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Xiaoting Zhang,Chunjuan Wang,Wenyao Zhu,Baojie Wang,Huiying Liang,Shougang Guo 대한신경과학회 2019 Journal of Clinical Neurology Vol.15 No.3
Background and Purpose Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common type of autoimmune encephalitis. This study aimed to explore the possible factors affecting the response to first-line treatments in patients with anti-NMDAR encephalitis. Methods We enrolled 29 patients who were diagnosed as anti-NMDAR encephalitis between January 1, 2015, and June 30, 2018. They were divided into the remission and nonremission groups according to their response to first-line treatments. The demographics, clinical manifestations, main ancillary examinations, follow-up treatments, and prognosis of patients were recorded. The symptoms reported on in this study occurred before treatments or during the course of first-line treatments. Results There were 18 patients (62.07%) in the remission group and 11 patients (37.93%) in the nonremission group. Compared to the remission group, a higher proportion of the patients in the nonremission group exhibited involuntary movements, decreased consciousness, central hypoventilation, lung infection, and hypoalbuminemia. The nonremission group had a high incidence of increased intracranial pressure and significant elevations of the neutrophilto- lymphocyte ratio in peripheral blood (NLR), aspartate aminotransferase, and fibrinogen. Six patients (54.55%) in the nonremission group received second-line immunotherapy. Only one patient (3.45%) died, which was due to multiple- organ failure. Conclusions Anti-NMDAR-encephalitis patients with more symptoms—especially involuntary movements, disturbance of consciousness, central hypoventilation, and accompanying hypoalbuminemia and pulmonary infection—may respond poorly to first-line treatments. Positive second-line immunotherapy therefore needs to be considered. Admission to an intensive-care unit, increased cerebrospinal fluid pressure, and increased NLR might be the significant factors affecting the response to first-line treatments.
Xiaoting Meng,Xiaofang Cheng,Dongrong Zhuang,Shaogui Yang,Cheng Sun 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2016 NANO Vol.11 No.9
A series of Ag3PO4/BiOCOOH composite photocatalysts have been successfully synthesized by a simple in situ ion precipitation method. The crystallinity, morphology, microstructure, composition and optical property were characterized by X-ray diffraction (XRD), scanning electron microscope (SEM), transmission electron microscopy (TEM), energy dispersive spectrum (EDS), Fourier transform infrared spectrometer (FT-IR), X-ray photoelectron spectroscopy (XPS), UVVis diffuse reflectance spectrophotometer (DRS). The as-prepared catalysts exhibited excellent photocatalytic activity for the degradation of RhB and MB under visible light irradiation, the 2:1 Ag3PO4/BiOCOOH exhibited the best photocatalytic activity. By adding different free radical scavengers, the catalytic mechanism was discussed. In the process of degradation of RhB, holes (h+) is the main active species, .O-2 played a certain active role, .OH played a small role. In the process of degradation MB, holes (h+) is the main active species too, .O-2 also played a certain active role, .OH almost does not work.
Adsorption of phosphate from aqueous solution by lanthanum modified macroporous chelating resin
Xiaoting Zhang,Chenghui Ma,Kang Wen,Runping Han 한국화학공학회 2020 Korean Journal of Chemical Engineering Vol.37 No.5
A highly effective adsorbent of lanthanum-modified D751 resin (D751 resin for macroporous styrene chelated resin, sodium form) was prepared to enhance the effect of removing phosphate from solution. FTIR, SEM were used to explore the functional groups and structural features on the surface of D751-La; XPS analyzed the action mechanism between phosphate and D751-La. The adsorption performance about D751-La toward phosphate was investigated by batch experiment. The results showed that Langmuir, Freundlich, Temkin, Koble-Corrigan as well as Redlich-Peterson models fitted well for the adsorption isotherms. The adsorption kinetics could be better fitted by Double Constant, Elovich, and Pseudo-second-order model. The effect of salinity was not significant, such as Cl and SO4 2. When the solid-liquid ratio was 15 g·L1 with setting the reaction time as 8 h, the unit adsorption quantity of D751-La to phosphate (calculated in P) reached up to 26.3mg·g1 under the solution pH=3 at 293 K. The process was spontaneous and exothermic from thermodynamic analysis. It shows that D751-La has potential to remove phosphate from solution.
Xiaoting Shen,DongJia Chen,Yan Xu,Yu Fu,Canquan Zhou 한국바이오칩학회 2019 BioChip Journal Vol.13 No.2
Here, we present the successful application of two different preimplantation genetic testing for monogenic diseases (PGT-M) methods for a couple facing the genetic risk of Achondroplasia (ACH). The first preimplantation genetic haplotyping (PGH) cycle was based on short tandem repeats (STRs) and 8 STRs were chosen. The multiple displacement amplification (MDA) products were analyzed using the informative STR loci and PCR-restriction enzyme digestion of FGFR3. A healthy girl was delivered. Two years later, we performed the second PGT-M cycle for this couple with a newly established PGT-M platform based on next generation sequencing (NGS). Haplotype analysis was established by a selection of several informative single nucleotide polymorphisms (SNPs). Preimplantation genetic testing for aneuploidy (PGT-A) was also performed on embryos with normal FGFR3 genotype. Another healthy girl was born. PGH system could be established using STRs or NGS-SNP systems. The NGS-SNP system could detect more sites and simultaneously performs PGT-A with an automated operation.
Removal of Cr(VI) from solution using UiO-66-NH2 prepared in a green way
Xiaoting Zhang,Shusheng Zhang,Gangfeng Ouyang,Runping Han 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
A zirconium-based metal organic framework (UiO-66-NH2) was prepared using a greener approach forthe removal of hexavalent chromium (Cr(VI)) from solution. The characterization of UiO-66-NH2 was performedusing several methods, and the influence of the solution pH, adsorbent dosage, salt, adsorption time, Cr(VI) concentrationand adsorption temperature on adsorption quantity was performed in batch mode. UiO-66-NH2 can efficientlyremove Cr(VI) through the synergistic effect of adsorption and reduction. At pH solution of 1.1 and solid-to-liquidratio of 2 g·L1, the removal rate of 100mg·L1 Cr(VI) increased to 95.2%. The maximum adsorption capacity of UiO-66-NH2 from Langmuir model was 252mg·g1. The adsorption equilibrium process can be well described by Langmuir,Koble-Corrigan and Temkin models, while the kinetic process can be predicted by pseudo-second-order andElovich model. UiO-66-NH2 showed a good adsorption capacity in a wide range of pH (pH=1.1-10) and also had betterregeneration performance after five cycles using 0.01 mol·L1 NaOH; consequently, it can be a promising adsorbentfor the removal of Cr(VI) from solution.
Xiaoting Song,Ailu Wu,Zhixiao Ding,Shixiong Liang,Chunyan Zhang 대한암학회 2020 Cancer Research and Treatment Vol.52 No.3
Purpose The purpose of this study was to evaluate the diagnostic value of soluble Axl (sAxl) in hepatocellular carcinoma (HCC) in comparison with serum "-fetoprotein (AFP). Materials and Methods Eighty HCC patients, 80 liver cirrhosis patients (LC), 80 patients with hepatitis B virus (HBV) infection, and 80 healthy controls (HC) were enrolled. sAxl levels were measured by an enzyme-linked immunosorbent assay, serum AFP levels were measured by an electrochemiluminescence immunoassay. Receiver operating characteristic (ROC) curves were used to evaluate diagnostic performances. Results The results show that levels of sAxl were high expression in patients with HCC (p < 0.05), varied with disease state as follows: HCC > LC > HC > HBV. Logistic regression and ROC curve analysis identified the optimal cut-off for sAxl in differentiating all HCC and non-HCC patients was 1,202 pg/mL (area under the receiver operating characteristic [AUC], 0.888; 95% confidence interval [CI], 0.852 to 0.924) with sensitivity 95.0%, specificity 73.3%. Furthermore, differential diagnosis of early HCC with non-HCC patients for sAxl showed the optimal cut-off was 1,202 pg/mL (AUC, 0.881; 95% CI, 0.831 to 0.931; sensitivity, 94.1%; specificity, 73.3%). Among AFP-negative HCC patients with non-HCC patients, the cut-off was 1,301 pg/mL (AUC, 0.898; 95% CI, 0.854 to 0.942) with a sensitivity of 84.6%, a specificity of 76.3%. The optimal cut-off for sAxl in differentiating all HCC and chronic liver disease patients was 1,243 pg/mL (AUC, 0.840; 95% CI, 0.791 to 0.888) with sensitivity 93.8%, specificity 61.9%. The combination of AFP and sAxl increased diagnostic value for HCC. Conclusion sAxl outperforms AFP in detecting HCC, especially in early HCC and in AFP-negative HCC. Combination sAxl with AFP improved the specificity for early HCC diagnosis. In summary, sAxl is a candidate serum marker for diagnosing HCC.
Lao Tzu’s Thought of the Baby and Its Spiritual Value
Prof. Xiaoting Liu 한국마음학회 2014 한국마음학회지 Vol.1 No.1
The “infant” plays an important role in the Eastern monastic tradition. There has been a lot of discussions in the works of Buddhism and early Christianity. As a comprehensive theoretic system, however, the theory of “infant” is mainly in the ideological system of Taoists. The “infant” is treated as the highest goal in the monastic practice of Lao Tzu.