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Multi-Project Sharing Human Resource Leveling Based on the Theory of Risk Element Transmission
Xiu Ren,Ying Li 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.12
By introducing the theory of risk element transmission, this paper analyzes the risk of human resource allocation in a multi-project environment based on Theory of Constraints, and it analyzes qualitatively completion risk of processes depending on the bottleneck resource in a multi-project environment. Through analyzing the bottleneck of resource allocation in a multi-Project environment, we set the bottleneck buffer based on the Theory of Constraints, combined with the characteristics of human resource, and establish sharing human resource equilibrium model in a multi-project environment based on the theory of risk element transmission, providing a specific quantitative management method to alleviate the contradiction between supply and demand of sharing human resource in a multi-project environment, and give the example to prove the feasibility and effectiveness of the approach.
KETCH1 imports HYL1 to nucleus for miRNA biogenesis in <i>Arabidopsis</i>
Zhang, Zhonghui,Guo, Xinwei,Ge, Chunxiao,Ma, Zeyang,Jiang, Mengqiu,Li, Tianhong,Koiwa, Hisashi,Yang, Seong Wook,Zhang, Xiuren National Academy of Sciences 2017 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.114 No.15
<P>MicroRNA (miRNA) is processed from primary transcripts with hairpin structures (pri-miRNAs) by microprocessors in the nucleus. How cytoplasmic-borne microprocessor components are transported into the nucleus to fulfill their functions remains poorly understood. Here, we report KETCH1 (karyopherin enabling the transport of the cytoplasmic HYL1) as a partner of hyponastic leaves 1 (HYL1) protein, a core component of microprocessor in Arabidopsis and functional counterpart of DGCR8/Pasha in animals. Null mutation of ketch1 is embryonic-lethal, whereas knockdown mutation of ketch1 caused morphological defects, reminiscent of mutants in the miRNA pathway. ketch1 knockdown mutation also substantially reduced miRNA accumulation, but did not alter nuclear-cytoplasmic shuttling of miRNAs. Rather, the mutation significantly reduced nuclear portion of HYL1 protein and correspondingly compromised the pri-miRNA processing in the nucleus. We propose that KETCH1 transports HYL1 from the cytoplasm to the nucleus to constitute functional microprocessor in Arabidopsis. This study provides insight into the largely unknown nuclear-cytoplasmic trafficking process of miRNA biogenesis components through eukaryotes.</P>