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Xiaonan Qi,Xiaonan Wang,Xinjun Shen,Pengcheng Huan,Zhenguang Liu,Hongshuang Di 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.9
Acicular ferrite has appeared in various low carbon microalloyed steel welds (e.g., laser-arc hybrid welds) due to its highgrain boundary density and toughness. However, the transformation kinetics and crystallographic structure characteristics ofacicular ferrite in laser-arc hybrid welds are still unclear. In this paper, the nucleation and growth kinetics of acicular ferritein laser-metal active gas hybrid welds with different cooling rates (1–150 K/s) were investigated and their crystallographiccharacteristics were revealed from the perspective of variant. The result showed that acicular ferrite can nucleate at all thetest cooling rates in weld metal, and the microstructure coexisting with acicular ferrite changes from polygonal ferrite andgranular bainite with a low cooling rate to lath martensite with a high cooling rate. As the cooling rate increases, the phasetransformation temperature of acicular ferrite decreased, and the phase transformation mode changed from partitioninglocal equilibrium to negligible partitioning local equilibrium. The variety of the phase transformation mode and the higherphase transformation driving force led to an increase in the growth rate of acicular ferrite. Compared with the bainite andmartensite in the base metal, the acicular ferrite had the characteristics of light variant selection, uniformly distributedoperating factor and small variant size, which resulted in high-density effective grain boundaries. To obtain more acicularferrite, the cooling rate should be increased as much as possible on the premise that the phase transformation terminationtemperature was higher than the Ms.
Xiaonan Wu,Zhiping Yang,Yan Zhao,Yahong Yao,Jun Li,Wangshi Wang 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.10
The cancer chemo-preventive effects of equol have been demonstrated for a wide variety of experimental tumours. In a previous study, we found that equol inhibited proliferation and induced apoptotic death of human gastric cancer MGC-803 cells. However, the mechanisms underlying equol-mediated apoptosis have not been well understood. In the present study, the dual AO (acridine orange)/EB (ethidium bromide) fluorescent assay, the comet assay, MTS, western blotting and flow cytometric assays were performed to further investigate the pro-apoptotic effect of equol and its associated mechanisms in MGC-803 cells. The results demonstrated that equol induced an apoptotic nuclear morphology revealed by AO/EB staining, the presence of a comet tail, the cleavage of caspase-3 and PARP and the depletion of cIAP1, indicating its pro-apoptotic effect. In addition, equol-induced apoptosis involves the mitochondria-dependent cell-death pathway, evidenced by the depolarization of the mitochondrial membrane potential, the cleavage of caspase-9 and the depletion of Bcl-xL and full-length Bid. Moreover, treating MGC-803 cells with equol induced the sustained activation of extracellular signal-regulated kinase (ERK), and inhibiting ERK by U0126, a MEK/ERK pathway inhibitor, significantly attenuated the equol-induced cell apoptosis. These results suggest that equol induces mitochondria-dependent apoptosis in human gastric cancer MGC-803 cells via the sustained activation of the ERK1/2 pathway. Therefore, equol may be a novel candidate for the chemoprevention and therapy of gastric cancer.
Xiaonan Fang,Lin-Bai Ye,Yijuan Zhang,Baozong Li,Shanshan Li,Lingbao Kong,Yuhua Wang,Hong Zheng,Wei Wang,Zhenghui Wu 한국미생물학회 2006 The journal of microbiology Vol.44 No.5
GST pull-down assays were used to characterize the SARS-CoV membrane (M) and nucleocapsid (N)interaction, and it was found that the amino acids 211-254 of N protein were essential for this interaction. When tetrad glutamines (Q) were replaced with glutamic acids (E) at positions of 240-243 of the N protein, the interaction was disrupted.
Xiaonan Li,Dave C. F. Chan,Rob Law Smart Tourism Research Center 2023 Journal of smart tourism Vol.3 No.3
This study examines the scientific publications on website evaluation in hospitality and tourism from 2010 to 2023 through a systematic review and discusses implications for future research. The reviewed literature from publication years, journals, research methods, website-related stakeholders, context, various forms of Internet presence (Internet forms), and theories are analyzed to create a comprehensive website evaluation dimension. Furthermore, a conceptual framework is developed to show the relationship between the website characteristics, stakeholders-channels interaction, and stakeholders' reactions. The proposed website evaluation framework in hospitality and tourism synthesizes the existing knowledge, identifies gaps, and further advances our understanding of this research area.
Xiaonan Li,Wenxing Pang,Su Ryun Choi,Yong Pyo Lim 한국육종학회 2014 한국육종학회 심포지엄 Vol.2014 No.07
We investigated the genetic diversity and structure of the 239 fixed lines with 47 simple sequence repeat (SSR) and 109 NGS-generated SNP markers evenly distributed in B. rapa genome. Phylogenetic analysis classified the vegetable fixed lines to four subgroups, with the three types forming a separate and relatively farther cluster. Population structure analysis identified four sub-populations corresponding to geographic origin and morphological traits, and revealed extensive admixture. The vegetable B. rapa fixed lines successfully developed in our study would be valuable materials for multinational B. rapa diversity resources establishment. Understanding the genetic diversity and population structure could be useful for utilization of the representing genetic variation and further genetic and genomic analysis.