lobe were subjected to a counter-staining method according to Synapse 3D to delineate their dimensions. We first examined whether the right margin of the caudate lobe exceeded the plane formed by the root of the right hepatic vein (RHV) and the right side of the inferior vena cava (IVC). Second, we determined whether the ventral margin of the caudate lobe exceeded the plane formed by the root of the middle hepatic vein (MHV) and the root of the RHV. Results: For the right margin, 17 cases (18%) exceeded the RHV-IVC plane by a mean of 10.2 mm (range, 2.4–27.2 mm). For the ventral margin, 28 cases (30%) exceeded the MHV-RHV plane by a mean of 17.4 mm (range, 1.2–49.1 mm). Conclusion: Evaluating the anatomy of caudate lobe using Synapse 3D preoperatively could be helpful for more precise anatomical resection of the caudate lobe.
QUADRATIC B-SPLINE FINITE ELEMENT METHOD FOR THE BENJAMIN-BONA-MAHONY-BURGERS EQUATION
Yong-Xue Yin,GUANG-RI PIAO 영남수학회 2013 East Asian mathematical journal Vol.29 No.5
A quadratic B-spline finite element method for the spatial variable combined with a Newton method for the time variable is proposed to approximate a solution of Benjamin-Bona-Mahony-Burgers (BBMB) equation. Two examples were considered to show the efficiency of the proposed scheme. The numerical solutions obtained for various viscosity were compared with the exact solutions. The numerical results show that the scheme is efficient and feasible.