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Xiao‑Xiao Gong,Bing‑Yu Yan,Jin Hu,Cui‑Ping Yang,Yi‑Jian Li,Jin‑Ping Liu,Wen‑Bin Liao 한국유전학회 2018 Genes & Genomics Vol.40 No.11
Tropical plant rubber tree (Hevea brasiliensis) is the sole source of commercial natural rubber and low-temperature stress is the most important limiting factor for its cultivation. To characterize the gene expression profiles of H. brasiliensis under the cold stress and discover the key cold stress-induced genes. Three cDNA libraries, CT (control), LT2 (cold treatment at 4 °C for 2 h) and LT24 (cold treatment at 4 °C for 24 h) were constructed for RNA sequencing (RNA-Seq) and gene expression profiling. Quantitative real time PCR (qRT-PCR) was conducted to validate the RNA-Seq and gene differentially expression results. A total of 1457 and 2328 differentially expressed genes (DEGs) in LT2 and LT24 compared with CT were respectively detected. Most significantly enriched KEGG pathways included flavonoid biosynthesis, phenylpropanoid biosynthesis, plant hormone signal transduction, cutin, suberine and wax biosynthesis, Pentose and glucuronate interconversions, phenylalanine metabolism and starch and sucrose metabolism. A total of 239 transcription factors (TFs) were differentially expressed following 2 h or/and 24 h of cold treatment. Cold-response transcription factor families included ARR-B, B3, BES1, bHLH, C2H, CO-like, Dof, ERF, FAR1, G2-like, GRAS, GRF, HD-ZIP, HSF, LBD, MIKC-MADS, M-type MADS, MYB, MYB-related, NAC, RAV, SRS, TALE, TCP, Trihelix, WOX, WRKY, YABBY and ZF-HD. The genome-wide transcriptional response of rubber tree to the cold treatments were determined and a large number of DEGs were characterized including 239 transcription factors, providing important clues for further elucidation of the mechanisms of cold stress responses in rubber tree.
The Kinase TBK1 controls lgA class switching by negatively regulating noncanonical NF-kF dignaling
( Jin Jin ),( Yichuan Xiao ),( Jae Hoon Chang ),( Jiayi Yu ),( Hongbo Hu ),( Robyn Starr ),( George C Brittain ),( Mikyoung Chang ),( Xuhong Cheng ),( Shao Cong Sun ) 영남대학교 약품개발연구소 2013 영남대학교 약품개발연구소 연구업적집 Vol.23 No.0
Immunoglobulin class switching is crucial for the generation of antibody diversity in humoral immunity and, when deregulated, also has severe pathological consequences. How the magnitude of immunoglobulin isotype switching is controlled is still poorly understood. Here we identify thekinase TBK1 as a pivotal negative regulator of class switching to the immunoglobulin A (IgA) isotype. B cell-specific ablation of TBK1 in mice resulted in uncontrolled production of IgA and the development of nephropathy-like disease signs. TBK1 negatively regulated IgA class switchingby attenuating noncanonical signaling via the transcription factor NF-κB, an action that involved TBK1-mediated phosphorylation and subsequent degradation of the NF-κB-inducing kinase NIK. Our findings establish TBK1 as a pivotal negative regulator of the noncanonical NF-κB pathway and identify a unique mechanism that controls IgA production.
Xiao-Zheng Jin,Guang-Hong Yang 제어·로봇·시스템학회 2009 International Journal of Control, Automation, and Vol.7 No.5
: In this paper, direct adaptive-state feedback control schemes are developed to solve the robust tracking and model matching control problem for a class of distributed large scale systems with actuator faults, faulty and perturbed interconnection links, and external disturbances. The adaptation laws are proposed to update the controller parameters on-line when all the eventual faults, the upper bounds of perturbations and disturbances are assumed to be unknown. Then a class of distributed state feedback controllers is constructed to automatically compensate the fault, perturbation and disturbance effects based on the information from adaptive schemes. The proposed distributed adaptive tracking controller can ensure that the resulting adaptive closed-loop large-scale system is stable and the tracking error decreases asymptotically to zero in the presence of uncertain faults of actuators and interconnections, perturbations in interconnection channels, and disturbances. The proposed adaptive design technique is finally evaluated in the light of a simulation example.
Experimental Study on the Performance of a Bidirectional Hybrid Piezoelectric-Hydraulic Actuator
Jin, Xiao Long,Ha, Ngoc San,Li, Yong Zhe,Goo, Nam Seo,Woo, Jangmi,Ko, Han Seo,Kim, Tae Heun,Lee, Chang Seop The Korean Society for Aeronautical and Space Scie 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
The piezoelectric-hydraulic actuator is a hybrid device that consists of a hydraulic pump driven by a piezo-stack coupled to a conventional hydraulic cylinder. The actuator is of compact size, but can produce a moderate energy output. Such hybrid actuators are currently being researched and developed in many industrialized countries due to the requirement for high performance and compact flight systems. In a previous study, we designed and manufactured a unidirectional hybrid actuator. However, the blocking force was not as high as expected. Therefore, in this study, we redesigned the pump chamber and hydraulic cylinder and also improved the system by removing the air bubbles. Two different types of piezo-stacks were used. In order to achieve bidirectional capabilities in the actuator, commercial solenoid valves were used to control the direction of the output cylinder. Experimental testing of the actuator in unidirectional and bidirectional modes was performed to examine performance issues related to driving frequency, bias pressure, reed valve thickness, etc. The results showed that the maximum blocking force was measured as 970.2N when the frequency was 185Hz.
Xiao-Zheng Jin,Guang-Hong Yang,Wei-Wei Che 제어·로봇·시스템학회 2012 International Journal of Control, Automation, and Vol.10 No.6
This paper utilizes the adaptive technique to design a class of active synchronizing master-slave large scale systems against imperfect actuators and networked interconnections with bias faults and signal attenuations, respectively. Without the requirement of knowledge of eventual faulty factors of bias-actuators on systems, and attenuation factors of connected networks, an adaptive mechanism is de-signed to estimate each unknown faulty factor on-line for constructing a class of distributed adaptive controllers. Then based on the adaptive adjustment parameters and Lyapunov stability theory, Lyapunov functions are addressed to prove that the proposed adaptive master-slave large-scale system can be guaranteed to be asymptotic synchronization with the improper actuator and faulty transmitted signals. Finally, a multiple vehicle large-scale system is used to verify the efficiency of the method.
Functional Components and Antioxidant Effects of Colored Onions
Xiao Nan Yang,Enning Xu,Mi Jin Park,In Jong Ha,Jin Seong Moon,Young-Hwa Kang 경북대학교 농업생명과학대학 2015 Current Research on Agriculture and Life Sciences Vol.33 No.2
The antioxidant capacities, total phenolic contents (TPC), and total quercetin contents (TQC) of a red (Chenjujuck), a yellow (Sunpower), and a white (Grasier) onion cultivar were determined in this study. Onion was separated into edible portion and dry skin. In the case of edible portion, the yellow onion had the highest antioxidant activity, followed by the red onion. The white onion showed neither antioxidant activity nor quercetin compounds. On the other hand, the dry skin of the red onion showed higher antioxidant activity than yellow onion skin. The white onion skin had slight antioxidant activity, low TPC, and no quercetin compounds. In addition, the flavonoid compounds of the edible portion and dry skins of these colored onions were analyzed by UFLC(ultra-fast liquid chromatography). The major compounds were quercetin 3,4-diglucoside and quercetin 4- glucoside in yellow and red onion edible portion, whereas the major compounds in yellow and red onion skins were quercetin 4- glucoside, quercetin, and quercetin 3,4-diglucoside.
Xiao, Juan,Zhang, Tao,Xu, Daichao,Wang, Huibing,Cai, Yu,Jin, Taijie,Liu, Min,Jin, Mingzhi,Wu, Kejia,Yuan, Junying Cold Spring Harbor Laboratory Press 2015 Genes & development Vol.29 No.2
<P>Vps34, the catalytic subunit in the class III phosphatidylinositol 3 kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy and receptor degradation. Xiao et al. show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34. This provides a signal to promote Vps34 ubiquitination and proteasomal degradation mediated by FBXL20, leading to inhibition of autophagy and receptor endocytosis. Importantly, they also find that expression of FBXL20 is regulated by p53-dependent transcription.</P><P>Vacuolar protein-sorting 34 (Vps34), the catalytic subunit in the class III PtdIns3 (phosphatidylinositol 3) kinase complexes, mediates the production of PtdIns3P, a key intracellular lipid involved in regulating autophagy and receptor degradation. However, the signal transduction pathways by which extracellular signals regulate Vps34 complexes and the downstream cellular mechanisms are not well understood. Here we show that DNA damage-activated mitotic arrest and CDK activation lead to the phosphorylation of Vps34, which provides a signal to promote its ubiquitination and proteasomal degradation mediated by FBXL20 (an F-box protein) and the associated Skp1 (S-phase kinase-associated protein-1)–Cullin1 complex, leading to inhibition of autophagy and receptor endocytosis. Furthermore, we show that the expression of FBXL20 is regulated by p53-dependent transcription. Our study provides a molecular pathway by which DNA damage regulates Vps34 complexes and its downstream mechanisms, including autophagy and receptor endocytosis, through SCF (Skp1–Cul1–F-box)-mediated ubiquitination and degradation. Since the expression of FBXL20 is regulated by p53-dependent transcription, the control of Vps34 ubiquitination and proteasomal degradation by FBXL20 and the associated SCF complex expression provides a novel checkpoint for p53 to regulate autophagy and receptor degradation in DNA damage response.</P>
Experimental Study on the Performance of a Bidirectional Hybrid Piezoelectric-Hydraulic Actuator
Xiao Long Jin,Ngoc San Ha,Yong Zhe Li,Nam Seo Goo,Jangmi Woo,Han Seo Ko,Tae Heun Kim,Chang Seop Lee 한국항공우주학회 2015 International Journal of Aeronautical and Space Sc Vol.16 No.4
The piezoelectric-hydraulic actuator is a hybrid device that consists of a hydraulic pump driven by a piezo-stack coupled to a conventional hydraulic cylinder. The actuator is of compact size, but can produce a moderate energy output. Such hybrid actuators are currently being researched and developed in many industrialized countries due to the requirement for high performance and compact flight systems. In a previous study, we designed and manufactured a unidirectional hybrid actuator. However, the blocking force was not as high as expected. Therefore, in this study, we redesigned the pump chamber and hydraulic cylinder and also improved the system by removing the air bubbles. Two different types of piezo-stacks were used. In order to achieve bidirectional capabilities in the actuator, commercial solenoid valves were used to control the direction of the output cylinder. Experimental testing of the actuator in unidirectional and bidirectional modes was performed to examine performance issues related to driving frequency, bias pressure, reed valve thickness, etc. The results showed that the maximum blocking force was measured as 970.2N when the frequency was 185Hz.
( Jin Xiao ),( Jun Jun Ma ),( Zhen Huang ),( Xinq I Qiao ) 한국액체미립화학회 2005 한국액체미립화학회 학술강연회 논문집 Vol.2005 No.-
Injection of fuel containing CO2 involves dissolving the gas into fuel prior to injection, which has potential to reduce the NOx and soot emissions in diesel engine. This paper presents an experimental study on the flash boiling and atomization process of transient spray of fuel containing CO2 spray by means of high speed imaging technology. Experiments were performed under atmospheric conditions on a diesel hole-type nozzle. The effect of injection pressure on the flash boiling and atomization process were evaluated, especially in the early stage of injection. The transient characteristics of the spray, such as spray-angle and spray tip penetration were also investigated. The images clearly display the developing process of flashing boiling spray . Experimental results show that fuel atomization will improve greatly when the concentration of dissolved CO2 in the fuel is larger enough. New insight into the flash boiling and atomization process of the fuel containing CO2 spray was obtained and possible mechanism to explain the phenomena was proposed.