Augmenter of Liver Regeneration Alleviates Renal Hypoxia-Reoxygenation Injury by Regulating Mitochondrial Dynamics in Renal Tubular Epithelial Cells

Xiao-hui Liao,Rui-ting Long,Jun-bo Peng,Li-li Huang,Gui-ping Jiang,Yue-juan Liao,Hang Sun,Yu-dong Hu 한국분자세포생물학회 2019 Molecules and cells Vol.42 No.12

Mitochondria are highly dynamic organelles that constantly undergo fission and fusion processes that closely related to their function. Disruption of mitochondrial dynamics has been demonstrated in acute kidney injury (AKI), which could eventually result in cell injury and death. Previously, we reported that augmenter of liver regeneration (ALR) alleviates renal tubular epithelial cell injury. Here, we gained further insights into whether the renoprotective roles of ALR are associated with mitochondrial dynamics. Changes in mitochondrial dynamics were examined in experimental models of renal ischemia-reperfusion (IR). In a model of hypoxia-reoxygenation (HR) injury in vitro, dynamin-related protein 1 (Drp1) and mitochondrial fission process protein 1 (MTFP1), two key proteins of mitochondrial fission, were downregulated in the Lv-ALR + HR group. ALR overexpression additionally had an impact on phosphorylation of Drp1 Ser637 during AKI. The inner membrane fusion protein, Optic Atrophy 1 (OPA1), was significantly increased whereas levels of outer membrane fusion proteins Mitofusin-1 and -2 (Mfn1, Mfn2) were not affected in the Lv-ALR + HR group, compared with the control group. Furthermore, the mTOR/4E-BP1 signaling pathway was highly activated in the Lv-ALR + HR group. ALR overexpression led to suppression of HR-induced apoptosis. Our collective findings indicate that ALR gene transfection alleviates mitochondrial injury, possibly through inhibiting fission and promoting fusion of the mitochondrial inner membrane, both of which contribute to reduction of HK-2 cell apoptosis. Additionally, fission processes are potentially mediated by promoting tubular cell survival through activating the mTOR/4E-BP1 signaling pathway.

Intraday Pattern in Bid-Ask Spreads and Its Power-Law Relaxation for Chinese A-Share Stocks

Xiao-Hui Ni,Wei-Xing Zhou 한국물리학회 2009 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.54 No.2

We use high-frequency data of 1364 Chinese A-share stocks traded on the Shanghai Stock Exchange and Shenzhen Stock Exchange to investigate the intraday patterns in the bid-ask spreads. The daily periodicity in the spread time series is confirmed by using a Lomb analysis and the intraday bid-ask spreads are found to exhibit an L-shaped pattern with an idiosyncratic fine structure. The intraday spread of individual stocks relaxes as a power law within the first hour of the continuous double auction from 9:30 AM to 10:30 AM with exponents βSHSE = 0.19 0.067 for the Shanghai market and βSZSE = 0.18 0.069 for the Shenzhen market. The power-law relaxation exponent β of individual stocks is roughly normally distributed. There is evidence showing that the accumulation of information widening the spread is an endogenous process.

Impact of spoiled constituent proportion in food waste on biochemical methane potential

( Xiao Hui Liu ),( Jae Young Kim ) 한국폐기물자원순환학회 2017 젊은 연구자 학술연구발표회 Vol.15 No.0

Canonical Transient Receptor Potential Channels and Their Link with Cardio/Cerebro-Vascular Diseases

Xiao, Xiong,Liu, Hui-Xia,Shen, Kuo,Cao, Wei,Li, Xiao-Qiang The Korean Society of Applied Pharmacology 2017 Biomolecules & Therapeutics(구 응용약물학회지) Vol.25 No.5

The canonical transient receptor potential channels (TRPCs) constitute a series of nonselective cation channels with variable degrees of $Ca^{2+}$ selectivity. TRPCs consist of seven mammalian members, TRPC1, TRPC2, TRPC3, TRPC4, TRPC5, TRPC6, and TRPC7, which are further divided into four subtypes, TRPC1, TRPC2, TRPC4/5, and TRPC3/6/7. These channels take charge of various essential cell functions such as contraction, relaxation, proliferation, and dysfunction. This review, organized into seven main sections, will provide an overview of current knowledge about the underlying pathogenesis of TRPCs in cardio/cerebro-vascular diseases, including hypertension, pulmonary arterial hypertension, cardiac hypertrophy, atherosclerosis, arrhythmia, and cerebrovascular ischemia reperfusion injury. Collectively, TRPCs could become a group of drug targets with important physiological functions for the therapy of human cardio/cerebro-vascular diseases.

The Exploration of Jiang Wen’s Artistic Style of Film

Xiao Hui(초혜) 한국엔터테인먼트산업학회 2016 한국엔터테인먼트산업학회논문지 Vol.10 No.5

강문은 낭만주의 재능을 가진 매력적인 감독이다. 그의 영화 작품은 독특한 예술풍격을 가지고 있다. 우리나라 영화 발전에 대한 촉진 작용이 크다고 생각한다. 주요 작품은 <햇빛 찬란한 날> <그놈들이 온다> <태양은 다시 떠오른다> <총알이 날고있다> 4부작 영화를 중심으로 정하였다. 그의 영화작품은 독특한 예술풍격을 탐색하고자 한다. 즉, 원초적인 욕망을 추구하고 개성적인 우울한 유머, 낭만적이고 독특한 표현, 강력한 시각충격, 특별한 청각체험, 그리고 강문의 성장경력, 학습실천과 개인의 예술추구, 세 가지 방면으로 강문의 영화풍격 형성된 원인을 분석한다. 그리고, “강시 영화”의 예술풍격은 중국영화산업에게 중요한 작용을 하고 있다. Jiang Wen is a director who is quite romantic and charming. With his unique artistic style, his Films play an important role to the development of Chinese film industry. This article takes his four films (In the Heat of the Sun, Devils on the Door, The Sun Also Rises and Let the Bullets Fly ) as the research objects. The writer explores Jiang Wen’s artistic characters by analyzing the four films, in which we can see his special style of art are: primitive desire, personality of black humor, exotic romantic performance, strong visual impact and unconventional auditory perception. This article analyses the reasons of this special art style emerged in Jiang Wen’s films which are from his growth experience, learning practice and pursuit of art. This paper shows us the great importance of Jiang’s film style to Chinese film industry.

Analysis and Prediction of Regional Land Subsidence with InSAR Technology and Machine Learning Algorithm

Hui Wang,Chao Jia,Pengpeng Ding,Keyin Feng,Xiao Yang,Xiao Zhu 대한토목학회 2023 KSCE Journal of Civil Engineering Vol.27 No.2

As a worldwide environmental and geological disaster, land subsidence may cause serious harm to urban development. Therefore, the prediction of land subsidence is a key scientific problem. Decheng county, Shandong Province in China is taken as the research object. Based on BP neural network (BPNN) and random forest (RF) method, the analysis and prediction of regional land subsidence are carried out by applying multi-source monitoring data, Geographic Information System (GIS), and machine learning algorithm. Combined with Short Baseline Synthetic Aperture Interferometric Radar (SBAS-InSAR) and GIS technology, the spatio-temporal evolution characteristics of land subsidence from 2017 to 2020 are analyzed. The impact of different groundwater levels on land subsidence is quantitatively analyzed by BPNN and RF algorithm. The real-time prediction model of regional land subsidence is established. The results show that: 1) The area with the most serious land subsidence is located in Songguantun town, the maximum annual average subsidence rate is -40.71 mm/yr. 2) Land subsidence is mainly affected by deep groundwater and shallow groundwater in the research area. 3) The accuracy of the prediction results of the BPNN model is higher than that of the RF model when groundwater level change is used to predict land subsidence.

Influence of different fatigue loads and coating thicknesses on service performance of RC beam specimens with epoxy-coated reinforcement

Xiao-Hui Wang,Yang Gao,Run-Dong Gao,Jing Wang,Xi-La Liu 사단법인 한국계산역학회 2017 Computers and Concrete, An International Journal Vol.19 No.3

Epoxy-coated reinforcing bars are widely used to protect the corrosion of the reinforcing bars in the RC elements under their in-service environments and external loads. In most field surveys, it was reported that the corrosion resistance of the epoxy-coated reinforcing bars is typically better than the uncoated bars. However, from the experimental tests conducted in the labs, it was reported that, under the same loads, the RC elements with epoxy-coated reinforcing bars had wider cracks than the elements reinforced with the ordinary bars. Although this conclusion may be true considering the bond reduction of the reinforcing bar due to the epoxy coating, the maximum service loads used in the experimental research may be a main reason. To answer these two phenomena, service performance of 15 RC beam specimens with uncoated and epoxy-coated reinforcements under different fatigue loads was experimentally studied. Influences of different coating thicknesses of the reinforcing bars, the fatigue load range and load upper limit as well as fatigue load cycles on the mechanical performance of RC test specimens are discussed. It is concluded that, for the test specimens subjected to the comparatively lower load range and load upper limit, adverse effect on the service performance of test specimens with thicker epoxy-coated reinforcing bars is negligible. With the increments of the coating thickness and the in-service loading level, i.e., fatigue load range, load upper limit and fatigue cycles, the adverse factor resulting from the thicker coating becomes noticeable.

Copy Detection Technique with Enhanced Efficiency by using Substring Comparison Algorithm

Xiao-hui Cheng,Meng Hu,Tong Wang,Yun Deng 보안공학연구지원센터 2016 International Journal of Security and Its Applicat Vol.10 No.12

As the information was being overloaded from time to time, a significant technique should be accomplished by several search engines that exists will use from the databases to eradicate the replicas of data which was available in articles and to present the outcomes of the search to users in terms of percentage of the amount of the data copied from the original file. Plagiarism is the process of bestowing one’s creative ideas as our individual conception. It is does not meant that anybody cannot use other’s considerations or workings, anybody can use their data by giving the actual credit the original users by stating their names in literature or in references and also by giving special note on acknowledgements. Copying the content of the others work is mainly considered to be a big crime in terms of research and in terms of the owning the idea of the others. The main idea of this work is to identify the extent of the data that was being copied or to identify the amount of data that was being copied from other peoples work or their own credited work. Performance of plagiarizing a document is not limited to word files or pdf files, it is possible to plagiarize even images and other files too. Hence, we were focused on finding the plagiarism in word files which includes academics and research articles.

A Collaborative Filtering Recommendation Algorithm Fusing Rating and Time Interval Similarity on Item Attributes

Xiao-hui Cheng,Yu Wu,Yun Deng 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.12

Traditional methods UBCF have limitations of poor recommendation quality and problems of data sparsity. To alleviate these problems, a novel collaborative filtering algorithm is designed, which firstly get the users’ ratings and time intervals for each attribute from the users’ ratings for items, then produce two methods to calculate the similarity between users, introduce a weighting parameters to control the weight between the two similarity methods in order to get a fusion similarity between two users. The results show that this method is able to improve the accuracy of predicted values, resulting in improving recommendation quality of the collaborative filtering recommendation algorithm.

Relationship Between Expression of Gastrokine 1 and Clinicopathological Characteristics in Gastric Cancer Patients

Xiao, Jiang-Wei,Chen, Jia-Hui,Ren, Ming-Yang,Tian, Xiao-Bing,Wang, Chong-Shu Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.11

The aim of the study was to clarify the role of gastrokine 1 in the process of formation and development of gastric cancer. The expression of gastrokine 1 in gastric cancer and corresponding non-cancerous gastric tissues of 52 gastric cancer patients was assessed with the real-time fluorescence quantitative polymerase chain reaction (RT-PCR) and immunohistochemistry. We also analyzed the relationship between the expression level and clinicopathological characteristics. Gastrokine 1 gene and protein expression in gastric cancer tissues was in both cases significantly lower than in corresponding non-cancerous gastric tissues (both P<0.01), but no significant relationship was found with clinicopathological parameters including tumor location, depth of invasion, differentiation, lymph node metastasis, stage, gender, age and carcinoembryonic antigen (CEA), and carbohydrate antigen 19-9 (CA19-9) level in peripheral blood preoperation of patients (P>0.05, respectively). Furthermore, gastrokine 1 gene expression was markedly lower in gastric cancer tissues of Helicobacter pylori (HP)-positive patients than negative ones (P<0.05). The result of the study showed that gastrokine 1 might play a significant role in the process of formation and development of gastric cancer as an anti-oncogene. Its effect might be weakened by HP infection.