Caveolin-₁ is involved in high glucose accelerated human glomerular mesangial cell senescence

( Xin Feng ),( Wei Gao ),( Yao Li ) 대한내과학회 2017 The Korean Journal of Internal Medicine Vol.32 No.5

Background/Aims: We demonstrated the role of caveolin-₁ involved in high glu-cose (HG)-induced glomerular mesangial cells (GMCs) senescence. Methods: HG was used to stimulate GMCs. The telomere lengths were analyzed by Southern blot. β-Galactosidase staining was determined. The expressions of caveolin-1 and P₅₃ proteins were determined by Western blot. Results: Treatment with high concentrations of glucose induced GMC senescence accompanied by shortened telomere length and increase of β-galactosidase stain-ing as well as P₅₃ protein, which was abrogated after application of caveolin-₁- siRNA. Conclusions: This study proved that HG induced cell senescence in GMCs. The caveolin-₁ is involved in HG-induced mesangial cell senescence, and blocking ca-veolin-₁ significantly reduced cell senescence. The effect of caveolin-1 is mediated by P₅₃ pathway.

Experimental study on the effect of EC-TMD on the vibration control of plant structure of PSPPs

Xin Feng,Tengfei Zhong,Yu Zhang,Jing Zhou 국제구조공학회 2022 Smart Structures and Systems, An International Jou Vol.29 No.3

A high-frequency vibration control method is proposed in this paper for Pumped Storage Power Plants (PSPPs) using Eddy Current Tuned Mass Damper (EC-TMD), based on which a new type of EC-TMD device is designed. The eddy current damper parameters are optimized by numerical simulation. On this basis, physical simulation model tests are conducted to compare and study the effect of structural performance with and without damping, different control strategies, and different arrangement positions of TMD. The test results show that EC-TMD can effectively reduce the control effect under high-frequency vibration of the plant structure, and after the additional damping device forms EC-TMD, the energy dissipation is further realized due to the intervention of eddy current damping, and the control effect is subsequently improved. The Multi-Tuned Mass Damper (MTMD) control strategy broadens the tuning band to improve the robustness of the system, and the vibration advantage is more obvious. Also, some suggestions are made for the placement of the dampers to promote their application.

Perceptual Fusion of Infrared and Visible Image through Variational Multiscale with Guide Filtering

Xin Feng,Kaiqun Hu 한국정보처리학회 2019 Journal of information processing systems Vol.15 No.6

To solve the problem of poor noise suppression capability and frequent loss of edge contour and detailedinformation in current fusion methods, an infrared and visible light image fusion method based on variationalmultiscale decomposition is proposed. Firstly, the fused images are separately processed through variationalmultiscale decomposition to obtain texture components and structural components. The method of guidedfilter is used to carry out the fusion of the texture components of the fused image. In the structural componentfusion, a method is proposed to measure the fused weights with phase consistency, sharpness, and brightnesscomprehensive information. Finally, the texture components of the two images are fused. The structurecomponents are added to obtain the final fused image. The experimental results show that the proposed methoddisplays very good noise robustness, and it also helps realize better fusion quality.

Infrared and Visible Image Fusion Based on NSCT and Deep Learning

Xin Feng 한국정보처리학회 2018 Journal of information processing systems Vol.14 No.6

An image fusion method is proposed on the basis of depth model segmentation to overcome theshortcomings of noise interference and artifacts caused by infrared and visible image fusion. Firstly, the deepBoltzmann machine is used to perform the priori learning of infrared and visible target and backgroundcontour, and the depth segmentation model of the contour is constructed. The Split Bregman iterativealgorithm is employed to gain the optimal energy segmentation of infrared and visible image contours. Then,the nonsubsampled contourlet transform (NSCT) transform is taken to decompose the source image, and thecorresponding rules are used to integrate the coefficients in the light of the segmented background contour. Finally, the NSCT inverse transform is used to reconstruct the fused image. The simulation results ofMATLAB indicates that the proposed algorithm can obtain the fusion result of both target and backgroundcontours effectively, with a high contrast and noise suppression in subjective evaluation as well as great meritsin objective quantitative indicators.

Research on Support Vector Machine in Image Denoising

Xinfeng Guo,Chunyan Meng 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.2

In this paper, a denoising algorithm and simulation experiments of algorithm based on wavelet transform and support vector machine (SVM) image is proposed, a new method is adopted in the selection of characteristic vector of support vector machine, based on training of support vector machine, the support vector machine model is used to distinguish between noise and the original image, to achieve the effect of denoising. The experimental results show that the method can well remove the noise, and can save some important details of images, compared with other denoising method based on wavelet transform, it has a good advantage.

Preparation and Investigation of Epoxy Syntactic Foam (Epoxy/Graphite Reinforced Hollow Epoxy Macrosphere/Hollow Glass Microsphere Composite)

Xinfeng Wu,Bo Tang,Jinhong Yu,Xiao Cao,Chongyin Zhang,Yonggen Lv 한국섬유공학회 2018 Fibers and polymers Vol.19 No.1

Graphite reinforced hollow epoxy macrospheres (GR-HEMS) and hollow glass microspheres (HGMS) were used to prepare three phase epoxy syntactic foam (ESF) using “molding method”, and the physical and mechanical properties of ESF were also studied and investigated. An innovative “rolling ball method” was implemented in the GR-HEMS preparationprocess. The performance tests show that higher GR-HEMS stacking volume fraction, lower GR-HEMS thickness, higher GR-HEMS diameter, higher HGMS volume fraction, lower HGMS density are beneficial to reducing the density of ESF, but the effects of the five factors on the strength of ESF are the opposite. Therefore, in order to obtain “high strength and low density” ESF composites, the various factors should be considered to achieve a balance of the strength and the density. Scanning electron microscope (SEM) shows that the “rolling ball method” can make graphite form a graphite spherical x-y network throughout the macrosphere wall, which can make GR-HEMS and ESF have great compressive strength. The ESF (450 kg/m3, 20.75 MPa) can withstand the 2075 meters water pressure and provide 550 kg/m3 buoyancy, which can givesome advice to the preparation of buoyancy material used in deepwater oil exploration.

Vibration Suppression Analysis of a Long-Span Bridge Subjected to Combined Service and Extreme Loads

Xinfeng Yin,Wanli Yan,Qian Liao,Xiang Chen,Yang Liu 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.5

The long-span bridge structures are loaded by service loads including traffic and/or wind loads almost every day. The earthquake load may occur on the bridges simultaneously except for these two common service loads. The vibration response of long-span bridges under earthquake and service loads usually exceeds the expected values. Therefore, the suppressed system should be extensively studied to control the vibration of the bridges. In the work, a pounding tuned mass damper (PTMD) system was designed, which can be effectively used for the dissipation of impact energy. It is mainly made up of a tuned mass and an additional limit device. Based on the earthquake/wind/traffic/bridge coupled system, the numerical simulation of multiple PTMDs (MPTMDs) was carried out. Different parameters of MPTMDs were studied including different numbers, mass ratio, pounding stiffness, and the gap values. The simulations show that the MPTMDs are very effective in suppressing the displacements of the bridge caused by both the traffic flows/wind and traffic/earthquake, and the suppressing effectiveness for bridge vibration under traffic and earthquake is more than that under traffic and wind.

Preparation and Properties Characterization of Interpenetrating Polymer Networks/Organically Modified Montmorillonite/Scrap Leather Fibers Composites

Xinfeng Wu,Zehui Duan,Ying Wang,Yuan Gao,Kai Sun,Runhua Fan,Xiaofeng Li 한국섬유공학회 2019 Fibers and polymers Vol.20 No.9

An interpenetrating polymer networks (IPNs) based on the anhydride-cured cycloaliphatic epoxy and the trifunctionalacrylate resin cross-linked by peroxide was modified by incorporation of organic montmorillonites (OMMTs) andscrap leather fibers (SLFs). OMMTs and SLFs were introduced into IPNs via a violently mechanical stirring technique whichprovided a very well-dispersed phase of OMMTs and SLFs in matrix. Non-isothermal curing behaviors of IPNs/OMMTs/SLFs composites were investigated by means of the differential scanning calorimeter (DSC). The results of DSC testsshowed that the introduction of OMMTs and SLFs into IPNs accelerated the curing reaction of epoxy systems. In comparisonwith the case of the pristine IPNs, the thermal stability properties, the glass transition temperature, mechanical properties ofIPNs/OMMTs/SLFs composites were markedly enhanced. A desirable toughening-strengthening balance of the compositeshad been obtained at 5 pbw(parts by weight) of OMMTs and 0.5 pbw of SLFs. Significant improvements in performances ofIPNs/OMMTs/SLFs composites obtained through the addition of OMMTs and SLFs in IPNs matrix were associated withtheir good co-reinforcement and co-dispersion effects. The macroscopic properties of the composites were found to bestrongly dependent on their concentrations, components, dispersion, and the resulted morphological structures.

Vibration behaviors of a damaged bridge under moving vehicular loads

Xinfeng Yin,Yang Liu,Bo Kong 국제구조공학회 2016 Structural Engineering and Mechanics, An Int'l Jou Vol.58 No.2

A large number of bridges were built several decades ago, and most of which have gradually suffered serious deteriorations or damage due to the increasing traffic loads, environmental effects, and inadequate maintenance. However, very few studies were conducted to investigate the vibration behaviors of a damaged bridge under moving vehicles. In this paper, the vibration behaviors of such vehicle-bridge system are investigated in details, in which the effects of the concrete cracks and bridge surface roughness are particularly considered. Specifically, two vehicle models are introduced, i.e., a simplified four degree-of-freedoms (DOFs) vehicle model and a more complex seven DOFs vehicle model, respectively. The bridges are modeled in two types, including a single-span uniform beam and a full scale reinforced concrete high-pier bridge, respectively. The crack zone in the reinforced concrete bridge is considered by a damage function. The bridge and vehicle coupled equations are established by combining the equations of motion of both the bridge and vehicles using the displacement relationship and interaction force relationship at the contact points between the tires and bridge. The numerical simulations and verifications show that the proposed modeling method can rationally simulate the vibration behaviors of the damaged bridge under moving vehicles; the effect of cracks on the impact factors is very small and can be neglected for the bridge with none roughness, however, the effect of cracks on the impact factors is very significant and cannot be neglected for the bridge with roughness.

A Corpus-based Analysis of Chinese EFL Learners` Use of Linking Adverbials

( Xinfeng Feng ),( Mun Hong Choe ) 대한언어학회 2016 언어학 Vol.24 No.1

This study investigated how the learners of English as a foreign language make use of linking adverbials (LAs) in academic writing, specifically concerned with the developmental aspects of Chinese college students’ ability to utilize them in argumentative essays. A corpus-based analysis was conducted with a learner corpus composed of four sub-corpora with respect to each year in college and a control corpus of English L1 writers’ essays. The results show that Chinese students use LAs excessively as compared to L1 writers. They overuse causal and sequential LAs across all years of study while gradually approaching the target norms in use of additive and adversative LAs. The frequencies of overused LAs fluctuate over time and then eventually decrease in the fourth year. They produce more various LAs as the amount of exposure and learning experience increases. However, they still tend to rely on a small number of LAs and overuse them in prefabricated patterns.