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Xiaoyi Hu,Jiyu Miao,Min Zhang,Xiaofei Wang,Zhenzhen Wang,Jia Han,Dongdong Tong,Chen Huang 한국분자세포생물학회 2018 Molecules and cells Vol.41 No.5
Studies have revealed that miR-103a-3p contributes to tumor growth in several human cancers, and high miR-103a-3p expression is associated with poor prognosis in advanced gastric cancer (GC) patients. Moreover, bioinformatics analysis has shown that miR-103a-3p is upregulated in The Cancer Genome Atlas (TCGA) stomach cancer cohort. These results suggest that miR-103a-3p may function as an oncogene in GC. The present study aimed to investigate the role of miR-103a-3p in human GC. miR-103a-3p expression levels were increased in 33 clinical GC specimens compared with adjacent nontumor stomach tissues. Gain- and loss-of-function studies were performed to identify the correlation between miR-103a-3p and tumorigenesis in human GC. Inhibiting miR-103a-3p suppressed GC cell proliferation and blocked the S-G2/M transition in MKN-45/SGC-7901 cells, whereas miR-103a-3p overexpression improved GC cell proliferation and promoted the S-G2/M transition in vitro. Bioin-formatics and dual-luciferase reporter assays confirmed that ATF7 is a direct target of miR-103a-3p. Analysis of the TCGA stomach cancer cohort further revealed that miR-103a-3p expression was inversely correlated with ATF7 expression. Notably, silencing ATF7 showed similar cellular and molecular effects as miR-103a-3p overexpression, namely, increased GC cell proliferation, improved CDK2 expression and decreased P27 expression. ATF7 overexpression eliminated the effects of miR-103a-3p expression. These findings indicate that miR-103a-3p promotes the proliferation of GC cell by targeting and suppressing ATF7 in vitro.
웹 서버 클러스터에서 Cyber Foraging 응용을 위한 비주기적 부하 갱신을 통한 부하 분산 기법
XiaoYi Lu,Zhen Fu,최원일,강정훈,옥민환,박명순 한국정보처리학회 2007 정보처리학회논문지. 컴퓨터 및 통신시스템 Vol.14 No.1
본 논문에서 웹 서버 클러스터 환경에서 웹 요청들의 분산을 위한 부하 분산 기법을 제안한다. 전통적인 주기적 부하 정보 갱신 기반의 부하 분산 기법에서는 동기화된 부하 정보와 동적 페이지에 포함된 스크립트들의 갱신 정보 때문에 Cyber Foraging 서비스 같은 동적 웹 응용 프로그램에서는 적합하지 않다. 이를 해결하기 위해 Update-on-Finish 부하 분산 알고리즘은 비주기적인 부하 갱신 방법을 사용하고 있다. 웹 스위치는 비주기적인 부하 리포팅 후, 서버들의 실제 부하 정보를 알 수 있다. 그런후 실제 정보에 따라 부하 분산 스케줄을 재배열 한다. 하지만 Update-on-Finish 알고리즘의 경우 부하 정보를 유지하기 위한 통신 부하가 크다는 문제점을 가진다. 본 논문에서는 각 서버가 K%의 작업을 마친 후 비주기적 부하 정보 보고를 통하여부하감소시킨 방법을 제안한다. 또한 서버의 처리능력이 다른 환경을 고려하여 서로 다른 threshold Ti값을 적용함으로써, 다양한 처리 능력을 가진 서버들을 위한 로드 밸런싱 알고리즘으로 확장하여 제안하고 있다. 시뮬레이션 결과에서 제안된 K-Percent-Finish Reporting 방법은 Update-on-Finish 방법보다 최소 50% 이상의 통신 부하를 감소시키면서, 기존 주기적 부하 정보 갱신 기반의 관련 연구들보다 향상된 시스템 처리 능력을 보여주고 있다. This paper introduces a load-balancing algorithm focusing on distributing web requests evenly into the web cluster servers. The load-balancing algorithms based on conventional periodic load-information update mechanism are not suitable for dynamic page applications, which are common in Cyber Foraging services, due to the problems caused by periodic synchronized load-information updating and the difficulties of work load estimation caused by embedded executing scripts of dynamic pages. Update-on-Finish algorithm solves this problem by using non-periodic load-update mechanism, and the web switch knows the servers’ real load information only after their reporting and then distributes new loads according to the new load-information table, however it results in much communication overhead. Our proposed mechanism improve update-on-finish algorithm by using K-Percents-Finish mechanism and thus largely reduce the communication overhead. Furthermore, we consider the different capabilities of servers with a threshold Ti value and propose a load-balancing algorithm for servers with various capabilities. Simulation results show that the proposed K-Percents-Finish Reporting mechanism can at least reduce 50% communication overhead than update-on-finish approach while sustaining better load balancing performance than periodic mechanisms in related work.
Xiaoyi Cao,Lin Chen,Lang Tian,Xiaolian Jiang 한국간호과학회 2015 Asian Nursing Research Vol.9 No.4
Purpose: The purposes of the study were to examine psychological distress and health-related quality of life (HRQoL) in relocated and nonrelocated survivors aged 60 years and older, and to analyze predictors for psychological distress and HRQoL in older survivors 5 years after the 2008 Sichuan earthquake. Methods: This was a cross-sectional descriptive study with 112 relocated older survivors and 156 nonrelocated older survivors. Our study used a multistage sampling method. The measurements used in the study included self-reporting questionnaire-20, medical outcomes study 36-item short form health survey, and an instrument measuring demographic and disaster-related characteristics. Descriptive and multiple linear regression analysis were performed to determine factors that contributed to psychological distress and HRQoL. Results: The prevalence of psychological distress in relocated group (20.5%) was significantly higher compared to those in nonrelocated group (4.8%). Scores for HRQoL in relocated older survivors was significantly lower than those in nonrelocated older survivors. Relocation from preearthquake residence was the most significant predictor for psychological distress and HRQoL in the total sample. Other predictors were advanced age, lower educational level, the loss of family members during the earthquake, and the presence of chronic illnesses as well as the death of a spouse after the earthquake. Conclusions: Strategies can be designed in postdisaster recovery program, particularly for older survivors at high risk for psychological distress and poor HRQoL.
Xiaoyi Zhang,Jie Wu,Xisheng Zhan,Tao Han,Huaicheng Yan 제어·로봇·시스템학회 2022 International Journal of Control, Automation, and Vol.20 No.12
In this paper, the bipartite time-varying formation tracking (BTVFT) problem is studied for multi-agent system (MAS) with the state of agents is unpredictable and a tracking leader of unknown bounded control input. Based on available states and unavailable states, a innovative kind of adaptive BTVFT protocols for MAS is respectively proposed in this article. Then by using Lyapunov stability theory, the result implies that under the appropriate assumptions, one group of followers will trace the leader agent and achieve given formation, while another group of followers will accomplish a given formation at the opposite to the origin. Furthermore, simulation example is represented to validate the performance and effectiveness of the design techniques.
Prescribed-time Stabilization with Time-varying Output Constraints for Switched Nonlinear Systems
Xiaoyi Tian,Yichen Li,Ruicheng Ma 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.5
This paper studies the problem of the prescribed-time stabilization for a class of switched nonlinear systems with time-varying output constraints. Firstly, a new coordinate design of the output enables the constraints to be incorporated into the original system. Secondly, a fractional term will be played an essential role in achieving prescribed-time stabilization. Then, based on the method of Barrier Lyapunov function (BLF) and backstepping, a recursive algorithm is developed to construct a controller to achieve the prescribed-time stabilization with timevarying output constraints. Finally, two examples are provided to show the effectiveness of the proposed results.