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재한 중국인 유학생의 문화적응 스트레스가 심리적 안녕감과 학업적응에 미치는 영향
Xiao XiaoLi(XiaoLi Xiao),안도희(Doehee Ahn) 중앙대학교 한국교육문제연구소 2016 한국교육문제연구 Vol.34 No.3
본 연구에서는 재한 중국인 유학생들을 대상으로 문화적응 스트레스가 심리적 안녕감과 학업적응에 미치는 직·간접효과와 이들 변인들에서 중국인 유학생의 교우관계 유형에 따른 두 집단(한국인 친구 다수집단, 중국인 친구 다수 집단) 간 차이가 있는지에 대해 탐색하고자 하였다. 본 연구의 최종분석 대상은 한국에 소재한 17개 대학교에서 유학 중인 중국인 유학생 총 363명이었다. 본 연구 결과, 문화 적응 스트레스는 심리적 안녕감과 학업적응에 직·간접적으로 부정적인 영향을 미치는 것으로 나타났 다. 또한, 한국인 친구 다수 집단은 중국인 친구 다수 집단에 비해 문화적응 스트레스가 낮으며 심리 적 안녕감 및 학업적응이 높은 것으로 나타났다. 이에, 재한 중국인 유학생의 보다 나은 학업적응을 위해 이들의 심리적 안녕감을 증진시키고, 이들의 문화적응 스트레스를 완화시킬 필요가 있다. 또한, 이들의 심리적 안녕감 증진을 위해 문화적응 스트레스 완화방안을 강구할 필요가 있는 것으로 판단된다. This study examined the direct and indirect influences of Chinese international students’ acculturative stress on psychological well-being and academic adjustment in Korea. The final sample consisted of 363 Chinese international students surveyed from 17 universities in Korea. Findings showed that Chinese international students with more Korean friends had less acculturative stress (i.e., perceived discrimination, homesickness, perceived hate, guilt, and miscellaneous), psychological well-being (i.e, self-acceptance, positive relations with others, autonomy, environment mastery, purpose in life, personal growth) and higher academic adjustment (i.e, motivation, application, performance and academic environment) than those with more Chinese friends. Moreover, it was found that acculturative stress had a direct negative effect on both psychological well-being and academic adjustment. Also, acculturative stress had a indirect negative effect on academic adjustment. Results are discussed in relation to theoretical implications in school settings.
Youmei Xiao,Zhanxue Xu,Yuan Cheng,Rufan Huang,Yuan Xie,Hsiang‑i Tsai,Hualian Zha,Lifang Xi,Kai Wang,Xiaoli Cheng,Yanfeng Gao,Changhua Zhang,Fang Cheng,Hongbo Chen 한국생체재료학회 2023 생체재료학회지 Vol.27 No.00
Background Ferroptosis, iron-dependent cell death, is an established mechanism for cancer suppression, particularly in hepatocellular carcinoma (HCC). Sorafenib (SOR), a frontline drug for the treatment of HCC, induces ferroptosis by inhibiting the Solute Carrier family 7 member 11 (SLC7A11), with inadequate ferroptosis notably contributing to SOR resistance in tumor cells. Methods To further verify the biological targets associated with ferroptosis in HCC, an analysis of the Cancer Genome Atlas (TCGA) database was performed to find a significant co-upregulation of SLC7A11 and transferrin receptor (TFRC), Herein, cell membrane-derived transferrin nanovesicles (TF NVs) coupled with Fe3+ and encapsulated SOR (SOR@TF-Fe3+ NVs) were established to synergistically promote ferroptosis, which promoted the iron transport metabolism by TFRC/TF-Fe3+ and enhanced SOR efficacy by inhibiting the SLC7A11. Results In vivo and in vitro experiments revealed that SOR@TF-Fe3+ NVs predominantly accumulate in the liver, and specifically targeted HCC cells overexpressing TFRC. Various tests demonstrated SOR@TF-Fe3+ NVs accelerated Fe3+ absorption and transformation in HCC cells. Importantly, SOR@TF-Fe3+ NVs were more effective in promoting the accumulation of lipid peroxides (LPO), inhibiting tumor proliferation, and prolonging survival rates in HCC mouse model than SOR and TF- Fe3+ NVs alone. Conclusions The present work provides a promising therapeutic strategy for the targeted treatment of HCC.
Jing Xiao,Xiaoli Zhang,Chensheng Fu,Qingmei Yang,Ying Xie,Zhenxing Zhang,Zhibin Ye 생화학분자생물학회 2018 Experimental and molecular medicine Vol.50 No.-
Hyperuricemia contributes to renal inflammation. We aimed to investigate the role of Na+–K+–ATPase (NKA) in hyperuricemiainduced renal tubular injury. Human primary proximal tubular epithelial cells (PTECs) were incubated with uric acid (UA) at increasing doses or for increasing lengths of time. PTECs were then stimulated by pre-incubation with an NKA α1 expression vector or small interfering RNA before UA (100 μg ml−1, 48 h) stimulation. Hyperuricemic rats were induced by gastric oxonic acid and treated with febuxostat (Feb). ATP levels, the activity of NKA and expression of its α1 subunit, Src, NOD-like receptor pyrin domain-containing protein 3 (NLRP3) and interleukin 1β (IL-1β) were measured both in vitro and in vivo. Beginning at concentrations of 100 μg ml−1, UA started to dose-dependently reduce NKA activity. UA at a concentration of 100 μg ml−1 time-dependently affected the NKA activity, with the maximal increased NKA activity at 24 h, but the activity started to decrease after 48 h. This inhibitory effect of UA on NKA activity at 48 h was in addition to a decrease in NKA α1 expression in the cell membrane, but an increase in lysosomes. This process also involved the subsequent activation of Src kinase and NLRP3, promoting IL-1β processing. In hyperuricemic rats, renal cortex NKA activity and its α1 expression were upregulated at the 7th week and both decreased at the 10th week, accompanied with increased renal cortex expression of Src, NLRP3 and IL-1β. The UA levels were reduced and renal tubular injuries in hyperuricemic rats were alleviated in the Feb group. Our data suggested that the impairment of NKA and its consequent regulation of Src, NLRP3 and IL-1β in the renal proximal tubule contributed to hyperuricemia-induced renal tubular injury.
Zhixiang Xiao,Cai Yao,Xiaoli Luo,Hongmei Sun 한국기상학회 2021 Asia-Pacific Journal of Atmospheric Sciences Vol.57 No.3
The offshore intensificationmechanisms of Supertyphoon Rammasun (2014) and Typhoon Rumbia (2013) are analyzed and compared based on the best track typhoon data provided by the Shanghai Typhoon Institute of China Meteorological Administration (STI/CMA), ECMWF (CMA and JMA) objective (subjective) predicted typhoon track and intensity, and reanalysis data of the National Centers for Environmental Prediction/National Center for Atmospheric Research (NCEP/NCAR). Results show that the offshore sea surface temperature over 28 °C was conducive to the intensification of the two typhoons in the coastal area prior to their landfall in South China. Rammasun was embedded in an extremely active phase of a 10–20-day oscillation in the summer monsoon over the South China Sea and western North Pacific prior to its landfall. The low-level jet transported warm and moist air to the inner core of Rammasun and the deepening of the southwesterly monsoon flow up to 200 hPa reduced vertical wind shear, both favorable for the offshore rapid intensification of Rammasun. In 2013, the summer monsoon over the South China Sea and western North Pacific experienced quasi-20-day and quasi-10-day oscillations. The out of phase of the two oscillations resulted in relatively weak tropical and subtropical summer monsoon flow prior to the landfall of Rumbia. As a result, the low-level monsoon flow transported relatively less moist air into Rumbia, and the shallow monsoon flow was not conducive to the weakening of vertical wind shear, resulting in a less rapid offshore intensification of Rumbia than Rammasun.
Jing Xiao,Sibo Zhu,Haochen Guan,Haochen Guan,Fengqin Li,Xiaoli Zhang,Hui Guo,Xiaojun Wang,Zhibin Ye 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
One of the mechanisms in hyperuricemia (HUA)-induced renal tubular injury is the impairment of Na+-K+-ATPase (NKA) signaling, which further triggers inflammation, autophagy, and mitochondrial dysfunction and leads to cell injury. Here, we used RNA sequencing to screen the most likely regulators of NKA signaling and found that the liver kinase B1(LKB1)/adenosine monophosphate (AMP)-activated protein kinase (AMPK)/ mammalian target of rapamycin (mTOR) pathway was the most abundantly enriched pathway in HUA. AMPK is a key regulator of cell energy metabolism; hence, we examined the effect of AMPK on HUA-induced dysregulation of NKA signaling and cell injury. We first detected AMPK activation in high uric acid (UA)-stimulated proximal tubular epithelial cells (PTECs). We further found that sustained treatment with the AMPK activator 5-aminoimidazole-4-carboxamide 1-β-d-ribofuranoside (AICAR), but not the AMPK inhibitor Compound C, significantly alleviated UA-induced reductions in NKA activity and NKA α1 subunit expression on the cell membrane by reducing NKA degradation in lysosomes; sustained AICAR treatment also significantly alleviated activation of the NKA downstream molecules Src and interleukin-1β (IL-1β) in PTECs. AICAR further alleviated high UA-induced apoptosis, autophagy, and mitochondrial dysfunction. Although AMPK activation by metformin did not reduce serum UA levels in hyperuricemic rats, it significantly alleviated HUAinduced renal tubular injury and NKA signaling impairment in vivo with effects similar to those of febuxostat. Our study suggests that AMPK activation may temporarily compensate for HUA-induced renal injury. Sustained AMPK activation could reduce lysosomal NKA degradation and maintain NKA function, thus alleviating NKA downstream inflammation and protecting tubular cells from high UA-induced renal tubular injury.
Assembly tightness detection of bolt connections using gray-level images with high-order cumulants
Yong Xia,Xiaoli Zhang,Qiang Yan,Yong Xiao 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.10
Bolt connections are widely used in aero-engine rotors and gas turbines because of their load-transferring and detachable characteristics. However, bolts are prone to looseness due to the influence of fatigue, shock, and thermal loads, which decreases the reliability of the bolted connection structure. Therefore, detecting the assembly tightness of bolted connections is critical to ensure structural integrity during the assembly phase. A high-order cumulant-gray-level image feature (HOC-GLI) method is proposed to detect the assembly tightness of bolt connections. The core of this new method is to obtain high-order cumulant images of vibration signals to eliminate noise and reserve rich nonlinear information. The amplitude distribution of the third-order cumulant reflects the energy distribution of the vibration signal in 3D images. Then, the third-order cumulant 3D images are converted to 2D gray-level images to extract the texture feature. Finally, the root entropy index of the normalized gray-level cooccurrence matrix (GLCM) based on gray-level images is used to indicate the complexity of image information. Experimental studies on six bolt connection states of the aero-engine rotor are conducted. The relationship between the root entropy index and bolted connection status is obtained to verify the effectiveness of the proposed method for assembly tightness detection in different bolt connection statuses. The result shows that the root entropy index has a decreasing trend with the loosening of the bolts, which can quantitatively detect the assembly tightness of the bolt connection structure.
Song Zejun,Xiao Longhai,Guo Xiaolan,Zhu Yunzheng,An Xiaoli,Tan Yi,Zhang Xinyu,Wang Delu 한국원예학회 2024 Horticulture, Environment, and Biotechnology Vol.65 No.1
The aim of this study was to explore the eff ects of inoculating with diff erent fungi on the structural characteristics of soil fungal communities and the nutrient absorption of blueberry plants. The fungi DSE ( Phialocephala fortinii ), SS ( Penicillium pinophilum ), ZB ( Cladosporium cladosporioides ), QMK ( Chaetomium globosum ), and LZ ( Schizophyllum commune ) were selected for this study. The soil fungal diversity and community structure in the blueberry rhizosphere were compared after inoculation with these diff erent mycorrhizal fungi. The fungal diversity in the blueberry rhizosphere soil was signifi cantly higher after inoculation with DSE, QMK, and ZB than after inoculation with SS and LZ. The dominant class, order, family, and genus of soil fungi were Eurotiomycetes (25.49–36.91%), Eurotiales (24.78–35.00%), Aspergillaceae (24.47–34.74%), and Penicllium (24.34–34.63%), respectively. Among all the fungal treatments, DSE led to the highest abundance of dominant classes, orders, families, and genera. Inoculation with SS, LZ, and DSE increased the contents of nitrogen, phosphorus, and potassium in blueberry plants. The uptake of nitrogen, phosphorus, and potassium were highest in DSE-inoculated plants. The nitrogen content was signifi cantly higher in ZB-inoculated plants than in the control. A TOPSIS analysis showed that among the fi ve fungi, DSE was the best strain to improve the diversity of the blueberry rhizosphere fungal community and promote nutrient uptake by blueberry plants, followed by LZ and ZB. These fi ndings provide scientifi c data for the develop ment and utilization of soil microbial resources, and provide useful information for improving the cultivation and production of blueberries.
Zhili Cui,Shiming Xiao,Xianli Luob,Yunxuan Liu,Ming Liu,Yuyun Zeng,Xiaoli Zhong,Hong Zheng,Haifeng Guo 한양대학교 청정에너지연구소 2023 Journal of Ceramic Processing Research Vol.24 No.5
In this paper, cheap mineral materials were used as the base materials of lightweight porous ceramics prepared through foamimpregnation method. The effect of the sintering temperature on the properties of the prepared porous ceramics was studied. The porous ceramic was mainly composed of amorphous silicon oxide, crystalline cordierite and mullite phases, and a smallamount of alumina phase. As the sintering temperature increased, the porosity of porous ceramics gradually decreased from94% to 92%, and the bulk density increased from 0.173 gcm-3 at 1100 ℃ to 0.194 gcm-3 at 1200 ℃. The best sinteringtemperature was 1180 ℃. The porosity of the porous ceramics sintered at 1180 ℃ was 92.14%, the volume weight was 0.189gcm-3, the shrinkage rate was 15.80%, the compressive strength was 0.79 MPa, and the thermal conductivity was 0.295 Wm-1k-1. The lightweight porous ceramic has high porosity, low density and good thermal insulation, as well as low cost, having greatpotential for application in fields such as thermal insulation, adsorption, and environmental protection.
Hongzhe Shi,Wen Zhang,Xingang Bi,Dong Wang,Zejun Xiao,Youyan Guan,Kaopeng Guan,Jun Tian,Hongsong Bai,Linjun Hu,Chuanzhen Cao,Weixing Jiang,Zhilong Hu,Jin Zhang,Yan Chen,Shan Zheng,Xiaoli Feng,Changlin 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose Reduced quality of life after cystectomy has made bladder preservation a popular research topic for muscle-invasive bladder cancer (MIBC). Previous research has indicated significant tumor downstaging after neoadjuvant chemotherapy (NAC). However, maximal transurethral resection of bladder tumor (TURBT) was performed before NAC to define the pathology, impacting the real evaluation of NAC. This research aimed to assess real NAC efficacy without interference from TURBT and apply combined modality therapies guided by NAC efficacy. Materials and Methods Patients with cT2-4aN0M0 MIBC were confirmed by cystoscopic biopsy and imaging. NAC efficacy was assessed by imaging, urine cytology, and cystoscopy with multidisciplinary team discussion. Definite responders (≤ T1) underwent TURBT plus concurrent chemoradiotherapy. Incomplete responders underwent radical cystectomy or partial cystectomy if feasible. The primary endpoint was the bladder preservation rate. Results Fifty-nine patients were enrolled, and the median age was 63 years. Patients with cT3-4 accounted for 75%. The median number of NAC cycles was three. Definite responders were 52.5%. The complete response (CR) was 10.2%, and 59.3% of patients received bladder-sparing treatments. With a median follow-up of 44.6 months, the 3-year overall survival (OS) was 72.8%. Three-year OS and relapse-free survival were 88.4% and 60.0% in the bladder-sparing group but only 74.3% and 37.5% in the cystectomy group. The evaluations of preserved bladder function were satisfactory. Conclusion After stratifying MIBC patients by NAC efficacy, definite responders achieved a satisfactory bladder-sparing rate, prognosis, and bladder function. The CR rate reflected the real NAC efficacy for MIBC. This therapy is worth verifying through multicenter research.