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( Ya-lan Wang ),( Rui-qun Qi ),( Jing Lan ),( Zheng-xiu Li ),( Xing-hua Gao ) 대한피부과학회 2021 Annals of Dermatology Vol.33 No.1
Background: Local hyperthermia is recommended for the treatment of patients with fixed cutaneous sporotrichosis, though the effectiveness and mechanisms of action remain elusive. While neutrophils represent the main inflammatory cells associated with sporotrichosis lesions, the issue of whether hyperthermia is involved with interactions between neutrophils and Sporothrix globosa remains unclear. Objective: To evaluate the effect of local hyperthermia on sporotrichosis and determine whether local hyperthermia involves effects of neutrophils against Sporothrix. Methods: For the in vivo study, mice were infected with yeast cells of S. globosa followed by treatment with local hyperthermia. In vitro, an isolated Sporothrix strain was co-cultured with or without neutrophils and subjected under different temperatures. Immunofluorescence was used to assess the formation of neutrophil extracellular trap (NETs) were formed under these different culture conditions and the number of fungi colony forming units were compared. Results: Hyperthermia was significantly more effective in clearing the lesions in the mouse model, as compared to sham treatment. Neutrophils failed to exert any fungicidal effects against S. globosa in response to hyperthermia. Moreover, NETs were formed after interaction with S. globosa, and the percentage of NETs formed was not significantly different at 41℃ or 37℃. Conclusion: While hyperthermia could serve as an effective therapy for fixed cutaneous sporotrichosis, this ability does not involve the formation of NETs. (Ann Dermatol 33(1) 37∼45, 2021)
中国福州酒店宴会竞争力提升策略研究 - 基于宴会消费属性开发与IPA分析-
Xiu-bai Li(李秀白),JIan-en Qin(覃建恩),Jiong-lan Lu(卢,炯兰,) 융합관광콘텐츠학회 2018 융합관광콘텐츠학회지 Vol.4 No.2
The purpose of this study is to explore the hotel banquet satisfaction in Fuzhou City of China, and provides theoretical reference for hotel banquet quality management based on the research results. The results of the study shows that the banquet environment (temperature, hygiene, scale), banquet equipment (audio, stage, projection), menu (price, quality) can meet the expectations of consumers; menu design, decoration of banquet room and other aspects exceed the period of consumers. However, the banquet signs, service attitudes, service standards, service speed, humanized service, parking convenience and transportation convenience still lag behind the expectations of consumers and need to be improved.
Research on Scheduling Strategy based on Trust in Hybrid Cloud
Xiao-Lan Xie,Shun-Bai Huang,Xiu-juan Guo 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.8
Hybrid cloud can help companies to maximize the potentiality of IT infrastructure, so the hybrid cloud is increasingly popular in the market. Hybrid cloud scheduling has become one of the important issues which cloud providers face in the current. How to effectively and safely make hybrid cloud scheduling is one of the main research topics in the field of hybrid cloud. This paper introduces an effective hybrid cloud resource management model, and proposes a hybrid cloud resource scheduling strategy based on the particle swarm leapfrog algorithm and trust mechanism in order to solve the problems. The experimental results show that the hybrid cloud scheduling strategy is effective in terms of security and throughput.
Research on Task Scheduling Algorithm Based on Trust in Cloud Computing
Xiao-Lan Xie,Xiu-Juan Guo 보안공학연구지원센터 2016 International Journal of Database Theory and Appli Vol.9 No.8
Cloud computing is regarded as a new computing mode in recent years, and has been widely applied. Its task scheduling affects the performance of the cloud computing system directly, and people pay more and more attention to the security problems of cloud computing. The paper introduces the trust in scheduling algorithm, improves and fuses the PSO and SA in order to make them complementary. By applying that to the task scheduling strategy of cloud computing, we can get a higher scheduling efficiency. We implement the proposed algorithm and verify its high efficiency through the simulation platform (CloudSim).
Collaborative Plotting System Based on Web and Multi-Agent
Xiao-Lan Xie,Shun-Bai Huang,Xiu-juan Guo 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.7
The traditional collaborative plotting system is a single user plot in which users are independent of each other, and the data can’t be shared among them. It can’t meet the requirements of multi-users to collaborative plot in the modern society. In this paper, we proposed multi-agent technology applying into the collaborative plotting system, and designed a collaborative plotting system based on web and multi-agent, which can solve the problem of real-time collaborative plotting for multi-users. At the same time, it provides the map editing interactive interface and realizes the dynamic exchange of the plotting information. Also, it supports a wide range of collecting effective plotting data, and realizes a new way of information acquisition. Experiments show that the system based on multi-agent can achieve fast and real-time cooperation under the Web environment, and its response time is short and the system performance is stable.
Li, Lan-Fang,Wang, Hua-Qing,Liu, Xian-Ming,Ren, Xiu-Bao Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Objective: To investigate the effect of epirubicin on soluble CD25 (sCD25) secretion by CD4+CD25+ regulatory T (Treg) cells isolated from diffuse large B-cell lymphoma (DLBCL) patients. Methods: Treg cells were isolated from the peripheral blood mononuclear cells isolated from the newly diagnosed DBLCL patients. The concentration of sCD25 in the supernatant was determined with a commercial sCD25 (IL-2R) enzyme-linked immunosorbent assay (ELISA) kit. The fluorescence intensity of CD25 was detected by flow cytometry. Results: Cell survival rate was significantly decreased along with the increase of epirubicin concentration after treatment for 24 h. There was also a significant difference in the concentration of sCD25 between the epirubicin group and the control group (P<0.01). A positive correlation between the Treg cells survival rate and the concentration of sCD25 was detected (r=0.993, P<0.01). When equal numbers of CD4+CD25+ Treg cells of the epirubicin group and the control group were cultured for another 24 h without epirubicin the CD25 fluorescence intensity on the surface of Treg cells was obviously higher in the epirubicin group than that in the control group (P<0.01), while the sCD25 concentration in the supernatant in the epirubicin group was significantly lower than that in the control group (P<0.05). Conclusion: Epirubicin may improve the body's immune functions by inhibiting the sCD25 secretion by Treg cells in DLBCL patients.
( Yan-jun Wang ),( Xiu-qiong Lang ),( Dan Wu ),( Yu-qin He ),( Chun-hui Lan ),( Xiao-xiao ),( Bin Wang ),( Duo-wu Zou ),( Ji-min Wu ),( Yong-bin Zhao ),( Peter W Dettmar ),( Dong-feng Chen ),( Min Yan 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims To determine the value of salivary pepsin in discriminating sub-types of gastroesophageal reflux disease (GERD) and GERD-related disorders. Methods Overall, 322 patients with different sub-types of GERD and 45 healthy controls (HC) were studied. All patients took Gastroesophageal Reflux Disease Questionnaire (GerdQ) and underwent endoscopy and 24-hour esophageal pH monitoring and manometry. Salivary pepsin concentration (SPC) was detected by using colloidal gold double-antibody immunological sandwich assay. Oral esomeprazole treatment was administrated in the patients with non-erosive reflux disease (NERD) and extra-esophageal symptoms (EES). Results Compared to HC, patients with erosive esophagitis, NERD, EES, EES plus typical GERD symptoms, or Barrett’s esophagus had a higher prevalence of saliva and SPC (all P < 0.001). There was no significant difference in the positive rate for pepsin in patients with functional heartburn or GERD with anxiety and depression, compared to HC. After esomeprazole treatment, the positive rate and SPC were significantly reduced in NERD (both P < 0.001) and in EES (P = 0.001 and P = 0.002, respectively). Of the 64 NERD patients, 71.9% (n = 46) were positive for salivary pepsin, which was significantly higher than the rate (43.8%, n = 28) of pathological acid reflux as detected by 24-hour esophageal pH monitoring (P = 0.002). Conclusions Salivary pepsin has an important significance for the diagnosis of GERD and GERD-related disorders. Salivary pepsin and 24-hour esophageal pH monitoring may complement with each other to improve the diagnostic efficiency.