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( Xinqiang Zhu ),( Gang Zhou ),( Peng Ni ),( Xuetong Jiang ),( Hailong Huang ),( Jianqiang Wu ),( Xiaohong Shi ),( Xiaoling Jiang ),( Jianing Liu ) 대한소화기학회 2021 Gut and Liver Vol.15 No.2
Background/Aims: Colorectal cancer (CRC) patients often exhibit peritoneal metastasis, which negatively impacts their prognosis. CD31 and D2-40 have recently been suggested to be predictors of breast cancer prognosis, but their role in colorectal peritoneal metastasis (CRPM) remains unknown. Methods: The expression profiles of CD31 and D2-40 were analyzed in CRC patients with or without CRPM and in CRC cell lines with increasing metastatic potential. Overexpression and short hairpin RNA knockdown assays were performed in CRC cells, and the effects of these alterations on epithelial-mesenchymal transition (EMT) in vitro, growth of xenograft tumors in vivo, and peritoneal metastasis potential in a mouse model of CRPM were examined. Results: The expressions of CD31 and D2-40 were upregulated in CRC tumor tissues and was elevated further in tumor tissues from patients with CRPM. CD31 and D2-40 expression levels exhibited increasing trends parallel to the EMT potential of CRC cells. CD31 and D2-40 are essential for CRC cell EMT in vitro as well as for xenograft tumor growth and peritoneal metastasis in vivo. Conclusions: CD31 and D2-40 contribute to CRPM by promoting EMT and may serve as prognostic markers and therapeutic targets for CRC, particularly in patients with peritoneal metastasis. (Gut Liver 2021;15:273-283)
Xinqiang Li,Shufen Wang,Li Zhang,Jiali Liu,Haoshu Luo,Kemian Gou,Sheng Cui,Lei Zhang 대한약학회 2019 Archives of Pharmacal Research Vol.42 No.4
Previous studies demonstrated that depression is more prevalent in women with polycystic ovary syndrome (PCOS). In this study, we aimed to determine whether amitriptyline (AMT), an antidepressant drug, plays a role in preventing PCOS. The results showed that AMT modified ovarian morphology improved the ovarian functions and estrus cycle in estradiol valerate (EV)-induced polycystic ovary (PCO). AMT restored the levels of estradiol (E2), testosterone (T) and progesterone (P4) to normal, and elevated the level of luteinizing hormone (LH) in EV-induced PCO. No significant changes in follicle stimulating hormone (FSH) levels were observed in rats with EV or AMT treatment. The restoration of norepinephrine (NE) level was detected in rats with EV-induced PCO. AMT also altered the expression levels of steroidogenesis genes and beta2-adrenoceptor (beta2-AR) in EV-induced PCO. Our data revealed that AMT improves the ovarian morphology and modifies ovarian expression of beta2-AR and steroidogenesis genes in rats with EV-induced rat PCO. Our data provide support for the hypothesis that AMT is considered as a candidate drug for preventing and treating PCOS along with depression.
TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells by Regulating the ITGB4 Pathway
Zhu Xinqiang,Jiang Xuetong,Zhang Qinglin,Huang Hailong,Shi Xiaohong,Hou Daorong,Xing Chungen 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.3
Background/Aims: This study aimed to investigate the biological function and regulatory mechanism of TCN1 in colorectal cancer (CRC). Methods: We studied the biological function of TCN1 by performing gain-of-function and loss-offunction analyses in HCT116 cell lines; examined the effects of TCN1 on the proliferation, apoptosis, and invasion of CRC cells; and determined potential molecular mechanisms using HCT116 and SW480 CRC lines and mouse xenotransplantation models. Tumor xenograft and colonization assays were performed to detect the tumorigenicity and metastatic foci of cells in vivo. Results: TCN1 knockdown attenuated CRC cell proliferation and invasion and promoted cell apoptosis. Overexpression of TCN1 yielded the opposite effects. In addition, TCN1-knockdown HCT116 cells failed to form metastatic foci in the peritoneum after intravenous injection. Molecular mechanism analyses showed that TCN1 interacted with integrin subunit β4 (ITGB4) to positively regulate the expression of ITGB4. TCN1 knockdown promoted the degradation of ITGB4 and increased the instability of ITGB4 and filamin A. Downregulation of ITGB4 at the protein level resulted in the disassociation of the ITGB4/plectin complex, leading to cytoskeletal damage. Conclusions: TCN1 might play an oncogenic role in CRC by regulating the ITGB4 signaling pathway.
Study on the Naphthenic Acid Erosion-Corrosion Behaviors and Prevention Methods of Carbon Steel
Wu, Xinqiang,Kim, In Sup,Zheng, Yugui,Ke, Wei 한국부식방식학회 2002 Corrosion Science and Technology Vol.31 No.6
The naphthenic acid erosion-corrosion (NAEC) behaviors of carbon steel, pack-aluminized carbon steel, and carbon steel covered by the high velocity oxygen-fuel (HVOF) thermal sprayed AISI 316L stainless steel coating, were investigated in laboratory and oil refinery. The results revealed that the NAEC rate of carbon steel increases markedly with increase of the velocity of flow, especially in high temperature range. The reasons may be ascribed to the enhanced mass transfer and the accelerated surface reaction as well as the rapid spallation of corrosion products from the metal surface. Both the aluminized carbon steel and the carbon steel covered by the HVOF coating show better resistance against the NAEC relative to the carbon steel due to the higher microhardness and corrosion resistance of their surface-layers. It is recommended the HVOF coating to be applied for NAEC prevention of the components in oil refineries in view of present experimental results.
Haitao Liu,Dong Wang,Xinqiang Yi 대한전기학회 2019 Journal of Electrical Engineering & Technology Vol.14 No.3
The multiphase independent winding induction motor (MIWIM) has wide application in AC drive systems of high control redundancy necessary to ships and coal mines. An accurate analysis of its phase loss transient process is a prerequisite for the phase loss fault-tolerant control. When a phase loss occurs, the internal magnetic fi elds of the MIWIM are asymmetric. In this case, conventional coordinate transformation or resultant space vector cannot be used to reduce the mathematical model of the motor phase loss to a lower order. Using a fi ve-phase induction motor as an object of study, this paper presents a full-order mathematical model suitable for the asymmetric state in the α – β –z1–z2–z3 coordinate system. The factor analysis of the frequency domain and no consideration of its small value make it possible to reduce the order of the analytical model. According to the constraint relationship between voltage and current, an analytical analysis is made of the motor dynamic characteristics after a phase loss. The results are in agreement with those of numerical simulation and experiment, which verify that the phase loss asymmetric transient model and analytic method of the MIWIM are feasible and eff ective.
Low-Cost Round Encryption Method for Embedded System
Qi Yue,Luo Xinqiang,Wan Yadong 보안공학연구지원센터 2015 International Journal of Security and Its Applicat Vol.9 No.4
Advanced Encryption Standard (AES) is used in many security systems for its high security. However, the high computation complexity of the round encryption of AES makes AES hard to be performed on many embedded systems with constrained resource. This paper proposes a novel round encryption method based on a 512-Byte lookup table. The experiments results show that, the AES implementation utilizing the round encryption method proposed reaches an encryption performance comparable to that of the widely used implementation with 4 1-KB lookup tables, while consumes much less storage overhead.
Zhang, Ziyu,Tan, Jibo,Wu, Xinqiang,Han, En-Hou,Ke, Wei Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.9
Corrosion fatigue crack growth (FCG) behavior of 316LN stainless steel was investigated in high-temperature pressurized water at different temperatures, load ratios (R = K<sub>max</sub>/K<sub>min</sub>) and rise times (t<sub>R</sub>). The environmental assisted effect on FCG rate was observed when both the R and t<sub>R</sub> exceeded their critical values. The FCG rate showed a linear relation with stress intensity factor range (ΔK) in double logarithmic coordinate. The environmental assisted effect on FCG rate depended on the ΔK and quantitative relations were proposed. Possible mechanisms of environmental assisted FCG rate under different testing conditions are also discussed.
Dynamic Characteristics Identification of an Arch Dam Model via the Phase-Based Video Processing
Qi Li,Gaohui Wang,Aral Sarrafi,Xinqiang Niu,Wenbo Lu,Zhu Mao 대한토목학회 2021 KSCE Journal of Civil Engineering Vol.25 No.1
In recent years, the extraction of structural dynamic characteristics by using phase-based video processing has attracted considerable attention. Edge detection routine is oftentimes employed to obtain the quantified operational deflection shape (ODS) vectors of structures. However, this approach is unreliable because of intensive human supervision and correction. To reduce operational uncertainty, a hybrid computer-vision-based approach called edge detection-region labeling, which involves vision sensor preparation, bottom-hat filtering, edge detection, hole filling, and region labeling, was presented in this work to extract the quantified ODS’s. The performance of this method was firstly evaluated by conducting a lab-scale cantilever beam test and subsequently the phase-based video processing was applied to extract the dynamic characteristics of an arch dam model. The operational modal analysis (OMA) test was conducted on the benchmark dam model. In-plane motions of the dam were captured and processed to identify the natural frequencies of the dam. The structural ODS’s were quantified using the proposed method. A comparison of the modal parameters of the dam identified from the video data with those obtained in the OMA test revealed that the two sets of results were consistent, and the video processing approach was able to bypass the requirement of human supervision, which facilitates the application of the phase-based video processing for complex structures.