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- 저자 : Xu-Chao (검색결과 205 건)
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Xu, Chunlan,Sun, Rui,Qiao, Xiangjin,Xu, Cuicui,Shang, Xiaoya,Niu, Weining,Chao, Yu The Korean Society of Pharmacology 2014 The Korean Journal of Physiology & Pharmacology Vol.18 No.4
The study was conducted to investigate the role of vitamin E in the high altitude hypoxia-induced damage to the intestinal barrier in rats. Sprague-Dawley rats were divided into control (Control), high altitude hypoxia (HH), and high altitude hypoxia + vitamin E (250 mg/kg $BW^*d$) (HV) groups. After the third day, the HH and HV groups were placed in a hypobaric chamber at a stimulated elevation of 7000 m for 5 days. The rats in the HV group were given vitamin E by gavage daily for 8 days. The other rats were given equal volume saline. The results showed that high altitude hypoxia caused the enlargement of heart, liver, lung and kidney, and intestinal villi damage. Supplementation with vitamin E significantly alleviated hypoxia-caused damage to the main organs including intestine, increased the serum superoxide dismutase (SOD) (p< 0.05), diamino oxidase (DAO) (p< 0.01) levels, and decreased the serum levels of interleukin-2 (IL-2) (p< 0.01), interleukin-4 (IL-4) (p<0.001), interferon-gamma ($IFN-{\gamma}$) (p<0.01) and malondialdehyde (MDA) (p<0.001), and decreased the serum erythropoietin (EPO) activity (p<0.05). Administration of vitamin E significantly increased the S-IgA (p<0.001) in ileum and significantly improved the expression levels of occludin and $I{\kappa}B{\alpha}$, and decreased the expression levels of hypoxia-inducible factor 1 alpha and 2 alpha ($HIF-1{\alpha}$ and $HIF-2{\alpha}$), Toll-like receptors (TLR4), P-$I{\kappa}B{\alpha}$ and nuclear factor-${\kappa}B$ p65(NF-${\kappa}B$ P65) in ileum compared to the HH group. This study suggested that vitamin E protectis from intestinal injury caused by high altitude hypoxia environment. These effects may be related to the HIF and TLR4/NF-${\kappa}B$ signaling pathway.
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Field Study on the Vacuum Preloading of Dredged Slurry with Wheat Straw Drainage
Chao Liu,Guizhong Xu,Bing Xu 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.11
In this paper, a new shallow reinforcement technique for dredged fill was proposed. In which wheat straw was used as vertical and horizontal drains in lieu of materials applied in the traditional vacuum preloading method. This was not only helpful to avoid permanent environmental damage caused by prefabricated vertical drains but also helpful to relieve the sand shortage and handle the problem triggered by noncontinuous sand cushion layer. On the other hand, this proposal was able to reduce the side effect to the environment triggered by improper handling method on agricultural associated waste greatly, for instance incineration and disposal. Based on prior indoor experimental findings, the feasibility and suitability of the vacuum drainage system composed by straw roller and straw blanket through field test was verified. After doing the comparison between new reinforcement technique and traditional method, it has been found that both the straw blanket and sand cushion performed good in vacuum transmission. Secondly, the vacuum degree of straw roller and prefabricated vertical drains decayed gradually along the depth, but the vacuum attenuation rate of straw roller was slightly smaller than PVD. Thirdly, the performance on the settlement, water content of reinforced soil and undrained shear strength of dredged fill obtained from new reinforcement technique were similar with that generated from traditional vacuum preloading method. Besides, as an agricultural associated waste, the wheat straw had great advantage on financial benefit. Most importantly, unlike PVD, this material is eco-friendly and degradable. Based on these findings, it was suggested that the new reinforcement technique is worth popularizing in real engineering projects.
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Damage and stiffness research on steel shape steel fiber reinforced concrete composite beams
Chao Xu,Kai Wu,Ping zhou Cao,Shi qi Lin,Teng fei Xu 사단법인 한국계산역학회 2019 Computers and Concrete, An International Journal Vol.24 No.6
In this work, an experimental research has been performed on Steel Fiber-Steel Reinforced Concrete (SFSRC)specimens subjected to four-point bending tests to evaluate the feasibility of mutual replacement of steel fibers and conventional reinforcement through studying failure modes, load-deflection curves, stiffness of characteristic points, stiffness degradation curves and damage analysis. The variables considered in this experiment included steel fiber volume percentage with and without conventional reinforcements (stirrups or steel fibers) with shear span depth ratios of S/D=2.5 and 3.5. Experimental results revealed that increasing the volume percentage of steel fiber decreased the creation and propagation of shear and bond cracks, just like shortening the stirrups spacing. Higher crack resistance and suturing ability of steel fiber can improve the stability of its bearing capacity. Both steel fibers and stirrups improved the stiffness and damage resistance of specimens where stirrups played an essential role and therefore, the influence of steel fibers was greatly weakened. Increasing S/D ratio also weakened the effect of steel fibers. An equation was derived to calculate the bending stiffness of SFSRC specimens, which was used to determine mid span deflection; the accuracy of the proposed equation was proved by comparing predicted and experimental results.
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Xu, Xin-Fang,Gao, Yan,Xu, Shu-Ya,Liu, Huan,Xue, Xue,Zhang, Ying,Zhang, Hui,Liu, Meng-Nan,Xiong, Hui,Lin, Rui-Chao,Li, Xiang-Ri The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3
Background: Temperature is an essential condition in red ginseng processing. The pharmacological activities of red ginseng under different steam temperatures are significantly different. Methods: In this study, an ultrahigh-performance liquid chromatography quadrupole time-of-flight tandem mass spectrometry was developed to distinguish the red ginseng products that were steamed at high and low temperatures. Multivariate statistical analyses such as principal component analysis and supervised orthogonal partial least squared discrimination analysis were used to determine the influential components of the different samples. Results: The results showed that different steamed red ginseng samples can be identified, and the characteristic components were 20-gluco-ginsenoside Rf, ginsenoside Re, ginsenoside Rg1, and malonyl-ginsenoside Rb1 in red ginseng steamed at low temperature. Meanwhile, the characteristic components in red ginseng steamed at high temperature were 20R-ginsenoside Rs3 and ginsenoside Rs4. Polar ginsenosides were abundant in red ginseng steamed at low temperature, whereas higher levels of less polar ginsenosides were detected in red ginseng steamed at high temperature. Conclusion: This study makes the first time that differences between red ginseng steamed under different temperatures and their ginsenosides transformation have been observed systematically at the chemistry level. The results suggested that the identified chemical markers can be used to illustrate the transformation of ginsenosides in red ginseng processing.
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CHAO-PING CHEN,Li,Xu,LI LI,YAN-QIN XU 장전수학회 2010 Proceedings of the Jangjeon mathematical society Vol.13 No.3
The Ioachimescu's constant I = 0.539645.... is defined as the limit of the sequence In = [수식] (n ∈ N). In this paper, we establish the asymptotic representation of the sequence (In)n∈N, and obtain the upper and lower bounds for In- and I.
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Do Foreign Investors Monitor Managers in Merger and Acquisition? Evidence from China
Chao Xu,Xiaofang Zhao,Hao Yang,Shiqing Li 한국증권학회 2022 Asia-Pacific Journal of Financial Studies Vol.51 No.1
Using foreign investors’ shareholding to proxy for foreign investors’ monitoring effect in the Chinese stock market, we find that those acquirers exhibit higher announcement returns with higher shareholding, and this effect is stronger when acquirers are private firms. We provide price efficiency and corporate governance channels through which foreign investors play a monitoring role in mergers and acquisitions. Finally, foreign investors decrease the likelihood that managers will conduct mergers in the future and significantly improve long-run performance. Our study provides new insights into the real effects of foreign investors on acquisition performance and the economy.
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Circ-SNX27 sponging miR-375/RPN1 axis contributes to hepatocellular carcinoma progression
Chao Zheng,Jin Liang,Shoude Yu,Hua Xu,Lin Dai,Dan Xu The Korean Society of Pharmacology 2023 The Korean Journal of Physiology & Pharmacology Vol.27 No.4
Hepatocellular carcinoma (HCC) is a prevalent malignant tumor with high fatality. It has yet to be reported whether circ-SNX27 can affect the progression of HCC. This study attempted to analyze circ-SNX27's precise role and underlying mechanisms in HCC. HCC cell lines and tumor specimens from HCC patients were analyzed using quantitative real-time PCR and Western blotting to quantify the expressions of circ-SNX27, miR-375, and ribophorin I (RPN1). Cell invasion and cell counting kit 8 experiments were conducted for the evaluation of HCC cell invasion and proliferation. Caspase-3 Activity Assay Kit was utilized to gauge the caspase-3 activity. Luciferase reporter and RNA immunoprecipitation assays were executed to ascertain the relationships among miR-375, circ-SNX27, and RPN1. To determine how circ-SNX27 knockdown affects the growth of HCC xenografts in vivo, tumor-bearing mouse models were constructed. Elevated expressions of circ-SNX27 and RPN1 as well as a reduced miR-375 expression were observed among HCC cells and HCC patient tumor specimens. Knocking-down circ-SNX27 in HCC cells abated their proliferative and invasive abilities but raised their caspase-3 activity. Moreover, the poor levels of circ-SNX27 inhibited HCC tumor growth among the mice. Circ-SNX27 enhanced RPN1 by competitively binding with miR-375. Silencing miR-375 in HCC cells promoted their malignant phenotypes. Nonetheless, the promotive effect of miR375 silencing was reversible via the knockdown of circ-SNX27 or RPN1. This research demonstrated that circ-SNX27 accelerated the progression of HCC by modulating the miR-375/RPN1 axis. This is indicative of circ-SNX27's potential as a target for the treatment of HCC.
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Xu, Jia,Liu, Chang,Zhou, Lei,Tian, Feng,Tai, Ming-Hui,Wei, Ji-Chao,Qu, Kai,Meng, Fan-Di,Zhang, Ling-Qiang,Wang, Zhi-Xin,Zhang, Jing-Yao,Chang, Hu-Lin,Liu, Si-Nan,Xu, Xin-Shen,Song, Yan-Zhou,Liu, Jun,Z Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.2
Serum alpha-fetoprotein (AFP) is a significant marker for clinical diagnosis and prognosis evaluation in hepatocellular carcinoma (HCC) patients. However, some proportion of liver cancer patients are AFP-negative (AFP ${\leq}$20ng/ml). In order to study the differences between clinicopathological factors and prognosis of alpha-fetoprotein negative and positive patients, a total of 114 cases (41 AFP-negative and 73 AFP-positive) were selected for our research. By systematically statistical analysis, the results demonstrated that compared with AFP-negative patients, AFP-positive examples were more likely to feature cirrhosis nodules, non-complete neoplasm capsules, and a poor Edmondson-steiner grade. Furthermore, AFP-negative patients demonstrated a favorable long-term prognosis. By univariate analysis and multivariate analysis with Cox's proportional hazards model, multiple tumors were found to be independent risk factors for worse survival of AFP negative patients; however, less tumor-free margins, multiple tumors and Edmondson-steiner grades III/IV, proved to be independent risk factors leading to a poor prognosis of AFP positive cases. Finally, we can infer that high levels of AFP signify a highly malignant tumor and unfavorable prognosis.
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