Upregulated Long Noncoding RNA LINC01234 Predicts Unfavorable Prognosis for Colorectal Cancer and Negatively Correlates With KLF6 Expression

Xiao Jiang,Qiaoying Zhu,Pengxi Wu,Fengsheng Zhou,Jun Chen 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.2

Background: LINC01234, a long noncoding RNA (lncRNA), is overexpressed in several cancers, including colorectal cancer (CRC). We investigated the role of LINC01234 in CRC development and confirmed its correlation with Krüppel-like factor 6 (KLF6), a tumor suppressor gene that is dysregulated in CRC. Methods: We tested mRNA levels using quantitative reverse transcription PCR (qRT-PCR). Tissue samples from patients with CRC, inflammatory bowel disease (IBD), hyperplastic polyp, and adenoma were included. Correlations between clinicopathological parameters, overall survival (OS) rate, and LINC01234 were analyzed using Kruskal-Wallis H test. Additionally, cell proliferation, apoptosis, and tumor formation in nude mice were tested to investigate the mechanism of LINC01234. Western blotting was used to determine protein levels. Results: LINC01234 expression was significantly upregulated in CRC tissues and CRC cell lines than in non-tumor tissues and normal epithelial cells, respectively. LINC01234 was associated with high tumor stage, larger tumor size, and metastasis. Patients with higher LINC01234 expression showed reduced OS. Cell proliferation was inhibited by LINC01234 knockdown, whereas apoptosis was enhanced. Mice injected with SW480 cells with LINC01234 knockdown displayed decreased tumor volume, weight, and Ki-67 levels compared with those injected with control cells. KLF6 was negatively regulated by LINC01234. Overexpression of KLF6 showed effects similar to those observed following LINC01234 knockdown on cell proliferation and apoptosis. Conclusions: LINC01234 could be a prognostic biomarker in CRC patients. Upregulation of LINC01234 in CRC promotes tumor development through negative regulation of KLF6.

Development Issues of An ISG PM Machine and Control System

Xiaojiang Chen,Murray Edington,Roger Thornton,Yunzhou Fang,Qingfeng Peng 전력전자학회 2007 ICPE(ISPE)논문집 Vol.- No.-

This paper focuses on addressing some practical considerations in developing an ISG PM system for hybrid electric-vehicle (HEV) applications. Extensive practical test results and theoretical analyses are presented and analyzed. Firstly, the ISG PM machine design is discussed in term of the machine size, pole-pair number, permanent magnet flux, inductance, etc. A cost-effective machine design example, which was successfully demonstrated in a mild ISG HEV application, is analyzed. Its performance test results are evaluated. Subsequently, the impacts of the position sensors on the ISG performance are investigated exclusively. Three prominent position sensor candidates are studied in detail to examine their limitation and feasibility for ISG applications. Furthermore, the control related issues are discussed. The torque control of the ISG machine is implemented through vector control algorithm. Flux-weakening control is employed to achieve a wide speed range of constant-power operation. The impact of the inverter DC-link voltage variation is explored. In addition the digital control delay influence and its effective compensation strategy are addressed.

Driving Mechanism of CSR Strategy in Chinese Construction Companies based on Neo-Institutional Theory

Xiaojiang Gao-Zeller,Xiaodong Li,Fan Yang,Weina Zhu 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.5

Chinese construction companies, represented by huge Chinese construction corporations (HCCCs), have taken steps to develop their CSR (corporate social responsibility) strategy. To investigate the driving mechanisms of the CSR strategy of HCCCs, an analytical framework is proposed based on neo-institutional theory to explore how organizational legitimacy affects managerial perceptible institutional pressures and ultimately affects the development of CSR strategy. Specific scales were developed for HCCCs, and a questionnaire survey was conducted. Structural equation modelling was adopted to verify the paths proposed by the theoretical model. The results show that the expectations of the public and subcontractors/suppliers do not constitute sources of HCCCs’ organizational legitimacy. Different stakeholders have different influences on different institutional pressures. Environmental organizations have the most prominent effects. Government can reduce concerns about the CSR performance of HCCCs in society, and clients have a significant influence on the formation of institutional pressure, but employees' demands still need to be taken seriously by management. Additionally, due to the lack of regulations and norms in China, the promotion of CSR strategies relies mainly on the spontaneous demands of HCCCs. The applicability of neo-institutional theory to construction corporations is verified. The identified driving mechanisms help to effectively promote business strategy for HCCCs.

A New Orthogonal Signal Generator with DC Offset Rejection for Single-Phase Phase Locked Loops

Xiaojiang Huang,Lei Dong,Furong Xiao,Xiaozhong Liao 전력전자학회 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1

This paper presents a new orthogonal signals generator (OSG) with DC Offset rejection for implementing a phase locked loop (PLL) in single-phase grid-connected power systems. An adaptive filter (AF) based on the least mean square (LMS) algorithm is used to constitute the OSG in this study. The DC offset in the measured grid voltage signal can be significantly rejected in the developed OSG technique. This generates two pure orthogonal signals that are free from the DC offset. As a result, the DC offset rejection performance of the presented single-phase phase locked loop (SPLL) can be enhanced. A mathematical model of the developed OSG and the principle of the adaptive filter based SPLL (AF-SPLL) are presented in detail. Finally, simulation and experimental results demonstrate the feasibility of the proposed AF-SPLL.

Where Have We Got to in the Last Fifty Years? : A Review of the Process of Chinese Women's Liberation and Growth

Li Xiaojiang 숙명여자대학교 아세아여성문제연구소 1999 Asian Women Vol.9 No.-

Creating a Public Sphere : A Self-Portrait in the Women's Studies Movement of China

Li, Xiaojiang Ewha Womans University Press 1996 Asian Journal of Women's Studies(AJWS) Vol.2 No.-

This self-portait of a Chinese Marxist and feminist academic woman reflects an experienced development of the Women's Studies Movement in China, a vast public sphere under the political system that has been labeled "centralized" or even, "totalitarian." While in college, being disappointed to discover no woman visible in the disciplines of history or philosophy, she turned to women in literature. She then found a "blank in science," i.e. the lack of a women's perspective, and has tried to fill that gap through a compilation of Chinese women's history on the one hand and through the study of Marxism and western feminism on the other. Despite some pessimism and criticism of her, the more she learned about women's lives, the more she realized that a movement for women, in the form of education and research, was inevitable. The movement should be beyond Marx, who presented his own ideas on women, but not a theoretical abstraction of women, from the tradition of women being molded by the state, and also deviate from the western feminist movement. She initiated a course in women's studies as well as a consciousness-raising program for those Chines women who, with the socialist "gift" of "equality with men," refused or feared to identify themselves as women. She also helped establish the Women's Association, the first "true" NGO in China, and the Women's Studies Center at Zhengzhou University. Together with her own research and writing about women, these are central features of the Women's Studies Movement in China. The process of these developments and the "tactics" used are described in detail.

A New Orthogonal Signal Generator with DC Offset Rejection for Single-Phase Phase Locked Loops

Huang, Xiaojiang,Dong, Lei,Xiao, Furong,Liao, Xiaozhong The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.1

This paper presents a new orthogonal signals generator (OSG) with DC Offset rejection for implementing a phase locked loop (PLL) in single-phase grid-connected power systems. An adaptive filter (AF) based on the least mean square (LMS) algorithm is used to constitute the OSG in this study. The DC offset in the measured grid voltage signal can be significantly rejected in the developed OSG technique. This generates two pure orthogonal signals that are free from the DC offset. As a result, the DC offset rejection performance of the presented single-phase phase locked loop (SPLL) can be enhanced. A mathematical model of the developed OSG and the principle of the adaptive filter based SPLL (AF-SPLL) are presented in detail. Finally, simulation and experimental results demonstrate the feasibility of the proposed AF-SPLL.

On Liang Shiqiu’s Translation of The Complete Works of Shakespeare in China

Yan Xiaojiang 한국셰익스피어학회 2010 셰익스피어 비평 Vol.46 No.1

Liang Shiqiu, who spent 38 years independently in translating the complete works of Shakespeare into Chinese and who had figured prominently in promoting the communication between mainland China and Taiwan, between China and the West, and between the past and the present, may be regarded as one of the greatest translators in China. Liang’s translation choice was rational under the specified historical backgrounds and was also the interpretation of his own literary thoughts. Liang abided by such translation principles as “clear distinction”, “careful inquiry”, “learned knowledge”, “careful thinking” and “sincere behaviors”. The main purpose of his translation was to introduce foreign culture and literature to Chinese readers. Liang’s translation strategies can be summarized as “the doctrine of the mean”, which means taking foreignizing as the main focus and domestication as the supplement. The importance of Liang’s translation can be measured in quantitative terms as well as in qualitative terms. Of course there are some flaws in his translation. In general, Liang Shiqiu’s translation gives us great enlightenment in comprehension of translation criticism.

Where Have We Got to in the Last Years?

Li Xiaojiang 숙명여자대학교 아시아여성연구원 1999 Asian Women Vol.9 No.-

The determination of epidermal growth factor in Edible bird's nest by enzyme-linked immunosorbent assay

Bai Weijuan,Deng Fenghong,Zhang Xiaojiang,Zhang Xiaojiang,Xiao Yue’e,Wang Nan,Liu Xuncai,Fan Qunyan,Guo Baozhong 한국응용생명화학회 2023 Applied Biological Chemistry (Appl Biol Chem) Vol.66 No.-

Edible bird's nest (EBN) is a traditional food which was nourishing and functional. Particularly, there is the epidermal growth factor (EGF) in EBN, which is thought to play an important role in promoting skin repair. However, the type and content of EGF in EBN were not determined yet. In this study, the type of EGF in EBN was identified as bird EGF by enzyme-linked immunosorbent assay and this method was validated to be accurate and precise. Moreover, it was found that the content of EGF in raw-unclean EBN, raw-clean EBN and stewed EBN was 3000 pg/g–4000 pg/g and there were no significant differences, which suggested that the batches, origins, forms, stewing temperatures and stewing times of EBN had no effect on the content of EGF in EBN. However, it was due to that enzyme destroyed the primary structure of EGF, the EGF content of neutral protease and trypsin hydrolysates of EBN was lower than that of flavor enzymes, alkaline protease and pepsin hydrolysates of EGF. This study was the first to determine the type and content of EGF in EBN, and provided a theoretical basis for the selection and processing of EBN and using EBN as a source of EGF.